Jürgen Steinmeyer- Prof. Dr.
- Professor at Justus Liebig University Giessen
Jürgen Steinmeyer
- Prof. Dr.
- Professor at Justus Liebig University Giessen
About
215
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Introduction
Skills and Expertise
Current institution
Additional affiliations
March 1990 - December 1998
March 1988 - February 1990
January 1984 - December 1987
Publications
Publications (215)
Background
Osteoarthritis (OA) is associated with abnormal lipid metabolism, wherein elevated levels of phospholipids (PLs) and sphingolipids (SLs) in human and canine synovial fluid (SF) have been observed. The aim of this lipidomic study was to evaluate how closely blood lipid levels reflect changes in SF, building on previous findings.
Methods...
Many studies now emphasize the intricate relationship between lipid metabolism and osteoarthritis (OA), a leading cause of disability. This narrative review examines alterations in the levels of phospholipids (PLs) and sphingolipids (SLs) in synovial fluid (SF), plasma, serum, and articular tissues; discusses their role in joint lubrication, inflam...
Die medikamentöse Therapie der Arthrose ist eine rein symptomatische Behandlung, denn es gibt keinen an den Ursachen der Knorpeldestruktion ansetzenden Wirkstoff. Es fehlt auch ein Arzneimittel, das gezielt die Bildung von neuem hyalinem Knorpel induziert. Richtschnur bei der Auswahl der am besten wirksamen medikamentösen Therapie ist der erhobene...
The (patho)physiological function of the sphingolipids ceramide-1-phosphate (C1P), sphingosine-1-phosphate (S1P), and sphingosylphosphorylcholine (SPC) in articular joints during osteoarthritis (OA) is largely unknown. Therefore, we investigated the influence of these lipids on protein expression by fibroblast-like synoviocytes (FLSs) from OA knees...
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood. This in vitro study was designed to test the hypothesis that various LPCs found elevated in OA SF and their metabolites, lysophosphatidic acids (LPAs), modulate the abund...
Rheumatoid arthritis (RA) is associated with systemic osteoporosis, which leads to severe disability and low quality of life. Current therapies target osteoclasts to reduce bone degradation, but more treatment options would be required to promote bone protection by acting directly on osteoblasts (OB). Recently, the local production of dopamine in i...
(1) Background: Synovial fluid (SF) from knee joints with osteoarthritis (OA) has increased levels of phospholipids (PL). We have reported earlier that TGF-ß and IGF-1 stimulate fibroblast-like synoviocytes (FLS) to synthesize increased amounts of PLs. The current study examined whether IL-1ß induces the release of PLs in FLS and the underlying mec...
Excessive pressure or overload induces and aggravates osteoarthritic changes in articular cartilage, but the underlying biomechanical forces are largely ignored in existing pharmacological in vitro models that are used to investigate drugs against osteoarthritis (OA). Here, we introduce a novel in vitro model to perform pathophysiological and pharm...
Osteoarthritis belongs to the most common joint diseases in humans and animals and shows increased incidence in older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study of 52 dogs as potential therapeutic treatment options in early osteoarthritis....
Differential diagnosis of muscle pain and weakness is extensive, including neurological, vertebral, arthrogenic, vascular, traumatic, immunological, endocrine, genetic and infectious aetiologies, as well as medication or toxin-related causes. Muscles are highly sensitive to a large number of drugs, especially with high doses. Although many drug cla...
Der Artikel vermittelt kurz zusammengefasst wichtige Aspekte der noch bis Ende 2022 gültigen S2k-Leitlinie ,,Gonarthrose", die von der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie (DGOOC) als federführende Fachgesellschaft erstellt wurde. Die Autoren waren maßgeblich an der Erstellung dieser Leitlinie beteiligt.
In: Orthopädie...
Datenlage zur chondrotoxischen Wirkung bei intraartikulärer Applikation.
Orthopädische-Unfallchirurgische Nachrichten 04(Special):39 (2021).
The current limitations in evaluating synovial fluid (SF) components in health and disease and between species are due in part to the lack of data on normal SF, because of low availability of SF from healthy articular joints. Our study aimed to quantify species-dependent differences in phospholipid (PL) profiles of normal knee SF obtained from equi...
Duncan Dowson, whom this issue commemorates, was a world leader in the field of biotribology, with prolific contributions both in fluid-based and boundary lubrication of biological tissues, in particular articular cartilage, a central issue in biotribology due to its importance for joint homeostasis. Here we explore further the issue of cartilage b...
