Julien Lecordier

Emile Durkheim Hospital, Epinal, France · Pharmacy

To use a mobile air decontamination unit (MADU) for a microbial destruction and decreased particle burden making a cleanroom controlled environment in a Centralized Chemotherapy Preparation Unit (CCPU). Good manufacturing practices (GMP) in France specify that the ambient air in the vicinity of a class III biosafety cabinet (isolator) complies with...

La préparation des chimiothérapies est une activité à risque, devant être réalisée en milieu stérile : sous hotte ou sous isolateur. Les Bonnes Pratiques de préparation (BPP), parues en décembre 2007, recommandent une zone d’atmosphère contrôlée (ZAC) de classe D dans l’environnement immédiat des unités centralisées de préparation des chimiothérapi...

We present the way to integrate gravimetric control (GC) in a centralized preparation of cytotoxic drugs unit. Two different modalities are described. In the first strategy, the balance is located inside the isolator, whereas in the second, it is located outside in order to remove many technical and ergonomic constraints. These two modalities are c...

To study in an in vitro model of erythrocytes exposed to free radicals the effects of hyperosmolarity and hypoosmolarity on the induced potassium efflux and hemolysis. Erythrocytes were separated from plasma and suspended in 3 different phosphate buffer solutions (HYPO, ISO, and HYPER) containing, respectively, 100, 150 and 200 mmol/l of Na. Free r...

Levofloxacin, a quinolone used in the treatment of an upper respiratory tract infection is involved in skin reactions. Patch tests are helpful for the aetiological diagnosis. Unfortunately, they are known for their lack of sensibility. A weak transcutaneous penetration due to the physicochemical characteristics of tested drugs is a well-known cause...

The aim of the study was to compare the potassium efflux measurements (flame photometry (FP), specific electrode (SE) and atomic absorption photometry (AAP)) using a model of erythrocytes exposed to an oxidative stress in various conditions of osmolarity. Human erythrocytes were incubated in 3 different values of osmolarity and in the presence of 5...

Crohn's disease (CD) is a chronic and invalidating inflammatory bowel disease of unknown etiology. The coordinated action of the cytochrome metabolizing subfamily CYP3A and the transport protein P-glycoprotein (P-gp) in the enterocyte results in a reduced bioavailability of drugs administered orally. Cytokines modulate the expression and functional...

La création d’un site Intranet s’intègre dans les missions d’information et de communication des Pharmacies à Usage Intérieur. Le but de cette thèse est d’apporter, à travers l’expérience de la pharmacie du CHU de Rouen, l’ensemble des informations qui devrait permettre à chaque Pharmacie Hospitalière, en l’adaptant à ses besoins spécifiques, de dé...