Juan Domínguez Robles

Juan Domínguez Robles
Queen's University Belfast | QUB · School of Pharmacy

PhD

About

88
Publications
24,594
Reads
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2,182
Citations
Citations since 2016
77 Research Items
2149 Citations
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
20162017201820192020202120220200400600
Introduction
Juan Domínguez-Robles graduated with a BSc in Biology from University of Seville and a MSc in Food, Industrial and Environmental Biotechnology from Pablo de Olavide University. He got an international PhD in Chemical Engineering at the University of Córdoba. After finishing his PhD in 2018, he moved to School of Pharmacy of Queen's University Belfast and started a research fellowship in the development of medical devices using 3D printing technology.

Publications

Publications (88)
Article
Full-text available
Levofloxacin (LVX) and amphotericin B (AMB) have been widely used to treat bacterial and fungal infections in the clinic. Herein, we report, for the first time, chitosan films loaded with AMB and LVX as wound dressings to combat antimicrobial infections. Additionally, we developed and validated a high-performance liquid chromatography (HPLC) method...
Article
Cada día es evidente como un recurso natural tan imprescindible para el desarrollo de la vida, como es el agua, se ve amenazado por diversos factores de contaminación; debido a diferentes procesos industriales necesarios para atender sus demandas (industria textil, alimenticia y cosmética)1 . Tal es el caso de la contaminación causada por los color...
Article
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Considered as one of the most common inflammatory arthritis, gout is characterised by a sudden onset of severe joint pain. As the first-line drug of choice used in treating acute gout, colchicine (CLC) is hindered by poor gastrointestinal permeability as well as unfavourable gastrointestinal side effects. Herein, we present, for the first time, the...
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Bacteroides fragilis is one of the most common causative group of microorganisms that is associated with skin and soft tissue infections (SSTI). Metronidazole (MTZ) is the drug of choice used in the treatment of SSTI caused by the bacterium. However, owing to its physiochemical properties, MTZ have limited skin permeation, which render the drug uns...
Article
Implantable drug delivery systems are an interesting alternative to conventional drug delivery systems to achieve local or systemic drug delivery. In this work, we investigated the potential of fused-deposition modelling to prepare reservoir-type implantable devices for sustained drug delivery. An antibiotic was chosen as a model molecule to evalua...
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In this work the preparation and characterisation of intranasal implants for the delivery of risperidone (RIS) is described. The aim of this work is to develop better therapies to treat chronic conditions affecting the brain such as schizophrenia. This type of systems combines the advantages of intranasal drug delivery with sustained drug release....
Article
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This work describes the use of fused deposition modelling (FDM) to prepare antiplatelet thermoplastic polyurethane (TPU)-based tubular grafts. FDM 3D-printing technology is widely available and provides the ability to easily design tubular grafts on demand, enabling the customisation of vascular prosthesis dimensions. An antiplatelet drug, dipyrida...
Article
According to the World Health Organization, about 422 million people worldwide have diabetes, with 1.5 million deaths directly attributed each year. Therefore, there is still a need to effectively monitor glucose in diabetic patients for proper management. Recently, wearable patches based on microneedle (MN) sensors provide minimally invasive analy...
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2022) 3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs, Drug Delivery, 29:1, ABSTRACT Implantable drug delivery systems offer an alternative for the treatments of long-term conditions (i.e. schizophrenia, HIV, or Parkinson's disease among many others). The objective of the prese...
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Intranasal delivery is an alternative administration route to deliver levodopa (L-Dopa) to the brain. This drug delivery route offers high drug permeability across the nasal epithelium and rapid absorption into the central nervous system (CNS) while bypassing first-pass metabolism. In this study, we developed a library of polymeric nanocarrier syst...
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Curcumin (CUR) and D-panthenol (DPA) have been widely investigated for wound-healing treatment. In order to analyse these two compounds from a dosage form, such as polymer-based wound dressings or creams, an analytical method that allows the quantification of both drugs simultaneously should be developed. Here, we report for the first time a valida...
Article
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Inclusion complexation of rifampicin (RIF) with several types of cyclodextrins (βCD, hydroxypropyl-βCD, γCD, hydroxypropyl-γCD) in aqueous solutions at different pH values was investigated to assess the interactions between RIF and cyclodextrins (CDs). Molecular modeling was performed to determine the possible interactions between RIF and CDs at se...
