Joshua Henrina- Doctor of Medicine
- Resident Medical Officer at Regional General Hospital Dr. TC Hillers
Joshua Henrina
- Doctor of Medicine
- Resident Medical Officer at Regional General Hospital Dr. TC Hillers
About
47
Publications
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Introduction
Skills and Expertise
Current institution
Regional General Hospital Dr. TC Hillers
Current position
- Resident Medical Officer
Publications
Publications (47)
Background and objective
The obesity paradox is a well-established clinical conundrum in COPD patients. This study aimed to provide an updated analysis of the relationship between body mass index (BMI) and mortality in this population.
Methods
A systematic search was conducted through Embase, PubMed, and Web of Science. International BMI cut-offs...
In this review article, we explore the interplay between obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM), highlighting a significant yet often overlooked comorbidity. We delve into the pathophysiological links between OSA and diabetes, specifically how OSA exacerbates insulin resistance and disrupts glucose metabolism. The researc...
Background:
Acute lung injury or acute respiratory distress syndrome (ARDS) is one of the most common complications of non-fatal drowning. Although respiratory societies' guidelines endorse the role of systemic corticosteroids in ARDS, the evidence for systemic corticosteroid use in ARDS due to non-fatal drowning is limited.
Methods:
A search wa...
Limited studies explore the use of AI for COVID-19 prognostication. This study investigates the relationship between AI-aided radiographic parameters, clinical and laboratory data, and mortality in hospitalized COVID-19 patients. We conducted a multicentre retrospective study. The derivation and validation cohort comprised of 512 and 137 confirmed...
Atrial fibrillation (AF), both new-onset (NOAF) and pre-existing (PEAF) are often encountered in patients presenting with acute coronary syndrome (ACS) and increases the risk of poorer outcomes. However, a significant difference in the risk of adverse outcomes between these two AF phenotypes in the ACS setting has yet been studied. This meta-analys...
Coronary artery disease (CAD) is one of the main global causes of death. Early diagnosis by physical examination may play important role to identify population at risk and reduce morbidity and mortality. Diagonal Ear Lobe Crease (DELC), also known as Frank’s sign, was observed to be associated with coronary artery disease. We report a case of patie...
Background
The artificial intelligence (AI) analysis of chest x-rays can increase the precision of binary COVID-19 diagnosis. However, it is unknown if AI-based chest x-rays can predict who will develop severe COVID-19, especially in low- and middle-income countries.
Objective
The study aims to compare the performance of human radiologist Brixia s...
BACKGROUND
The artificial intelligence (AI) analysis of chest x-rays can increase the precision of binary COVID-19 diagnosis. However, it is unknown if AI-based chest x-rays can predict who will develop severe COVID-19, especially in low- and middle-income countries.
OBJECTIVE
The study aims to compare the performance of human radiologist Brixia s...
Malaria is an infection caused by protozoa of the genus Plasmodium, commonly found in tropical and subtropical regions worldwide. Plasmodium falciparum causes the most severe form of the disease and may progress to life-threatening manifestations. This case describes a 26-year-old man who suffered cerebral malaria with multiple organ dysfunction an...
Introduction: Congenital heart disease (CHD) is the most prevalent congenital disability found in newborns. Many cases remain unknown until complications occur, usually in young adults. Transthoracic and Doppler echocardiography are modalities of choice for CHD detection, but these are limited in Indonesia. Electrocardiography (ECG) is a widely ava...
Introduction:
Patients with kidney disease and COVID-19, whether on hemodialysis (HD) or not, have a higher risk of contracting COVID-19 accompanied by a higher mortality rate due to suppressed immune functions. Diabetes, one of the ubiquitous etiology of kidney disease, is also associated with a composite of poor outcomes.
Methods:
Meta-analysi...
Normal weight obesity (NWO) is a new emerging phenotype of obesity, defined as a normal body mass index with a high body fat percentage. While several studies have described the impact of NWO on cardiometabolic risk factors, the association between them remains uncertain. This meta‐analysis systematically evaluated cardiometabolic risk factors in a...
Iron deficiency is prevalent in chronic heart failure (CHF) patients. Nonetheless, the diagnosis is often overlooked and, often, the treatment is commenced just when overt anemia has ensued. Therefore, a better appreciation of this disease is needed, and all seasoned cardiologists should know how to approach CHF patients with iron deficiency correc...
Multisystem inflammatory syndrome in adults (MIS-A) is a rare but severe complication in adults infected with SARS-CoV-2. However, the pathophysiology remains elusive, as the limited number of reports preclude a broader understanding of this syndrome. We conducted this systematic review to explore the clinical spectrum of MIS-A, in particular its r...
Background:
This study aimed to assess the factors contributing to the outcomes of recently hospitalized patients with heart failure (HF).
Methods:
A prospective data of 76 adults who were admitted due to acute HF between October 1, 2019 and June 30, 2020 at our center were analyzed. Endpoints included survival and rehospitalization within six m...
