Julian Londoño

University of Antioquia | UdeA · Agro-industrial Development - DIA

Phytosterols (PS) are bioactive compounds widely distributed in nature and are similar to cholesterol in structure and function. They contribute to the decrease of cardiovascular diseases, which are associated with high‐cholesterol consumption. Plant sterols are lipophilic and need to be encapsulated to improve their solubility to be applied in foo...

Sugarcane bagasse, is one of the largest agriculture residues in the world and its chemical composition is interesting for several areas. Among one of the lipid components was found phytosterols. These are structurally and functionally similar to cholesterol, they are contributing to the reduction of cholesterol in the blood when consumed. Phytoste...

Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are plant oxylipins (isoprostane-prostaglandin-like compounds) formed by the free radical-catalyzed oxidation of α-linolenic acid (ALA, C18:3, n-3). These oxylipins have been previously described in an array of plant-based foods with similar concentrations as phenolics in some fruits and vegetables...

The aim of this work was to determine the effect of temperature on the formation of acrylamide in cocoa beans during drying treatment by an experimental and computational study, in order to assess the presence of this neoformed compound from postharvest stage. The computational study was conducted on the reaction between fructose, glyoxal from gluc...

The profile of reducing sugars developed during each stage of the postharvest of cocoa beans is an important quality index; these sugars are found to be one of the main precursors of flavor and neoformed compounds. However, its quantification after extraction from different parts of the bean is a challenge due to the complexity of the matrix. The p...

The aim of this study was to compare the quality of a mixture of cocoa harvested and fermented in three subregions of Antioquia (Colombia), from the chemometric profile based on multivariate statistical analysis. A mixture of clones CCN-52, ICS-1, FLE-2, and FEC-2 harvested in Bajo Cauca, Uraba and Magdalena Medio were subjected to a spontaneous fe...

Oxidative stress and inflammatory injury are responsible for a number of diseases, being strongly associated with neurodegenerative disorders, among others. Caffeinated and decaffeinated coffees act as antioxidant and anti-inflammatory agents in therapeutic processes or exert preventive roles in different pathological situations. Coffee's therapeut...

An exploration of the antioxidant power of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, three natural antioxidants found in curcuma longa is reported in this work. We exhaust all structural possibilities leading to intramolecular hydrogen bonding and evaluate 15 isomers in total. Calculations were carried out in gas phase and in solution...

Cocoa has been widely discussed as a bioactive food rich in sensory stimulation and health benefits. However, no information has been provided concerning phytoprostanes (PhytoPs) and phytofurans (PhytoFs) in cocoa. These compounds are of interest because they play a role in the regulation of immune function. The present study included 31 cocoa clon...

Oxidative stress and inflammatory injury are responsible for a number of diseases, being strongly associated with neurodegenerative disorders, among others. Caffeinated and decaffeinated coffees act as antioxidant and anti-inflammatory agents in therapeutic processes or exert preventive roles in different pathological situations. Coffee´s therapeut...

The agronomic production systems may affect the levels of food metabolites. Metabolomics approaches have been applied as useful tool for the characterization of fruit metabolome. In this study, metabolomics techniques were used to assess the differences in phytochemical composition between goldenberry samples produced by organic and conventional sy...

En este trabajo se evaluó la capacidad inhibidora de la oxidación de Lipoproteínas de Baja Densidad (LDL) y la actividad captadora de radicales libres de tres especies de plantas medicinales con alta demanda de comercialización en Colombia: Calendula officinalis, Passiflora mollisima, Cynara scolymuus. Se establecieron relaciones entre el perfil cr...

Heavy metals are toxic compounds, which in low quantities can cause severe damage to human health. Heavy metal compounds appear in water naturally, but some anthropogenic activities can generate large discharges. Once in the water bodies, these compounds dilute and remain in quantities that are difficult to detect with most common analytical proced...

Lutein, a xanthophyll, is associated with decreasing age-related macular degeneration, the risk of atherosclerosis and preventing some diseases (Bovier, Lewis, & Hammond, 2013; El-raey, Ibrahim, & Eldahshan, 2013). When lutein is extracted, it becomes highly unstable, reducing its functionality as an antioxidant. The aim of this research was to imp...

