Jukka HuttunenKuopio University Hospital | KYS · Department of Neurosurgery
Jukka Huttunen
Doctor of Medicine
About
48
Publications
2,507
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518
Citations
Citations since 2017
Introduction
Spine surgery,
Neuromodulation - Pain
Additional affiliations
June 2009 - present
Education
August 2001 - April 2008
Publications
Publications (48)
Purpose
To study the effect of antithrombotic therapy (ATT) on the outcome of operatively treated chronic subdural hematomas (CSDH).
Methods
A retrospective population-based cohort study from Eastern Finland including all adult patients who underwent a burr-hole craniostomy (BHC) for CSDH during 2016 and 2017. The follow-up time for recurrence was...
Background:
Spinal cord stimulation (SCS) is an effective treatment for failed back surgery syndrome (FBSS). In patients with FBSS, opioids have often been initiated, even before SCS is trialed.
Objective:
We studied the effect of retirement on opioid use in patients with chronic pain after failed back surgery.
Study design:
A retrospective st...
Purpose
This study aims to elucidate the incidence of and independent risk factors for spinal cord stimulator implantations for patients who underwent lumbar spine surgery.
Methods
The PERFormance, Effectiveness, and Cost of Treatment (PERFECT) episodes database, which was established for selected diseases and procedures in Finland, includes all p...
Background:
Pathophysiological studies of saccular intracranial aneurysm (sIA) disease have shown that inflammation plays a crucial role in a sIA development. Pharmaceutical inhibition of COX-2 -PGE2 - NFkB signaling has been shown in animal models to inhibit sIA formation and progression suggesting that use of medication inhibiting COX-2 could re...
Background:
Hypertension is a risk factor for subarachnoid hemorrhage and is also considered a risk factor for saccular intracranial aneurysm (sIA) formation. However, there is little direct evidence that antihypertensive medication would reduce sIA formation.
Methods:
We studied the impact of antihypertensive medication on de novo sIA formation...
Objective
We conducted an open-label cross-over study assessing the global effect of two high-frequency protocols of electric-field navigated repetitive transcranial magnetic stimulation (rTMS) targeted to functional facial motor cortex and comparing their efficacy and tolerability in patients with chronic facial pain. Outcome predictors were also...
Background
Shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequelae leading to poorer neurological outcomes and predisposing to various complications.
Methods
A total of 2191 consecutive patients with aSAH were acutely admitted to the Neurointensive Care at the Kuopio University Hospital between 1990 and 2...
Background
To define the prevalence of pre-eclampsia, gestational hypertension, chronic hypertension, and gestational diabetes during pregnancy in a defined population of patients with saccular intracranial aneurysms (sIAs).
Methods
We included all patients with sIA, first admitted to Neurosurgery of Kuopio University Hospital from its defined cat...
Background:
Spinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). The effect of neuropathic pain medication use on SCS outcome is poorly understood.
Objective:
To study the effect of gabapentinoid use on SCS outcome measured by trial success, explantation rate and opioid dose reduction during a 2-yr foll...
Background:
Spinal cord stimulation (SCS) is an effective treatment in chronic neuropathic pain, but its efficacy in complex regional pain syndrome (CRPS) needs to be proven.
Objective:
To study the outcome of SCS in CRPS as measured by trial success, explantation rate, complications, and changes in opioid and neuropathic pain medication use ove...
Objective
To characterize surgical treatment and outcomes of C1 fractures in a population-based setup.
Methods
Consecutive C1 fracture patients treated at Kuopio University Hospital (KUH) Neurosurgery were retrospectively identified from January 1996 to June 2017. C1 fractures were classified according to the AOSpine Upper Cervical and Gehweiler c...
Background
To study the clinical condition of poor-grade aneurysmal subarachnoid hemorrhage (aSAH) patients alive at 3 years after neurointensive care.
Methods
Of the 769 consecutive aSAH patients from a defined population (2005–2015), 269 (35%) were in poor condition on admission: 145 (54%) with H&H 4 and 124 (46%) with H&H 5. Their clinical life...
Objective
Spinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). We studied the effect of preimplantation opioid use on SCS outcome and the effect of SCS on opioid use during a two‐year follow‐up period.
Materials and methods
The study cohort included 211 consecutive FBSS patients who underwent an SCS trial...
Objective:
The authors set out to study whether autosomal dominant polycystic kidney disease (ADPKD), an established risk factor for intracranial aneurysms (IAs), affects the acute course and long-term outcome of aneurysmal subarachnoid hemorrhage (aSAH).
Methods:
The outcomes of 32 ADPKD patients with aSAH between 1980 and 2015 (median age 43 y...