Die Gonarthrose ist eine häufige Erkrankung, ihr chronischer Verlauf ohne Aussicht auf Heilung bedeutet eine Herausforderung für die Arzt-Patienten-Beziehung. Die Therapieangebote sind für den einzelnen Patienten nicht mehr überschaubar. Auch der Arzt hat Schwierigkeiten, die verschiedensten Behandlungsmethoden nach den Maßstäben der evidenzbasiert...
Zusammenfassung
Derzeit empfehlen eine Reihe nationaler und internationaler Leitlinien die topische Applikation nichtsteroidaler Antirheumatika (NSAR) als eine frühe Option zur Therapie symptomatischer Beschwerden bei Arthrose. Pharmakokinetische Daten belegen eine Anreicherung von NSAR in intraartikulären Strukturen, die zum Arthroseschmerz beitra...
Objective
Previous work has established that the deacetylase sirtuin-1 (SIRT1) is cleaved by cathepsin B in chondrocytes subjected to proinflammatory stress, yielding a stable but inactive N-terminal (NT) polypeptide (75SIRT1) and a C-terminal (CT) fragment. The present work examined if chondrocyte-derived NT-SIRT1 is detected in serum and may serv...
Zur Behandlung der Gonarthrose gibt es eine Vielzahl an konservativen (medikamentös, nichtmedikamentös) wie auch operativen (gelenkerhaltend, gelenersetzend) Therapieoptionen, die je nach Ausprägung und Präferenz der Patienten zum Einsatz kommen. In mehreren nationalen und internationalen Initiativen wurden auf der Basis verfügbarer Evidenz die ein...
Epidemiologie; Adipositas; Ernährung; Biomarker; Medikamentöse Therapie; Plättchenreiches Plasma und Mesenchymale Stammzellen; Bewegungstherapie
Obesity—in which free fatty acid (FFA) levels are chronically elevated—is a known risk factor for different rheumatic diseases, and obese patients are more likely to develop osteoarthritis (OA) also in non-weight-bearing joints. These findings suggest that FFA may also play a role in inflammation-related joint damage and bone loss in rheumatoid art...
Background:
Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample venous blood, and (c) to correlate biomarker levels with radiological and clinical scores.
Methods...
Seit 15 Jahren werden immer mehr Fallberichte und Studien publiziert, die auf eine zytotoxische Wirkung von intraartikulär applizierten Lokalanästhetika insbesondere auf Chondrozyten hindeuten.
Insulin and lysozyme share the common features of being prone to aggregate and having biomedical importance. Encapsulating lysozyme and insulin in micellar nanoparticles probably would prevent aggregation and facilitate oral drug delivery. Despite the vivid structural knowledge of lysozyme and insulin, the environment-dependent oligomerization (dim...
Phospholipids (PLs) possess the unique ability to contribute to synovial joint lubrication. The aim of our study was to determine for the first time the effect of dexamethasone and some adrenergic and cholinergic agonists on the biosynthesis and release of PLs from human fibroblast-like synoviocytes (FLS). Osteoarthritic human knee FLS were treated...
The pharmacological treatment of knee osteoarthritis (OA) is a purely symptomatic therapy, which often ensures that the mobility of the patient is successfully retained. This article refers to the recommendations and opinions regarding the pharmacotherapy of knee OA contained in the new guideline of the Association of the Scientific Medical Societi...
Collagen hydrolysates (CHs) are heterogeneous mixtures of collagen peptides that are often used
as nutraceuticals for osteoarthritis (OA). In this study, we compared the peptide composition and
pharmacological effects of three different CH preparations (CH-Alpha®, Peptan® B 2000 and
Mobiforte®) as well as their production batches. Our biochemical a...
Die medikamentöse Therapie der Gonarthrose stellt eine rein symptomatische Behandlung dar, die häufig erfolgreich den Erhalt der Mobilität der Patienten ermöglicht. Der vorliegende Beitrag nimmt Bezug auf die Empfehlungen und Stellungnahmen zur Pharmakotherapie der Gonarthrose der neuen deutschen AWMF-Leitlinie, hebt besonders wichtig erscheinende...
Elevated levels of growth factors and phospholipids (PLs) have been found in osteoarthritic synovial
fluid (SF), although the metabolic regulation of PLs is currently unknown. This study aimed to
determine the effects of growth factors on the biosynthesis of PLs by fibroblast-like synoviocytes (FLS)
obtained from human osteoarthritic knee joints. E...
Objective:
Phospholipids (PLs), together with hyaluronan and lubricin, are involved in boundary lubrication within human articular joints. Levels of lubricants in synovial fluid have been found to be associated with the health status of the joint. However, the biosynthesis and release of PLs within human joints remains poorly understood. This stud...
