Juan Saulo González-González

Universidad de la Cañada · Instituto de Farmacobiología

The synthesis, density functional theory (DFT) molecular structure and Fourier transform infrared spectroscopy (FTIR) molecular recognition study of diethyl phenylenebis(methylene) dicarbamates with 1,2- and 1,3-benzenediols is described. The formation of the complexes was confirmed by the shift of the O-H stretching bands in the IR spectra of the...

Abstract The cocrystal formed by diethyl N,N´-[1,3-(2-methyl)phenyl]dioxalamate (1) and resorcinol (2), namely 1·2 cryst (C21H24N2O8) was prepared by mechanochemical complexation. IR spectroscopy and powder X-ray diffraction studies allowed to determine the complexation and the conformational switching of the ethyl oxalamate side arms. In the cryst...

Pharmaceutical co-crystals emerge as a possibility to improve the biopharmaceutical properties and pharmacotechnical of an Active Pharmaceutical Ingredient (API). The co-crystals are crystalline solids composed of an API and a former, which are located in the same crystal cell. The search for new pharmaceutical co-­crystals is the responsibility of...

The mechanochemically induced complexation between diethyl N,N′-1,3-phenyldioxalamate tweezers and resorcinol, orcinol, 4,6-di-tert-butyl-1,3-benzenediol, and 4-hexyl-1,3-benzenediol is described. IR-spectroscopy, X-ray powder diffraction, 13C CPMAS, and single X-ray diffraction allowed establishing the structures of the complexes as hydrogen-bonde...

This work reports the synthesis of aminoazobenzene compounds derived from 3,5-dimethylaniline (1a–1f) via a diazo-coupling reaction with aromatic amines. These aminoazobenzenes were acylated with maleic anhydride to obtain the corresponding maleimides (2a–2f). The maleimides were then used as dienophiles in a Dies–Alder cycloaddition reaction with...

The receptor ability of diethyl N , N ′-(1,3-phenylene)dicarbamate ( 1 ) to form host–guest complexes with theophylline (TEO) and caffeine (CAF) by mechanochemistry was evaluated. The formation of the 1 –TEO complex (C 12 H 16 N 2 O 4 ·C 7 H 8 N 4 O 2 ) was preferred and involves the conformational change of one of the ethyl carbamate groups of 1 f...

Resumen Las plantas medicinales son fuente de compuestos químicos que pueden utilizarse con fines terapéuticos. El uso de las plantas con fines medicinales ha sido registrado desde tiempos ancestrales por la medicina tradicional. La legislación mexicana contempla tres tipos de productos a base de plantas medicinales como son: medicamentos herbolari...

Dehydrohalogenation of 1,4‐dihalobenzenes and 1,2,4‐trichlorobenzene is performed using n ‐BuLi to form benzynes. These benzynes are used as dienophiles in a Diels–Alder reaction with the dienes furan and 2,5‐dimethylfuran to prepare new benzonorbornadiene derivatives. The cycloadducts of furan are polymerized by a ring‐opening metathesis reaction...

Cocrystals of 2,7-di­hydroxy­naphthalene (DHN, or naphthalene-2,7-diol) with isoniazid (pyridine-4-carbohydrazide) (INH), denoted DHN–INH [C10H8O2·C6H7N3O, (I)], and piracetam [2-(2-oxopyrrolidin-1-yl)acetamide] (PIR), denoted DHN–PIR [C10H8O2·C6H10N2O2, (II)], were obtained by the solvent-assisted grinding method and characterized by IR spectrosco...

Sulfamethazine [N¹-(4,6-di­methyl­pyrimidin-2-yl)sulfanilamide] is an anti­micro­bial drug that possesses functional groups capable of acting as hydro­gen-bond donors and acceptors, which make it a suitable supra­molecular building block for the formation of co­crystals and salts. We report here the crystal structure and solid-state characterizatio...

Pharmaceutical cocrystallization offers the possibility to modify the physicochemical and biopharmaceutical properties of active pharmaceutical ingredients. The mechanochemical synthesis and spectroscopic characterization of the catechol-theophylline (CAT-TEO) cocrystal is reported. The cocrystal was prepared by the solvent-assisted grinding method...

The crystal structure and the supramolecular architectures of the antiallergic compounds N,N′-(4,4′-methanediyl-di-phenyl)-bis-diethyl dioxalamate (1); N′,N′-(4,4′-oxydi-p-phenylene)-bis-diethyl dioxalamate (2); N,N′-(4,4′-biphenylene)-bis- diethyl dioxalamate (3) are reported. The supramolecular self-assembly in 1-3 is driven by N-H···O=C hydrogen...

Isoniazid is used as anti-tuberculosis drug which possesses functional groups capable of forming hydrogen bonds. A series of cocrystals of isoniazid (INH) with polyphenolic coformers such as catechol (CAT), orcinol (ORC), 2-methylresorcinol (MER), pyrogallol (PYR), and phloroglucinol (PLG) were prepared by solvent-assisted grinding. Powder cocrysta...

Molecular complexation is a strategy used to modify the physicochemical or biopharmaceutical properties of an active pharmaceutical ingredient. Solvent assisted grinding is a common method used to obtain solid complexes in the form of cocrystals. Lidocaine is a drug used as an anesthetic and for the treatment of chronic pain, which bears in its che...

