Josiane de Fátima Gaspari Dias

Universidade Federal do Paraná | UFPR · Department of Pharmacy

Objetivo: Avaliar o potencial de toxicidade de medicamentos homeopáticos de origem animal e mineral. Métodos: Foi realizada uma revisão integrativa com busca nas bases de dados Medline, Scielo, Web of Science, Lilacs e Scopus, utilizando palavras-chave específicas para identificar estudos publicados nos últimos 30 anos. A seleção dos artigos seguiu...

A artrite reumatoide (AR) é uma doença autoimune sistêmica e crônica caracterizada por inflamação das articulações, dor e eventual deterioração da função articular. Estudos elucidam o potencial de alívio e tratamento dos sintomas da AR com canabinoides e agonistas CB2 sintéticos. Esta revisão tem como objetivo comparar os usos dos agonistas CB2 sin...

Os estágios curriculares são essenciais para a formação dos futuros profissionais da saúde, permitindo a aplicação prática do conhecimento adquirido durante a graduação. Os desafios impostos pela pandemia levaram as instituições de ensino a se adaptarem para garantir a continuidade das atividades acadêmicas, incluindo práticas e Estágios Curricular...

O ensino em Farmácia incorpora práticas e estágios como parte fundamental do desenvolvimento de habilidades profissionais, representando 20% da carga horária total do curso. Em 2020, a pandemia de COVID-19 impôs desafios significativos, levando as instituições de ensino a se adaptarem para garantir a continuidade das atividades acadêmicas, incluind...

The order Sapindales is comprised of nine families and in Brazil it is represented by six, including Rutaceae Juss., which constitutes the largest group of this order. A variety of species of Zanthoxylum L. are distributed throughout the country, and among them is the species Zanthoxylum kleinii (R.S. Cowan) P.G. Waterman, which is found in the sta...

Objetivo: Analisar sobre os efeitos dos canabinoides no tratamento e/ou alívio de sintomas de doenças neurodegenerativas, como: Parkinson, Doença de Alzheimer e Esclerose Múltipla. Métodos: Foi realizada uma revisão integrativa intencionando compilar os principais resultados do uso dos canabinoides na prevenção e controle de doenças neurodegenerati...

O gênero Dalbergia Linn. f. (Fabaceae) contém cerca de 250 espécies e encontra-se ameaçado em extinção devido ao alto valor econômico da sua madeira. Muitas espécies do gênero são utilizadas na medicina tradicional chinesa. A espécie Dalbergia brasiliensis ocorre de forma natural no Brasil (Cerrado e Floresta Atlântica) e possui poucos estudos na l...

Objetivo: Analisar sobre os efeitos dos canabinoides no tratamento e/ou alívio de sintomas de doenças neurodegenerativas, como: Parkinson, Doença de Alzheimer e Esclerose Múltipla. Métodos: Foi realizada uma revisão integrativa intencionando compilar os principais resultados do uso dos canabinoides na prevenção e controle de doenças neurodegenerati...

Objetivo: avaliar as interações medicamentosas entre AINES e medicamentos prescritos para Diabetes tipo 2. Método foi efetuada uma revisão integrativa de artigos dos últimos 25 anos nas principais as bases de dados Science direct, Pub Med, Scielo, Lilacs, Portal Capes e para a seleção dos artigos foi utilizado o programa Intelligent Systematic Revi...

Gabiroba, a native fruit in Brazil’s Atlantic Forest region, has significant nutritional and therapeutic properties. However, due to its seasonality, consumption by the population is limited. Thus, the development of gabiroba byproducts would add significant value to the food and therapeutic industries. Therefore, it is essential to study and suppo...

A pesquisa explorou a relação entre disbiose intestinal e atividade física, investigando associações com doenças neurológicas. Os documentos foram extraídos das bases de dados e ferramentas Scielo, Pubmed e Web of Science Search de acordo com as palavras-chave definidas pelo DeCS/MeSH. Utilizou revisões sistemáticas, meta-análise para garantir qual...

Aedes aegypti (Diptera: Culicidae) é o principal vetor das arboviroses dengue, zika, chikungunya e febre amarela. A busca por inseticidas naturais para combater o mosquito ganha destaque nos países de clima tropical. Considerando a atividade larvicida presente no gênero Monteverdia o objetivo do estudo foi avaliar o potencial larvicida dos extratos...

Alzheimer's disease is a chronic neurodegenerative condition that affects mainly memory and other cognitive functions. Interest in finding treatments effective for this disease has increased in recent years, leading to the investigation of the use of medicinal plants and isolated compounds as possible therapeutic treatments. This study aims to iden...

