Jürgen Vormann

Jürgen Vormann
Institute for Prevention and Nutrition, Ismaning/Munich, Germany

Nutritionist, Professor of Biochemistry

About

281
Publications
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3,829
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Additional affiliations
January 2000 - May 2016
Independent Researcher
Position
  • Managing Director

Publications

Publications (281)
Article
Magnesium wird in ausreichender Menge für die Gesunderhaltung des Körpers benötigt. Fehlt Magnesium, ist das Risiko für Herzerkrankungen, Krebs oder Diabetes mellitus erhöht. Magnesium wird jedoch nicht nur über die Nahrung, sondern auch über das Trinkwasser aufgenommen. Studien zeigen, dass eine geringe „Wasserhärte“ bzw. ein niedriger Magnesiumge...
Article
Zusammenfassung Die beim Abbau von Proteinen im Körper entstehenden Säuren können durch basische Nahrungsbestandteile sowie die Puffersubstanzen im Blut ausgeglichen werden. Die gegenwärtig übliche Ernährung geht mit einem Säureüberschuss einher, der bes. in Verbindung mit der in zunehmendem Alter abnehmenden Nierenfunktion das Krankheitsrisiko erh...
Article
Magnesium deficiency can have serious health consequences. Low magnesium intake or low serum levels are risk factors for e.g. type 2 diabetes and cardiovascular diseases. Despite its scientifically recognized importance, too little attention is paid to magnesium in clinical practice. This may be due to the fact that there is no uniform and evidence...
Article
Full-text available
Magnesium (Mg) supplementation was shown to improve metabolic syndrome (MetS) parameters in hypomagnesemic patients. The current study evaluated the role of Mg in normomagnesemic individuals with MetS. Patients were randomly assigned to 400 mg Mg as Mg citrate or placebo daily for 12 weeks. Blood pressure (BP), HbA1c, plasma concentrations of gluco...
Article
Zusammenfassung Der pH-Wert des gesunden Menschen ist immens wichtig. Schon geringe Abweichungen führen zu massiven Störungen im Stoffwechsel, die unter Umständen lebensbedrohlich sind. Für den korrekten Ablauf biologischer Funktionen ist es wichtig, ein konstantes Verhältnis zwischen Säuren und Basen aufrechtzuerhalten. Ändert sich die Säurekonzen...
Article
Background Atopic dermatitis (AD) is the most common cause of eczema. The skin condition affects millions of people worldwide. Severe cases of AD demand systemic treatment, but most AD cases rely on local therapy with topical corticosteroids, emollients, and moisturizing agents to alleviate eczema. Commonly, derma‐cosmetics with a pH around 5.5 are...
Technical Report
Full-text available
Akute respiratorische Infektionserkrankungen werden überwiegend durch Erreger einer großen Gruppe von Viren verursacht, während bakterielle Primärinfektionen eine eher seltenere Rolle spielen. Letzteren kommt allerdings eine große Bedeutung bei Sekundärinfektionen zu, die sich im Rahmen komplikationsreicher Verläufe von Virusinfektionen entwickeln....
Article
Full-text available
Zusammenfassung In der Bevölkerung und vor allem bei Risikogruppen muss mit Magnesiummangel gerechnet werden. Magnesiummangel kann zahlreiche Symptome verursachen, ist per se pathologisch und deshalb therapiebedürftig. Die Diagnostik stützt sich auf die klinische Symptomatik in Verbindung mit anamnestischen Hinweisen und Laborparametern. Eine schle...
Article
The paper “Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?” by TC Wallace, which was published in the Journal of the American College of Nutrition highlights the importance of adequate magnesium (Mg) supply in relation to COVID-19. Wallace notes that Mg deficiency is associated with low-grade chronic inf...
Article
Full-text available
Background/Objectives Metabolism is controlled by macro- and micronutrients. Protein-rich diets should lead to latent acidosis at tissue level with further negative implications. Food supplements with alkaline salts are available and popular pretending to prevent these changes. Subjects/Methods Within a randomised double-blind placebo-controlled t...
Article
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Background: Intermittent fasting (IF) combined with exercise has been suggested to enhance weight loss. However, both procedures might negatively influence acid-base status. The aim of this study was to determine the combined effects of IF, exercise training and alkaline supplementation in overweight subjects on body composition and running perfor...
Article
Der Mineralstoff Magnesium übernimmt eine Vielzahl wichtiger Funktionen im Körper. Eine gute Versorgung mit Magnesium ist wichtig, um einer Reihe von Krankheiten vorzubeugen. Gleichzeitig können verschiedene Erkrankungen durch einen Magnesiummangel mit verursacht werden. Der Magnesiumbedarf ist bei bestimmten Vorerkrankungen sowie zum Beispiel auch...
