Juan Carlos Romero-Benavides

Juan Carlos Romero-Benavides
Universidad Técnica Particular de Loja | UTPL · Departamento de Química y Ciencias Exactas

PhD

About

31
Publications
12,291
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393
Citations
Citations since 2017
22 Research Items
382 Citations
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Introduction
Juan Carlos Romero-Benavides is currently Professor of Organic Chemistry and chemistry of natural products and Researcher in the Department of Chemistry at Universidad Técnica Particular de Loja, Ecuador, since October 2002. He is the Coordinator of the Natural Products: cancer and parasitism research group (PNCyP). He received his BSc in Chemical engineering from Escuela Politecnica National University, Ecuador, and his PhD. in Biomedical Sciences at the Universidad Nacional Autonoma de Mexico. His main research interests focus on the natural products (biochemistry and chemistry), synthetic methodology and natural product derivatization with the goal of discovering leads from natural sources and optimization of novel anti-inflammatory, anticancer and anti-parasitic drugs.
Additional affiliations
January 2009 - December 2015
Universidad Nacional Autónoma de México
Position
  • Estudiante de Doctorado
June 2008 - present
Universidad Técnica Particular de Loja
Position
  • Principal Investigator
Description
  • Isolation, identification and chemical transformations of secondary metabolites of plants
June 2008 - present
Universidad Técnica Particular de Loja
Position
  • Researcher
Description
  • Línea de Investigación: Bioconocimiento para la innovación y el desarrollo.
Education
October 1994 - November 2002
Escuela Politécnica Nacional
Field of study
  • Chemical engineering

Publications

Publications (31)
Article
Full-text available
Some species of the Clusia genus have been shown to have important biomedical properties, including the ability to inhibit tumor growth in vitro and the usefulness for skin care. In this study, we examined the cytotoxic effect of hexane, ethyl acetate and methanol extracts from Clusia latipes Planch. & Triana, Clusiaceae, leaves on survival of huma...
Article
Full-text available
Ecuador is well known for its biodiversity and its ancient richness. This review provides an overview of Ecuadorian plant species in terms of the ethnobotany and chemistry of natural products in relation to anticancer activity. Plant species were classified into two groups: (a) Ethnomedical species with confirmed antitumor activity and (b) species...
Article
Full-text available
Cancer remains a public health problem with a high unmet medical demand. However, in recent decades, the knowledge of several functional molecular and biological traits that distinguish tumor cells from normal cells, known as the hallmarks of cancer as described by Hannahan and Weinberg, has led to new and modern therapeutic approaches against this...
Article
Full-text available
Although the western discovery of borojó [ Alibertia patinoi Cuatrec. (Delprete & C.H.Perss.)] is as recent as 1948, its several traditional uses in gastronomy and medicine, and its fame as an aphrodisiac are long standing and strong: the “love juice” extracted from it is very appreciated in Colombia, Ecuador, and Panama. Its medicinal potential, t...
Article
Full-text available
A pre-Columbian staple, Bactris gasipaes Kunth. is a palm tree domesticated around 4000 years ago, so appreciated that a Spanish chronicler wrote in 1545, “only their wives and children were held in higher regard” by the Mesoamerican natives. The peach palm is an integral part of the foodways and gastronomy of Ecuador, Colombia, Bolivia, Peru, Braz...
Article
Full-text available
Xylosma G. Forst. is a genus of plants belonging to the Salicaceae family with intertropical distribution in America, Asia, and Oceania. Of the 100 accepted species, 22 are under some level of conservation risk. In this review, around 13 species of the genus used as medicinal plants were found, mainly in Central and South America, with a variety of...
Article
Full-text available
Tragia L. is a genus of plants belonging to the Euphorbiaceae family with worldwide intertropical distribution, composed of more than 150 species. In this literature review, 26 species of the genus used as medicinal plants were found, mainly in East Africa and the Indian subcontinent, with a variety of uses among which antibacterial, anti-inflammat...
Conference Paper
Full-text available
Pyrazoles and their derivatives have attracted particular attention because they have a wide variety of biological activities, and recently, we found that 4,4’-(arylmethylene)-bis-(1-phenyl-3-methyl-1H-pyrazole-5-ols) have good leishmanicidal activity against promastigotes of Leishmania mexicana. 4-Arylidenepyrazolone derivatives also have antipara...
Article
Full-text available
This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We then characterized their potential application in therapeutic use. For this, the in vitro biolo...
Article
Full-text available
Background Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several drugs currently on the market have this heterocycle as the key structural motif, and some have been approved for the treatment of di...
Article
Full-text available
RESUMEN Las especies del género Picramnia se encuentran a lo largo de América tropical, evidenciando una amplia distribución. Además, se han descrito los metabolitos secundarios que presentan algunas de ellas. En la provincia de Napo, ubicada en la Amazonía ecuatoriana, se encuentra una de las especies de este género, cuyos metabolitos aún no han s...
Article
Full-text available
Traditional herbal medicine has become an important alternative in the treatment of various cancer types, including colon cancer, which represents one of the main health problems around the world. Therefore, the search for new therapies to counteract this disease is very active. Grias neuberthii is an endemic plant located in the Ecuadorian Amazon...
Article
Full-text available
Introduction: The prevalence of diabetes has increased more rapidly in low and middle- income countries than in high-income countries. Type 2 diabetes mellitus (DM2), which is the most common form of diabetes, is caused by the inefficient use of insulin in the body and is characterized by disrupted insulin action or secretion. Also, oxidative stres...
Chapter
Solanum betaceum belongs to the Solanaceae family. Its fruit is mainly consumed in South America, but in recent years, it has been distributed to other regions. The different varieties of this fruit are closely linked to its components. Nutritionally, they contain an excellent source of vitamin C and also provide vitamins A, B6, and E. However, in...
Article
Full-text available
The "horchata" is a herbal mixture infusion consumed in Southern Ecuador. It remains unknown how vendors group the plant species to sell them at traditional markets. This research documented the following: 1) a list of medicinal plant species sold for the drink; 2) the culturally important medicinal plant species; 3) the agreement among vendors reg...
Article
Full-text available
Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in cancer cell lines of prostate (PC-3), colon (RKO), astrocytoma (D-384), and breast (MCF-7). The methanolic extrac...
Article
Full-text available
The unique etiology of cancer requires a multidimensional approach for its treatment, control, and prevention. Therefore, all approaches to drug discovery and development should be exploited. Argentatin B (1) is a cycloartane triterpene isolated from Parthenium argentatum with inhibitory activity on tumor lines. The aim of this study is to investig...
Article
Full-text available
Background“Horchata” is an herbal mixture infusion consumed in Southern Ecuador; 66% of its plants are anti-inflammatory medicinal plant, and 51% are analgesics. Anti-inflammatory substances can prevent carcinogenesis mediated by cytotoxic effects and can prevent DNA damage. The aim of this study was to evaluate the cytotoxicity and apoptotic/antig...
Article
Full-text available
The “horchata” is a herbal mixture infusion consumed in Southern Ecuador. It remains unknown how vendors group the plant species to sell them at traditional markets. This research documented the following: 1) a list of medicinal plant species sold for the drink; 2) the culturally important medicinal plant species; 3) the agreement among vendors reg...
Article
Intestinal parasites delay mental and physical development in children. Infection with these parasites can result in complications during pregnancy and alter the health of newborns, which has long-term effects on educational attainment and economic productivity. The appearance of resistance against classical drug treatments generates interest in th...
Article
Natural compounds from various plants, microorganisms and marine species play an important role in the discovery novel components that can be successfully used in numerous biomedical applications, including anticancer therapeutics. Since uncontrolled and rapid cell division is a hallmark of cancer, unraveling the molecular mechanisms underlying mit...
Article
Full-text available
Background: The traditional markets in southern Ecuador and within the Andean region are especially important for plant resource trading among local people, even since before Spanish colonization; therefore, ethnobotanical studies are currently necessary and important. These strategic spaces persist for the traditional medicine cultural value refl...
Article
Full-text available
Pulverized immature fruits of Annona montana M. are commonly used for biomedical applications, especially in the treatment of dysentery. The aim of this study was to investigate whether hexane, ethyl acetate or methanol extracts of A. montana M. can be cytotoxic to human tumor cells or exhibit genotoxic effects on normal human cells. The organic ex...
Article
Full-text available
Nanotechnology is the study, design, creation, synthesis, manipulation and application of materials through the control of matter at the nanometer scale, between 1-100 nanometers. Nanotechnology is revolutionizing our world. Nanomaterials are widely used in various fields thanks to their unique properties. However, nanomaterials can also result in...