Obesity is a multifactorial disease, defined by the excessive accumulation of body fat, causing negative consequences for health. Metabolic syndrome (MS) is characterized by the association between abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Experimental models are essential to elucidate the pathophysiology, development...

As plantas ornamentais foram selecionadas pelo homem a partir de caracteres atraentes e começaram a ser cultivadas por sua beleza. São utilizadas frequentemente em arquitetura e paisagismo de espaços externos, porém, pode possuir princípios ativos que as tornam tóxicas e que podem causar danos a saúde como irritações na pele e mucosas. No Brasil há...

Objective: This review aims to show the studies related to the acetylcysteine molecule in Alzheimer's disease, the glutamatergic hypothesis, and to show the difference of this drug in the use of medications and food supplements. Methods: The integrative review was performed in 6 detailed steps, the articles for the construction of the research were...

Objetivo: o presente estudo teve como objetivo realizar uma revisão de literatura para verificar a utilização das espécies vegetais nas patologias asma, bronquite, COVID-19 e identificar os compostos responsáveis pela ação farmacológica. Metodologia: A pesquisa foi realizada nos bancos de dados Medline, Scielo, Web of Science, Lilacs e Scopus, usan...

A caracterização fitoquímica de plantas da biodiversidade brasileira são uma importante ferramenta na descoberta de novas moléculas bioativas. O objetivo desta pesquisa foi realizar a termogravimetria da espécie, o screening fitoquímico e a atividade alelopática dos extratos das partes aéreas de Phoradendron ensifolium. A análise térmica foi realiz...

Introdução: O trato gastrointestinal é envolvido por um complexo sistema que tem suma importância no cotidiano na homeostasia intestinal. O intestino é responsável pela produção da serotonina e a baixa e/ou alta concentração desse hormônio, talvez seja, o causador da doença diverticulite. Objetivo: mostrar a hipótese da serotonina na doença diverti...

Abstract Bjerkandera adusta, a globally distributed fungus, is commonly used in the nutritional practices of the East Asian population. In this study, we evaluated the nutritional composition of the lyophilized mycelium of B. adusta as well as the phenolic composition and antioxidant activity of its extracts. The mycelium exhibited moisture (7.97 %...

Abstract Population aging is a worldwide occurrence that has become urgent in developing countries. Quality of life can be measured to identify functional capacity and determine the degree of impact on quality of life exerted on an individual. This study aimed to measure the quality of life of elderly people who have been living in different long-t...

Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health. The limitations in the treatment of viral diseases and the constant resistance to conventional antiviral treatments encourage researchers to discover new compounds. In this perspective, this literature...

Com a declaração da pandemia de Covid-19, em março de 2020 pela Organização Mundial da Saúde, medidas governamentais foram implantadas. As Instituições de Ensino Superior tiveram que se adaptar para o desenvolvimento das atividades acadêmicas, incluindo as práticas em serviço e os Estágios Curriculares Supervisionados (ECS), tornando oportuna a ref...

Objetivo: Realizar uma revisão integrativa narrativa sobre plantas alimentícias não convencionais (PANC), que apresentam ação inibitória da enzima acetilcolinesterase, utilizando para isso as bases de dados mais consultadas na atualidade; Alencar os metabolitos identificados nas espécies alimentícias não convencionais com aplicação anticolinesteras...

O processo de globalização, o aumento do trânsito internacional de pessoas e mercadorias e a mudança contínua da situação epidemiológica mundial, trouxeram como consequência, o aumento da porosidade das fronteiras dos países para a entrada de doenças infecciosas emergentes e reemergentes. Esse estudo realizou uma revisão da importância das fronteir...

This article describes the morpho‐anatomies of the leaves and stems of Ocotea paranaensis Brotto, Baitello, Cervi & Santos (Lauraceae) using light and scanning electron microscopy. The main anatomical features characterizing the species are the presence of simple non‐glandular trichomes in the leaves and stems, large secretory cells in the leaves,...

A rápida disseminação da COVID-19 no mundo, resultante da alta transmissibilidade viral do Sars-CoV-2, associada à nexistência de vacinas e antivirais específicos e eficazes para a prevenção e tratamento da doença, tornou as intervenções não farmacológicas as opções mais eficientes para a mitigação e controle da pandemia. Esse estudo investigou med...

