Jukka Kemppainen

Jukka Kemppainen
University of Turku | UTU · Turku PET (Positron Emission Tomography) Centre

Professor

About

147
Publications
16,703
Reads
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3,547
Citations
Additional affiliations
May 1997 - December 2013
University of Turku
Position
  • University of Turku, Turku University Hospital
Education
March 2010
University of Turku
Field of study
August 2008
University of Turku
Field of study
November 2007
University of Turku
Field of study

Publications

Publications (147)
Article
Full-text available
A 47-year-old man had fever, fatigue, abdominal pain, and claudication due to antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Whole-body [18 F] FDG PET/CT scan was performed as a diagnostic procedure, and it revealed abnormal [18 F] FDG accumulation in small-and medium-sized vessels of the upper extremities and in the lower extrem...
Article
(18)F-Fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies. Pheochromocytomas, paragangliomas, and medullary thyroid cancers especially are amenable to FDOPA imaging because of the high specific uptake of this amino acid analogu...
Article
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A novel [68Ga]-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 peptide (BAY86-7548) having high affinity to bombesin receptor subtype 2 to detect primary and metastatic prostate carcinoma (PCa) using PET/CT was synthesized and evaluated for prostate cancer (PCa). In this first human study with BAY86-7548, f...
Article
Purpose: The muscle perfusion response to post-exercise cold water immersion (CWI) is not well understood. We examined the effects of graded post-exercise CWI upon global and regional quadriceps femoris muscle perfusion using positron emission tomography (PET) and [15O]H2O. Methods: Using a matched-group design, 30 healthy men performed cycle er...
Article
Full-text available
Purpose: The aim of this study was to correlate immunohistochemical (IHC) tissue levels of SSTR1-5 with the receptor density generated from [68Ga]Ga-DOTANOC uptake in a prospective series of NF-PNENs. Methods: Twenty-one patients with a total of thirty-five NF-PNEN-lesions and twenty-one histologically confirmed lymph node metastases (LN+) were...
Preprint
Full-text available
Purpose: Overexperssion of Gastrin-releasing-peptide receptor (GRPr) in prostate carcinoma (PCa) suggests new means in the detection of prostate cancer foci. The bombesin derivative RM2 (DOTA-4-amino-1-carboxy­methyl­piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) is a GRPr antagonist with strong binding affinity. Based on promising results f...
Article
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PurposeTo prospectively compare 18F-prostate-specific membrane antigen (PSMA)-1007 positron emission tomography (PET)/CT, whole-body magnetic resonance imaging (WBMRI) including diffusion-weighted imaging (DWI) and standard computed tomography (CT), in primary nodal staging of prostate cancer (PCa).Methods Men with newly diagnosed unfavourable inte...
Article
Full-text available
Prostate cancer is the second most common cancer type in men globally. Although the prognosis for localized prostate cancer is good, no curative treatments are available for metastatic disease. Better diagnostic methods could help target therapies and improve the outcome. Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein tha...
Article
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Objective: Endocrine Society guidelines recommend adrenal venous sampling (AVS) in primary aldosteronism (PA) if adrenalectomy is considered. We tested whether functional imaging of adrenal cortex with ¹¹ C-metomidate ( ¹¹ C-MTO) could offer a noninvasive alternative to AVS in the subtype classification of PA. Design: We prospectively recruited 58...
Article
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Introduction We investigated the effects of a supervised progressive sprint interval training (SIT) and moderate-intensity continuous training (MICT) on adipocyte morphology and adipose tissue metabolism and function; we also tested whether the responses were similar regardless of baseline glucose tolerance and sex. Research design and methods 26...
Article
Full-text available
Background The diagnosis of cardiac implantable electronic device (CIED) infection is challenging because of its variable presentations. We studied the value of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the detection of CIED infection.Methods and resultsThirty patients with suspected CIED...
