Juan Pablo del Rio

University of Chile · Departamento de Psiquiatría y Salud Mental

Disclosure: J.P. del Rio: None. R. Gonzalo: None. M. Maliqueo: None. B. Echiburu: None. A. Ladron de Guevara: None. P. Gaspar: None. M. Alejandro: None. N.R. Crisosto: None. Introduction: Polycystic Ovarian Syndrome (PCOS) is the most prevalent endocrine disorder in adolescents. PCOS is characterized by hyperandrogenism, which can modulate brain ma...

Disclosure: J.P. del Rio: None. R. Gonzalo: None. M. Maliqueo: None. B. Echiburu: None. A. Ladron de Guevara: None. P. Gaspar: None. M. Alejandro: None. N.R. Crisosto: None. Introduction: Polycystic Ovarian Syndrome (PCOS) is the most prevalent endocrine disorder in adolescents. PCOS is characterized by hyperandrogenism, which can modulate brain ma...

Introduction Polycystic Ovarian Syndrome (PCOS) is the most prevalent endocrine disorder in adolescents. It affects brain maturation, specially in highly neuronal plasticity periods However, there is a lack of information about the impact of this exposure during brain plasticity windows. Objectives Characterize the consequences of hyperandrogenism...

Introduction Hormones produced by the hypothalamic–pituitary–adrenal-gonadal (HPAG) axis are crucial for modulating central nervous system (CNS) function and development throughout a person’s life. Disruptions in HPAG function can impact psychological development, particularly during adolescence—a period marked by psychological growth and the matur...

INTRODUCTION Polycystic ovary syndrome (PCOS) is the most prevalent cause of endocrine disorders in teenagers. Hyperandrogenism affects brain maturation, especially in high plasticity periods (intrauterine and adolescence), potentially modulating the social-emotional status of affected adolescents (aPCOS). This study characterizes the consequences...

Obesity in women of reproductive age has a number of adverse metabolic effects, including Type II Diabetes (T2D), dyslipidemia, and cardiovascular disease. It is associated with increased menstrual irregularity, ovulatory dysfunction, development of insulin resistance and infertility. In women, estradiol is not only critical for reproductive functi...

La pandemia por COVID-19 que afectó al mundo entero ha traído desafíos complejos, especialmente para las familias con niños y adolescentes. Se ha descrito que el impacto del encierro o confinamiento de la pandemia sobre la salud mental ha sido devastador, ya que ha limitado los recursos con los que las familias contaban, incrementando en los cuidad...

Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB’s actions...

Mammalian spermatozoa are highly complex specialized cells that survive a long and fascinating journey from the site of insemination to the upper third of the oviduct, where fertilization occurs. During this journey, these cells have to go through different microenvironments, which provide appropriate conditions for the occurrence of sperm capacita...

Sex hormones significantly impact women's lives. Throughout the different stages of life, from menarche to menopause and all stages in between, women experience dramatic fluctuations in the levels of progesterone and estradiol, among other hormones. These fluctuations affect the body as a whole, including the central nervous system (CNS). In the CN...

The Arab medical tradition profoundly contributed to current health sciences. Muhammad ibn Zakariya Al-Razi (865-925 AD), also known as Rhazes, was one of the masters of the classical Arabic Medicine. This article aims to discuss the work of Al-Razi, who, apart from being a prominent physician, was also a chemist (alchemist) and philosopher, a poly...

This review explains the main effects exerted by sex steroids and other hormones on the adolescent brain. During the transition from puberty to adolescence, these hormones participate in the organizational phenomena that structurally shape some brain circuits. In adulthood, this will propitiate some specific behavior as responses to the hormones no...

The objective of this editorial is to show that a harmonious relationship between science and faith is possible, as exemplified by great saints of the Catholic Church. It begins with the definitions of science and faith, followed by an explanation of the apparent conflict between them. A few saints that constitute an example that a fruitful relatio...

The onset of puberty has been a fascinating topic for reproductive endocrinologists for decades; however, its underlying physiological mechanisms have remained elusive until recently. The discovery and understanding of the effects exerted by the peptide hormone kisspeptin have shed light on this research area. This review is aimed to discuss the fu...

I. Introducción. La fertilidad es un estado biológico transitorio que depende del potencial de fertilidad de la pareja (Vigil et al., 2006). Durante el ciclo de vida de la mujer, el ovario pasa por distintos estados en relación a su capacidad ovulatoria y de secreción hormonal. El concepto de ciclo ovárico como un continuo-conocido este como el «co...