Article
Fungal infections affect millions of people globally and are often unreceptive to conventional topical or oral preparations because of low drug bioavailability at the infection site, lack of sustained therapeutic effect, and the development of drug resistance. Amphotericin B (AmB) is one of the most potent antifungal agents. It is increasingly impo...
Article
Levothyroxine (LEVO) sodium is an FDA-approved drug that is used to treat underactive thyroid (hypothyroidism) and other conditions. It is generally used as a thyroid-stimulating hormone administered orally. However, this approach has some drawbacks such as this drug should be taken every day 30 min to 1 h prior to breakfast with an empty stomach,...
Chapter
Long-acting drug delivery system is a development in pharmaceutical technology to minimize the disadvantages of other routes of administration such as oral, transdermal, and injectable administration. The major advantage of this system is the ability to maintain the drug concentration in plasma between the therapeutic ranges after a single administ...
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Small-diameter synthetic vascular grafts are required for surgical bypass grafting when there is a lack of suitable autologous vessels due to different reasons, such as previous operations. Thrombosis is the main cause of failure of small-diameter synthetic vascular grafts when used for this revascularization technique. Therefore, the development o...
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Cardiovascular disease (CVD) is a general term for conditions which are the leading cause of death in the world. Quick restoration of tissue perfusion is a key factor to combat these diseases and improve the quality and duration of patients’ life. Revascularization techniques include angioplasty, placement of a stent, or surgical bypass grafting. F...
Article
This work aimed to develop a subcutaneous implant for prolonged delivery of LEVO to treat hypothyroidism. This could overcome challenges with patient compliance and co-administration and could improve treatment of this condition. For this purpose, implants were produced by solvent casting mixtures of poly(caprolactone) (PCL), poly(ethylene glycol)...
Chapter
Lignin is, after cellulose, the second most abundant biopolymer on the earth. It is found in most terrestrial plants in the approximate range of 15–40% dry weight and provides the plant with structural integrity. Lignin is an aromatic polymer synthesized mainly from three primary monolignols (p-coumaryl alcohol, coniferyl alcohol, and sinapyl alcoh...
Article
In this work, we introduce, for the first time, novel hybrid microneedle patches with implantable poly(lactic-co-glycolic acid) (PLGA) tips aligned with hydrogel-forming microneedle bases (HFMB) using a dissolvable material. A model dye, Nile red, and an antifungal drug, amphotericin B, were loaded into the PLGA tips in a controlled manner by multi...
Article
Diabetes affects approximately 450 million adults globally. If not effectively managed, chronic hyperglycaemia causes tissue damage that can develop into fibrosis. Fibrosis leads to end-organ complications, failure of organ systems occurs, which can ultimately cause death. One strategy to tackle end-organ complications is to maintain normoglycaemia...
Article
Deficiency of thyroid hormones (hypothyroidism) is treated with oral levothyroxine (LEVO). However, the effectiveness of oral administration is highly dependent on the co-administration of food and other drugs. This factor, in combination with the chronic nature of this condition, mean that there are concerns with patient compliance. Development of...
Article
Microneedles (MN) have the potential to become a highly progressive device for both drug delivery and monitoring purposes as they penetrate the skin and pierce the stratum corneum barrier, allowing the delivery of drugs in the viable skin layers and the extraction of body fluids. Despite the many years of research and the different types of MN deve...
Article
Cardiovascular diseases constitute a number of conditions which are the leading cause of death globally. To combat these diseases and improve the quality and duration of life, several cardiac implants have been developed, including stents, vascular grafts and valvular prostheses. The implantation of these vascular prosthesis has associated risks su...
Article
Current therapy of tuberculosis (TB) has several limitations, such as risk of liver injury and intestinal dysbiosis due to frequent oral administration of antibiotics. Transdermal administration could be used to improve antibiotic delivery for treatment of Mycobacterium tuberculosis infection. Therefore, we developed a novel approach, using hydroge...