This study aims to develop a formulation of a turmeric-based dye extract using supercritical antisolvent (SAS) technology and different encapsulating polymers to improve the aqueous stability and solubility of curcumin. The dye formulation obtained by SAS consists of a mixture of Eudragit® L100 and Pluronic® 127 using tween 20 as a surfactant The c...

At present, people with today's busy lifestyle have a general trend of consuming fruit like banana passion fruit (Passiflora tripartita var. mollisima) as juices or smoothies, being an increasing tendency that can generate a large amount of agro-industrial residues. Whereby, food industries have a significant investment to minimize these wastes gen...

At present, people with today's busy lifestyle have a general trend of consuming fruit like banana passion fruit (Passiflora tripartita var. mollisima) as juices or smoothies, being an increasing tendency that can generate a large amount of agro-industrial residues. Whereby, food industries have a significant investment to minimize these wastes gen...

The accumulation of oxidized ApoB-100-containing lipoproteins in the vascular intima and its subsequent recognition by macrophages results in foam cell formation and inflammation, key events during atherosclerosis development. Agents targeting this process are considered potentially atheroprotective. Since natural biflavonoids exert antioxidant and...

The processing and commercialization of fruit and vegetables produces considerable amounts of by-products, the disposal of which can be a problem for the industry, but can also provide a valuable source of bioactive compounds. The aim of this research was to evaluate the potential of different by-products generated in Central Mayorista de Antioquia...

Actually by-products from lettuce and cabbage have not been properly used despite the fact that they are rich in bioactive compounds as lutein. It is known that lutein plays an important role in the prevention of degenerative diseases. Lutein, is recommended as a health supplement for the prevention of cancer and diseases related to retinal degener...

In recent years, polyphenols from Theobroma cacao and other plant sources have been widely used as natural chemopreventive agents due to their antioxidant properties. Some studies indicate that the polyphenol content, particularly flavan-3-ols, is strongly correlated to the intensity of the purple color in fresh cocoa seeds. However, no visual mark...

Abstract Introduction and aim: Accumulation of oxidized low density lipoproteins (oxLDL) in the vascular intima and the subsequent macrophage-mediated pro-inflammatory response are two key events during atherosclerosis development. Agents that target these two processes are considered to be potentially atheroprotective. Since natural Biflavonoids...

The production of rainbow trout in Colombia supports 11.36% of domestic production; profit residues can be used for the extraction of oil, either by heating (Soxhlet), or by Supercritical Fluids (SF) (critical temperature and pressure of the gases). It was proposed to extract and characterize fish oil-derived by-products of rainbow trout using Soxh...

This report presents evidence that the following Solanum steroids: solasodine, diosgenin and solanine interact with human erythrocytes and molecular models of their membranes as follows: a) X-ray diffraction studies showed that the compounds at low molar ratios (0.1-10.0mol%) induced increasing structural perturbation to dimyristoylphosphatidylchol...

In this study, the influence of furazolidone, an anti-leishmanial drug, on dimyristoylphosphatidylcholine (DMPC) liposome hydration degree, mobility and thermodynamics was investigated by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC). FTIR results showed that furazolidon...

Generally, citrus fruits are waxed in the postharvest stage to restore the natural wax removed in the washing procedure and to improve the appearance of the fruit, providing luster. Nowadays, in Colombia, the waxes employed in this step of citrus fruits are imported, which represents a high cost for producers and marketers. On the other hand, the c...

ntroducción: Los residuos agroindustriales son fuente de compuestos bioactivos que tienen efectos benéficos sobre la salud humana, sin embargo, no han sido aprovechados debido, principalmente, a la falta de métodos de extracción efectivos para obtener sustancias con la calidad e innocuidad requerida para servir como materia prima en productos desti...

There is a concern about the use of agro-industrial wastes, which are sources for bioactive compounds with beneficial effects for human health. In this sense, massive consumption foods as egg, becomes in a good vehicle to the design of functional foods, since it is possible to impact a large number of people, which requires the intervention of the...

