Julia Klawohn

Julia Klawohn
MSB Medical School Berlin · Department of Medicine

PhD

About

63
Publications
10,036
Reads
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1,161
Citations
Additional affiliations
September 2019 - present
Humboldt-Universität zu Berlin
Position
  • PostDoc Position
September 2017 - September 2019
Florida State University
Position
  • PostDoc Position

Publications

Publications (63)
Article
Reduced neural responses to reward and pleasant stimuli-indicators of anhedonia and reduced emotional reactivity, respectively-have been reported among individuals with depressive disorders. The current study examined whether these neural measures could prospectively predict the course of depression among a community-based sample of 83 participants...
Article
Background Depressive disorders have been associated with altered effort-cost decision making (ECDM) in behavioral investigations, such as a decreased willingness to expend effort for reward attainment. However, little is known about neural mechanisms implicated in altered ECDM. Methods The study investigates neural correlates of reward attainment...
Article
Event-related potentials (ERPs) bring many strengths to the study of emotion regulation, including: direct measurement of neural activity, high temporal resolution, affordability and suitability to a wide range of participants. Research using ERPs to study emotion regulation began approximately two decades ago, but has grown exponentially over the...
Article
Full-text available
The error-related negativity (ERN), a neural response to errors, has been associated with several forms of psychopathology and assumed to represent a neural risk marker for obsessive-compulsive disorder (OCD) and anxiety disorders. Yet, it is still unknown which specific symptoms or traits best explain ERN variation. This study investigated perform...
Article
Background Examining predictive biomarkers to identify individuals who will likely benefit from a specific treatment is important for the development of targeted interventions. The late positive potential (LPP) is a neural marker of attention and elaborated stimulus processing, and increased LPP responses to negative stimuli are characteristic of p...
Article
Full-text available
Overactive performance monitoring, as reflected by enhanced neural responses to errors (the error-related negativity, ERN), is considered a biomarker for obsessive-compulsive disorder (OCD) and may be a promising target for novel treatment approaches. Prior research suggests that non-invasive brain stimulation with transcranial direct current stimu...
Article
b> Ziel: Diese Arbeit gibt einen Überblick über bisherige wissenschaftliche Empfehlungen zur Implementierung der blended therapy, d.h. der Kombination von Therapien in Präsenz und via digitaler Medien. Die Empfehlungen um­fassen die Themen: (1) wahrgenommene Barrieren von Psychotherapeut*innen, (2) Format der blended therapy und (3) Indikationen fü...
Article
Background The late positive potential (LPP) to pleasant content is an electrocortical indicator of blunted emotional reactivity in depression. A reduced time-frequency delta power has never been investigated in clinical samples. The present study examined time-frequency delta in depression and at investigated whether the combination of time-domain...
Article
Motivation Depressive disorders are highly prevalent and impairing psychiatric conditions with neurocognitive abnormalities, including reduced event-related potential (ERP) measures of reward processing and emotional reactivity. Accurate classification of Major Depressive Disorder (MDD) based on ERP data could help improve our understanding of thes...
Article
Full-text available
Studies have shown that people with obsessive–compulsive disorder (OCD) have impairments in spatial working memory (SWM) performance. However, it remains unclear whether this deficit represents a cognitive endophenotype preceding symptoms or a correlate of OCD. We investigated SWM in 69 people with OCD, 77 unaffected first-degree relatives of peopl...
Preprint
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD case-control sample (N = 14,140 OCD cases and N = 562,117 controls) to date. We explored the genetic architect...
Article
Research on action monitoring and error processing has begun to consider the role of emotion, motivation, and peripheral autonomic arousal. To date, little is known about the specific nature of evaluative processing during action monitoring and its interaction with autonomic arousal. This study aimed to replicate and extend previous findings on aff...
Article
Full-text available
Alterations in frontal and parietal neural activations during working memory task performance have been suggested as a candidate endophenotype of obsessive-compulsive disorder (OCD) in studies involving first-degree relatives. However, the direct link between genetic risk for OCD and neuro-functional alterations during working memory performance ha...
Article
Full-text available
Background The COVID-19 pandemic is a major life stressor posing serious threats not only to physical but also to mental health. To better understand mechanisms of vulnerability and identify individuals at risk for psychopathological symptoms in response to stressors is critical for prevention and intervention. The error-related negativity (ERN) ha...
Article
Obsessive-compulsive disorder (OCD) has recently been linked to increased methylation levels in the oxytocin receptor (OXTR) gene, and OXTR hypermethylation has predicted a worse treatment response to cognitive-behavioural therapy (CBT). Furthermore, OCD is associated with childhood trauma and stressful life events, which have both been shown to af...
Article
Background Indicators of increased error monitoring are associated with obsessive-compulsive disorder (OCD), as shown in EEG and fMRI studies. As most studies used strictly controlled samples (excluding comorbidity and medication) it remains open whether these findings extend to naturalistic settings. Thus, we assessed error-related brain activity...
Poster
Full-text available
Indirekte Zusammenhänge der ERN über Risikowahrnehmung und Stresserleben auf die Entstehung von internalisierender Symptomatik während der ersten COVID 19 Welle in Deutschland.
Article