Article
Autoimmune-mediated inflammatory skin diseases, such as psoriasis, alopecia areata, and vitiligo, have been reported as the 4th leading cause of nonfatal disease burden worldwide. This is mainly related to the poor quality of life experienced by these patients. Although topical and systemic steroids represent the most common treatment, the variabil...
Article
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The aim of this work was to study the feasibility of using orange tree pruning to obtain lignocellulose nanofibers (LCNFs) and their application in paperboard recycling process. The orange tree pruning was treated with an environmentally friendly process (13% NaOH on dry matter, at liquid/solid ratio of 8, 170 °C and 40 min). The cellulosic pulp ob...
Article
Lignin is an aromatic biopolymer and a primary component of the cell walls in lignocellulosic biomass, where it constitutes between 15 and 40% of its dry mass. This percentage can vary, not only among plant species, but also among different cell types. Currently, the pulping and biorefinery industries worldwide extract large amounts of lignin, whic...
Article
Current treatment for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) involves transvaginal implantation of surgical mesh, conventionally made of polypropylene (PP). However, it has recently become apparent that the mechanical properties of PP are unsuitable, resulting in serious complications such as tissue erosion. In this study...
Article
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Pulp and paper mills generate a huge amount of wastewater and some of them, especially non-wood paper mills, do not possess recovery systems. In this research work, the effectiveness of coagulation–flocculation using poly (ethylene oxide), poly aluminium chloride and poly (dimethyl diallyl ammonium chloride) for the treatment of a black liquor obta...
Article
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Implantable devices are versatile and promising drug delivery systems and their advantages are well established. Of these advantages, long acting drug delivery is perhaps the most valuable. Hydrophilic compounds are particularly difficult to deliver for prolonged times. This work investigates the use of poly(caprolactone) (PCL)-based implant coatin...
Article
Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI) are two prevalent disorders affecting 30-40% of women worldwide. Current strategies to repair or improve these medical conditions are non-surgical options such as physiotherapy, or surgical options such as the use of vaginal meshes. The synthetic material polypropylene (PP), which ha...
Article
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We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm and 4.5 mm length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation. Using excised neonatal porcine skin as tissue model, it was seen that insertion capabilities...
Article
The high demand on medical devices and personal protective equipment (PPE) during the COVID-19 crisis left millions of health care professionals unprotected in the middle of this situation, as governments around the world were not prepared for such pandemic. The three-dimensional printing (3DP) community, from universities to 3DP enthusiasts with p...
Article
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Current strategies for the treatment of superficial non-melanoma skin cancer (NMSC) lesions include topical imoquimod, 5-fluorouracil, and photodynamic therapy. Although these treatments are effective, burning pain, blistering, and dermatitis have been reported as frequent side effects, making these therapies far from ideal. Plasmonic materials hav...
Article
The use of biomass resources different from conventional wood materials fosters the sustainable growth of the paper industrial sector and finds a development path in line with the concept of circular bioeconomy. In this work, six nonwood materials (Leucaena leucocephala, tagasaste, rice straw, Paulownia fortunei, Hesperaloe funifera and empty fruit...
Article
Full-text available
Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, delivery of lower doses of drug, thus, potentially reducing side-effects and improving patient compliance. 3D printing is a flexible technique, which has been subject to increasing interest in the past few years, especially in the area of...
Article
Full-text available
Current strategies to treat pelvic organ prolapse (POP) or stress urinary incontinence (SUI), include the surgical implantation of vaginal meshes. Recently, there has been multiple reports of issues generated by these meshes conventionally made of poly(propylene). This material is not the ideal candidate due to its mechanical properties leading to...
Article
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Biopolymers are materials synthesised or derived from natural sources, such as plants, animals, microorganisms or any other living organism. The use of these polymers has grown significantly in recent years as industry shifts away from unsustainable fossil fuel resources and looks towards a softer and more sustainable environmental approach. This r...
Article
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Lignin (LIG) is a renewable biopolymer with well-known antimicrobial and antioxidant properties. In the present work LIG was combined with poly(butylene succinate) (PBS), a biocompatible/biodegradable polymer, to obtain composites with antimicrobial and antioxidant properties. Hot melt extrusion was used to prepare composites containing up to 15% (...
