Julien Bensalem

Julien Bensalem
South Australian Health and Medical Research Institute | SAHMRI · Hopwood Centre for Neurobiology

PhD

About

20
Publications
10,842
Reads
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729
Citations
Additional affiliations
April 2018 - present
South Australian Health and Medical Research Institute
Position
  • PostDoc Position
January 2015 - February 2017
Activ'Inside
Position
  • Project Manager
October 2011 - December 2014
University of Bordeaux
Position
  • PhD Student
Description
  • Effect of polyphenol-rich extracts from berries on age-related cognitive decline Supervisor: Pr Véronique Pallet
Education
October 2011 - December 2014
University of Bordeaux
Field of study
  • Biology and Health, Nutrition
September 2009 - June 2010
Paul Sabatier University - Toulouse III
Field of study
  • Neuroscience, Behavior and Cognition
September 2008 - June 2009
University of Bordeaux
Field of study
  • Neuroscience and Neuropsychopharmacology

Publications

Publications (20)
Article
Background Intermittent fasting (IF) activates autophagy in cardiac muscle and pancreatic islets. We examined the effect of IF on markers of autophagy in liver and skeletal muscle in mice and in humans. Methods Ten-week-old C57BL/6J male mice were ad-libitum fed a high-fat (HFD) or chow diet for 8 weeks, before randomisation to AL or IF (24h fast,...
Article
Full-text available
Lysosomal network abnormalities are an increasingly recognised feature of Alzheimer’s disease (AD), which appear early and are progressive in nature. Sandhoff disease and Tay-Sachs disease (neurological lysosomal storage diseases caused by mutations in genes that code for critical subunits of β-hexosaminidase) result in accumulation of amyloid-β (A...
Article
Full-text available
Age‐related diseases represent some of largest unmet clinical needs of our time. While treatment of specific disease‐related signs has had some success (for example the effect of statin drugs on slowing progression of atherosclerosis), slowing biological ageing itself represents a target that could significantly increase health‐span and reduce the...
Article
Preclinical research shows that autophagy is a modifiable process that holds promise for preventing human age-related disease. However, this knowledge has not been clinically translated. Here, we discuss recent developments in the ability to measure human autophagy, and why it is a critical step for translation.
Article
Degradation and clearance of cellular waste in the autophagic and endo-lysosomal systems is important for normal physiology and prevention of common late-onset diseases such as Alzheimer's disease (AD). Phosphatidylinostol-binding clathrin assembly protein (PICALM) is a robust AD risk factor gene and encodes an endosomal protein clathrin-binding cy...
Article
Full-text available
Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for...
Article
Autophagy is a catabolic process that collects and degrades damaged or unwanted cellular materials such as protein aggregates. Defective brain autophagy has been linked to diseases such as Alzheimer’s disease. Autophagy is regulated by the protein kinase mTOR (mechanistic target of rapamycin). Although already demonstrated in vitro, it remains cont...
Article
Full-text available
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monit...
Article
Measurement of autophagic flux in vivo is critical to understand how autophagy can be used to combat disease. Neurodegenerative diseases have a special relationship with autophagy, which makes measurement of autophagy in the brain a significant research priority. Currently, measurement of autophagic flux is possible through use of transgenic constr...
Article
Autophagic flux is a critical cellular process that is vastly under-appreciated in terms of its importance to human health. Preclinical studies have demonstrated that reductions in autophagic flux cause cancer and exacerbate chronic diseases, including heart disease and the pathological hallmarks of dementia. Autophagic flux can be increased by tar...
Article
Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. The present study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60–70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted wit...
Article
Full-text available
Ageing is characterised by memory deficits, associated with brain plasticity impairment. Polyphenols from berries, such as flavan-3-ols, anthocyanins, and resveratrol, have been suggested to modulate synaptic plasticity and cognitive processes. In the present study we assessed the preventive effect of a polyphenol-rich extract from grape and bluebe...
Article
Objective: To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study. Methods: We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followe...
Conference Paper
Full-text available
Il est maintenant bien établi que le vieillissement est lié à l’apparition de troubles cognitifs. Ces altérations mnésiques liées à l’âge peuvent être mises en évidence à la fois chez l’Homme et l’animal. Plusieurs études ont évoqué le rôle bénéfique des polyphénols sur les fonctions mnésiques et en particulier sur le déclin cognitif lié à l’âge. L...
Article
Full-text available
Background Grape and blueberry extracts are known to protect against age-related cognitive decline. However, beneficial effects achieved by mixing grape and blueberry extracts have yet to be evaluated in dogs, or their bioavailability assessed. Of concern to us were cases of acute renal failure in dogs, after their ingestion of grapes or raisins. T...
Article
Full-text available
Spatial learning and memory deficits associated with hippocampal synaptic plasticity impairments are commonly observed during aging. Besides, the beneficial role of dietary polyphenols has been suggested as potential functional food candidates to prevent this memory decline. Indeed, polyphenols could potentiate the signaling pathways of synaptic pl...
Data
Swim path efficiency during spatial learning. Swim path efficiency is only affected by age but PEGB-enriched diet tends to improve learning (age effect: **p < 0.01; diet effect: p = 0.0828; age × diet effect: p = 0.0547 by 3-way ANOVA. n = 9–11 per group).
Article
Full-text available
A growing body of evidence suggests that dietary interventions may delay or halt the progression of age-related health disorders and cognitive decline. Among the components of the human diet, polyphenols from berries are essential micronutrients that have been particularly studied for improving cognitive functions. In the present review, we highlig...
Thesis
Il est maintenant bien établi que le vieillissement est lié à l’apparition de troubles cognitifs. Ces altérations mnésiques liées à l’âge peuvent être mises en évidence à la fois chez l’Homme et l’animal. Plusieurs études ont pu mettre en évidence le rôle bénéfique des polyphénols sur les fonctions mnésiques et en particulier sur le déclin mnésique...

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