Article
Full-text available
Background: Low magnesium (Mg) levels are linked to many diseases. Studies suggest that organic salts of Mg are more readily bioavailable than its oxide or inorganic salts used for supplements production. Unfortunately, the plethora of variables in the previous study designs complicates the making of any clear and reliable conclusions. Methods:...
Book
The Essential 28-Day Low-Carb High-Fat Weight-Loss Plan
Article
Magnesiummangel ist ein wichtiger Risikofaktor für verschiedene Krankheiten. Die Mechanismen der Magnesiumhomöostase wurden in den letzten Jahren aufgeklärt. Ein Magnesiummangel in der Nahrung führt nicht zu schnellen Mangelsymptomen, da die Knochen die extrazelluläre Magnesiumkonzentration puffern. Die Magnesiumkonzentration im Serum nimmt erst na...
Book
Schnelle basische Rezepte für jeden Tag
Article
ZUSAMMENFASSUNG Seit einigen Jahren wird die äußerliche Anwendung von Magnesium zur Behandlung von Magnesiummangel und Muskelkrämpfen beworben. Seriöse Studien konnten jedoch keine transdermale Aufnahme des essenziellen Mineralstoffs aus magnesiumreichem Badewasser oder Lotionen nachweisen. Demgegenüber ist die orale Magnesiumsupplementierung in Th...
Article
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Article
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In the following review, we evaluated the current literature and evidence-based data on transdermal magnesium application and show that the propagation of transdermal magnesium is scientifically unsupported. The importance of magnesium and the positive effects of magnesium supplementation are extensively documented in magnesium deficiency, e.g., ca...
Article
Full-text available
Although the relevance of magnesium in obstetrics has been known for a long time and its effect in many diseases is well documented, oral magnesium supplementation during pregnancy is a subject of discussion. The evaluation of the variety of studies regarding magnesium supplementation in pregnancy clearly shows positive effects of oral substitution...
Article
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Guaiazulene-containing ointments are routinely used for breast care during breastfeeding. It has also been proposed that nipple and areola area of non-breastfeeding women might benefit from use of this azulene. In a study with 51 women, it was investigated whether the use of a guaiazulene- containing ointment (Garmastan®) would improve look, elasti...
Article
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CNNM2 is associated with the regulation of serum Mg concentration, and when mutated, with severe familial hypomagnesemia. The function and cellular localization of CNNM2 and its isomorphs (Iso) remain controversial. The objective of this work was to examine the following: (1) the transcription-responsiveness of CNNM2 to Mg starvation, (2) the cellu...
Article
Full-text available
The essential mineral magnesium is involved in numerous physiological processes. Recommended dietary intake is often not met and a low magnesium status increases the risk for various diseases. Magnesium status is regulated by several magnesium transport systems either in cellular or paracellular pathways. Numerous drugs either interfere with magnes...
Book
The modern western diet is a testament to our affluence but has also become a major contributor to ill health and chronic disease. As recently as twenty years ago, the medical establishment, at the coal face of service delivery, doubted there was any close correlation between diet and disease. However, researchers were uncovering a very different p...
Article
Full-text available
Hypothesis: Although mineral deficiency in par-ticular magnesium is a known risk factor for car-diovascular disease intervention experiments with magnesium show only modest results. Previously published data suggest that there may be parti-cular risk groups in the population. The study was undertaken to investigate if such risk groups could be iden...
Article
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Obwohl die Bedeutung von Magnesium in der Geburtshilfe seit Langem bekannt und seine Wirksamkeit bei einer Vielzahl von Erkrankungen gut dokumentiert ist, ist die orale Substitution von Magnesium in der Schwangerschaft Gegenstand der Diskussion. Die Bewertung der Vielzahl von Studien zur Magnesiumsupplementation in der Schwangerschaft zeigt im Gege...
Article
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Disturbed magnesium (Mg2+) homeostasis and increased levels of oxidative stress (OS) are associated with poor clinical outcomes in patients suffering from neurodegenerative, cardiovascular, and metabolic diseases. Data from clinical and animal studies suggest that Mg2+ deficiency (MD) is correlated with increased production of reactive oxygen speci...
