Juan Carlos López Robledillo

Juan Carlos López Robledillo
Hospital Infantil Universitario Niño Jesús · Paediatric Rheumatology

MD PhD Rheumatology

About

71
Publications
5,002
Reads
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538
Citations
Introduction
Skills and Expertise
Additional affiliations
February 2016 - present
Hospital Beata Maria Ana
Position
  • Jefe de Unidad
April 1995 - November 2015
Hospital Infantil Universitario Niño Jesús
Position
  • Head of Faculty

Publications

Publications (71)
Article
Few studies have been published focusing on the differences between juvenile idiopathic inflammatory myopathy (JIIM) and adult IIM. This study aimed to describe the characteristics of JIIM main subgroups (juvenile dermatomyositis [JDM] and juvenile polymyositis [JPM]) and to compare their differences with adult IIM subgroups (adult DM and adult PM)...
Article
Full-text available
Objective To evaluate the long‐term efficacy, safety of canakinumab and explore prediction of response in systemic juvenile idiopathic arthritis (sJIA) patients with and without fever at treatment initiation. Methods At enrollment, active sJIA patients (2–<20 years) started open‐label canakinumab (4mg/kg every 4 weeks [q4w] subcutaneously). Effica...
Poster
Background: Membrane-bound receptor for advanced glycation endproducts (mRAGE) expression increases in the presence of its ligands (e.g., High Mobility Group Box 1, HMGB1) and triggers an inflammatory immune response. In contrast, soluble RAGE (sRAGE) acts as a decoy receptor and downmodulates inflammation. Some studies have demonstrated that decre...
Conference Paper
Background Switching from paediatric rheumatology to the adult rheumatology care units has a negative impact on disease control and adherence in young patients with juvenile idiopathic arthritis (JIA) but also in other chronic diseases. Transitional care services provide the opportunity of being followed-up by an adult rheumatology specialized in j...
Conference Paper
Background Juvenile dermatomyositis (JDM) is characterized by the presence of microangiopathy which can be assesed by nailfold capillaroscopy (NFC), a simple and noninvasive imaging technique. Morphological abnormalities in scleroderma NFC are well described, but it is known that they may be present in other autoimmune diseases, such as JDM. Objec...
Conference Paper
Full-text available
Background Juvenile idiopathic inflammatory myopathies (JIIM) are a heterogeneous group of autoimmune diseases affecting children, characterized by symmetric muscular weakness, cutaneous rash and systemic organ involvement. Given its low incidence, there are few studies describing the characteristics of this disease and its subtypes in Spanish pati...
Article
Full-text available
Background: Inflammatory idiopathic myositis (IIM) comprises a heterogeneous group of systemic muscular diseases that can occur together with other connective tissue diseases (CTD), named overlap myositis (OM). The question of whether OM is a distinct entity still remains controversial. Aim: The present study was conducted to assess the clinical...
Article
Objective To study prognostic factors in different types of idiopathic inflammatory myopathies (IIM) associated with interstitial lung disease (ILD). Patients and methods Multicenter retrospective study of a Spanish cohort of patients diagnosed with IIM. Patients were classified into four categories: polymyositis (PM), dermatomyositis (DM), antisy...
Article
Resumen La artritis idiopática juvenil (AIJ) y especialmente las conectivopatías son un grupo heterogéneo de enfermedades poco frecuentes en la adolescencia. Son enfermedades ocasionadas por la inflamación de diversas estructuras corporales debido a una desregulación del sistema inmune. Los síntomas y signos pueden ser inespecíficos y aparecer dura...
Article
We report two unrelated infants in whom chronic urticaria was the first clinical manifestation of cryopyrin‐associated periodic syndrome, which should be suspected in infants with early‐onset chronic urticaria, especially if there is a neutrophil‐rich infiltrate in the skin biopsy. Early diagnosis of cryopyrin‐associated periodic syndrome may lead...
Conference Paper
Full-text available
Background Among the subtypes of idiopathic inflammatory myopathy (IIM), it has been recognised that primary polymyositis (PM) and primary dermatomyositis (DM) have a worse prognosis than overlap syndrome (OM). However, the benign course of OM has not been confirmed in other studies. The identification of specific characteristics that could allow a...
Conference Paper
Background Deficiency of the interleukin (IL)−36 receptor antagonist (DITRA) is an autosomal recessive autoinflammatory syndrome caused by mutations in the IL36RN gene. Clinical manifestations of DITRA include recurrent episodes of generalised skin postulation, fever, systemic inflammation and leukocytosis. An uniformly effective treatment for DITR...
Conference Paper
Full-text available
Background Calcinosis is a cutaneous manifestation that produces disability and complications in patients with idiopathic inflammatory myopathies (IIM). Studies about associated factors are limited. Objectives To investigate cutaneous manifestations and factors associated with calcinosis in patients with IIM from the REMICAM registry. Methods A m...
Conference Paper