Background Recent efforts to classify subtypes of major depressive disorder marked by different psychophysiological indicators have identified blunted reward-related brain activation in gambling tasks as a characteristic linked specifically to depressed participants with impaired mood reactivity. Methods The current study compared individuals diag...
Article
Neurocognitive impairments commonly observed in depressive disorders are thought to be reflected in reduced P300 amplitudes. To date, depression‐related P300 amplitude reduction has mostly been demonstrated cross‐sectionally, while its clinical implication for the course of depression remains largely unclear. Moreover, the relationship between P300...
Article
Attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental syndrome characterized by impulsivity and distractibility, has been linked to blunted neural indicators of executive function and motivational processing. In the current study, we examined cross-sectional and prospective associations between P300 to feedback stimuli, the reward p...
Article
Attentional biases are thought to be involved in the etiopathogenesis of depressive disorders. Recent studies indicate eye-tracking techniques could overcome methodological issues of traditional reaction time bias measures and be used to reliably quantify biases in attention. In the current study, 50 participants with a current depressive disorder...
Preprint
Full-text available
Despite extensive standardization, diagnostic interviews for mental health disorders encompass substantial subjective judgment. Previous studies have demonstrated that EEG-based neural measures can function as reliable objective correlates of depression, or even predictors of depression and its course. However, their clinical utility has not been f...
Article
Full-text available
Objective Obsessive‐compulsive disorder (OCD) is a complex psychiatric disorder with a substantial genetic contribution. While the specific variants underlying OCD’s heritability are still unknown, findings from genome‐wide association studies (GWAS) corroborate the importance of common SNPs explaining the phenotypic variance in OCD. Investigating...
Article
The error-related negativity (ERN) is an event-related potential (ERP) component that is widely used to study human performance monitoring. However, substantial methodological differences exist across studies and it is unclear to what extent these differences may impact the reliability and replicability of observed effects. The current study used m...
Article
Because obsessive-compulsive disorder (OCD) is a highly impairing and often chronic psychiatric disorder, there is high interest in novel add-on or alternative intervention approaches. The error-related negativity (ERN), a response-related ERP occurring shortly after incorrect responses, might provide a promising target for novel interventions. Inc...
Article
Background Multiple studies have found a reduced reward positivity (RewP) among individuals with major depressive disorder (MDD). Event-related potential studies have also reported blunted neural responses to pleasant pictures in MDD as reflected by the late positive potential (LPP). These deficits have been interpreted broadly in terms of anhedoni...
Article
Full-text available
Individuals with current depression show reduced amplitude of the P300 component of the stimulus-locked event-related potential (ERP)-an effect most often examined in oddball tasks. Although imperative stimuli in response-monitoring paradigms (e.g., the flanker task), also elicit a P300, it is unclear whether a blunted P300 can be observed in depre...
Article
Full-text available
Researchers in clinical psychophysiology make several methodological decisions during the analysis of event-related potentials (ERPs). In the current study, we review these choices from the perspective of individual differences. We focus on baseline period and reference scheme (i.e., average, mastoid, current source density), as well as choices reg...
Article
Full-text available
Research has identified the neural response to errors (the error-related negativity; ERN) as a marker of current anxiety, as well as risk for future anxiety. Previous work found that traditional cognitive behavioral therapy approaches do not impact the ERN. However, none of these approaches directly target the psychological constructs linked to an...
Article
Hyperactive error monitoring is a robust neurocognitive characteristic in obsessive-compulsive disorder (OCD). Yet, relatively little is known about the flexibility and potential moderators of error monitoring in OCD. The current study investigates error monitoring in 30 healthy participants and 28 patients with OCD using a flanker task in 2 condit...
Article
Full-text available
Blunted reward processing both characterizes major depressive disorder and predicts increases in depressive symptoms. However, little is known about the interaction between blunted reward processing and other risk factors in relation to increases in depressive symptoms. Stressful life events and sleep problems are prominent risk factors that contri...
Article
Full-text available
Event-related potentials (ERPs) are direct measures of brain activity that can be leveraged for clinically meaningful research. They can relate robustly both to continuous measures of individual difference and to categorical diagnoses in ways that clarify similarities and distinctions between apparently related disorders and traits. ERPs can be lin...
Article
The menstrual cycle is known to impact mood and cognitive function and has been shown to lead to variability in symptoms of obsessive-compulsive disorders and anxiety. Using a within-subject design, the present study examined ovarian hormones, the error-related negativity (ERN), and self-reported checking symptoms in both the mid-follicular and mid...
Article
Full-text available
Adolescence is frequently described as a developmental period characterized by increased sensitivity to rewards. However, previous research on age-related changes in the neural response to gains and losses have produced mixed results, with only some studies reporting potentiated neural responses during adolescence. The current study examined the ER...
Article
Full-text available
Patients with obsessive-compulsive disorder (OCD) show dysfunctions of the fronto-striatal circuitry, which imply corresponding oculomotor deficits including smooth pursuit eye movements (SPEM). However, evidence for a deficit in SPEM is inconclusive, with some studies reporting reduced velocity gain while others did not find any SPEM dysfunctions...