Background
Spinal cord stimulation is an efficient treatment for selected patients with chronic neuropathic pain. Since 2015, neuromodulation nurses at Kuopio University Hospital have been responsible for patient education and stimulator adjustments.
Aims
The purpose is to determine what factors professionals perceived to affect patients' wellbein...
Background
Vestibular schwannoma (VS) is a benign tumor originating from the vestibulocochlear nerve. The optimal treatment strategy is debated, since surgery may result in iatrogenic facial nerve injury. We report the results of VS surgery in a population-based unselected cohort in a center with access to Cyber Knife (CK) radiosurgery.
Methods
We...
Spinal cord stimulation (SCS) is an established and cost-effective treatment for neuropathic pain resulting from failed back
surgery syndrome (FBSS). Psychological distress is a risk factor both in the development of FBSS and for reduced efficacy
in SCS. The impact of psychological factors on SCS outcome is still poorly understood, and more researc...
Background
Varying degrees of co‐occurrence of intracranial aneurysms ( IA ) and aortic aneurysms ( AA ) have been reported. We sought to compare the risk for AA in fusiform intracranial aneurysms ( fIA ) and saccular intracranial aneurysms ( sIA ) disease and evaluate possible genetic connection between the fIA disease and AA s. Additionally, the...
Objectives:
The aim of the study is to investigate whether benzodiazepine use differs between patients with favorable and unfavorable spinal cord stimulation (SCS) treatment outcome. We hypothesize that the patients with unfavorable SCS outcome would exhibit a higher level of benzodiazepine use.
Materials and methods:
Using a case-control study...
Background and Purpose—
At acute phase and neurointensive care, patients with aneurysmal subarachnoid hemorrhage (aSAH) may become agitated or delirious. We found no previous studies on psychotic disorders or antipsychotic drug (APD) use by long-term aSAH survivors. We defined the APD use and its risk factors among 12-month survivors of aSAH in an...
Background:
The purpose of this population-based case-control study was to evaluate analgesic use after subarachnoid hemorrhage (SAH) caused by rupture of a saccular intracranial aneurysm (sIA).
Methods:
The study consisted of 1187 patients alive 12 months after an sIA-SAH who were admitted to Kuopio University Hospital (KUH) between 1995 and 20...
Background:
Spinal cord stimulation (SCS) relieves pain by delivering doses of electric current to the dorsal column of the spinal cord and has been found to be most effective in the treatment of neuropathic pain. Psychological distress is a significant risk factor for the development of chronic pain and has been found to affect the outcome of SCS...
Background:
Spinal cord stimulation (SCS) has proven to be a cost-effective treatment for failed back surgery syndrome (FBSS). However, the effect on patients' working capability remains unclear.
Objective:
To evaluate the impact of SCS on working capability and to identify the factors behind permanent disability in FBSS patients.
Methods:
The...
Background
Secondary hypertension is a serious form of hypertension, involving 5% to 10% of all hypertension patients. Hypertension is a risk factor of the saccular intracranial aneurysm (sIA) disease and subarachnoid hemorrhage from ruptured sIA (aSAH), but the impact of secondary hypertension on sIA disease is poorly known. In a defined Eastern F...
Background
To analyze the organ donation action in population-based neurointensive care of acute aneurysmal subarachnoid hemorrhage (aSAH) and to seek factors that would improve the identification of potential organ donors (PODs) and increase the donor conversion rate (DCR) after aSAH. Methods
The Kuopio Intracranial Aneurysm Database, prospective...
Background:
Failed back surgery syndrome (FBSS) is a challenging condition that lacks a curative treatment. In selected patients, spinal cord stimulation (SCS) has provided a satisfactory outcome.
Objective:
To evaluate the long-term outcome of SCS in FBSS, as measured by (1) the explantation rate, (2) complications, and (3) patient satisfaction...
Background:
Saccular intracranial aneurysm (sIA) growth during follow-up is associated with high risk for subsequent rupture. Finnish patients have been suggested to have higher risk for subarachnoid hemorrhage, but follow-up studies of sIA growth in the Finnish population are scarce.
Objective:
To identify the strongest risk factors for sIA gro...
OBJECTIVE
Craniectomy is a common neurosurgical procedure that reduces intracranial pressure, but survival necessitates cranioplasty at a later stage, after recovery from the primary insult. Complications such as infection and resorption of the autologous bone flap are common. The risk factors for complications and subsequent bone flap removal are...
Introduction: Craniectomy is a common neurosurgical procedure which reduces intracranial pressure, but survival necessitates
cranioplasty at a later stage, after recovery from the primary insult. Complications such as infection and resorption of the autologous
bone flap are common. The risk factors for complications and subsequent bone flap removal...
