Julien Hering

Tree of Science · Science 2.0 - Open Science

Open science and science 2.0 : the keys for the future of biomedical researches Biomedical researchers are facing stronger challenges every year since the never-ending increase of complexity in life sciences. Basic, pharmaceutical, and medical researchers need to find a way to overcome the huge costs of experiments, the reproducibility crises that...

Ca2+ entry into neuronal cells is modulated by the activation of numerous G-protein-coupled receptors (GPCRs). Much effort has been invested in studying direct G-protein-mediated inhibition of voltage-dependent CaV2 Ca2+ channels. This inhibition occurs through a series of convergent modifications in the biophysical properties of the channels. An i...

Despite the marked influence on neuronal physiology of the low-voltage activated T-type Ca(2+) currents, little is known about the intracellular pathways and neurotransmitters involved in their regulations. Here, we report that in thalamocortical neurons a phosphorylation mechanism induces an increase both in the current amplitude (1.5 +/- 0.27-fol...

T-type calcium channels (the Ca(V)3 channel family) are involved in defining the resting membrane potential and in neuronal activities such as oscillations and rebound depolarization. Their physiological roles depend upon the channel activation and inactivation kinetics. A fast inactivation that stops the ionic flux of calcium in tens of millisecon...

Intracellular Ca2+ concentration controls a number of physiological functions some of which are initiated at quite negative membrane potentials (-80 mV to -50 mV). Such is the case for the oscillations recorded in thalamic neurons, but also in non-excitable cells, for spermatozoid capacitation, terminal differentiation of myoblasts or aldosterone s...

De nombreux processus physiologiques sous le contrôle du Ca2+ intracellulaire surviennent à des potentiels membranaires proches du potentiel de repos. A ces potentiels, les canaux calcium de type T sont des acteurs privilégiés du contrôle calcique, capables d’engendrer soit un courant dépolarisant de grande amplitude mais transitoire, soit un coura...