Julien Boudon

Julien Boudon
University of Burgundy | UB · Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB)

PhD

About

49
Publications
7,961
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712
Citations
Additional affiliations
September 2011 - present
Université Bourgogne Franche-Comté UBFC, Dijon, France
Position
  • Professor (Associate)
Description
  • Organic/biological molecules grafting on metal oxide nanoparticles Elaboration of new nanoparticle-based contrast agents Elaboration of novel theranostic nanomaterials
October 2010 - August 2011
University of Burgundy
Position
  • PostDoc Position
Description
  • Bioconjugation on metal oxide nanoparticles
October 2009 - September 2010
Institut de Chimie de la matière condensée de Bordeaux
Position
  • PostDoc Position
Description
  • Développement d'agents de contraste pour l'imagerie des plaques d'athérome vulnérables/Development of contrast agents for imaging of vulnerable atheroma plaques

Publications

Publications (49)
Article
Full-text available
The association between chemotherapeutic drugs and metal oxide nanoparticles has sparked a rapidly growing interest in cancer nanomedicine. The elaboration of new engineered docetaxel (DTX)‑nanocarriers based on titanate nanotubes (TiONts) was reported. The idea was to maintain the drug inside cancer cells and avoid multidrug resistance mechanisms,...
Chapter
The concept of nanomaterials that can be designed and administered into the human body to improve health is of great interest. During the past years there has been an increasing amount of research on the uses of nanomaterials in diverse areas of biomedical research including biological sensing, labelling, imaging, cell separation and therapy. In th...
Article
Full-text available
Copper-doped zinc oxide nanoparticles (NPs) CuxZn1xO (x = 0, 0.01, 0.02, 0.03, and 0.04) were synthesized via a sol-gel process and used as an active electrode material to fabricate a non-enzymatic electrochemical sensor for the detection of glucose. Their structure, composition, and chemical properties were characterized using X-ray diffraction (X...
Article
Full-text available
Nanomaterials have a huge potential in the research fields from nanomedicine to medical devices. However, surface modifications of nanoparticles (NPs) and thus of their physicochemical properties failed to predict their biological behavior. This requires investigating the “missing link” at the nano-bio interface. Protein corona (PC), the set of pro...
Article
Full-text available
Nanohybrids based on titanate nanotubes (TiONts) were developed to fight prostate cancer by intratumoral (IT) injection, and particular attention was paid to their step-by-step synthesis. TiONts were synthesized by a hydrothermal process. To develop the custom-engineered nanohybrids, the surface of TiONts was coated beforehand with a siloxane (APTE...
Article
Introduction. The objective of this study was to evaluate the feasibility and toxicity of superparamagnetic iron oxide nanoparticles (SPIONs) administered into the cochlea through the round window (RW) by an external magnetic field. Materials and Methods. In 5 Wistar rats, the left RW was punctured. SPIONs suspended in hyaluronic gel (5 mg/mL) were...
Article
In this study, Superparamagnetic iron oxide nanoparticles (SPION) were functionalized in one pot with two organic molecules. Firstly, polyethylene glycol (PEG) was mixed for 46 hours to improve steric stability and then, two hours before the end of the reaction, dimercaptosuccinic acid (DMSA) was added to provide negative charges and thiol groups f...
Article
Full-text available
Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrotherm...
Article
Full-text available
In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule of trans-resveratrol (RSV), a natural antioxidant molecule, which can be useful for brain disease treatment. The derivative molecule was chemically synthesized (4’-hydrox...
Article
Titanate nanotubes (TiONts) are promising agents for biomedical applications. Microglial activation and associated oxidative burst are major challenges in drug delivery applications across the brain. Here, TiONts were designed for drug delivery systems by functionalizing them with (3-aminopropyl) triethoxysilane (APTES), their interactions and bioc...
Article
Iron oxide nanoparticles have the capability to cross Blood Brain Barrier (BBB) and hence are widely investigated for biomedical operations in the central nervous system. Before being used for the biomedical purpose, it is necessary to investigate its biocompatibility, dosimetry and biological interaction. In the present study, in-house synthesized...
Chapter
Full-text available
The lack of toxicological data on nanomaterials makes it difficult to assess the risk related to their exposure, and as a result further investigation is required. This chapter presents the synthesis of controlled oxide nanoparticles followed by the evaluation of their safety profile or toxicity (iron, titanium and zinc oxides). The controlled surf...
