Julia DlugaiczykUniversitätsspital Zürich · Otorhinolaryngologie
Julia Dlugaiczyk
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Introduction
Skills and Expertise
Publications
Publications (51)
This article describes the surgical treatment of superior semicircular canal dehiscence syndrome (SCDS) by isolating the dehiscence using transmastoid two-point canal plugging while preserving the high-frequency vestibulo-ocular reflex (VOR) of the affected semicircular canal. The superior semicircular canal is opened via a transmastoid approach an...
This article describes the surgical treatment of superior semicircular canal dehiscence syndrome (SCDS) by isolating the dehiscence using transmastoid two-point canal plugging while preserving the high-frequency vestibulo-ocular reflex (VOR) of the affected semicircular canal. The superior semicircular canal is opened via a transmastoid approach an...
Objective
Vestibular evoked myogenic potentials (VEMPs) have been suggested as biomarkers in the differential diagnosis of Menière’s disease (MD) and vestibular migraine (VM). The aim of this study was to compare the degree of asymmetry for ocular (o) and cervical (c) VEMPs in large cohorts of patients with MD and VM and to follow up the responses....
Hypothesis:
Bone-conducted vibration (BCV) at 100 Hz causes endolymph displacement at hair cell stereocilia in semicircular canal (SCC) ducts of the intact bony labyrinth resulting in activation of irregularly discharging afferent neurons.
Background:
Suprathreshold 100 Hz BCV is employed in the clinic to evoke skull vibration-induced nystagmus,...
Background: Vestibular evoked myogenic potentials (VEMPs) are increasingly being used for testing otolith organ function. Objective: This article provides an overview of the anatomical, biomechanical and neurophysiological principles underlying the evidence-based clinical application of ocular and cervical VEMPs (oVEMPs and cVEMPs). Material and me...
Background
Vestibular evoked myogenic potentials (VEMPs) are increasingly being used for testing otolith organ function.Objective
This article provides an overview of the anatomical, biomechanical and neurophysiological principles underlying the evidence-based clinical application of ocular and cervical VEMPs (oVEMPs and cVEMPs).Material and method...
Background: Vestibular evoked myogenic potentials (VEMPs) are increasingly being used for testing otolith organ function. Objective: This article provides an overview of the anatomical, biomechanical and neurophysiological principles of an evidence-based clinical application of ocular and cervical VEMPs (oVEMPs and cVEMPs). Material and methods: Sy...
Background:
Recent research findings have improved the understanding of the diagnosis, pathophysiology, genetics, etiology, and treatment of peripheral, central, and functional vestibular vertigo syndromes.
Method:
A literature search, with special attention to the current classification, treatment trials, Cochrane analyses, and other meta-analy...
Synopsis
Galvanic vestibular stimulation (GVS) is a simple and useful technique to probe morpho-physiological aspects of vestibular computations and to characterize vestibular disorders. The motion-free activation of both semicircular canal and otolith organs with this method and electrophysiological recordings of vestibular cellular elements revea...
Purpose of review:
To examine the recent literature concerning the neural basis and clinical evidence for the response of the labyrinth to sound and vibration: vestibular-evoked myogenic potentials (VEMPs) and vibration-induced nystagmus (VIN).
Recent findings:
There are two streams of information from each otolith - a sustained stream (afferent...
Background
Vestibular evoked myogenic potentials (VEMPs) are increasingly being used for testing otolith organ function.
Objective
This article provides an overview of the anatomical, biomechanical and neurophysiological principles of an evidence-based clinical application of ocular and cervical VEMPs (oVEMPs and cVEMPs).
Material and methods
Sys...
Galvanic vestibular stimulation (GVS) plays an important role in the quest to understand sensory signal processing in the vestibular system under normal and pathological conditions. It has become a highly relevant tool to probe neuronal computations and to assist in the differentiation and treatment of vestibular syndromes. Following its accidental...
Hypothesis:
In superior canal dehiscence (SCD), fluid displacement of the endolymph activates type I vestibular hair cells in the crista of the affected canal and thus irregular superior canal (SC) neurons in Scarpa's ganglion, which provides the neurophysiological basis for the clinical presentation of SCD.
Background:
Patients with SCD display...