Article
Full-text available
Background Increased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion,...
Article
Patients with obsessive-compulsive disorder (OCD) show deficient planning capacity in the Tower of London (TOL) problem solving task. Preliminary evidence for similar deficits in unaffected first-degree relatives suggests that impaired planning may constitute an endophenotype of OCD. However, results on this issue are inconsistent, possibly owing t...
Article
Full-text available
Increasing evidence indicates that patients with obsessive-compulsive disorder (OCD) exhibit alterations in fronto-striatal circuitry. Performance deficits in the antisaccade task would support this model, but results from previous small-scale studies have been inconclusive as either increased error rates, prolonged antisaccade latencies, both or n...
Article
Full-text available
Touch is central to mammalian communication, socialisation, and wellbeing. Despite this prominence, interpersonal touch is relatively understudied. In this preregistered investigation, we assessed the influence of interpersonal touch on the subjective, neural, and behavioural correlates of cognitive control. Forty-five romantic couples were recruit...
Preprint
Touch is central to mammalian communication, socialisation, and wellbeing. Despite this prominence, interpersonal touch is relatively understudied. In this preregistered investigation, we assessed the influence of interpersonal touch on the subjective, neural, and behavioural correlates of cognitive control. Forty-five romantic couples were recruit...
Article
Full-text available
Previous research in patients with obsessive-compulsive disorder (OCD) has indicated performance decrements in working memory (WM) and response inhibition. However, underlying neural mechanisms of WM deficits are not well understood to date, and empirical evidence for a proposed conceptual link to inhibition deficits is missing. We investigated WM...
Article
Frontal electroencephalographic alpha asymmetry as an indicator of trait approach and trait inhibition systems has previously been studied in individuals with obsessive–compulsive disorder (OCD) with mixed results. We explored frontal alpha asymmetry as a possible risk factor in OCD by investigating a large sample of OCD patients (n = 113), healthy...
Article
Recent evidence indicates that patients with obsessive-compulsive disorder (OCD) as well as their unaffected first-degree relatives show deficits in the volitional control of saccades, suggesting that volitional saccade performance may constitute an endophenotype of OCD. Here, we aimed to replicate and extend these findings in a large, independent...
Article
Objective: The etiology of obsessive-compulsive disorder (OCD) is assumed to involve interactions between genetically determined vulnerability factors and significant environmental features. Here, we aim to investigate how the personality trait harm avoidance and the experience of childhood adversities contribute to OCD. Method: A total of 169 p...
Article
Background: Feelings of doubt and perseverative behaviours are key symptoms of obsessive-compulsive disorder (OCD) and have been linked to hyperactive error and conflict signals in the brain. While enhanced neural correlates of error monitoring have been robustly shown, far less is known about conflict processing and adaptation in OCD. Method: W...
Article
Background Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder, which aggregates in families. Its etiology is assumed to involve interactions between genetically determined vulnerability factors and critical environmental influences. In the present study, we aim to investigate how the personality trait harm avoidance and the experi...
Article
Endophenotypes are conceived as measurable but not directly observable features of mental disorders that link clinical symptoms with their genetic underpinnings. They promise to guide the search for specific causal gene variants but also to understand mechanisms of symptom generation more precisely. Several criteria have been listed that must been...
Article
Full-text available
Brain correlates of performance-monitoring have been shown to be hyperactive in patients with obsessive-compulsive disorder (OCD), indexed by enhanced amplitudes of the error-related negativity (ERN) in the event-related potential (ERP). This hyperactivity was found to be temporally stable, independent of symptom remission, and could not be further...
Article
The present study investigated the modulation of the N2 and the correct-related negativity (CRN) by conflict frequency. Conflict costs, as measured by reaction times and error rate, were reduced with increasing conflict frequency, indicating improved conflict resolution. N2 amplitudes in incompatible trials increased with higher conflict frequency,...
Article
Full-text available
Hyperactive performance monitoring is a robust finding in obsessive-compulsive disorder (OCD). Patients show increased amplitudes of the error-related negativity (ERN) and correct-related negativity (CRN). Recently, two temporo-spatial factors were shown to contribute to both ERPs in healthy individuals. In the present study, it was investigated wh...
Article
Full-text available
Previous research on performance monitoring revealed that errors are followed by an initial fronto-central negative deflection (error-related negativity, ERN or Ne) and a subsequent centro-parietal positivity (error positivity, Pe). It has been shown that error awareness mainly influences the Pe, whereas the ERN seems unaffected by conscious awaren...
Article
Two ERP components have been observed following correct and incorrect responses, the error-related negativity (ERN/Ne) and the correct-related negativity (CRN). The function of these components is still under debate. We used a visual size discrimination task at three difficulty levels and utilized a temporospatial principal component analysis (PCA)...
Article
Obsessive-compulsive disorder (OCD) has repeatedly been associated with hyperactivity in fronto-striatal brain regions and regions related to performance monitoring. The aim of the current study was to further investigate electrophysiological correlates of performance monitoring. Specifically, we intended to replicate previous results revealing enh...

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