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22
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Publications
Publications (22)
Background
Up to 30% of pregnant individuals experience high levels of stress. At the same time, 15-20% of new mothers develop postpartum depression, and 25-35% experience postpartum anxiety. Mobile applications have the potential to provide an accessible, scalable solution to these mental health challenges. However, previous evidence indicates tha...
Targeted Memory Reactivation (TMR) during sleep benefits memory integration and consolidation. In this pre-registered study, we investigated the effects of TMR applied during non-rapid eye movement (NREM) sleep following modulation and updating of aversive autobiographical memories using imagery rescripting (ImR). During 2–5 nights postImR, 80 heal...
Recalling positive autobiographical memories has been associated with various positive psychological outcomes, including enhanced mental well-being and self-efficacy. Given the known impact of stress on cognitive functioning, we investigated how momentary stress affects the repeated recall of selected autobiographical mastery memories (e.g., memori...
Objective
Self-efficacy is associated with positive mental health outcomes. We developed and tested a digital self-efficacy training for daily recall of autobiographical self-efficacy memories (e.g., memories of successfully overcoming a personal challenge).
Method
In this randomized controlled trial, we investigated the effects of the week-long d...
Background
Up to 30% of pregnant individuals experience high levels of stress. At the same time, 15-20% of new mothers develop postpartum depression, and 25-35% experience postpartum anxiety. Mobile applications have the potential to provide an accessible, scalable solution to these mental health challenges. However, previous evidence indicates tha...
Background
Up to 30% of pregnant individuals experience high levels of stress. At the same time, 15-20% of new mothers develop postpartum depression, and 25-35% experience postpartum anxiety. Mobile applications have the potential to provide an accessible, scalable solution to these mental health challenges. However, previous evidence indicates tha...
Objective: This pilot case series investigated the feasibility and efficacy of an eight-week therapy program, combining nasally administered ketamine (0.5 mg/kg) with trauma-focused psychotherapy, for individuals with chronic, treatment-resistant post-traumatic stress disorder (PTSD). Method: Three patients with chronic, treatment-resistant PTSD un...
Background
The mobile Agnew Relationship Measure (mARM) is a self-report questionnaire for the evaluation of digital mental health interventions and their interactions with users. With the global increase in digital mental health intervention research, translated measures are required to conduct research with local populations.
Objective
The aim o...
Trauma-focused psychotherapy (tf-PT) is the first-line treatment for posttraumatic stress disorder (PTSD). Tf-PT focuses on processing and modulating trauma memories. Not all patients benefit, however, and there is room for improvement of efficacy. Pharmacologically augmenting trauma memory modulation in the context of tf-PT may help optimise treat...
BACKGROUND
Digital tools such as Ecological Momentary Assessments (EMA) make it possible to assess transient mental health states and their parameters. Ecological Momentary Interventions (EMI) offer mental health interventions that fit well into individuals’ daily lives and routines.
OBJECTIVE
The aim of our study was twofold. First, to determine...
BACKGROUND
The mobile Agnew Relationship Measure (mARM) is a self-report questionnaire for the evaluation of digital mental health interventions and their interactions with users. With the global increase in digital mental health intervention research, translated measures are required to conduct research with local populations.
OBJECTIVE
The aim o...
Background: Network analysis has gained increasing attention as a new framework to study complex associations between symptoms of post-traumatic stress disorder (PTSD). A number of studies have been published to investigate symptom networks on different sets of symptoms in different populations, and the findings have been inconsistent.
Objective: W...
Background: Self-efficacy is associated with positive mental health outcomes. We developed and tested a digital self-efficacy training involving repeated recall of autobiographical self-efficacy memories.Methods: In this randomized controlled trial, we investigated the effects of our digital training on key mental health outcomes, including anxiety...
ZUSAMMENFASSUNG
Einleitung Eine wachsende Zahl psychologischer Behandlungsangebote erfolgt über das Smartphone, bzw. über Apps. Viele der wissenschaftlich geprüften Apps basieren auf den Prinzipien der kognitiven Verhaltenstherapie (KVT), Goldstandard zur Behandlung vieler psychischer Problematiken. Ziel dieses Reviews war es, den Status Quo der Fo...
Background: A growing number of psychological interventions are delivered via smartphones with the aim of increasing the efficacy and effectiveness of these treatments and providing scalable access to interventions for improving mental health. Most of the scientifically tested apps are based on cognitive behavioral therapy (CBT) principles, which a...
Background
A growing number of psychological interventions are delivered via smartphones with the aim of increasing the efficacy and effectiveness of these treatments and providing scalable access to interventions for improving mental health. Most of the scientifically tested apps are based on cognitive behavioral therapy (CBT) principles, which ar...
Behavioral evidence from human studies suggests that the γ-aminobutyric acid type B receptor (GABAB receptor) agonist baclofen modulates reinforcement learning and reduces craving in patients with addiction spectrum disorders. However, in contrast to the well established role of dopamine in reinforcement learning, the mechanisms by which the GABAB...
Pica is the developmentally and culturally inappropriate eating of nonnutritive substances for at least 1 month. Herein, we present the case of a male patient that suddenly showed behavioral changes including aggressiveness, withdrawal, and perceptional disturbances at the age of 12. About 7 years later, pica symptoms emerged additionally. Neither...
Objectives: Arachnoid cysts are benign congenital malformations of the arachnoid. Many anecdotal reports as well as a few systematic studies indicate an association of various psychiatric symptoms and several aspects of cognitive problems in arachnoid cyst patients. Here we report to the best of our knowledge the first coincidence of bipolar disord...
Presynaptic metabotropic glutamate receptors (mGluRs) at glutamatergic synapses play a major role in governing release probability. Previous reports indicated a downregulation of group III mGluRs at the lateral perforant path-granule cell synapse in the chronically epileptic hippocampus. Here, we investigated the mGluR-dependent presynaptic inhibit...