Vestibular evoked myogenic potentials (VEMPs) are short-latency, otolith-driven vestibular reflexes evoked by sound, vibration or galvanic stimulation and recorded from ocular (oVEMPs) or cervical muscles (cVEMPs). While oVEMPs are predominantly an indicator of contralateral utricular function, cVEMPs predominantly reflect ipsilateral saccular func...
Schwindel als häufiges Leitsymptom in der klinischen Praxis kann otologische, neurologische, internistische und psychiatrische Ursachen haben und stellt damit eine interdisziplinäre Herausforderung dar. Durch eine systematische Anamnese und umfassende klinische Untersuchung gelingt in aller Regel eine eindeutige Zuordnung zu peripher-, zentral- ode...
Hypothesis:
Implementation of the "aVOR app" into teaching courses at medical school enhances students' satisfaction with the course and increases their competence in treating benign paroxysmal positional vertigo (BPPV).
Background:
BPPV is often underdiagnosed and left untreated. One problem in teaching the management of BPPV to health care pro...
Objective:
Over the last decade, ocular vestibular evoked myogenic potentials (oVEMPs) have evolved as a new clinical test for dynamic otolith (predominantly utricular) function. The aim of this review is to give an update on the neurophysiological foundations of oVEMPs and their implications for recording and interpreting oVEMP responses in clini...
Hearing is an essential sense for communication in animals and humans. Normal function of the cochlea of higher vertebrates relies on a fine-tuned interplay of afferent and efferent innervation of both inner and outer hair cells. Efferent inhibition is controlled via olivocochlear feedback loops, mediated mainly by acetylcholine, γ-aminobutyric aci...
Mesenchymal-endothelial transition is proposed for juvenile angiofibromas (JAs). Propranolol might be an interesting new medical option in JA treatment, as it reduces mesenchymal cell growth and decreases the number of CD31-positive cells in vitro.
Juvenile angiofibromas (JAs) are rare fibro-vascular tumors affecting almost exclusively adolescent m...
Menière’s disease and vestibular migraine (VM) are the most common causes of spontaneous recurrent vertigo. The current diagnostic criteria for the two disorders are mainly based on patients’ symptoms, and no biological marker is available. When applying these criteria, an overlap of the two disorders is occasionally observed in clinical practice....
Background
Predilection of juvenile angiofibromas in adolescent boys has prompted the hypothesis of hormone-dependent tumor growth. However, knowledge on expression and function of sex hormone receptors in juvenile angiofibromas is still sparse and inconsistent. Methods
Transcript and protein expression of sex hormone receptors in juvenile angiofib...
Surgery of the ear and the lateral skull base is a fascinating, yet challenging field in otorhinolaryngology. A thorough knowledge of the associated complications and pitfalls is indispensable for the surgeon, not only to provide the best possible care to his patients, but also to further improve his surgical skills.
Following a summary about gene...
Surgery of the ear and the lateral skull base is a fascinating, yet challenging field in otorhinolaryngology. A thorough knowledge of the associated complications and pitfalls is indispensable for the surgeon, not only to provide the best possible care to his patients, but also to further improve his surgical skills.Following a summary about genera...
Der benigne paroxysmale Lagerungsschwindel infolge von Osteotomien bei einer Septorhinoplastik ist eine sehr seltene Komplikation der Rhinoplastik, deren Therapie mit etwas Übung leicht durchführbar ist. Unbehandelt kann sie beim Patienten jedoch starke Schwindelbeschwerden auslösen. Daher sind die Kenntnis dieser Komplikation für den Operateur, di...
Cervical (c) and ocular (o) vestibular evoked myogenic potentials (VEMPs) provide important tools for measuring otolith function. However, two major drawbacks of this method are encountered in clinical practice. First, recording of oVEMPs is compromised by small n10 amplitudes. Second, VEMP analysis is currently based on the averaging technique, re...
Glucocorticoids (GCs) not only regulate metabolic and inflammatory mechanisms, but also are known to suppress tumor growth. Despite previous detection of glucocorticoid receptors (GRs) in juvenile angiofibromas, their distribution and function have not further been studied.
Juvenile angiofibroma tissue (n = 30), nasal mucosa specimens (n = 10), sub...
