Julie Leblanc

Julie Leblanc
Canadian Nuclear Safety Commission | CNSC · Health Sciences and Environmental Compliance

Ph.D Biochemistry

About

12
Publications
1,262
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118
Citations
Introduction
I am a Radiation and Health Sciences Officer working at the Canadian Nuclear Safety Commission. My work involves understanding the biological mechanisms that act at low doses of ionizing radiation and their implications on the radiation protection framework. Currently, my team is working on increasing capacity in conducting systematic reviews for risk assessment. I am a researcher and coordinator for the Canadian Organization on Health Effects from Radiation Exposure (COHERE).

Publications

Publications (12)
Article
Purpose: The Adverse Outcome Pathway (AOP) framework, a systematic tool that can link available mechanistic data with phenotypic outcomes of relevance to regulatory decision-making, is being explored in areas related to radiation risk assessment. To examine the challenges including the use of AOPs to support the radiation protection community, an i...
Article
Full-text available
Background: The purpose of toxicology is to protect human health and the environment. To support this, the Organisation for Economic Co-operation and Development (OECD), operating via its Extended Advisory Group for Molecular Screening and Toxicogenomics (EAGMST), has been developing the Adverse Outcome Pathway (AOP) approach to consolidate eviden...
Article
Polar body emission is a special form of cytokinesis in oocyte meiosis that ensures the correct number of chromosomes in reproduction-competent eggs. The molecular mechanism of the last step, polar body abscission, is poorly understood. While it has been proposed that Ca2+ signaling plays important roles in embryonic cytokinesis, to date transient...
Article
Purpose Canadian Organization on Health Effects from Radiation Exposure (COHERE) is a government initiative to better understand biological and human health risks from ionizing radiation exposures relevant to occupational and environmental settings (< 100 mGy, < 6 mGy/hr). It is currently a partnership between two federal agencies, Health Canada (H...
Article
Full-text available
Background: Decades of research to understand the impacts of various types of environmental occupational and medical stressors on human health have produced a vast amount of data across many scientific disciplines. Organizing these data in a meaningful way to support risk assessment has been a significant challenge. To address this and other chall...
Article
The linear no-threshold (linear-non-threshold) model is a dose-response model that has long served as the foundation of the international radiation protection framework, which includes the Canadian regulatory framework. Its purpose is to inform the choice of appropriate dose limits and subsequent as low as reasonably achievable requirements, social...
Article
The year 2018 saw both the Canadian Nuclear Safety Commission (CNSC) and Health Canada (HC) staff participate in several international workshops and conferences on the subject on low dose radiation research (LDRR). The key events were: 1) the scoping meeting for global coordination of low dose research, hosted by the Nuclear Energy Agency’s Organiz...
Article
Purpose: In 2012, the Organization for Economic Cooperation and Development (OECD) formally launched the Adverse Outcome Pathway (AOP) Programme. The AOP framework has the potential for predictive utility in identifying early biological endpoints linked to adverse effects. It uses the weight of correlative evidence to identify a minimal set of meas...
Article
Full-text available
Existing and future nuclear fusion technologies involve the production and use of large quantities of tritium, a highly volatile, but low toxicity beta-emitting isotope of hydrogen. Tritium has received international attention because of public and scientific concerns over its release to the environment and the potential health impact of its intern...
Article
Intracellular calcium transients are a universal phenomenon at fertilization and are required for egg activation, but the exact role of Ca(2+) in second polar body emission remains unknown. On the other hand, similar calcium transients have not been demonstrated during oocyte maturation and, yet, manipulating intracellular calcium levels interferes...
Article
Polar body emission is a specialized cell division throughout the animal kingdom, serving to reduce chromosome ploidy while preserving the egg cytoplasm. Critical to polar body emission are the asymmetric positioning of the meiotic spindle prior to anaphase, with one pole attached to the oocyte cortex, and the simultaneous membrane protrusion durin...

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Projects

Projects (2)
Project
The International Journal of Radiation Biology (IJRB) will have the special issue “Adverse outcome pathways in radiation protection” and this Project aims to give an update on this special issue.
Project
1) Better align Health Canada and the Canadian Nuclear Safety Commission's research priorities to focus and leverage resources, 2) Maintain and enhance expertise in radiobiology and epidemiology within the Government of Canada, 3) Provide an informed and consistent federal message to the public and stakeholders on matters involving low dose ionizing radiation, and 4) Strengthen Canada’s contribution towards international efforts on the assessment of ionizing radiation doses and effects for application into international recommendations, Canadian regulations and national guidance.