Background Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory polygenic bone disease characterised by aseptic bone inflammation in paediatric population. Its management, clinical, radiological findings and treatment have not yet been standardised. Objectives Retrospective, descriptive multicentric study of patients diagno...
Article
Full-text available
The present study was undertaken to assess mortality, causes of death, and associated prognostic factors in a large cohort of patients diagnosed with idiopathic inflammatory myositis (IIM) from Spain. A retrospective longitudinal study was carried out in 467 consecutive patients with IIM, identified from 12 medical centers. Patients were classified...
Article
Objective To analyze clinical characteristics, survival and causes of death of patients diagnosed with autoimmune inflammatory myositis in the REMICAM registry from the Society of Rheumatology in the Community of Madrid (SORCOM). Methods Multicenter cohort of patients diagnosed with autoimmune inflammatory myopathy with follow-up between January 1...
Article
Osteoporosis is defined as a bone disorder with low bone mass and altered bone quality leading to fractures, it may be primary due to an intrinsic bone abnormality (usually genetic in origin) or secondary due to an underlying medical condition and/or its treatment. Causes for secondary osteoporosis include immobility, leukemia, inflammatory conditi...
Article
Objective: To analyze clinical characteristics, survival and causes of death of patients diagnosed with autoimmune inflammatory myositis in the REMICAM registry from the Society of Rheumatology in the Community of Madrid (SORCOM). Methods: Multicenter cohort of patients diagnosed with autoimmune inflammatory myopathy with follow-up between Janua...
Article
Background: Recurrent panniculitis in children with lipoatrophy has been loosely described and reported under different names, but has never been systematically evaluated by immunohistochemical stains. Objective: To depict the profile of children with recurrent idiopathic panniculitis. Methods: Study of clinical, histopathological and immunohi...
Article
Objectives: To describe and evaluate clinical and imaging differences between patients with familial and sporadic early spondyloarthritis (SpA). Methods: This was a cross-sectional study analysing the baseline dataset from ESPERANZA, a national programme developed for the early identification of patients with SpA. Patients fulfilling SpA ASAS cl...
Article
Background Currently we have biological treatments for control juvenile idiopathic arthritis (JIA), we have specific protocols that help us to handle, and do not know the exact time they keep these treatment, which conducted this study survival the biological agent. Objectives The purpose this work is describe the survival time of biological drugs...
Article
Background Biologic drugs are a mainstay in the treatment of juvenile idiopathic arthritis (JIA). The early use of these drugs allows controlling disease activity avoiding its consequences and improving the quality of life of patients. We know the main characteristics of our cohort of JIA patients treated with biologics. Objectives To describe the...
Article
Objectives: To develop a consensus document of recommendations for the use of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA). Material and method: A group of eleven experts proposed several clinical questions on the use of MTX in patients with JIA. A systematic review was conducted and the evidence and recommendations fo...
Article
To develop a consensus document of recommendations for the use of methotrexate (MTX) in patients with juvenile idiopathic arthritis (JIA).
Article
Full-text available
To develop recommendations on the transition from pediatric care to adult care in patients with chronic inflammatory rheumatic diseases with childhood onset based. Recommendations were generated following nominal group methodology and Delphi technique. A panel of 16 experts was established. A systematic literature review (on transitional care) and...
Article
Background Primary pyomyositis is a rare condition in children that should be included in the differential diagnosis of musculoskeletal infections. Objectives To describe the clinical features of pyomyositis as well as its diagnostic and therapeutic approach. Methods A descriptive and retrospective study was performed by reviewing medical records o...
Article
Full-text available
Background Many young people with rheumatic childhood-onset diseases continue to require medical care into adult life. There are many differences between pediatric and adult care. Although there is an extensive evidence base for the need of transitional care, there is a paucity of robust outcome data and a great variability on the models of transit...
Article
To determine the prevalence of abnormalities detected by ultrasonography (US) in children with juvenile idiopathic arthritis (JIA) showing clinically inactive disease (ID) on medication and off medication. Inclusion criteria: 1) JIA patients, 2) clinician-determined ID, 3) JIA drugs withdrawal or stably dosed modified anti-rheumatic drugs (DMARDs)...
Article
Background Juvenile idiopathic arthritis (JIA) is a heterogeneous group of arthritides that all present with chronic joint inflammation that can lead to structural damage. The advances in therapeutic effectiveness have created a need for looking for imaging tools that describe more precisely the clinical state of disease inactivity. The well-known...
