Juliana Kagura

Juliana Kagura
University of the Witwatersrand | wits · Faculty of Health Sciences

Msc (Med) Child Health

About

40
Publications
4,694
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513
Citations
Citations since 2017
32 Research Items
503 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100

Publications

Publications (40)
Article
Hypertension is a major risk factor for cardiovascular diseases and its prevalence among the Sub-Saharan African population has risen extremely in the last decades. Moreover, there is growing evidence that suggest that hypertension has its roots in childhood and adolescence and persist into adulthood. However, the epidemiology of hypertension in th...
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Introduction: Scientific data concerning the trends, nature, and incidence of OIs in the tourism sector specifically in the South African game parks and nature reserves is not easily available thus it is perceived that it is a safe working environment. The purpose of this study was to describe the trends and nature of occupational injuries (OIs) am...
Article
Objectives: Cardiovascular disease is increasing in many low and middle-income countries, including those in Africa. To inform strategies for the prevention of cardiovascular disease in South Africa, we sought to determine the broad heritability of phenotypic markers of cardiovascular risk across three generations. Design: A cross-sectional stud...
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There is a need to predict occupational injuries in South African National Parks for the purpose of implementing targeted interventions or preventive measures. Machine-learning models have the capability of predicting injuries such that the employees that are at risk of experiencing occupational injuries can be identified. Support Vector Machines (...
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Background This cross-sectional study examined the relationship between socioeconomic status (SES), dietary knowledge and patterns, and physical activity level with body mass index of urban South African young women. Methods Data were collected on 160 black South African women (aged 18–24 years) and included household SES, food frequency and nutri...
Preprint
Full-text available
Objectives Cardiovascular disease is increasing in many low-middle income countries, including those in Africa. To inform strategies for the prevention of cardiovascular disease in South Africa, we sought to determine the broad heritability of phenotypic markers of cardiovascular risk across three generations. Design A cross-sectional study conduc...
Article
Background. Factors associated with menstrual hygiene management (MHM) and practices affect school absenteeism, with up to 7 million girls missing 25% of their given school year each month in South Africa (SA). Objective. To identify the most significant factors associated with MHM and practices affecting school absenteeism among adolescents in Joh...
Article
Background: The long-term consequences for offspring born to mothers with hyperglycaemia first detected in pregnancy (HFDP) are not yet well understood and its influence on childhood blood pressure has not previously been assessed in sub-Saharan Africa. Objective: The objective of this study was to evaluate the association between maternal HFDP...
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Background: There is growing evidence from high-income countries suggesting that hypertension developed in childhood and adolescence persists into adulthood. The objective of this study was to investigate the incidence and risk factors of high blood pressure (BP) in urban black children. Methods: We used data from the Birth to Twenty (BT20+) coh...
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Childhood rapid growth and earlier puberty onset have been associated with adult obesity. However, the association between childhood stunting, pubertal timing and adult obesity is unclear. We examined whether the relationship between stunting at age 2 years (y) and body composition at 23 years is mediated by adolescent body mass index, and pubertal...
Article
The prevalence of non-communicable disease (NCDs) is rising globally, with a large burden recorded in sub-Saharan countries and populations of black race/ethnicity. Accelerated vascular deterioration, otherwise known as early vascular aging (EVA), is the underlying factor for highly prevalent NCDs such as hypertension. The etiology of EVA is multif...
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Background: Maternal and Child health remains at the core of global health priorities transcending the Millennium Development Goals into the current era of Sustainable Development Goals. Most low and middle-income countries including Ghana are yet to achieve the required levels of reduction in child and maternal mortality. This paper analysed the...
Preprint
Background Blood transfusion has been associated with a high risk of transfusion-transmissible infections (TTIs). These infections pose great threats to the availability and safety of blood supply for transfusion, particularly in sub-Saharan Africa (SSA) where the burden of disease is alarmingly high. We describe the incidence and determinants of T...
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Background Female genital mutilation (FGM) is commonly practiced in sub-Saharan Africa and results in adverse pregnancy outcomes among affected women. This paper assessed the prevalence and effects of FGM on pregnancy outcomes in a rural Ghanaian setting. Methods We analyzed 9306 delivery records between 2003 and 2013 from the Navrongo War Memoria...
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Background: Anaemia in pregnancy is associated with adverse obstetric outcomes. When detected early in pregnancy, it can be treated; however, information on its prevalence and associated factors is limited in rural Ghana. Aim: The aim of this study was to determine the prevalence and maternal factors associated with anaemia in pregnancy at first a...
Article
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Multiple perinatal and early life risk factors have been implicated in the development of hypertension. The BT20 (Birth to Twenty Plus) cohort in urban Soweto, South Africa, previously showed a prevalence of elevated blood pressure (EBP) that ranged from 22.4% at 5 years of age to 34.9% at 18 years of age. We sought to determine the prevalence of E...