Abstract
According to four small, placebo-controlled clinical trials, oral administration of frankincense shall alleviate osteoarthritic pain. The results obtained with three special frankincense extracts need to be confirmed in larger, confirmatory studies. In Germany frankincense containing preparations are not approved as pharmaceuticals, and ar...
Background
Various inflammatory cardiovascular and metabolic diseases such as atherosclerosis, coronary heart diseases and type 2 diabetes are associated with chronically elevated free fatty acid (FFA) levels. With inflammation being a factor in pathological bone loss, FFA may also be contributors to bone loss in osteoarthritis (OA) and/or rheumato...
In rheumatoid arthritis (RA), cartilage and bone matrix are degraded, and extracellular matrix (ECM) proteins, acting as cellular activators, are liberated. Similar to ECM proteins, matrix-bound chemokines, cytokines, and growth factors (GFs) influence functional properties of key cells in RA, especially synovial fibroblasts. The role of these mole...
Background
Increased amounts of visceral fat are often associated with lower bone density. Also, in obese patients an increased risk of osteoarthritis can be seen in non-weight bearing joints. Chronically elevated free fatty acid (FFA) levels as occurring in obesity may therefore also play a role in bone loss. We hence analysed if and how FFA influ...
The most frequent disease of the locomotor system is osteoarthritis (OA), which, as a chronic joint disease, might benefit more from nutrition than acute illnesses. Collagen hydrolysates (CHs) are peptidic mixtures that are often used as nutraceuticals for OA. Three CHs were characterized biochemically and pharmacologically. Our biophysical (MALDI-...
Objectives:
Adiponectin is an effector molecule in the pathophysiology of rheumatoid arthritis, e.g. by inducing cytokines and matrix degrading enzymes in synovial fibroblasts. There is growing evidence that adiponectin affects osteoblasts and osteoclasts although the contribution to the aberrant bone metabolism in rheumatoid arthritis is unclear....
Objective:
Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associ...
Objectives: Surface-active phospholipids (PLs), hyaluronan and lubricin were reported to provide boundary lubrication within human articular joints. The PLs are thought to be synthesized and released by fibroblast-like synoviocytes (FLS). We recently published two lipidomic studies about 103 PLs species with altered levels in synovial fluid of late...
Therapieoptionen und Risiken sind wesentlich von Komorbiditäten abhängig - Beratung ist Therapie.
Extracellular RNA (exRNA) has been characterized as a molecular alarm signal upon cellular stress or tissue injury and to exert biological functions as a proinflammatory, prothrombotic, and vessel permeability-regulating factor. In this study, we investigated the contribution of exRNA and its antagonist RNase1 in a chronic inflammatory joint diseas...
Objective:
The lipid profile of synovial fluid (SF) is related to the health status of joints. The early stages of human osteoarthritis (OA) are poorly understood, which larger animals are expected to be able to model closely. This study examined whether the canine groove model of OA represents early OA in humans based on the changes in the lipid...
Changes in the content of aggrecan, an essential proteoglycan of articular cartilage, have been implicated in the pathophysiology of osteoarthritis (OA), a prevalent age-related, degenerative joint disease. Here, we examined the effect of SOX9 acetylation on ACAN transactivation in the context of osteoarthritis. Primary chondrocytes freshly isolate...
Background
Adipose tissue secretes numerous bioactive substances, which contribute to inflammation. Chronically elevated free fatty acid (FFA) levels are known to be associated with numerous inflammatory cardiovascular and metabolic diseases such as atherosclerosis, coronary heart diseases and type 2 diabetes. Conversely, inflammation can contribut...
Background
A body of studies demonstrates the influence of the nervous system on the immune response. We recently described that dopamine, a neurotransmitter of the sympathetic nervous system, is locally produced by synovial fibroblasts of rheumatoid arthritis (RA) patients and influences in vitro cytokine release and inflammation (1). In addition,...
Fig. S1 SOX9 identification after treatment with EX527.
Fig. S2 Gene expression of alginate encapsulated chondrocytes under hydrostatic load conditions.
Fig. S3 Reduced SOX9 protein in primary human chondrocytes from OA patients.
Polysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand-receptor interactions with biochemical processes and...
OBJECTIVE:
Osteoarthritis is not only characterized by cartilage degradation but also involves subchondral bone remodeling and osteophyte formation. Osteophytes are fibrocartilage-capped bony outgrowths originating from the periosteum. The pathophysiology of osteophyte formation is not completely understood. Yet, different research approaches are...