Pharmaceutical cocrystals are crystalline solids formed by an active pharmaceutical ingredient and a cocrystal former. The cocrystals 2,6-di­amino­pyridine (DAP)–piracetam [PIR; systematic name: 2-(2-oxopyrrolidin-1-yl)acetamide] (1/1), C5H7N3·C6H10N2O2, (I), and 2,6-di­amino­pyridine–theophylline (TEO; systematic name: 1,3-dimethyl-7H-purine-2,6-d...

Caffeine and theophylline are methyl-xantine drugs, which are affected by water leading to their hydrated forms. The purpose of this work was to prepare and characterize hydrated forms of caffeine and theophylline by mechanochemistry. The obtained products were characterized by infrared spectroscopy and X-ray powder diffraction. The infrared spectr...

Introducción La Organización Mundial de la Salud 1 (OMS) men-ciona que las infecciones asociadas a la atención sanitaria, también conocidas como infecciones nosocomiales o infecciones hospitalarias, son las infecciones que el paciente contrae durante su tratamiento o estancia en un hospital o centro de salud y que dicha infección no está presente a...

En México y el mundo los residuos peligrosos incluyen diversos grupos, dentro de los cuales están los medicamentos caducos, considerados como una fuente de contaminación ambiental. La normatividad en México en este aspecto es pobre, sin embargo, se sugiere que estos residuos deben tener un tratamiento previo antes de llevarlos a su destino final. E...

El alcohol etílico o etanol es una sustancia contenida en una gran variedad de bebidas, las cuales son ingeridas por una gran cantidad de personas de manera ocasional (aguda) o crónica (alcoholismo). Sus efectos agudos sobre el sistema nervioso incluyen al inicio, una fase de estimulación, la cual, conforme aumenta la dosis se transforma en depresi...

Cis-diaminedichloroplatinum (II), [cis-(NH 3) 2 PtCl 2 ], is one of the most successful anticancer compounds. In recent years the search for new drugs with antineoplastic activity has led to synthesis of palladium complexes, because of its analogy with Platinum (II). The aim in this study was to show the interaction between DNA-diimine}PdCl 2). Our...

La toxicidad de insecticidas organo-fosforados y carbamatos en insectos y mamíferos está determinada por factores que pueden afectar desde la absorción, hasta la inhibición de la acetilcolinestera-sa (AChE), enzima que degrada la acetil-colina neurotransmisor importante en la conducción de los impulsos eléctricos en el cerebro provocando la muerte....

Bio-hazardous waste are those generated as a result of health care or research activities, which have come in contact with pathogens, organs, blood, or which can also generate damage to the environment. Mexican universities working with biological and chemical issues should be considered as bio-hazardous waste generating facilities. The University...

Experiencias de la práctica Resumen Los Residuos Peligrosos Biológico-Infecciosos (RPBI) son aquellos que se generan como resultado de actividades de atención médica o de investigación, que han estado en contacto con agentes patógenos para el ser humano, o que pueden causar daño al medio ambiente. En este sentido, las universidades de nuestro país...

Pharmaceutical co-crystals emerge as a possibility to improve the biopharmaceutical properties and pharmaceutical of an Active Pharmaceutical Ingredient (API). Theco-crystalsare crystalline solids composed of on API and a former, which are located in the same crystal cell. The search for new pharmaceutical co-crystals is the responsibility of supra...

Las tioureas, son compuestos resultantes de sustituir el átomo de oxígeno de la urea (NH2CONH2) por un átomo de azufre (NH2CSNH2). Actualmente se ha visto que las tioureas presentan diversas actividades biológicas, dentro de las que se encuentra la antimicrobiana. En el presente estudio se evaluó la actividad antibacteriana mediante acoplamiento mo...

In the title compound, C24H36N6O6·C2H6OS, the carbonyl groups are in an anti­periplanar conformation, with O=C—C=O torsion angles of 178.59 (15) and −172.08 (16)°. An intra­molecular hydrogen-bonding pattern is depicted by four N—H⋯O inter­actions, which form two adjacent S(5)S(5) motifs, and an N—H⋯N inter­action, which forms an S(6) ring motif. I...

Herein, an overview of the work that our group has developed using oxalamate/oxalamide derivatives is presented. First, we deal with general aspects of oxalic acid in the context of pharmacy, followed by a brief description of structural features of these molecules supported on multinuclear NMR spectroscopy, IR, voltamperometric studies and x-ray d...

In this contribution the supramolecular architecture of a series of six 1,3-phenyl-dioxalamic molecular clefts is described. The conformation was controlled by the use of Me and OMegroup substitution in the phenyl spacer. The structural and conformational study was carried out by X-ray diffraction analysis, DFT calculations at PBEPBE 6-31+G (3df, 3...

In the title compound, C16H18N4O2, the two carbonyl groups are in an anti­periplanar conformation with an O=C—C=O torsion angle of 173.86 (17)°. In the crystal, a pair of inter­molecular N—H⋯O hydrogen bonds, forming an R2²(10) ring motif, connect the mol­ecules into an inversion dimer. The dimers are further linked by N—H⋯N and C—H⋯π inter­actions...