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Objectives Varying hypertension prevalence across different socioeconomic strata within a population has been well reported. However, the causal factors and pathways across different settings are less clear, especially in sub-Saharan Africa. Therefore, this study aimed to compare blood pressure (BP) levels and investigate the extent to which socioe...
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Background: There is a high and increasing prevalence of overweight and obesity in South Africans of all ages. Risk factors associated with overweight and obesity must be identified to provide targets for intervention. Objective: To identify the demographic, socio-economic and behavioural factors associated with body mass index (BMI) in middle-aged...
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Background Ninety-seven independent single nucleotide polymorphisms (SNPs) are robustly associated with adult body mass index (BMI kg/m²) in Caucasian populations. The relevance of such variants in African populations at different stages of the life course (such as childhood) is unclear. We tested whether a genetic risk score composed of the aforem...
Article
The effects of environmental lead exposure in the neuro-endocrine system have been shown to impact the maturation and tempo of puberty development in adolescents. In low and middle income countries very little is known regarding the detrimental health effects of childhood lead exposure with regard to the tempo of puberty development. To help addres...
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Background: To report associations between different adiposity indices [anthropometric and dual-energy X-ray absorptiometry (DXA) measures] and blood pressure (BP) and hypertension in urban black South African adults. Methods: Anthropometric and DXA whole body measures were performed on 1026 men and 982 women. Participants were classified as bei...
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Background: Violence against children is a significant cause of personal suffering and long-term ill health, poor psychological adjustment, and a range of social difficulties, including adverse effects intergenerationally. Objectives: Using a large corpus of longitudinal data collected in the Birth to Twenty Plus cohort, to give an overview of e...
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Background The growing prevalence of overweight and obesity in low- or middle-income countries precipitates the need to examine early life predictors of adiposity. Objectives To examine growth trajectories from birth, and associations with adult body composition in the Birth to Twenty Plus Cohort, Soweto, South Africa. Methods Complete data at ye...
Data
Comparison of sociodemographic profiles of participants in the study sample and excluded sample. (DOCX)
Article
Background: There is growing evidence of variations in adiposity trajectories among individuals, but the influence of early life growth patterns on these trajectories is underresearched in low- and middle-income countries. Therefore, our aim was to examine the association between early life conditional weight gain and childhood adiposity trajector...
Article
Stunting is a measure of overall nutritional status and is a major public health concern because of its association with child mortality and morbidity and later adult performance. This study examined the effects of pregnancy events, birth characteristics and infant risk exposure on stunting at age 2 years. The study, established in 1990 in Soweto,...
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Early growth is associated with blood pressure measured on one occasion, but whether early life growth patterns are associated with longitudinal blood pressure trajectories is under-researched. Therefore, we sought to examine the association between early growth and blood pressure trajectories from childhood to adulthood. Blood pressure was measure...
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Background: Elevated blood pressure in childhood is a risk factor for adult hypertension which is a global health problem. Excess adiposity in childhood creates a predisposition to develop adult hypertension. Our aim was to explore distinct sex-specific adiposity trajectories from childhood to late adolescence and examined their association with b...
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Objective Social epidemiology models suggest that socioeconomic status (SES) mobility across the life course affects blood pressure. The aim of this study was to investigate the association between SES change between infancy and adolescence, and blood pressure, in young adults, and the impact of early growth on this relationship. Setting Data for t...
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Low birth weight and a rapid weight gain in early childhood may lead to an increased risk for developing cardiovascular disease later in life, such as hypertension and dyslipidaemia. In this study, we examined the associations between size at birth, relative weight gain in infancy and childhood with specific cardiovascular disease risk factors in e...
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Hypertension is an emerging public health problem in South Africa. Recent evidence from longitudinal studies has shown that hypertension in adulthood can be traced back to childhood. There is scarcity of longitudinal data on paediatric blood pressure (BP) particularly in African populations. The objective of this study is to assess the prevalence o...
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Early life nutrition and growth are related to subsequent obesity risk in high-income countries. We investigated the association between nutrition and growth during infancy, and body composition at 10 years of age in 140 children selected from the Bone Health sub-study of the Birth-to-Twenty cohort from Soweto, Johannesburg, South Africa. Infant fe...
Article
Full-text available
Association between infant nutrition and anthropometry, and pre-pubertal body composition in urban South African children – ERRATUM - Volume 3 Issue 6 - J. Kagura, A. B. B. Feeley, L. K. Micklesfield, J. M. Pettifor, S. A. Norris

Questions

Question (1)
Question
I want to use LCGM to identify subgroups in blood pressure from age5  to 18yrs but most of the studies l have come across have used proc traj instead of MPlus. Anyone who has used Mplus, may please let me know.

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Projects

Projects (2)
Project
Exploring different aspects of longitudinal analysis of genetic risk factors of cardiovascular disease in the Birth to Twenty Plus Cohort
Project
Understanding mechanisms undelying elevated blood pressure in childhood