Julie Lavoie

Julie Lavoie
Université de Montréal | UdeM · Department of Kinesiology

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97
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Publications

Publications (97)
Article
Introduction: Preeclampsia (PE) is characterized by high blood pressure, proteinuria and/or multi-organ damage, reaching 10% of all pregnancies globally. To date, no medication can treat PE. We recently identified an upregulation of the antiangiogenic protein Thrombospondin-1 (THBS1) in human and experimental PE. THBS1 is a main activator of latent...
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Preeclampsia is a gestational disorder characterized by hypertension and proteinuria. Excessive release of pro-inflammatory cytokines, particularly tumour necrosis factor-alpha, has been demonstrated to contribute to endothelial activation and poor trophoblast invasion in placental development, resulting in preeclampsia's clinical symptoms. Genetic...
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The abnormal production of matrix metalloproteinases (MMPs), especially MMP-9 and MMP-2, plays a pivotal role in hypertensive disorders of pregnancy, and as such, can influence the development of preeclampsia. These alterations may result from functional genetic polymorphisms in the promoter region of MMP-9 and MMP-2 genes, which modify MMP-9 and M...
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Potassium-coupled chloride transporters (KCCs) play crucial roles in regulating cell volume and intracellular chloride concentration. They are characteristically inhibited under isotonic conditions via phospho-regulatory sites located within the cytoplasmic termini. Decreased inhibitory phosphorylation in response to hypotonic cell swelling stimula...
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Preeclampsia is a common hypertensive disorder in pregnant women and whose causes and consequences have focused primarily on cardiovascular outcomes on the mother and offspring, often without taking into consideration the possible effects on the brain. One possible cause of preeclampsia has been attributed to alterations in the renin-angiotensin sy...
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Objectives Several studies have focused on the benefits of physical activity to prevent and treat PE, given that PE and cardiovascular disease share several risk factors. However, none of these studies have been conducted in Africa. Moreover, it has been demonstrated that exercise training has preventive effects on the development of preeclampsia i...
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Background: Thrombospondin-1 (Thbs1) is an anti-angiogenic focal adhesion glycoprotein. It binds to receptors CD36, LRP1 and CD47 activating anti-proliferative and anti-migratory mechanisms. Pre-eclampsia (PE) is characterized by poor placenta perfusion and angiogenesis, which is stimulated by oxidant and endoplasmic reticulum (ER) stresses contrib...
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Background: Hypertensive disorders reach one in ten pregnancies worldwide, significantly increasing rates of maternal and neonatal morbidity and mortality. Children born to hypertensive pregnancies can develop special clinical features that are consistent with a preterm or accelerated aging process with signs of cardiac remodeling as early as child...
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Association between Tumor Necrosis Factor Alpha (TNF-α) polymorphisms and haplotypes and preeclampsia risk N. Raguema1, 2, 3, 4, M. Ben Ali Gannoun1, H. Zitouni1, D. Benletaifa1, O. Seda5, T. Mahjoub1, J.L. Lavoie 3, 4. 1Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy of Monastir, University of Monastir, Monas...
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Objective: We evaluated the association between the Fas-670A/G and the Fas ligand FasL IVS2nt 124 A/G polymorphisms and the risk of preeclampsia and its complications. Design: A case-control study. Setting: University Hospitals in most areas of Tunisia. Population: We recruited 300 pregnant women who developed preeclampsia and 300 age-matche...
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Compared to other tissues, white adipose tissue has a considerably less RNA and protein content for downstream applications such as real-time PCR and Western Blot, since it mostly contains lipids. RNA isolation from adipose tissue samples is also challenging as extra steps are required to avoid these lipids. Here, we present a procedure to collect...
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Objectives: Interleukin-10 (IL-10) is implicated in several aspects of pregnancy. As genetic predisposition can be involved in the development of preeclampsia, the association between IL-10's promoter region polymorphisms and this pathology has been investigated, although with conflicting results. To date, only a small cohort study (total n = 40)...
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Long before the molecular identity of the Na(+)-dependent K(+)-Cl(-) cotransporters was uncovered in the mid-nineties, a Na(+)-independent K(+)-Cl(-) cotransport system was also known to exist. It was initially observed in sheep and goat red blood cells where it was shown to be ouabain-insensitive and to increase in the presence of N-ethylmaleimide...