Red jambo (RJ) is used by traditional medicine to treat diabetes, so far there are no reports on the relationship of its fiber content with monosaccharide composition and the bioaccessibility of the phenolic compounds. The aim of this study was to characterize the nutritional profile, minerals, the composition of sugars, the antioxidant potential,...

O objetivo deste estudo foi avaliar as potenciais propriedades antioxidantes, antimicrobianas e toxicológicas dos extratos brutos e frações obtidos das folhas e caule de Psychotria fractistipula L.B. Sm., Klein & Delprete. O conteúdo de compostos fenólicos variou significativamente entre as amostras (783,70-78,22 GAE mg / g), com as concentrações m...

The genus Myrcia is used in folk medicine to treat diabetes. The plants used in folk medicine require morphological and anatomical references to attest to its authenticity. This is the first report of the microscopic study of Myrcia hatschbachii. In this sense, the aim of the present study was to describe the anatomical characteristics, in order to...

Research with fungi in search of substances with potential biological activity is gaining more prominence since they are sustainable sources of new molecules. Diplodia pinea is a phytopathogenic fungus found in forest species, which has shown few reports of molecules with biological activity and may present promising biotechnological potential. Thu...

A espécie Ocotea puberula (Rich.) Nees (Lauraceae) (nome popular é canela-guaiacá) é rica em metabólitos secundários dentre eles, os alcaloides. A dicentrina é um alcaloide de O. puberula e possui ações famacológicas tais como, anti-inflamatória, analgésica, ansiolítica e antimalárica. O objetivo trabalho foi investigar o potencial antioxidante e b...

Several species of the Myrcia genus have been used in folk medicine to treat diabetes. Therefore, the aim of this work was to investigate the inhibitory activity of α-glucosidase and pancreatic lipase in the crude extract (EBF) and in the ethyl acetate fraction (FFA) of Myrcia hatschbachii, as well as to identify isolated phenolic compounds and to...

The Ocotea genus exhibits a variety of pharmacological, antibacterial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antibacterial properties of the ethyl acetate fraction of Ocotea nutans leaves. Isolation and identification of the phenolic compounds from the fraction was also carried out. The i...

Intending to highlight new fruits with nutraceutical potential, the present work reports the nutritional and antioxidant content of Syzygium cumini (L.) Skeels (S. cumini) and Syzygium malaccense (L.) Merr. & LM Perry (S. malaccense), and evaluates the anticancer potential against CP-H460 (lung carcinoma line) and its functionality over HEK-293 (he...

Article Psychotria fractistipula L.B.Sm, R.M. Klein & Delprete (Rubiaceae) is found in the existing Atlantic Forest in the South of Brazil, in the Paraná and Santa Catarina States. The members of Rubiaceae are characterized chemically by the presence of alkaloids, some pharmacological properties of which include antifungal, antibacterial, analgesic...

INTRODUCTION: Aedes aegypti is the main vector of dengue and yellow fever. Recently, the use of plant-sourced larvicides has gained momentum. METHODS: The hydroethanolic extracts and fractions ofOcotea nutansleaves and stems were bioassayed to determine the larvicidal efficacy of these samples. RESULTS: S-HEX (hexane fraction from the crude stem...

Introduction: Aedes aegypti is the main vector of dengue and yellow fever. Recently, the use of plant-sourced larvicides has gained momentum. Methods: The hydroethanolic extracts and fractions of Ocotea nutans leaves and stems were bioassayed to determine the larvicidal efficacy of these samples. Results: S-HEX (hexane fraction from the crude stem...

The species of the Lamiaceae family produce essential oils in the glandular trichomes, leaf surfaces, and in inflorescences, and can also produce many secondary compounds, which indicates great potential for study. The aim of this paper was to describe the chemical composition and the biological, antioxidant, antimicrobial, and antitumor activities...

Inúmeros metabólitos primários e secundários provenientes de fungos tem-se destacado na pesquisa devido o potencial biológico de suas moléculas, com aplicação direta na área da saúde. A dengue é uma patologia transmitida por um vetor, o mosquito Aedes aegypti, e possui grande relevância epidemiológica em diversos países, incluindo o Brasil. Como es...

Studies have demonstrated that diet rich in cruciferous vegetables of the Brassicaceae family can reduce the risk of cardiovascular diseases and oxidative stress levels. Nasturtium officinale (Brassicaceae), commonly known as watercress is a perennial dicotyledonous plant usually found close to water. Although previous investigations have demonstra...

Essential oils are an important natural source of pesticides and can be suitable used in ectoparasite control. The goal of this paper was to investigate the chemical composition of the volatile oils obtained from leaves and stems of Philodendron meridionale Buturi & Sakur by gas chromatography/mass spectrometry and to evaluate their insecticidal ef...

