Juan-Bosco López-Sáez

• MD
• Medical Doctor at Universidad de Cádiz

Introduction Sex differences exist in risk factors and comorbidities of older adults (aged ⩾ 65 years) with pulmonary embolism (PE). Clinically relevant sex-based treatment disparities for PE have not been adequately addressed. The few existing show conflicting results due to small sample size (type II error) and suboptimal methods (overreliance on...

Background Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long-term complication of acute pulmonary embolism (PE). We aimed to evaluate the impact of a symptom screening programme to detect CTEPH in PE survivors. Methods This was a multicentre cohort study of patients diagnosed with acute symptomatic PE between January 20...

This study sought to determine the survival duration of patients who underwent palliative sedation, comparing those who received prescriptions from referring physicians versus on-call physicians. It included all patients over 18 years old who died in the Palliative Care, Internal Medicine, and Oncology units at the Hospital Universitario of Jerez d...

Sex-specific factors are implicated in pulmonary embolism (PE) presentation in young patients, as indicated by increased risk in pregnancy. Whether sex differences exist in PE presentation, comorbidities, and symptomatology in older adults, the age group in which most PEs occur, remains unknown. We identified older adults (aged ≥65 years) with PE i...

Background: Sex differences in symptoms of acute pulmonary embolism (PE) in older adults (aged ≥65 years) may correlate with differences in the imaging modality used for confirming PE. It is also unknown if sex disparities exist in early use of echocardiography for prognostication. Methods: Using data from RIETE, a prospective multinational registr...

Background: Biological sex is linked with pulmonary embolism (PE) disease presentation in young patients, such as the risk incurred by pregnancy. Whether sex differences exist in PE presentation, co-morbidities, risk factors, and symptomatology in older adults, the age group in which most of these events occur, remains unknown. Methods: We identifi...

Background and objectives Vitamin D (vitD) participates in phospho-calcium metabolism and exerts multiple pleiotropic effects. There is tissue 1-α (OH)ase that converts 25-OH cholecalciferol (25 (OH) D) in calcitriol that exerts autocrine and paracrine effects. 25 (OH)D deficiency could limit these tissue effects of vitD. The administration of nutr...

Importance: Insufficient data exist about the clinical presentation, short-term, and long-term outcomes of patients with isolated distal deep vein thrombosis (IDDVT), that is, thrombosis in infrapopliteal veins without proximal extension or pulmonary embolism (PE). Objective: To determine the clinical characteristics, short-term, and 1-year outc...

Resumen Antecedentes y objetivos La vitamina D (vitD) ejerce efectos pleiotrópicos como son las modificaciones de la función arterial y descenso de la albuminuria. Existe 1-alfa-hidroxilasa tisular que convierte el 25-hidroxicolecalciferol (25[OH]D) en calcitriol que ejerce acciones autocrinas y paracrinas que intervienen en los efectos pleiotrópi...

Phytochemicals in the ethanol extract of Artemisia herba-alba were examined and evaluated for the antioxidant and cytotoxicity potential. The extraction was performed using an accelerated solvent extraction (ASE300), analyzed by GC-MS and the total phenolics was estimated by Folin–Ciocalteau method. The antioxidant activity of the extract was evalu...

The ideal duration of anticoagulation therapy in patients with autoimmune disorders and venous thromboembolism (VTE) is controversial. We used the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) database to compare the incidence rate of major bleeding during anticoagulation versus the incidence rate of VTE recurrences after its disconti...

Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbólica) registry to compare mortality, VTE recur...

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acu...

Background: The choice of the imaging modality for diagnosis of pulmonary embolism (PE) could be influenced by provider, patient or hospital characteristics, or over time. However, little is known about the choice of the diagnostic modalities in practice. The aim of this study was to evaluate the variations in the use of imaging modalities for pat...

Background The influence (if any) of the use of psychotropic drugs on outcome in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Methods We used data from the RIETE (Registro Informatizado Enfermedad TromboEmbólica) database to compare the risk for VTE recurrences, major bleeding, or de...

Introduction Oral antidiabetic inhibitors of the sodium-glucose cotransporter (SGLT2i) reduce cardiovascular morbidity and mortality in DM2. The increase in arterial stiffness can participate in this morbidity and mortality. The aim of this study was to analyse the effect of the administration of dapagliflozin on arterial stiffness. Patients and m...

Resumen Introducción y objetivos Los antidiabéticos orales inhibidores del cotransportador sodio-glucosa (iSGLT2) reducen la morbimortalidad cardiovascular en la DM2. El aumento de la rigidez arterial puede participar en esta morbimortalidad. El objetivo de este trabajo fue analizar el efecto de la administración de dapagliflozina en la rigidez ar...

This paper aimed to determine factors that influence the onset of postthrombotic syndrome after an acute episode of deep venous thrombosis in patients from the RIETE registry. We conducted a prospective study that analyzed 1183 consecutive cohort patients in the RIETE registry after a first episode of deep venous thrombosis is and assessed for post...

In patients receiving anticoagulant therapy for venous thromboembolism (VTE), the important issue of anemia influence on the risk of bleeding has not been consistently studied. We used the large registry data RIETE (Registro Informatizado Enfermedad Tromboembólica) to compare the rate of major bleeding in patients receiving anticoagulant therapy fo...

Resumen Introducción y objetivo Impartir la materia de cuidados paliativos a nivel universitario se ha iniciado hace pocos años, con un progresivo aumento de las universidades donde este hecho está ocurriendo. En nuestro caso llevamos 2 cursos haciéndolo, con la sensación de ser algo positivo para nuestros alumnos. Quisimos valorar si nuestros alu...

Introduction Patients with arterial disease receiving antiplatelet agents may develop venous thromboembolism (VTE) and need anticoagulant therapy, although concomitant use of these drugs may increase bleeding risk. We analyzed RIETE data and compared clinical outcomes depending on decision to discontinue or maintain antiplatelet therapy at VTE diag...

Introduction. IOERT is a therapeutic variety of selective overimpression on tumoral volumes or area at relapse risk. That allows to protect the adjacent healthy tissues. AIMS Assessment of toxicity and survival of IOERT in exclusive treatment or overimpression of primary tumors and relapse. Materials and methods. Retrospective study carried out bet...

This is a critical review of the biological basis of the p53 protein in apoptosis, it's importance in the experimental and human carcinogenesis and the laboratory procedures used for it's determination in cancer patients. The hyperexpression of p53 due to a mutation originates an excesive tissue acumulation, related to the long half life of mutated...

We are interested to study the accuracy of TPS serum quantification in the diagnosis of solid tumors, to evaluate this serum test as a biological marker of malignancies. We have studied TPS levels in serum of cancer patients with breast cancer, lung cancer, head and neck squamous cell carcinoma and other solid tumors. TPS was determined by ELISA in...

A large number of highly potent peptide factors, such us the various interleu-kins, interferons, colony stimulating factors (CSF) and Tumor Necrosis Factor (TNF), all of them referred as cytokines, have been discovered in the past 10–20 years. Cytokines regulate or modify cellular responses in inflammatory and immune reactions, and this feature is...

Assessment of the accuracy of diagnostic procedures is made independent of diagnostic criteria by means of a receiver-operating-characteristics (ROC) curve. We performed ROC analysis for the major serum antiproteases: alpha-1-antitrypsin (A1AT) and alpha-2-macroglobulin (A2M), in 99 cancer patients compared with 71 normal individuals. A1AT and A2M...