Objective:
To define the association of autosomal dominant polycystic kidney disease (ADPKD) with the characteristics of aneurysmal subarachnoid hemorrhage (aSAH) and unruptured intracranial aneurysm (IA) disease.
Methods:
We fused data from the Kuopio Intracranial Aneurysm database (n = 4,436 IA patients) and Finnish nationwide registries into...
Objective:
To elucidate the epilepsy-associated causes of death and subsequent excess long-term mortality among 12-month survivors of subarachnoid hemorrhage from saccular intracranial aneurysm (SIA-SAH).
Methods:
The Kuopio SIA Database (kuopioneurosurgery.fi) includes all SIA-SAH patients admitted to the Kuopio University Hospital from its def...
Background:
Formation and rupture of saccular intracranial aneurysms (sIAs) may have different pathobiologies in patients with younger age at first diagnosis of sIA disease.
Objective:
To study the phenotype of sIA disease and formation of new (de novo) sIAs in patients below 40 yr.
Methods:
A population-based cohort study was conducted in 613...
![Table 2 . Manifestations of NF1 in different organ systems[8]....](profile/Antti-Lindgren/publication/317322731/figure/tbl1/AS:614320887050276@1523476921636/Manifestations-of-NF1-in-different-organ-systems8-Pigmentary-abnormalities_Q320.jpg)
Background
The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population based cohort of IA patients and, on the other hand, the occurrences of subarachnoid haemorrhage and unruptured intracranial ane...
http://www.eurostroke.net/Berlin/index.html page 173
Background and purpose:
We investigated which aneurysm-related risk factors for rupture best discriminate ruptured versus unruptured saccular intracranial aneurysms (sIAs) in subarachnoid hemorrhage patients with multiple sIAs.
Methods:
We included 264 subarachnoid hemorrhage patients with a ruptured sIA and at least one additional unruptured sI...
Background and purpose:
Shunt dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequela that may lead to poor neurological outcome and predisposes to various interventions, admissions, and complications. We reviewed post-aSAH shunt dependency in a population-based sample and tested the feasibility of a clinical ri...
Background and purpose:
To elucidate the predictors of antidepressant use after subarachnoid hemorrhage from saccular intracranial aneurysm (sIA-SAH) in a population-based cohort with matched controls.
Methods:
The Kuopio sIA database includes all unruptured and ruptured sIA cases admitted to the Kuopio University Hospital from its defined catch...
Introduction:
Shunt-dependent hydrocephalus (HCP) after aneurysmal subarachnoid hemorrhage (aSAH) is a common sequela that may lead to poor neurological outcome and predisposes to various interventions, (re)admissions, and complications, including a high rate of shunt failure and infections. We tested the feasibility of a new clinical risk score t...
Background and purpose:
Formation of new (de novo) aneurysms in patients carrying saccular intracranial aneurysm (sIA) disease has been published, but data from population-based cohorts are scarce.
Methods:
Kuopio sIA database (http://www.uef.fi/ns) contains all unruptured and ruptured sIA patients admitted to Kuopio University Hospital from its...
The aim was to elucidate the incidence and risk factors of epilepsy after subarachnoid hemorrhage (SAH) from saccular intracranial aneurysm (sIA) in a population-based cohort.
The Kuopio sIA Database (www.uef.fi/ns) includes all unruptured and ruptured sIA cases admitted to the Kuopio University Hospital from its defined catchment population in Eas...
Background and purposeThis study determined the correlation between uptake of the amyloid positron emission tomography (PET) imaging agent [18F]flutemetamol and amyloid-β measured by immunohistochemical and histochemical staining in a frontal cortical biopsy. Methods
Fifteen patients with possible normal pressure hydrocephalus (NPH) and previous br...
Projects
Projects (4)
Our research aims to study (1) Risk factors of sporadic and familial saccular intracranial aneurysm (sIA) disease, (2) Genomic variants predisposing to familial sIA disease, (3) Concomitant diseases in sIA disease carriers, (4) Longterm neurological and psychosocial outcome after sIA-SAH. We aim to develope clinical risk calculators for different aspects of sIA disease. www.kuopioneurosurgery.fi
(1) To evaluate the long-term outcome of neuromodulation therapies in chronic neuropathic pain, (2) To improve neuromodulation outcome in chronic neuropathic pain by developing algorithms for optimizing patient selection and treatment, and (3) To investigate mechanisms of pain chronification and molecular effect of different neuromodulation therapies with activity-based protein profiling of serine hydrolases from CSF and blood.