In an effort to identify novel biopesticides, the present study aimed to assess the effects of Philodendron meridionale (Buturi & Sakur) stem and leaf ketonic and ethanolic extracts (SKE, SEE, LKE, and LEE, respectively) on the germination, growth, root respiration, and enzymatic activities of Lactuca sativa L. seeds, and to measure the associated...

Fungi are organisms capable of synthesizing metabolites of industrial interest and the standardization of biomass production for the extraction of these compounds has biotechnological applications. The objective of this work was to optimize the in vitro cultivation process for fungi isolated from Pinus sp., standardizing the best conditions for the...

This article enumerates the anatomy of the leaves, petioles and stems of Ocotea nutans (Lauraceae) illustrated with optical and scanning electron micrographs. The anatomical markers include the presence of sclerenchyma in the midrib and the absence of trichomes in the leaves. The presence of brachysclereids and prismatic crystals in the petioles an...

The growing interest in the discovery of new compounds from medicinal plants justifies the study of phytochemical components of these plants and their biological activities. The genus Ocotea exhibits a variety of pharmacological, antimicrobial and antioxidant effects. The aim of the present study was to evaluate the antioxidant potential and antimi...

The chemical composition of the essential oil obtained from the branches of Ocotea paranaensis was studied by gas chromatography/mass spectrometry (GC/MS). Twenty-seven compounds, comprising 94.82% of the total components, were identified. The oil showed relatively high concentration of sesquiterpenes (62.96%), oxygenated sesquiterpenes (33.33%), a...

Natural products, especially plants, have been investigated as sources of new substances with antimicrobial properties. In this context, the Myrcia genus is extensively researched for presenting such activities. This work aims to evaluate the antifungal, antibacterial, and antioxidant properties of extracts and fractions of stems of Myrcia hatschba...

The species Tynanthus micranthus Corr. Méllo, is popularly known as "Cipó Cravo" or "Craveiro", and is usually used as a stimulant and aphrodisiac, and found in the north of the State of Paraná - Brazil. The isolate the alkane dotriacontane from T. micranthus and to verify its action on the activation of human neutrophils to produce superoxide anio...

Popularly known as red jamb, the species Syzygium malaccense (L.) Merr. L.M. Perry is an Asian tree from India, Malaysia, Vietnam and Thailand that has adapted to the climate and soil of the North, Northeast and Southeast of Brazil. The antioxidant and anti-inflammatory activities of this species have already been cited in the literature. This stud...

Objective: The Oral Health Impact Profile-14 (OHIP- 14) and the Geriatric/General Oral Health Assessment Index (GOHAI) have never been compared to a group of the same subjects in the Brazilian population. The aim of the study was to compare the OHIP-14 and GOHAI measures. Material and Methods: 129 independently living people over the age of 60 were...

Several essential oils have allelochemicals with phytotoxic effects. Croton species are producers of secondary metabolites with biological potential. In the present study, chemical composition of the essential oil extracted from aerial parts of Croton glandulosus Linnaeus was evaluated by gas chromatography and the phytotoxicity of the oil on Lactu...

The aim of this work is to develop a W1/O/W2 multiple emulsion with gallic acid in the internal aqueous phase (W1). A quantification method for gallic acid using HPLC-UV was developed and validated. In the first step, a simple W1/O emulsion was prepared with distilled water, polyglycerol polyricinoleate, sodium chloride, gallic acid and pH 5.0 sodi...

Myrcia hatschbachii D. Legrand (Myrtaceae) is a native and endemic species from Brazil. This study investigated the essential oil composition, phytotoxic potential, in vitro toxicity, antioxidant properties and antibacterial activity of species. Chromatographic analysis of essential oil identified trans-calamanene, (E)-caryophyllene and spathulenol...

The article has aimed to characterize the essential oil extracted from Ocotea diospyrifolia (Meisn.) Mez. leaves, in terms of its chemical composition and antioxidant, hemolytic, and phytotoxic potentials, as well as its toxicity against Artemia salina. The major constituents identified by CG-MS were d-elemene, spathulenol, and b-atlantol. When scr...

The Lauraceae family is predominantly found in Asia and in the rainforests of the Americas, and consists mostly of aromatic trees. Being an essential oil producer, this family is used in the food, pharmaceutical, and cosmetic industries. This work presents a systematic review of the chemical composition and bioactivity of the essential oils from th...