The precision of sound information transmitted to the brain depends on the transfer characteristics of the inner hair cell (IHC) ribbon synapse and its multiple contacting auditory fibers. We found that brain derived neurotrophic factor (BDNF) differentially influences IHC characteristics in the intact and injured cochlea. Using conditional knock-o...
Juvenile angiofibroma (JA) is a unique fibrovascular tumor, which is almost exclusively found in the posterior nasal cavity of adolescent males. Although histologically classified as benign, the tumor often shows an aggressive growth pattern and has been associated with chromosomal imbalances, amplification of oncogenes and epigenetic dysregulation...
Distortion product otoacoustic emissions (DPOAEs) are widely used as an objective examination procedure to determine cochlear function. In a clinical routine setting, the amplitude of the DPOAE signal at 2 f <sub>1</sub>- f <sub>2</sub> is applied as an indicator for a potential hearing loss up to 8 kHz. Due to their poor signal-to-noise ratio, mea...
To study the involvement of the different semicircular canals in posttraumatic benign paroxysmal positioning vertigo (BPPV) with special reference to the anterior canal (AC).
Retrospective review.
Tertiary referral center.
Seventy-four BPPV patients.
Neurotologic assessment with video-oculography; treatment of BPPV with the canalith repositioning p...
Efferent olivocochlear feedback innervation modulates the stream of auditory information from cochlea to brainstem by regulating auditory nerve activity and controlling the contribution of cochlear outer hair cells to basilar membrane motion. In our previous work, we gave a first description of glycine receptors (GlyRs) in the rat cochlea indicatin...
Die vielfältigen und hoch differenzierten Leistungen unseres vestibulären Systems sind nur durch das fein abgestimmte Zusammenspiel zahlreicher neuronaler vestibulärer Netzwerke möglich. Dabei stellen diese Verbindungen keine Einbahnstraßen dar, welche lediglich die afferente vestibuläre Information von der Peripherie ins ZNS leiten. Vielmehr finde...
Francisella tularensis, the causative agent of tularemia, has been recognized as a human and zoonotic pathogen for almost 100 years. The increasing number of tularemia outbreaks in regions of Europe outside the classic endemic areas in recent years has prompted renewed interest in this rare infectious disease. We report on a case of oropharyngeal t...
Die Gestalt der Lippen geht auf die Herkunft aus verschiedenen Gesichtswülsten zurück (4. Embryonalwoche)
There are two important features of benign tumors of the nose and paranasal sinuses: they are rare and they cover a great variety of different tumor entities.
■ Symptoms of tumors of the nose and paranasal sinuses are unspecific in most cases and mimic the clinical picture of inflammatory disorders. Moreover, many tumors are diagnosed by chance i...
Liposarkome stellen mit weniger als 100 beschriebenen Fällen im Kopf-Hals-Bereich eine Rarität dar. Wir berichten hier über einen 54-jährigen Patienten mit einem Liposarkom der rechten Halsweichteile. Nach einer kompletten Tumorexstirpation erfolgte eine postoperative Strahlentherapie. Anhand des vorgestellten Falles und einer Literaturübersicht we...
The cochlear efferent feedback system exerts direct impact on cochlear nerve activity and balances interaural sensitivity. So far, acetylcholine, GABA and dopamine are known to be transmitters of the inhibitory efferent system. Despite the wealth of information about glycinergic neurotransmission in the central auditory system, the inhibitory glyci...
Liposarkome stellen mit weniger als 100 beschriebenen Fällen im Kopf-Hals-Bereich eine Rarität dar. Wir berichten hier über
einen 54-jährigen Patienten mit einem Liposarkom der rechten Halsweichteile. Nach einer kompletten Tumorexstirpation erfolgte
eine postoperative Strahlentherapie. Anhand des vorgestellten Falles und einer Literaturübersicht we...
With less than 100 cases described in the literature, the incidence of liposarcoma in the head and neck is very low. We report on a 54-year-old patient with a liposarcoma of the right cervical soft tissue. After complete tumor extirpation the patient underwent radiotherapy. Diagnostics, histopathological classification, therapy and prognosis of lip...
Sialolithiasis is one of the most frequent causes of inflammatory changes within the major salivary glands in Europe. Salivary stone formation affects the submandibular gland in 80%, the parotid gland in 20% of cases, and rarely the sublingual gland.
