Julien Gicquiaud

• Université Bordeaux-I

A chiral Brønsted acid‐catalyzed synthesis of axially chiral alkenes was developed via an enantioselective and para‐selective Friedel–Crafts reaction between phenols and 1‐alkynylnaphth‐2‐ols. This methodology features an efficient hydroarylation with high functional group tolerance, complete para‐selectivity, excellent yields (up to 99%), and enan...

This review focuses on the carbocyclization reactions of alkyne-containing substrates catalyzed by Brønsted acids. The electrophilic activation occurs either by direct protonation of the alkyne or by formation of an intermediate cation that further reacts with the alkyne to give a key vinyl cation intermediate. Specific focus is placed on the selec...

The first example of an enantioselective carbocyclization of an alkyne‐containing substrate catalyzed by chiral Brønsted acids was achieved. The use of the 2‐hydroxynaphthyl substituent on the alkyne as a directing group constituted the key parameter enabling both efficient regioselective protonation of the carbon–carbon triple bond and chiral indu...

Ortho‐alkynyl biaryls react in the presence of catalytic amount of Brønsted acids to give phenanthrenes in high yields under mild conditions. The activity and selectivity of this transformation are governed by the substitution pattern of the diarylalkyne moiety. Selectivity shifts are observed between the carbophilic Lewis and Brønsted acid‐catalyz...