Antecedentes: Los antioxidantes se han convertido en uno de los conceptos comerciales de mayor impacto en el mercado de los alimentos funcionales; sin embargo, su declaración resulta ser un tema controvertido entre los entes regulatorios a nivel global debido a la complejidad que comprende demostrar la presencia y bioactividad de éstos en un alimen...

One of the main reasons for unsuccessful recovery of carotenoids from agroindustrial by-products is the absence of effective extraction procedures. In this work, lutein was obtained from a mixture of agroindustrial wastes produced in tropical conditions (lettuce, cabbage, auyama) using an optimized supercritical fluid extraction method (SFE-CO2). T...

Background: Antioxidants have been one of the commercial concepts with highest impact in functional food market; however, their statement turns out a controversial topic among regulatory agencies worldwide, due to the complexity involved in demonstrating the presence and bioactivity of these antioxidants in the food. In this context, recent researc...

Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was st...

Introduction. Oil is the most important component of avocado, achieving levels up to 25% depending on the variety and the maturity. Such oil is known as a very beneficial product for health. Objective. Compare the avocado oil (Persea americana Mill), Hass variety, cultivated in Colombia and obtained by supercritical fluids, with those obtained by c...

Introduction. Oil is the most important component of avocado, achieving levels up to 25% depending on the variety and the maturity. Such oil is known as a very beneficial product for health. Objective. Compare the avocado oil (Persea americana Mill), Hass variety, cultivated in Colombia and obtained by supercritical fluids, with those obtained by c...

Introduction. The studies about natural additives obtained through commercially, environmentally and nutritionally competitive technologies applied to alimentan/ matrices, are necessary to offer new alternatives to the industry that respond to the consumption trends of natural and healthy producís. Therefore, obtaining a natural dye from paprika's...

Traditionally, obtaining a cell suspension culture oriented to the production of primary and secondary metabolites takes 10 to 12 months, depending on the plant species, physiological stage and growing conditions, among others. This process involves the induction of friable callus suitable for the establishment of a cell suspension. However, this p...

Many studies have demonstrated that the flavonoid quercetin protects against cardiovascular disease (CVD) and related risk factors. Atherosclerosis, the underlying cause of CVD, is also attenuated by oral quercetin administration in animal models. Although macrophages are key players during fatty streak formation and plaque progression and aggravat...

A new procedure has been used to separate and quantify the free radical-scavenging activity of individual compounds 18 samples of Thymus vulgaris and 12 samples of Rosmarinus officinalis (both used as natural food preservatives), based on the combination of HPTLC (High Performance Thin Layer Chromatography) and postchromatographic DPPH● radical der...

Clementines are especially appreciated for their delicious flavor, and recent years have seen a great increase in the consumption of clementine juice. In previous decades, antioxidant compounds have received particular attention because of widely demonstrated beneficial health effects. In this work, the organoleptic, volatile flavor, and antioxidan...

Citrus fruits, such as orange (Citrus sinensis), grapefruit (Citrus paradisi) and mandarin (Citrus reticulata) are widely consumed around the world as fresh fruit, juice and juice concentrate. In fact, a variety of methods is available or has been developed for extracting juice from citrus fruits. These technologies affect different parts of the fr...

Antioxidants belong to one of the most important group of compounds presented in herbs, nutraceuticals and functional food, which prevent oxidative stress avoiding cell damage. Hence, antioxidants have a high demanding and also their natural sources. A new procedure has been used to separate and quantify the free radical-scavenging activity of indi...

Patients with systemic lupus erythematosus (SLE) have a high risk of developing cardiovascular disease; however, the mechanisms involved in the early onset of atherosclerosis in these patients are not clear. Scavenger receptors, CD36 and CD163 are expressed by mononuclear phagocytes and participate in the binding and uptake of oxidized low-density...

Our cities generate more and more waste which final disposal is made in open dumps or watercourses, creating a public health problem. The volumes of such waste are so big that collection and disposal costs get higher and higher. Despite this, organic waste is also a source of compounds that can be used, given their technological and nutritional pro...

Citrus species contain various typical flavonoids. However, absorption and metabolism of flavonoids are complex processes that determine its bioavailability which remain not clear until now. The aim of this study was to investigate the interactions among dimyristoyl-phosphatidyl choline (DMPC) liposomes and the flavanones hesperidin (glycoside) and...