Article
Background The clinical utility of positron emission tomography/magnetic resonance imaging (PET/MRI) in comparison to standard work-up with patients with known or suspected inflammatory bowel disease (IBD) is unknown. Purpose To evaluate the value of 18F-fluorodeoxyglucose (18F-FDG) PET/MRI in the diagnostics of IBD and further compare the data ob...
Article
Full-text available
Background Computed tomography (CT) and bone scintigraphy (BS) are the imaging modalities currently used for distant metastasis staging of prostate cancer (PCa). Objective To compare standard staging modalities with newer and potentially more accurate imaging modalities. Design, setting, and participants This prospective, single-centre trial (NCT...
Article
Full-text available
The aim of this prospective single-institution clinical trial (NCT02002455) was to evaluate the potential of advanced post-processing methods for ¹⁸F-Fluciclovine PET and multisequence multiparametric MRI in the prediction of prostate cancer (PCa) aggressiveness, defined by Gleason Grade Group (GGG). 21 patients with PCa underwent PET/CT, PET/MRI a...
Article
We examined the influence of graded cold-water immersion (CWI) on global and regional quadriceps muscle perfusion using positron emission tomography (PET) and [ ¹⁵ O]H 2 O. In thirty healthy males (33±8 yrs; 81±10 kg; 184±5 cm; percentage body fat: 13±5%; V̇O 2peak : 47±8 mL·kg ⁻¹ ·min ⁻¹ ) quadriceps perfusion, thigh and calf cutaneous vascular co...
Article
Full-text available
Purpose Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression. Therefore, we hypothesised that ADT improves the performance of PSMA-PET imaging in primary staging of prostate cancer. The purpose of the study was to demonstrate the time course effect of ADT on PS...
Article
Full-text available
Background: Predicting the aggressive behavior of non-functional pancreatic neuroendocrine tumors (NF-PNET) remains controversial. We wanted to explore, in a prospective setting, whether the diagnostic accuracy can be improved by dual-tracer functional imaging 68Ga-DOTANOC and 18F-FDG-PET/CT in patients with NF-PNETs. Methods: Thirty-one patient...
Article
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Abstract Background Epithelial ovarian cancer (EOC) typically spreads intra-abdominally, but preoperative evaluation with FDG PET/CT often reveals metabolically active supradiaphragmatic lymph nodes (sdLNs). Their clinical significance and behavior during treatment has not been established. Methods EOC patients with PET positive sdLNs at diagnosis...
Article
Full-text available
18F-Fluorodeoxyglucose positron-emission tomography (18F-FDG-PET) with computed tomography (CT) is effective for diagnosing large vessel vasculitis, but its usefulness in accurately diagnosing suspected, unselected vasculitis remains unknown. We evaluated the feasibility of 18F-FDG-PET/CT in real-life cohort of patients with suspicion of vasculitis...
Article
Ovarian cancer is the leading cause of death from gynecologic cancer in the developed countries. It is usually diagnosed in advanced stage since it is often symptomless or symptoms are nonspecific in early course of the disease. It has a high recurrence rate and poor prognosis in advanced disease. Ovarian cancer has distinct type of disease spread...
Article
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Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and tested an optimized novel meth...
Article
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Purpose: To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of 18F-1-amino-3-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) which is approved for the detection of recurrent PCa. Methods: Twenty-five hormone-naïve patient...
Article
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Background Despite recent technological advances allowing for quantitative single-photon emission computed tomography (SPECT), quantitative SPECT has not been widely used in the clinical practice. The aim of this study is to evaluate the feasibility of quantitative SPECT for measuring metastatic bone uptake in breast and prostate cancer by comparin...
Article
Purpose The aim of this retrospective single-center analysis was to evaluate the feasibility of fluorine-18 fluorodeoxyglucose (FDG)-PET imaging in evaluating metabolic response of preoperative chemotherapy in the treatment of locally advanced operable gastroesophageal adenocarcinoma and to investigate the association between histopathologic and FD...