The ability of Diplodia pinea to inhibit Armillaria sp., Bjerkandera adusta, Botrytis cinerea, and Rhizoctonia sp. mycelium growth was analyzed using the double-culture method. Wild-type fungal strains were incubated in a biochemical oxygen demand incubator using potato agar dextrose medium at 24 ± 2 °C for 35 days in darkness. D. pinea significant...

The objective of this study was to evaluate the effects of the ethanolic crude extracts and fractions of the species Senecio westermanii Dusén on Lactuca sativa L. (lettuce) and Allium cepa L. (onion) seeds. We assessed the germination, growth, root respiration and photosynthesis of the target species in Petri dishes (9.0 cm diameter) containing fi...

The present study was undertaken to assess the potential uses of the essential oil obtained from Ocotea nutans (Nees) Mez. The hydrodistilled essential oil from O. nutans leaves was analyzed by gas chromatography-mass spectrometry. Fifty-eight compounds representing 87,29% of the total leaf essential oil components were identified, of which biciclo...

Introduction: Ocotea nutans (Nees) Mez is a plant from the family Lauraceae. Lack of previous research into the molecular composition of Ocotea has generated interest in the study of this species. The Brazilian Pharmacopoeia recommends the quality control of plant drugs to ensure their identity and purity. This is the reason why humidity and ash te...

The essential oil composition of the Ocotea bicolor, native plant of Brazil, was studied for the first time. The essential oil of the leaf was obtained by hydrodistillation and analyzed by GC/MS. The analytical procedure revealed a predominance of sesquiterpenes, δ-cadinene (7.39%), β-sesquiphellandrene (6.67%), β-elemene (5.41%) and α-cadinol (5,2...

Background Plants and their parts are a part of life in many Brazilian communities, as observed in the jackfruit. The jackfruit seeds are consumed, usually, as roasted, boiled, steamed, and are eaten as a snack. Objective The present study was carried out to identify the Artocarpus heterophyllus seeds toxicity and cytotoxic activity. Methods The...

Caracterizadas por serem um sistema carreador complexo contendo duas emulsões distintas que coexistem simultaneamente, as emulsões múltiplas apresentam muitas vantagens e aplicações, contudo manter a sua estabilidade apresenta-se ainda como um grande desafio. Foi realizada uma revisão da literatura existente além de uma análise sobre os principais...

O presente trabalho teve como objetivo realizar o estudo de possíveis bases para formulação de gel higienizante bucal de cães, prevenindo assim periodontite, gengivite e outros possíveis problemas bucais. A metodologia do trabalho foi por meio de revisão bibliográfica para verificar quais os principais tipos de Carbopol® utilizados no desenvolvimen...

The frequent use of synthetic pesticides to control Aedes aegypti population can lead to environmental and/or human contamination and the emergence of resistant insects. Linalool and methyl cinnamate are presented as an alternative to the synthetic pesticides, since they can exhibit larvicidal, repellent and/or insecticidal activity and are conside...

Introduction: Due to the growing number of scientific studies and the advances in national and international legislation, phytotherapy has consolidated as a therapeutic option complementary to traditional medicine. The National List of Essential Medicines (RENAME), published by the Unified Health System (SUS) in 2014, contains 12 medicinal herbs. H...

This study aimed to investigate the prevalence of oral health impact on the daily performance of Brazilian elderly, living in the city ofCuritiba – PR. The oral health-related quality of life (OHRQoL) of 129 elderly people aged from 60 to 80 years was assessed. Also, the influence of gender, income, attendance to the dentist, self-assessment of hea...

The aim of this paper is to review the herbal registration regulations (RDC no. 26/14) and to evaluate the outlook for prescription of herbal medicine at SUS. For this purpose, we’ve tracked and analyzed the record of political measures related to herbal medicine within the Brazilian health system as well as herbal registration norms which existed...

A Política Nacional de Práticas Integrativas e Complementares (PNPIC) inserida no Sistema Único de Saúde (SUS) apresenta práticas não convencionais ao usuário como a Acupuntura, Homeopatia e Fitoterapia. Estas práticas podem ser desenvolvidas pelo farmacêutico, o qual pode auxiliar, beneficiando a sociedade. Assim, o presente artigo tem como objeti...

Resumo Xerostomia se caracteriza por ser um sintoma causado pela hipossalivação, que pode ocorrer por motivos como idade, polimedicação, radioterapia, entre outros. Atualmente existe uma escassez de produtos disponíveis no mercado para o tratamento de boca seca, tema ainda subestimado por muitos profissionais da área de saúde. Assim, realizou-se um...