One of the main reasons for unsuccessful recovery of flavonoids from citrus by-products is the absence of effective extraction procedures. In this work, flavonoid fractions were obtained from citrus peels (lime, orange and tangerine) growing in South American cultivars using an optimized aqueous ultrasound-assisted extraction method with high yield...

El propósito de esta investigación fue el establecimiento de suspensiones celulares de cacao (Theobroma cacao) para analizar el contenido de polifenoles totales en dos variedades de cacao colombianas y comparar estos resultados con el contenido total de polifenoles para las mismas variedades de campo. Los resultados finales mostraron que es posible...

The aim of this research was to establish cocoa (Theobroma cacao) cell suspensions culture to analyze the total polyphenols content for two Colombian cocoa varieties and to compare the results with the total polyphenols content from the same field varieties. The final results showed that it is possible to produce big amount of cocoa cell biomass ab...

Metabolism of Plasmodium sp. produces toxic free heme and detoxifies it by dimerizing it into hemozoin. Most of antimalarial drugs including artemisinine inhibit the heme dimerization, and this pathway remains of considerable interest. Mass spectrometry is a highly selective tool to assess interaction of drugs with heme and detect active compounds...

Skin pigmentation is the consequence of melanin production and dispersion, this pigment is formed by a successive oxidation of L-Tyrosine into L-Dihydroxyphenylalanine (L-DOPA) and dopaquinone by Tyrosinase enzyme. Skin pigmentation irregularities become an aesthetic problem for many people. Therefore there is a big interest in research on products...

Skin pigmentation is the consequence of melanin production and dispersion, this pigment is formed by a successive oxidation of L-Tyrosine into L-Dihydroxyphenylalanine (L-DOPA) and dopaquinone by Tyrosinase enzyme. Skin pigmentation irregularities become an aesthetic problem for many people. Therefore there is a big interest in research on products...

Un evento imperativo en la generación de células espumosas en la aterosclerosis es la oxidación de la LDL; cuando estas partículas son oxidadas se convierten en epítopes para macrófagos los cuales se comienzan a transformar en células muy reactivas produciendo promotores de crecimiento e induciendo la replicación de células musculares lisas. Los pr...

Hesperidin is a flavonoid related to different biological activities. In this work it has demonstrated the potential of some vegetal material as sources of bulk hesperidin, which was tested in two key models on cardiovascular pathology: HDL uptake by liver cells and the LDL oxidation. However, hesperidin present a drawback for its pharmaceutical us...

En este trabajo se hace una caracterización preliminar del enzima Polifenol Oxidasa (PPO), responsable del deterioro nutricional de Physalis peruviana L (uchuva) y Solanum hirtum X Solanum quitoense (lulo), frutas de alto potencial en mercados internacionales. Para ello, se evalúan la cinética de reacción de un extracto enzimático concentrado y la...

Epidemiological studies have shown that consumption of fruits and vegetables are associated with beneficial effects on human health including the reduction of coronary artery disease (CAD) risk. Fruits and their juices contain phytochemicals that inhibit in vitro the low-density lipoprotein (LDL) oxidation, a key process involved in the generation...

Epidemiological studies have shown that consumption of fruits and vegetables are associated with beneficial effects on human health including the reduction of coronary artery disease (CAD) risk. Fruits and their juices contain phytochemicals that inhibit in vitro the low-density lipoprotein (LDL) oxidation, a key process involved in the generation...

Free radicals scavenger activity of 53 extracts of different polarity which belong to species of Annonaceae family was evaluated by DPPH (2,2-diphenil-1-picryl hydrazil) method. The percentage of DPPH radical was calculated measuring the change in absorbance at 517 nm; EC50 (Extract concentration necessary to decolorate DPPH radical in a 50%) was d...

Resumen En este capítulo se describen las principales sustancias químicas presentes en los residuos de la industrializa-ción de cítricos. Especialmente se detallan en los caro-tenoides, aceites fijos y esenciales, flavonoides, limo-noides y pectina. Finalmente se relacionan aplicaciones de estos componentes en los sectores pecuario, farma-céutico,...