Article
Objectives To: 1) describe the distribution of the public sector rheumatologists; 2) identify variables on which the workload in Rheumatology depends; and 3) build a predictive model on the need of rheumatologists for the next 10 years, in the Community of Madrid (CM). Methodology The information was obtained through structured questionnaires sent...
Article
Objectives: To: 1) describe the distribution of the public sector rheumatologists; 2) identify variables on which the workload in Rheumatology depends; and 3) build a predictive model on the need of rheumatologists for the next 10 years, in the Community of Madrid (CM). Methodology: The information was obtained through structured questionnaires...
Article
Background and objectivesPrevious to the development of a clinical pathway (CP) for early spondyloarthritis (SpA), a qualitative study was performed to know the attitude of primary care physicians (PCP) with respect to CP implementation.Methods5 discussion groups (2 in Madrid, 2 in Barcelona and 1 in Sevilla) and 3 interviews in Bilbao, were perfor...
Article
Background and objectives: Previous to the development of a clinical pathway (CP) for early spondyloarthritis (SpA), a qualitative study was performed to know the attitude of primary care physicians (PCP) with respect to CP implementation. Methods: 5 discussion groups (2 in Madrid, 2 in Barcelona and 1 in Sevilla) and 3 interviews in Bilbao, wer...
Article
Objective: Chronic infantile neurologic, cutaneous, articular syndrome (CINCA), also known as neonatal-onset multisystem inflammatory disease (NOMID), is a severe, early-onset autoinflammatory disease characterized by an urticaria-like rash, arthritis/arthropathy, variable neurologic involvement, and dysmorphic features, which usually respond to i...
Article
Several syndromes manifest as recurrent daily fevers, skin lesions, and multisystem inflammation. We describe 4 patients with early-onset recurrent fevers, annular violaceous plaques, persistent violaceous eyelid swelling, low weight and height, lipodystrophy, hepatomegaly, and a range of visceral inflammatory manifestations. Laboratory abnormaliti...
Article
Objective. To determine the prevalence and etiology of bacterial meningitis in childhood and its profile of antibiotic susceptibility of agents. Patients and methods. Prospective study of bacterial meningitis diagnosed in the laboratory of Niño Jesús Infant Hospital of Madrid, in children between 10 days and 17 years-old, from 1996 to 2001, and com...
Article
Case report. A case of supratentorial subdural empyema extending to the superior subdural cervical space in a 14-year-old patient with systemic lupus erythematosus is presented. The presumed etiology of the empyema was an intestinal nontyphoidal salmonella infection. Discussion. We review the neurological and neurosurgical complications in systemic...
Article
We report the case of a girl aged 2 years and 8 months with monoarticular arthritis of the knee. Onset and outcome were slow. The child had suffered uncomplicated pharyngitis and a diarrheal process 1 and 2 weeks respectively prior to developing the disease. Additional data suggested the presence of reactive arthritis after Streptococcus infection....
Article
Cutaneous polyarteritis nodosa is a form of polyarteritisnodosa. It is a rare disease in children and is characterizedby its benign and chronic course. There is no evidence ofhypertension or organ dysfunction. The aim of this studywas to present a case of cutaneous polyarteritis nodosaand to review the literature. We describe the case of a3-year-ol...
Article
Cutaneous polyarteritis nodosa is a form of polyarteritis nodosa. It is a rare disease in children and is characterized by its benign and chronic course. There is no evidence of hypertension or organ dysfunction. The aim of this study was to present a case of cutaneous polyarteritis nodosa and to review the literature. We describe the case of a 3-y...
Article
We report the case of a girl aged 2 years and 8 months with monoarticular arthritis of the knee. Onset and outcome were slow. The child had suffered uncomplicated pharyngitis and a diarrheal process 1 and 2 weeks respectively prior to developing the disease. Additional data suggested the presence of reactive arthritis after Streptococcus infection....
Article
A case report of a young man with isolated cervical hydatidosis treated postoperatively with sustained cyclical albendazole therapy for 9 years of follow-up. To communicate the efficacy and safety of prolonged albendazole treatment in the postoperative management of spinal hydatid disease, and recommend therapeutic regimes for preventing its recurr...
Article
Introduction: Synoviorthesis is an intraarticular therapy used in persistent synovitis of several etiologies. In this work we review the knee synoviorthesis performed with osmic acid in the last ten years. Objective: To assess effectiveness and side effects of the synoviorthesis. Patients: 53 joints had been treated with osmic acid. The patients me...

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Project (1)
Project
Analyze clinical features, prognosis and survival of idiopathic myopathies in several departements of Rheumatology in Madrid.