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Projects (3)
Project
Actualmente existen varios tratamientos curativos y paliativos para el cáncer. Entre ellos están; la quimioterapia, radioterapia, la inmunoterapia, o incluso la terapia dirigida a oncogenes. No obstante, toda esta diversidad de terapias tienen como objetivo común la erradicación de las células tumorales (Cragg, et. al. 2009). Uno de los tratamientos más utilizado es la quimioterapia, que como su nombre lo indica implica la utilización de una serie de compuestos químicos, ya sean naturales o sintéticos; considerando que una importante fuente de sustancias bioactivas han sido los metabolitos secundarios aislados de microorganismos, hongos, plantas, especies marinas, entre otras. La producción de diversos metabolitos secundarios se ve favorecida por un microambiente diverso, siendo el Ecuador uno de los países con enorme diversidad biológica (Balunas, 2005). De acuerdo a lo mencionado previamente; es importante considerar a las especies de hongos como posibles agentes terapéuticos contra el cáncer; para lo cual inicialmente se obtendrán los extractos naturales, realizaremos un estudio fitoquímico preliminar para evaluar la presencia de metabolitos secundarios para luego ser evaluados in vitro sobre células tumorales humanas, con el fin de determinar si presentan o no un potencial anticancerígeno. Dichos estudios además brindarán información sobre la bioactividad que presentan dichas especies de hongos, pudiéndose extender su estudio a metabolitos aislados con enfoques en otras propiedades farmacológicas.
Project
Determinar la existencia de resistencia antiparasitaria a los esquemas terapéuticos nacionales actuales, asi como el potencial de acción antiparasitaria de extractos de plantas nativas con ensayos preclínicos