Diabetes, one of the most prevalent chronic diseases in the world, is strongly associated with a poor prognosis in COVID-19. Scrupulous blood sugar management is crucial, since the worse outcomes are closely associated with higher blood sugar levels in COVID-19 infection. Although recent observational studies showed that insulin was associated with...
In tropical countries, endemic diseases such as malaria can be challenging to distinguish from COVID-19 because of the similarities in presenting symptoms. Here we reported a case of a young soldier with fever and myalgia six days before admission, with non-productive cough, chills, nausea and vomiting, dizziness, and headache for two days. Previou...
Background
Chest computed tomography (CT) provides an effective modality to evaluate patients with suspected
coronavirus disease 2019 (COVID-19). However, overlapping imaging findings with cardiogenic pulmonary
edema is not uncommon. Reports comparing the chest CT features of these diseases have not been
elaborated. Thus, we aimed to show the diffe...
Introduction: Coronary Artery Calcification (CAC) score may give information in cardiovascular risk stratification asymptomatic individuals. Profiles and distribution of CAC scores are still scarce in Indonesia. This study aimed to evaluate the distribution of CAC based on age and gender in asymptomatic patients.
Methods: Subjects were asymptomati...
CrossFit, a high-intensity interval training, keeps growing in trend and is one of the most favorable types of fitness, after wearable technology. However, an excessive workout is detrimental to the human body, particularly the muscle tissue. CrossFit is known to cause exercise-induced rhabdomyolysis, a concerning disease with potentially devastati...
Background
The negative impacts of proton pump inhibitor (PPI), including the risk of pneumonia and mortality, have been reported previously. This meta-analysis aimed to address the current interest of whether the administration of PPI could increase the susceptibility and risk of poor outcome in COVID-19.Methods
We performed a systematic literatur...
Background and Aims
Body mass index (BMI) has previously been shown to increase mortality and disease severity in patients with COVID-19, but the pooled effect estimate was heterogeneous. Although BMI is widely used as an indicator, it cannot distinguish visceral from subcutaneous fat. This systematic review and meta-analysis aimed to investigate t...
Objective
This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.
Methods
A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outc...
In this systematic review and dose-response meta-analysis, we aim to assess whether coffee and tea consumption is related to the risk of glioma. We performed a systematic literature search using PubMed, Embase, Scopus, and the EuropePMC up until 1 st October 2020. Exposures in this study were coffee and tea consumption. The main outcome of this stu...
Heart failure is currently one of the leading causes of morbidity and mortality. Patients with heart failure often present with acute symptoms and may have a poor prognosis. Recent evidence shows differences in clinical characteristics and outcomes between de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADCHF). Based on...
Introduction
The evidence on the association between obesity and atrial fibrillation (AF) recurrence was equivocal. We aimed to evaluate the dose‐reponse relationship between body mass index (BMI) and AF recurrence and adverse events.
Methods
A systematic literature search was conducted using PubMed, Europe PMC, EBSCO, ProQuest, and Cochrane Libra...
![Fig. 1. Study profile [15].](profile/Joshua-Henrina/publication/349078926/figure/fig1/AS:996603561271298@1614620213652/Study-profile-15_Q320.jpg)
Venous thromboembolism is prevalent in hospitalized COVID-19 patients. Through systematic review and meta-analysis, we have investigated the differences in clinical characteristics and outcome of hospitalized COVID-19 patients with (+) and without (-) venous thromboembolism (VTE). 45 studies with a total of 8859 patients were included in the qualit...
Objective
This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association.
Methods
A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study's main outc...
Background:
Paediatric inflammatory multisystem syndrome (PIMS) temporally associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (PIMS-TS) is a rare clinical syndrome associated with a multiorgan system dysfunction, especially acute cardiac injury, and mandates a higher level of care.
Aim of review:
To investigate cardiac...
Introduction
National Institute for Health and Care Excellence (NICE) endorsed clinical frailty scale (CFS) to help with decision-making. However, this recommendation lacks an evidence basis and is controversial. This meta-analysis aims to quantify the dose-response relationship between CFS and mortality in COVID-19 patients, with a goal of supplem...
Background and aims
Diabetes is one of the most common comorbidities, and it is associated with poorer outcomes in patients with coronavirus disease 2019 (COVID-19). Preliminary findings showed that mortality was reduced in those who consume metformin compared to those who did not, and given its low cost and widespread availability; metformin is an...
Background and aims
The ongoing COVID-19 pandemic is disproportionately affecting patients with comorbidities. Therefore, thorough comorbidities assessment can help establish risk stratification of patients with COVID-19, upon hospital admission. Charlson Comorbidity Index (CCI) is a validated, simple, and readily applicable method of estimating th...
Initially, SARS-CoV-2 infection had been reported as a relatively mild case in children than in adults. Nevertheless, recent evidence found that a subset of children then developed a significant systemic inflammatory response that resembles atypical/ typical Kawasaki's disease (KD) and toxic shock syndrome. This novel clinical syndrome later identi...