Article
Full-text available
In this work, we have discussed for the first time the elaboration of nanohybrid materials intended for drug delivery systems, based on titanate nanotubes (TiONts) which are coated by chitosan polymer (CT). Chitosan has been used to enhance the biocompatibility of hydrothermally synthesized nanotubes in biological medium in order to substitute the...
Article
Full-text available
Around 40% of high-risk prostate cancer patients who undergo radiotherapy (RT) will experience biochemical failure. Chemotherapy, such as docetaxel (DTX), can enhance the efficacy of RT. Multidrug resistance mechanisms often limit drug efficacy by decreasing intracellular concentrations of drugs in tumor cells. It is, therefore, of interest to deve...
Presentation
F. Sallem, R. Haji , A. Luce, J. Boudon , D. FasseurVervandier , A. Megriche, M. El Maaoui and N. Millot.,
Presentation
Synthesis, characterizations and functionalization of titanate nanotubes for biomedical applications. DIJON - JED 2017, 25-26 mai 2017, Dijon, France.
Article
Full-text available
The combination of anticancer drugs and metal oxide nanoparticles is of great interest in cancer nanomedicine. Here, the development of a new nanohybrid, titanate nanotube-docetaxel (TiONts-DTX) is reported, the two parts of which are conjugated by covalent linkages. Unlike most nanoparticles currently being developed for biomedical purposes, TiONt...
Presentation
Elaboration of nanohybrid materials based on titanate nanotubes for biomedical applications, F. Sallem, J. Boudon, R. Haji, D. Fasseur-Vervandier, A. Megriche, M. El Maaoui and N. Millot, 8th international Congress Nanotechnology in Medicine and Biology congress- BioNanoMed, 20-22 mars 2017, Krems, Autriche.
Article
For the first time, phosphonate-functionalized magnetite nanoparticles (Fe3O4 NPs) were synthesized using a one-step continuous hydrothermal process. The NP surface was modified using a hydrophilic organic molecule, namely 6-phosphonohexanoic acid (PHA). NPs were fully characterized (TEM, XRD, DLS, ζ-potential, TGA, FTIR, XPS and specific surface a...
Article
The search for convenient molecular probes for detecting DNA and RNA quadruplexes in vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher-order nucleic acid structures play in many genetic dysregulations. Here, we contribute to this search, reporting on a palladated porphyrin named Pd·TEGPy: its efficiency as q...
Article
Full-text available
Nanocomposite films composed of gold nanoparticles (AuNPs) embedded in a TiO2 matrix have been prepared by direct liquid injection chemical vapor deposition process, using preformed nanoparticles and titanium isopropoxide as precursors. The spherical AuNPs about 4.1 nm in diameter were synthesized by using gold (III) chloride trihydrate and stabili...
Article
Full-text available
In the present study, we report the dispersion of titanate nanotubes (TiONts) via polymer grafting (PolyEthylene Glycol, PEG) or polymer adsorption (polyethylene imine, PEI) where different TiONts/polymer ratios have been investigated. The TiONts/PEI and TiONts/PEG nanohybrids were characterized by scanning and transmission electron microscopy as w...
Article
Full-text available
TiONts-phthalocyanine nanohybrids combining an efficient optical probe and a promising nanovector have been developed in a step-by-step approach and were thoroughly characterized. Each 150-nm long TiONts–Pc bear ca. 450 Pc. Three nanohybrids were prepared including three different linkers in quest for the best stability.
Chapter
Full-text available
Titanate nanotubes (TiONts) have received more and more attention since their pioneering hydrothermal synthesis. Recently they have been considered for biomedical applications but not yet as carriers of therapeutic molecules. The synthesis of TiONts with a controlled morphology has been reported and the studies have demonstrated that TiONts were in...
Article
Full-text available
The use of a liquid injection delivery system to form composite films containing nanoparticles was investigated. Al2O3–TiO2 films were grown on silicon substrates by direct liquid injection MOCVD (DLI-MOCVD) at 400 °C. The α-Al2O3 nanoparticles (α-Al2O3NPs) dispersed in TiO2 films resulted from co-deposition using colloidal α-Al2O3 solution and tit...
Article
Full-text available
A SPIO-phthalocyanine nanohybrid is developed as a bimodal contrast agent for Optical and Magnetic Resonance Imaging. The organic coating was covalently attached onto SPIO in a step-by-step approach. Each coated-SPIO was thoroughly characterized. The hydrodynamic size of the SPIO-Pc is ca. 60 nm with a coverage of ca. 690 Pc/SPIO.
Article
Background and purpose: One of the new challenges to improve radiotherapy is to increase the ionizing effect by using nanoparticles. The interest of titanate nanotubes (TiONts) associated with radiotherapy was evaluated in two human glioblastoma cell lines (SNB-19 and U87MG). Materials and methods: Titanate nanotubes were synthetized by the hydroth...