Purpose
Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated effectiveness in treating isolated cartilage defects of the knee but medium- and long-term evidence and information on the management of postoperative complications or partially successful cases are sparse. This study hypothesised that MACI is effective for up to 5...
Résumé
Objectif
L’arthrose est non seulement caractérisée par une dégradation du cartilage, mais comporte également un remodelage de l’os sous-chondral et la formation d’ostéophytes. Les ostéophytes sont des excroissances osseuses coiffées de fibrocartilage provenant du périoste. La physiopathologie de la formation d’ostéophytes n’est pas complète...
BACKGROUND: Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study is the first reporting quantitative data about the molecular weight (MW) forms of HA, lubricin, and PLs in SF from cohorts of healthy donor...
https://doi.org/10.1016/j.joca.2015.02.667
Lysosomal cathepsins have been reported to contribute to Osteoarthritis (OA) pathophysiology due to their increase in pro-inflammatory conditions. Given the causal role of cathepsins in OA, monitoring their specific activity could provide a means for assessing OA severity. To this end, we herein sought to assess cathepsin activity-based probes (ABP...
Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study is the first reporting quantitative data about the molecular weight (MW) forms of HA, lubricin, and PLs in SF from cohorts of healthy donors, patients...
Articular synovial fluid (SF) is a complex mixture of components that regulate nutrition, communication, shock absorption, and lubrication. Alterations in its composition can be pathogenic. This lipidomic investigation aims to quantify the composition of sphingolipids (sphingomyelins, ceramides, and hexosyl- and dihexosylceramides) and minor glycer...
Adiponectin is a strong effector molecule in the pathophysiology of RA, for example by contributing to the production of proinflammatory chemokines and matrix degrading enzymes synthesised by RA synovial fibroblasts. In addition, there is growing evidence that adiponectin influences bone metabolism. Our immunohistochemical analysis of RA bone tissu...
Objective:
Membrane phospholipid species contribute to boundary lubrication that is provided by synovial fluid (SF). Altered levels of lubricants can be associated with increased friction, leading to articular cartilage damage. This study was undertaken to determine whether the composition of phospholipid species is altered in diseases of human kn...
Destruction of articular cartilage is a characteristic feature of osteoarthritis (OA). Collagen hydrolysates are mixtures of collagen peptides and have gained huge public attention as nutriceuticals used for prophylaxis of OA. Here, we evaluated for the first time whether different bovine collagen hydrolysate preparations indeed modulate the metabo...
Osteoarthritis (OA) is a degenerative joint disease particularly affecting the elderly population. Although several genetic features have been characterized as risk factors for OA susceptibility, a growing body of evidence indicates that epigenetic effectors may also modulate gene expression and thus contribute to OA pathology. One such epigenetic...
Background and Objectives Although obesity is an established risk factor in osteoarthritis (OA), there is limited information about the role of adipose tissue derived factors in bone formation. Adipocytokines such as adiponectin, resistin, and visfatin, are known to be associated with the pathogenesis of rheumatoid arthritis (RA) and OA. Adipocytok...
OBJECTIVES:
Several clinical studies have suggested the adipocytokine adiponectin is involved in the progression of rheumatoid arthritis (RA). From this point of view, adiponectin might present a new therapeutic target. However, as adiponectin also exerts beneficial effects in the human organism, a strategy that would allow its detrimental effects...
Heterogeneous mixtures of collagen fragments can be used as nutrition supplement or as key ingredients for ointments with therapeutic relevance in wound healing. Some mixtures of collagen fragments are referred to as collagen hydrolysates owing to the production process with hydrolytic enzymes. Since the precise composition of collagen hydrolysates...
Adipokines such as adiponectin and visfatin/pre-B-cell colony-enhancing factor (PBEF) have been recently shown to contribute to synovial inflammation in rheumatoid arthritis (RA). In this study, we evaluated the pathophysiological implication of visfatin/PBEF in the molecular patterns of RA synovial tissue, focusing on RA synovial fibroblasts (RASF...
Background In rheumatoid arthritis (RA), aggressive synovial fibroblasts (SFs) play a central role in cartilage destruction and the spreading of the disease based on a long-distance migratory potential in vivo. In this setting, the adhesion of RASFs to extracellular matrix (ECM) is a central feature required for subsequent cartilage invasion. There...
Several clinical studies have suggested the adipocytokine adiponectin is involved in the progression of rheumatoid arthritis (RA). From this point of view, adiponectin might present a new therapeutic target. However, as adiponectin also exerts beneficial effects in the human organism, a strategy that would allow its detrimental effects to be abolis...