Article
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Background: Magnesium deficiency is a common complication of diabetes with an unclear molecular background. Objective: Our aim was to investigate the effect of the insulin (INS)-signaling pathway (ISP) on the regulation of Mg(2+) efflux (Mg(2+)E) conducted by solute carrier family 41, member A1 (SLC41A1; activated by protein kinase A) in transge...
Article
There is an abundance of data regarding the importance of magnesium (Mg) in a variety of human functions such as regulation of muscular tonus, insulin sensitivity, and cardio-vascular function [1-4]. In spite of this the results from intervention studies with the aim to ameliorate or prevent pathological processes in relation to these mechanisms re...
Article
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Mangel an Magnesium (Mg) ist ein wichtiges und haufiges Begleitphanomen bei Patienten mit Diabetes mellitus oder Vorstufen eines Diabetes Typ 2 wie dem Metabolischen Syndrom. Mg-Mangel erhoht das Risiko, einen Diabetes Typ 2 zu entwickeln. Diese Empfehlungen resumieren die gegenwartigen Kenntnisse zur Physiologie des Mg im Kohlenhydratstoffwechsel...
Article
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Magnesium erfüllt im Körper zahlreiche Funktionen und hat u. a. protektive Bedeutung für das kardiovaskuläre System. Neuere Studien zeigen, dass Magnesium das Diabetesrisiko senken und den Krankheitsverlauf bei manifestem Diabetes Typ 2 positiv beeinflussen kann. Da der Magnesiumstatus von Diabetikern häufig schlecht ist, sollte ein Defizit ausgegl...
Article
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Parkinson's disease (PD) is a complex multifactorial ailment predetermined by the interplay of various environmental and genetic factors. Systemic and intracellular magnesium (Mg) deficiency has long been suspected to contribute to the development and progress of PD and other neurodegenerative diseases. However, the molecular background is unknown....
Data
Confocal immunolocalization of HA-strep-SLC41A1 (wt) and HA-strep-SLC41A1-p.A350V in -tet (24 h) cells. Strep-tagged wt and p.A350V were immunolabeled with primary mouse anti-strep and secondary GAM Alexa-488 antibodies (green signal). Plasma membranes were fluorescently contrasted with wheat germ agglutinin (WGA) conjugated to Alexa-647 (red signa...
Article
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Objective: To examine expression profile of magnesium responsive genes (MRGs) in placentas of normoevolutive and preeclamptic women. Methods: The expression profiles of MRGs were determined in placentas of normoevolutive (N=26) and preeclamptic (N=25) women by RT-qPCR. Results: Among all tested MRGs (9) only SLC41A1 (encoding for Na(+)/Mg(2+)...
Article
Full-text available
The Na(+)/Mg(2+) exchanger SLC41A1 is involved in the pathophysiology of various disease conditions. It forms high-molecular-mass, possibly hetero-oligomeric protein complexes in transgenic HEK293 cells. Therefore, we attempted to identify binding partners of SLC41A1 by utilizing the split-ubiquitin modification of the yeast two-hybrid assay. As th...
Article
Out of 100 microliters of capillary blood of 15 ensigns of the Theresianische Militärakademie, ionized magnesium, ionized potassium, ionized calcium pH, basexcess, pCO2 and HCO3 were determined with a CCX device (NOVA Biomedical, Vienna, Austria) and CSA Software (PLK, Judendorf-Strassengel, Austria), before and after a 2,400-m run, and before and...
Article
Out of 100 μl of capillary blood of 15 ensigns from the Theresian Military Academy, ionized magnesium was determined with a CCX device (NOVA Biomedical) and CSA Software (PLK, Judendorf-Strassengel, Austria), before and after a 2,400 m run, both before and after an 8 week-long supplementation of 300 mg magnesium per day. It turned out that Mg chang...
Article
Full-text available
Purpose: To assess if hypertension during the last part of pregnancy could be prevented by magnesium supplementation. Methods: Pregnant primagravida women from a local antenatal care unit were given an oral supply of 300 mg magnesium as citrate or placebo from pregnancy week 25 in a randomised double-blind setup. Blood pressure was recorded duri...
Article
Full-text available
Objectives High blood pressure during the last part of pregnancy is a risk indicator of pre-eclampsia and eclampsia which augment infant and maternal morbidity and mortality. Magnesium deficiency has been related to the risk of hypertension. A study was performed to assess the relation between pregnancy induced hypertension, excretion of urinary ma...