Chronic heart failure (CHF) is a pandemic with a high mortality rate and a high economic burden. The complexity of heart failure clinical syndromes requires approaches through different therapeutic targets. Intestinal dysbiosis is a condition in the human intestinal tract characterized by an imbalance of bacteria, causing various adverse effects. I...
All good research is based on a meticulous and well-designed question in the form of a hypothesis. To test this hypothesis, one must conduct an experiment with strict guidelines to obtain robust results. The results are then tested using statistics to examine its significance and conclude if a new treatment/ diagnostic modalities/biomarker is a bet...
At the beginning of 2020, the national health system and medical communities are faced with unprecedented public health challenges. A novel strain of coronavirus, later identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally, marking another pandemic of coronaviruses. This viral disease is responsible for dev...
COVID-19 and Misinformation: How an Infodemic Fueled the prominence of Vitamin D - Joshua Henrina, Michael Anthonius Lim, Raymond Pranata
Objective: To investigate the clinical characteristics and outcomes of Coronavirus Disease of 2019 (COVID-19) patients complicated with venous thromboembolism (VTE)
Method: We performed a comprehensive literature search of several databases to find studies that assessed VTE in hospitalized COVID-19 patients with a primary outcome of all-cause mort...
Background: Lung CT provides an effective modality to evaluate patients with suspected COVID-19. However, overlapping imaging findings with cardiogenic pulmonary oedema have been reported. Reports comparing lung CT features of these diseases have not been elaborated. Thus, we aimed to investigate these gaps in the knowledge regarding low-dose lung...
With a rapidly growing pandemic of coronavirus disease of 2019 (COVID-19), a public health emergency of international concern, the medical communities and national health systems are being tested for their preparedness. The culprit that is responsible for this viral respiratory disease, is a novel type of coronavirus, now identified as severe acute...
With a rapidly growing pandemic of coronavirus disease of 2019 (COVID-19), a public health emergency of international concern, the medical communities and national health systems are being tested for their preparedness. The culprit that is responsible for this viral respiratory disease, is a novel type of coronavirus, now identified as severe acute...
Coronavirus Disease of 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2). On March 12, 2020, the World Health Organization (WHO) announced the pandemic
state of COVID-19. Later, this disease has already known to affect multiple organs, including the heart. Therefore,
higher morbidity and...
The outcomes of coronary artery bypass grafting (CABG) surgery are determined by numerous factors. This study aimed to analyze the factors contributing to short-term outcomes of patients undergoing isolated CABG. This retrospective analysis enrolled all adult patients undergoing isolated CABG at our center between January 2013 and December 2016. Cl...
Questions
Questions (13)
Hi, I am just wondering where the zone of inhibition classification originated from. Many papers such as this article cited David and Stout's article as the reference for the following statement: zone of inhibition (ZOI) in four intensities corresponding to ZOI diameters: >20 mm, very strong; 10-20 mm, strong, 5-10 mm, medium; and <5 mm, no response
Nonetheless, I did not find anything that stated the aforementioned statement in David and Stout's article
(Disc Plate Method of Microbiological Antibiotic Assay I.Factors Influencing Variability and Error)
Any explanation is highly appreciated.
Hi, I am conducting a systematic review and meta-analysis. I encounter an issue, which is not all included studies reported with mean +/- SD. Some reported with a mean (IQR 1-3). However, I can circumvent this problem using a formula derived from this study by Wan et al. from BMC Medical Research Methodology. My question though, can someone explain the meaning of this verbatim " where Φ−1(z) is the inverse function of (z), or equivalently, the upper zth percentile of the standard normal distribution". What is the upper zth percentile? Thanks in advance.
Hi, my teams and I are currently working on a literature review. We also want to make our article to be better processed and understood by others, thus we want to create medical illustrations. However, I always wonder how can we create medical illustrations without causing copyright infringement. For instance, if we want to draw an image of the heart and we used an available image on the internet. Can we take that image as an inspiration? If we can't, I'm just plain confused because of how many different images of a heart could it be?
I know that this publisher is included in Beall's list of predatory journals. However, that list is already three years ago. Maybe there is development regarding this publisher much like Hindawi?
Why does the cutoff being used in febrile seizure criteria are children aged between 6 months of age until 60 months of age? Is there any reason behind that? I have tried my best to find it but no results whatsoever. Is it just a consensus?
Why does a patient with dengue infection which classified as dengue hemorrhagic fever needed Maintenance + 5% deficit for the fluid therapy? I know it's because dehydration, but is there any rationale behind that? Does this rule apply to all patients with Dengue hemorrhagic fever?
Is there any epidemiological data/ prevalence of left atrial remodelling (assessed mainly by left atrial volume) in patients with HFrEF AND AF
Hi. Do we need to ask permission from the related publishers if we want to use tables and figures from journal article or a citation is enough ?
The most commonly affected valve in rheumatic heart disease is the mitral valve. But why? is there any specific pathomechanism. I haven't found the evidence based answers yet.