Article
Human bone marrow is a metabolically active tissue that responds to acute low intensity exercise by having increased glucose uptake. Here we studied whether bone marrow glucose uptake increases more with increased exercise intensities. Femoral bone marrow glucose uptake was measured using positron emission tomography and 18F-fluoro-deoxyglucose in...
Article
Full-text available
Intrinsic factors related to muscle metabolism may explain the differences in mechanical efficiency (ME) during exercise. Therefore, this study aimed to investigate the relationship between muscle metabolism and ME. Totally 17 healthy recreationally active male participants were recruited and divided into efficient (EF; n = 8) and inefficient (IE;...
Article
Positron emission tomography (PET) has been commonly and successfully used, in combination with computed tomography (CT) and more recently magnetic resonance (MRI), in the workup of intermediate or high-risk prostate cancer (PCa). Nowadays, new specific receptor targeted PET tracers in prostate cancer imaging have been introduced; one of the most u...
Article
Full-text available
Background: To evaluate the accuracy of 11C-acetate Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) in bladder cancer (BC) staging and monitoring response to neoadjuvant chemotherapy (NAC). Methods: Eighteen patients were prospectively enrolled. Fifteen treatment naive patients underwent 11C-acetate PET/MRI before transurethral...
Article
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Objective: To evaluate the predictive potential of total metabolic tumor volume (MTV) reduction during neoadjuvant chemotherapy (NACT) with18F-FDG-PET/CT in an advanced FIGO stage III/IV epithelial ovarian cancer (EOC) patient cohort. Methods: Twenty-nine primarily inoperable EOC patients underwent18F-FDG-PET/CT before and after NACT. The pre- a...
Article
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Platinum-based chemotherapy constitutes the backbone of clinical care in advanced solid cancers such as high-grade serous ovarian cancer (HGSOC) and has prolonged survival of millions of cancer patients. Most of these patients, however, become resistant to chemotherapy, which generally leads to a fatal refractory disease. We present a comprehensive...
Article
We describe a rare case of prosthetic valve endocarditis caused by the canine bacterium Capnocytophaga canimorsus in a male aged 73 years. The diagnosis of infective endocarditis was unequivocal, as it blood cultures were positive for C. canimorsus and vegetations were detected on transesophageal echocardiography; the modified Duke criteria were fu...
Article
Aims: To prospectively evaluate the use of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in the definition of the treatment response after primary treatment of advanced epithelial ovarian cancer (EOC). Materials and methods: Forty-nine patients with advanced EOC had an 18F-FDG PET/CT scan before and aft...
Article
Full-text available
Purpose: The purpose of this study was to evaluate (18)F-FACBC PET/CT, PET/MRI, and multiparametric MRI (mpMRI) in detection of primary prostate cancer (PCa). Methods: Twenty-six men with histologically confirmed PCa underwent PET/CT immediately after injection of 369 ± 10 MBq (18)F-FACBC (fluciclovine) followed by PET/MRI started 55 ± 7 min fro...
Conference Paper
Full-text available
Purpose To evaluate the potential of advanced post-processing methods for 18F-FACBC (Fluciclovine) PET and MRI in the characterization of prostate cancer. Materials and Methods Twenty one patients with histologically confirmed prostate cancer (PCa) scheduled for robotic–assisted prostatectomy underwent PET/CT immediately after injection of 369 ±1...
Poster
Full-text available
RESULTS AIM In total, 8, 5, and 5 patients presented with Ta/Tis, T1, T2 or higher (MIBC) stage, respectively..The sensitivity, specificity and accuracy values of 11 C-acetate PET/MRI for MIBC To evaluate accuracy of 11 C-acetate PET-MRI in bladder cancer (BC) staging in a prospective, registered trial. METHODS Eighteen patients with a suspected bl...
Article
Full-text available
Purpose This study evaluated the potential of ⁶⁸Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[¹⁸F]fluoro-2-deoxy-D-glucose (¹⁸F-FDG) PET/CT. Methods Four patients admitted to hospital due to S. aureus bacteraemia u...
