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Pyrazolines are five-membered heterocyclic compounds with two nitrogen atoms in their structure. They have many applications, especially in medicines. The following work presents the experimental and theoretical studies on the reaction between 3,3,3-trichloro-1-nitroprop-1-ene (TNP) 1 and N-(4-bromophenyl)-C-arylnitrylimine (NIs) 2a-c. The experim...
[3+2] Cycloaddition reactions with the participation of Z-C-(3-pyridyl)-N-methylnitrone and series of E-2-R-nitroethenes were explored both experimentally and theoretically in the framework of Molecular Electron Density Theory. It was found that all considered processes are realized under mild conditions and in full regio- and stereocontrol. In all...
The possibility of the construction of five-membered heterocycles, including single heteroatom or systems with two, three and four heteroatoms were critically reviewed based on the recent reports regarding to the [3+2] cycloaddition reactions. Almost all of analysed reaction are realized with high regio- and stereoselectivity.
[3+2] cycloaddition reactions of -COOMe and -CN trans-substituted nitroethenes with (Z)-C,N-diphenylimine N-oxide were tested. For the contrast to most known nitroalkene/nitrone cycloaditions, the reactions studied realized with the formation of 5-nitroisoxazolidines
[3+2] Cycloaddition reactions with the participation of Z-C-(3-pyridyl)-N-methylnitrone and series of E-2-R-nitroethenes were explored experimentally and theoretically in the framework of Molecular Electron Density Theory. It was found that all considered processes are realised under very mild conditions and under full regio- and stereocontrol. The...
The experimental and theoretical studies of reaction between (E)-3,3,3-trichloro-1-nitroprop-1-ene and N-(4-bromopnenyl)-C-arylnitrylimine was performed. It was found, that the title process lead unexpectedly to 1-(4-bromophenyl)-3-phenyl-5-nitropyrazole instead of expected 2-pyrazoline molecular system. This is a result of unique CHCl3 elemination...
Pyrrolidines are important heterocyclic organic compounds which show biological effects. Many of them are successfully used in medicine. These compounds can also be applied in industry, for example as dyes or agrochemical substances. Therefore, the study of pyrrolidines chemistry is important for modern science. In this paper the pyrrolidines synth...
This poster summarises author's research of reaction between N-methylazomethine ylide and trans-3,3,3-trichloro-1-nitroprop-1-ene. Both synthetic and computational approach were discussed.