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Ephrin B2 (EFNB2) is a ligand for erythropoietin-producing hepatocellular kinases (EPH), the largest family of receptor tyrosine kinases. It has critical functions in many biological systems, but is not known to regulate blood pressure. We generated mice with a smooth muscle cell (SMC)-specific deletion of EFNB2 and investigated its roles in blood...
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Objective We previously demonstrated that the handle-region peptide, a prorenin/renin receptor [(P)RR] blocker, reduces body weight and fat mass and may improve insulin sensitivity in high-fat fed mice. We hypothesized that knocking out the adipose tissue (P)RR gene would prevent weight gain and insulin resistance. Methods An adipose tissue-specif...
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Objective: Administration of the handle region peptide (HRP), a (pro)renin receptor blocker, decreases body weight gain and visceral adipose tissue (VAT) in high-fat/high-carbohydrate (HF/HC) diet-fed mice. The objective of this study was to elucidate potential mechanisms implicated in these observations. Methods: Mice were given a normal or a H...
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In this study, we assessed the effects of oxytocin (OT) on mean arterial blood pressure (MAP), heart rate (HR), and locomotor activity (LA) in male spontaneous hypertensive rats (SHR) and Sprague-Dawley (SDR) controls using telemetry. OT was given by intravenous injections of 0.1, 0.2 or 0.4mg/kg to assess short term acute effects or by daily subcu...
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EPH kinases are the largest family of receptor tyrosine kinases, and their ligands, ephrins (EFNs), are also cell surface molecules. This work present evidencethat EPHB4 on vascular smooth muscle cells (VSMCs) is involved in blood pressure (BP) regulation. We generated gene knockout (KO) mice with smooth muscle cell-specific deletion of EPHB4. Male...
Conference Paper
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Circulating RAS in Mice with Prorenin Receptor Gene Deletion Specificly in Adipose Tissue Zulaykho Shamansurova1,2,3, Paul Tan1,2,3, Basma Ahmed1, Catherine Michel1, Sonia Kajla1, Ondrej Seda1 and Julie Lavoie1,2,3 + Author Affiliations 1CRCHUM University of Montreal Quebec Canada 2Depts. Physiology,Biochemistry, Kinesiology University of Montr...
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Gestational hypertensive disorders affect 6-8% of all pregnancies and are the leading cause of maternal mortality in industrialized countries, accounting for 16% of all deaths. Women with hypertension have an increased risk (15-25%) of developing preeclampsia. Our aim was to investigate the role of the angiotensin-(1-7) axis in preeclampsia superim...
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Objective Obesity is a worldwide epidemic and current treatments have limited success thus, novel therapies are warranted. Our objective was to determine whether the prorenin/renin receptor [(P)RR] is implicated in obesity.Methods Mice received a normal or high-fat/high-carbohydrate diet with the handle region peptide (HRP), a (P)RR blocker, or sal...
Conference Paper
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W270 1173.6 Genetic blockade of (pro)renin receptor in adipose tissue modulate the mice body weight and glucose homeostasis Z. Shamansurova, B.M. Ahmed, S. Kajla, C. Michel and J.L. Lavoie. Univ. of Montreal Hosp. Res. Ctr. and Univ. of Montreal.
Conference Paper
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The (pro)renin receptor blocker peptide effects on regulation of body weight and glucose homeostasis in mice with diet-induced obesity (1101.10) Zulaykho Shamansurova1,5, Paul Tan3,1, Sandra Bisotto1, Catherine Michel1, Thi Nguyen2, Peter Schiller2 and Julie Lavoie1,4 + Author Affiliations 1CR-CHUM Montreal QC Canada 2IRCM Montreal QC Canada 3Bi...
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The potent vasoconstrictor peptides, endothelin 1 (ET-1) and angiotensin II control adaptation of blood vessels to fluctuations of blood pressure. Previously we have shown that the circulating level of ET-1 is regulated through its proteolytic cleavage by secreted serine carboxypeptidase, cathepsin A (CathA). However, genetically-modified mouse exp...
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Gestational hypertensive disorders, such as preeclampsia, affect 6% to 8% of all pregnancies in North America, and they are the leading cause of maternal mortality in industrialized countries, accounting for 16% of deaths. Women with hypertension have an increased risk (15% to 25%) of developing preeclampsia. Our aim was to investigate the mechanis...
Conference Paper
Full-text available
1183.5 Link between the prorenin/renin receptor and glucose homeostasis in mice fed a high-fat/high-carbohydrate diet Zulaykho Shamansurova1,2, Paul Tan1,3, Sandra Bisotto1, Catherine Michel1, Thi M-D Nguyen6, Peter W Shiller6, Jolanta Gutkowska1,4 and Julie L Lavoie1,5 1 CRCHUM, Montreal, QC, Canada 2 Physiology, University of Montreal, Montreal,...