Article
Size exclusion chromatography (SEC) on a semipreparative scale (10 mg and more) was used to size-select ultrasmall gold nanoclusters (<2 nm) from polydisperse mixtures. In particular, the ubiquitous byproducts of the etching process toward Au(38)(SR)(24) (SR, thiolate) clusters were separated and gained in high monodispersity (based on mass spectro...
Article
Ligand exchange on [Au25(SCH2CH2Ph)18-] [TOA+] is studied with two chiral ligands R/S-BINAS and NILC/NIDC in THF with induction of metal-based optical activity. Under the applied condition the ligand exchangeis only partial, showing that also within a mixed ligand shell significant optical activity can be induced. The ligand exchange resulted in th...
Article
Full-text available
The cationic organometallic aqua complexes formed by hydrolysis of [(C<sub>6</sub>H<sub>6</sub>)<sub>2</sub>RuCl<sub>2</sub>]<sub>2</sub> in water, mainly [(C<sub>6</sub>H<sub>6</sub>)Ru(H<sub>2</sub>O)<sub>3</sub>]<sup>2+</sup>, intercalate into white sodium hectorite, replacing the sodium cations between the anionic silicate layers. The yellow he...
Article
Full-text available
Ligand exchange on [Au25(SCH2CH2Ph)18-] [TOA+] is studied with two chiral ligands R/S-BINAS and NILC/NIDC in THF with induction of metal-based optical activity. Under the applied condition the ligand exchange is only partial, showing that also within a mixed ligand shell significant optical activity can be induced. The ligand exchange resulted in t...
Article
Liquid-crystalline dendrons carrying either a thiol or disulfide function which display nematic, smectic A, columnar, or chiral nematic phases have been synthesized. Their mesomorphic properties are in agreement with the nature of the mesogenic units and structure of the dendrons. The first-generation poly(aryl ester) dendron containing two cyanobi...
Poster
Full-text available
Gold nanoparticles have generated a growing interest in the past two decades due to their interesting properties and potential applications. Gold particles covered by liquid-crystalline dendrimers are a basis for the elaboration of new optical materials. Such composite materials could organize in such a way that the gold cores self- assemble in eve...
Article
A combination of in situ attenuated total reflection infrared (ATR-IR) spectroscopy, UV−vis spectroscopy and transmission electron microscopy was used to study the adsorption of thiol-protected gold nanoparticles on TiO2 films and the behavior of the resulting composite films upon UV irradiation. The gold nanoparticles were covered by charged thiol...
Poster
Full-text available
Dendrimers are regularly branched molecules characterized by a well-defined structure which have found a great scientific interest because of their perfect molecular architecture.[1] On the other hand, gold nanoparticles exhibit optical properties depending on their size and organization.[2] The functionalization of gold nanoparticles with dendrime...
Article
Herein we report the studies of Heck alkynylation (copperfree Sonogashira) with aryl halides (I, Br, Cl) employing various metallic precursors, tertiary phosphanes and bases in [BMIM][BF4] as the solvent. As a result, we provide the first method that allows the coupling of a large array of substrates, either activated or deactivated bromides in an...
Article
Full-text available
Chiral metal surfaces and nanoparticles have the potential to be used for the selective production, the resolution and the detection of enantiomers of a chiral compound, which renders them highly attractive in view of the tremendous consequences of homochirality on earth. Their capability to distinguish between enantiomers of a chemical compound re...
Article
Full-text available
The synthesis of the title compound was achieved by reacting PtCl2(PhCN)2 with the 1,1'-bis[bis(5-methyl-2-furyl)phosphino]ferrocene chelating ligand. Crystals of the compound are triclinic.
Article
Full-text available
The synthesis of the title compound, [FePtCl2(C15H14O2P)2]·0.5CH2Cl2, has been achieved by reacting PtCl2(PhCN)2 with the 1,1′-bis­[bis­(5-methyl-2-furyl)phosphino]ferrocene chelating ligand. The environment at the Pt atom can be described as distorted square-planar, with two cis-Cl atoms and two cis-P atoms.

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Projects

Projects (3)
Archived project
Post-doc in the elaboration of nanocomposite by direct liquid injection MOCVD and ALD. I made gold nanoparticles embedded in a oxide layer matrix for the surface plasmon resonance, Pt-CeO2 nanocomposite films for the fuel cells. Now I work on gallium oxides for the dental implants.
Project
1-Role of peroxisome and pathological consequences of its dysfunction; 2 Identification of natural and synthetic molecules with anti-oxidative properties