Article
This study aims to develop fully bio-based lignocellulosic fiberboards from wheat straw fibers without any additional bonding agents. The wheat straw biomass was used to produce a semichemical pulp, which was treated by means of enzymatic refining, on the one hand, and mechanical refining, on the other. The morphological analysis for both refined f...
Article
Catheter associated infections are a common complication that occurs in dialysis patients. Current strategies to prevent infection include catheter coatings containing heparin, pyrogallol or silver nanoparticles, which all have an increased risk of causing resistance in bacteria. Therefore, a novel approach for manufacture, such as the use of addit...
Article
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Extensive efforts are being made to find alternative uses for lignin (LIG). In the present work the use of this biopolymer as excipient to prepare tablets was studied. For this purpose, LIG was combined with microcrystalline cellulose (MCC) and used as excipients to prepare directly compressed tablets containing a model drug, tetracycline (TC). The...
Article
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The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk o...
Article
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Lignin (LIG) is a natural biopolymer with well-known antioxidant capabilities. Accordingly, in the present work, a method to combine LIG with poly(lactic acid) (PLA) for fused filament fabrication applications (FFF) is proposed. For this purpose, PLA pellets were successfully coated with LIG powder and a biocompatible oil (castor oil). The resultin...
Article
Hydrogels have been extensively investigated as a platform for drug delivery. However, their use for the delivery of hydrophobic drugs has been limited by their incompatibility with hydrophobic drug molecules. The chemical modification of the structure of the hydrogels to include hydrophobic moieties has been proven to be a good alternative to incr...
Article
Full-text available
The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug deliver...
Article
This paper is dedicated to the 70 th anniversary of Acad. Bogdan C. Simionescu in acknowledgement of his major contribution to the quality of the research in Romania. Due to the environmental awareness in our society, this paper explores the possibility of obtaining high value-added products from agricultural wastes, such as cereal straw. The raw m...
Article
Full-text available
Lignin is the second most abundant biopolymer on the planet. It is a biocompatible, cheap, environmentally friendly and readily accessible material. It has been reported that these biomacromolecules have antimicrobial activities. Consequently, lignin (LIG) has the potential to be used for biomedical applications. In the present work, a simple metho...
Article
Lignin is a complex natural polymer and it is one of the main constituent of the lignocellulosic biomass. Moreover, it is a bio-renewable material and it is available in large amounts as by-product of residues from the wood and paper industries. Lignin-based hydrogels with high swelling capabilities were prepared by crosslinking poly (methyl vinyl...
Article
En este proyecto docente se han desarrollado una serie de actividades académicamente dirigidas dedicadas a los reactores químicos y biológicos, en concreto, se ha empleado una herramienta denominada lección que se encuentra disponible a través de la plataforma virtual Moodle, dichas lecciones se basan en una serie de ventanas secuenciales que permi...
Article
This study describes the use of lignin as natural adhesive for the production high density fiberboards (HDF) made from wheat straw. In the present work, this agricultural residue was used to produce thermomechanical pulp and the used lignin was obtained from the spent liquors generated in the same process. A hot pressing process was conducted to ma...
Article
Recycling is becoming one of the main activities of the papermaking industry to palliate the consumption of natural resources. However, with the recycling process, the fibers experience structural damages due to the hornification phenomena and the mechanical refining. The present work aims to compare the effect of mechanical refining during recycli...
Article
Full-text available
Technical lignins are structurally heterogeneous and polydisperse. This work describes the use of a simple and green method for lignin fractionation, using different proportions of acetone (40 and 60%) in water. Lignins from three different sources (wheat straw organosolv lignin, wheat straw soda lignin and softwood kraft lignin) were used in this...
Article
Three different lignin-rich fractions have been used as binder material for electrodes in rechargeable lithium batteries. Lignin samples were obtained through three different pulping processes; kraft, soda and organosolv pulping processes, using wheat straw as raw material. Physico-chemical characterization of three types of lignins was evaluated....
Article
Rapidly growing vegetables could be an abundant and cheap sources of lignocellulose biomass for lignocellulose nanofibre (LCNF) production. The aim of this work is to study the feasibility of using Chamaecytisus proliferus and Leucaena leucocephala for LCNF isolation by mechanical, enzymatic and TEMPO-mediated oxidation pre-treatments. Characterisa...