Article
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Background: ⁶⁸Ga-DOTANOC PET/CT is routinely used to image neuroendocrine tumors (NETs). A case of lymphoma initially thought to be NET based on a positive ⁶⁸Ga-DOTANOC PET/CT was recently seen at our institution. This prompted us to determine prospectively somatostatin receptor (SSTR) status in patients with lymphoma by immunohistochemical analysi...
Article
Full-text available
Aims: Little is known about the effects of exercise training on brown adipose tissue (BAT) metabolism in humans. We tested the hypothesis that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) improve BAT insulin sensitivity. Materials and methods: Healthy middle-aged men (n = 18, age 47 [CI: 49, 43] years...
Conference Paper
Full-text available
PURPOSE To evaluate diagnostic accuracy of 18FFACBC PET/CT, PET/MRI and multiparametric MRI (mpMRI) for detection of primary prostate cancer (PCa) and prediction of its aggressiveness. METHOD AND MATERIALS Twenty six patients with histologically confirmed PCa underwent PET/CT performed immediately after injection of 369±10 MBq 18FFACBC (fluciclovin...
Article
Background: Whole body positron emission tomography (PET)/computed tomography (CT) is a sensitive imaging technique in patients with metastatic melanoma, but its role in the follow-up of asymptomatic high-risk patients is unclear. The aim was to study the role of PET/CT as a routine surveillance imaging tool in asymptomatic high-risk patients at t...
Article
Full-text available
Objective. Increased atherosclerosis in RA is not fully explained by the ordinary risk factors, but it may be related to vascular inflammation. The aim of this study was to investigate the degree of carotid artery inflammation in drug-naive patients with early RA before and after DMARD triple therapy. Methods. Fifteen non-diabetic patients with re...
Article
Background: Advanced echocardiographic methods may reveal signs of late anthracycline cardiac toxicity (ACT) even in asymptomatic patients. We studied echocardiographic tissue Doppler imaging (TDI) and velocity vector imaging (VVI) in long-term survivors of childhood acute lymphoblastic leukemia (ALL) before and after an exercise intervention. Me...
Article
Prospective evaluation of planar bone scintigraphy, SPECT, SPECT/CT, 18 F-NaF PET/CT and whole body 1.5T MRI, including DWI, for the detection of bone metastases in high risk breast and prostate cancer patients: SKELETA clinical trial, Acta Oncologica, 55:1, 59-67,
Article
80 Background: Gastrin-releasing-peptide receptor (GRPr) is overexpressed in prostate carcinoma (PCa) and offer new means to detect prostate cancer. The bombesin derivative RM2 (DOTA-4-amino-1-carboxymethylpiperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2) is a GRPr antagonist with high binding affinity (Kd 3 nM). A first-in-man study was perfor...
Article
Full-text available
Background: The diagnosis of infective endocarditis (IE), especially the diagnosis of prosthetic valve endocarditis (PVE) is challenging since echocardiographic findings are often scarce in the early phase of the disease. We studied the use of 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) i...
Article
Full-text available
Background: High-grade gliomas (HGGs) express somatostatin receptors (SSTR), rendering them candidates for peptide receptor radionuclide therapy (PRRT). Our purpose was to evaluate the potential of 68Ga-DOTA-1-Nal3-octreotide (68Ga-DOTANOC) or 68Ga-DOTA-Tyr3-octreotide (68Ga-DOTATOC) to target SSTR subtype 2 (SSTR2) in HGGs, and to study the associ...
Article
Objective: The aim of this study was to examine the relationship between the reduction of maximum standardized uptake values (SUVmax) in (18)F-FDG-PET/CT to histopathological changes obtained with neoadjuvant chemotherapy (NACT) in advanced epithelial ovarian cancer (EOC). We wanted to evaluate whether (18)F-FDG-PET/CT is useful for identifying pa...