Julien Delarocque

Julien Delarocque
University of Veterinary Medicine Hannover | TiHo · Klinik für Pferde

PhD

About

32
Publications
8,554
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
64
Citations

Publications

Publications (32)
Article
More than 70 million people worldwide are still infected with the hepatitisCvirus30yearsafteritsdiscovery,underscoringtheneedforavaccine.Todevelopaneffective prophylactic vaccine, detailed knowledge of the correlates of protection and an immunocompetent surrogate model are needed. In this study, we describe the minimum dose required for robust equi...
Article
Full-text available
Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine studies was investigated, while equine host responses following vaccination with EqHV E2 recombinant pr...
Article
Full-text available
The aim of this prospective clinical trial was to compare the influence of butorphanol, buprenorphine and levomethadone on sedation quality and postoperative analgesia in horses undergoing cheek tooth extraction. Fifty horses were assigned to three groups prior to oral cheek tooth extraction. Horses were treated with acepromazine, followed by a det...
Article
Full-text available
High-definition oscillometry (HDO) over the metatarsal artery (MA) in anaesthetised horses has not yet been evaluated. This study aimed to assess agreement between HDO and invasive blood pressure (IBP) at the metatarsal artery, and to evaluate compliance with the American College of Veterinary Internal Medicine (ACVIM) consensus guidelines. In this...
Article
Full-text available
The naturally occurring betulinic acid (BA) and its derivative NVX-207 induce apoptosis in equine melanoma cells in vitro. After topical application, high concentrations of the substances can be reached in healthy equine skin. With the aim to investigate the effect and safety of topically applied BA and NVX-207 in horses with melanocytic tumors, th...
Article
Full-text available
Background. Insulin dysregulation (ID) is an equine endocrine disorder, which is often accompanied by obesity and various metabolic perturbations. The relationship between weight variations and fluctuations of the insulin response to oral glucose tests (OGT) as well as the metabolic impact of ID have been described previously. The present study see...
Article
Full-text available
Background: Insulin dysregulation (ID) is a key risk factor for equine endocrinopathic laminitis, but in many cases ID can only be assessed accurately using dynamic tests. The identification of other biomarkers could provide an alternative or adjunct diagnostic method, to allow early intervention before laminitis develops. The present study charact...
Article
Full-text available
Background: Little is known about the implications of hyperinsulinemia on energy metabolism, and such knowledge might help understand the pathophysiology of insulin dysregulation. Objectives: Describe differences in the metabolic response to an oral glucose test, depending on the magnitude of the insulin response. Animals: Twelve Icelandic horses...
Article
Full-text available
Equine sarcoid (ES) is the most prevalent skin tumor in equids worldwide. Additionally, aging grey horses frequently suffer from equine malignant melanoma (EMM). Current local therapies targeting these skin tumors remain challenging. Therefore, more feasible topical treatment options should be considered. In order to develop a topical therapy again...
Conference Paper
Insulin Dysregulation (ID) encompasses different disorders like hyperinsulinemia and insulin resistance. The aim of this study was to determine if ID is associated with altered expression of key proteins of the insulin signaling cascade (ISC) in liver tissue under basal and/or stimulated conditions. Twelve Icelandic horses were subjected to an Oral...
Article
Full-text available
Background: Insulin dysregulation (ID) goes along with lasting or transient hyperinsulinemia able to trigger equine laminitis, a painful and crippling foot condition. Promoting weight loss through dietary changes and physical activity is currently the main option to prevent this disease. This study aimed at describing the relationship between weig...
Article
Full-text available
Background: Equine malignant melanoma (EMM) is a frequently occurring dermoepidermal tumor in grey horses. Currently available therapies are either challenging or inefficient. Betulinic acid (BA), a naturally occurring triterpenoid, is a promising compound for cancer treatment. To evaluate the potential of BA as a topical therapy for EMM, its anti...
Conference Paper
Hintergrund: Die Insulindysregulation bei Pferden geht oftmals mit einerperipheren Insulinresistenz einher, die mit einem Insulinstimulationstest (IST)diagnostiziert werden kann. Bei Verwendung von rekombinantem Human-insulin (RHI) sollte hierbei eine 50%ige Reduktion der initialen Glukosekon-zentration im Blut innerhalb von 30 Minuten erreicht wer...
Conference Paper
Insulin dysregulated (ID) horses are prone to develop laminitis. Recent studies show promise that ID may be improved and laminitis may be prevented by the sodium-glucose linked cotransporter 2 (SGLT-2) inhibitor velagliflozin. The aim of the study was to investigate the metabolic responses and efficacy of velagliflozin treatment during the transiti...
Article
Full-text available
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translate...
Conference Paper
Oral glycemic challenge tests are recommended for diagnosis of insulin dysregulation in equines. Several different protocols are used, but all of them have limitations in terms of palatability, ease of use in the field, not fully disclosed composition and/or region specific availability. The aim of the study was to evaluate new carbohydrate formula...
Article
There are few investigations relating anti-nociception to plasma concentrations of fentanyl in horses. The study objective was to evaluate analgesic efficacy and duration in horses and determine the minimum anti-nociceptive plasma concentrations. Eight horses were treated with saline (P) and fentanyl (F2.5 = 2.5 μg/kg; F5 = 5 μg/kg; F10 = 10 μg/kg)...
Article
The objective of this study was to determine whether the assessment of cytological features of secretions from the paranasal sinuses represents a useful diagnostic tool in equine sinusitis to distinguish between different etiologies. Secretion samples from 50 horses with sinusitis and 10 healthy horses were taken transendoscopically from the draina...
Article
Full-text available
Background: Infections with the West Nile virus (WNV) can attack neurological tissues in the host and alter gene expression levels therein. Several individual studies have analyzed these changes in the transcriptome based on measurements with DNA microarrays. Individual microarray studies produce a high-dimensional data structure with the number o...
Article
Full-text available
Background Insulin dysregulation (ID) with basal or postprandial hyperinsulinemia is one of the key findings in horses and ponies suffering from the equine metabolic syndrome (EMS). Assessment of ID can easily be performed in clinical settings by the use of oral glucose challenge tests. Oral glucose test (OGT) performed with 1 g/kg bodyweight (BW)...
Conference Paper
Assessment of insulin dysregulation (ID) is essential to diagnose EMS. However, protocols for implementation of oral diagnostic test vary from glucose administration with the animals' feed to glucose administration via naso-gastric tubing. Manipulation-induced stress response during naso-gastric tubing is a common concern, resulting in missing owne...

Network

Cited By