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For a few decades now, the renin-angiotensin system (RAS) has been well known for its implication in the regulation of blood pressure and fluid homeostasis. Furthermore, dysregulation of the RAS has been implicated in many pathological states including obesity, hypertension, diabetes and chronic kidney disease. Due to the elevated consumption of fo...
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RÔLE DU RÉCEPTEUR À LA RÉNINE DANS L’EXPRESSION GÉNIQUE DANS LES GRAS ET LA RÉSISTANCE À L’INSULINE DANS UN MODÈLE D'OBÉSITÉ MURIN Shamansurova Z, Tan P, Mic hel C, Nguyen TMD, Schiller PW, Gutkowska J, Lavoie JL CRCHUM, Montréal, Québec Introduction: Le système rénine-angiotensine (SRA) a été impliqué dans la pathogenèse de l'obésité. Toutefois, p...
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Preeclampsia is characterized by hypertension and de novo proteinuria after 20 weeks of pregnancy. It is the leading cause of perinatal morbidity and mortality in the developed world, and to date, the only means of treating the disease is by inducing delivery. Many studies have shown the benefits of exercise training on normal pregnancy. Conversely...
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Chronic hypertension is an important risk factor for preeclampsia, increasing the prevalence of the disease to 15-25% in pregnant women. Unfortunately there are no known treatments for this disease aside from inducing delivery of the fetus. Nonetheless, several studies have found exercise training to have a protective effect on the risk of developi...
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Full-text available
Eph kinases constitute the largest receptor tyrosine kinase family, and their ligands, ephrins (Efns), are also cell surface molecules. Although they are ligands, Efns can transduce signals reversely into cells. We have no prior knowledge of the role played by any members of this family of kinases or their ligands in blood pressure (BP) regulation....
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Eph kinases constitute the largest receptor tyrosine kinase family, and their ligands, ephrins (Efns), are also cell surface molecules. Our study is the first to assess the role of Ephb6 in blood pressure (BP) regulation. We observed that EphB6 and all three of its Efnb ligands were expressed on vascular smooth muscle cells (VSMC) in mice. We disco...
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Over the last few years, the implication of the (pro)renin receptor [(P)RR] in the pathogenesis of end-organ damage has been shown through many different studies. The (P)RR plays a dual role when stimulated by renin or prorenin as it enhances both cell surface production of angiotensin and stimulates angiotensin-independent intracellular signaling...
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The repair of the kidney after ischemia/reperfusion injury involves proliferation of proximal tubular epithelial cells as well as cell migration and differentiation. Immediately after reperfusion, expression of hypertension-related calcium-regulated gene (HCaRG/COMMD5) decreases, but its expression increases even higher than baseline during repair....
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Exercise training benefits have been widely investigated and used as alternative treatment for different pathological conditions. Since preeclampsia is a severe pregnancy-associated disease for which no treatment is available, our aim was to investigate the protective role of exercise training on pregnancy outcome using a mouse model of the disease...
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Preeclampsia is the major cause of maternal and fetal mortality/morbidity. Because hypertension is an important risk factor for preeclampsia, we investigated whether hypertensive mice that overexpress human renin and angiotensinogen develop superimposed preeclampsia. Given that the mechanisms underlying this disease are still poorly understood, ani...
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This study examines the action of agonists and antagonists of P2 receptors on mouse mesenteric artery contractions and the possible involvement of these signaling pathways in myogenic tone (MT) evoked by elevated intraluminal pressure. Both ATP and its non-hydrolyzed analog alpha,beta-ATP triggered transient contractions that were sharply decreased...
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The objective of our study was to determine whether methylenetetrahydrofolate reductase (Mthfr)-deficient mice develop preeclampsia (PE). Mice were placed on a normal or low-folate/high-methionine (LF/HM) diet to assess the impact of mild and severe homocysteinemia. Blood pressure and proteinuria were measured throughout gestation in Mthfr-deficien...
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In smooth muscles, inhibition of Na(+),K(+),2Cl(-) cotransport (NKCC) by bumetanide decreased intracellular Cl(-) content ([Cl(-)](i)) and suppressed the contractions triggered by diverse stimuli. This study examines whether or not bicarbonate, a regulator of several Cl(-) transporters, affects the impact of NKCC in excitation-contraction coupling....