Josephine Jung

Josephine Jung
King's College Hospital NHS Foundation Trust · Department of Neurosurgery

Doctor of Philosophy

About

35
Publications
3,113
Reads
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171
Citations
Citations since 2017
35 Research Items
170 Citations
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Introduction
Currently working on 100k Genomics England whole genome sequencing data of patients with glioma.
Additional affiliations
August 2017 - present
King's College Hospital NHS Foundation Trust
Position
  • Fellow

Publications

Publications (35)
Article
Full-text available
Background Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack of standardised clinical definitions and outcome measures. Methods This is a prospective multi-centre observational coho...
Article
Full-text available
We describe the first ever-reported occurrence of a post-operative tension pneumosyrinx occurring after a resection of an intradural intramedullary spinal tumour in a 40-year-old patient. Post-operatively, he developed sudden onset paraplegia and imaging revealed a tension pneumosyrinx which was subsequently surgically decompressed. He made a gradu...
Article
The UK neurosurgical community has a track record of delivering high-quality, practice-changing clinical research studies, facilitated by a robust clinical research infrastructure and close collaborations between neurosurgical centers. More recently, these large-scale studies have been conceived, developed, and delivered by neurosurgical trainees,...
Article
Full-text available
Introduction Europe was the epicentre of the COVID-19 pandemic in March 2020, with the highest number of cases and deaths between March and April. In May, the infection numbers registered a fall followed by a second new rise, not proportionally reflected by an increase in the number of deaths. We aimed to investigate the relationship between diseas...
Article
Background Low-grade gliomas (LGG) are a heterogeneous group with significant changes in their management during the last decade. Objective To assess how our multidisciplinary team approach to the management of LGG has evolved over the past 10 years and its implications for outcomes. Methods Retrospective single-center cohort study of adult patie...
Article
Full-text available
Introduction and objectives The novel severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has had drastic effects on global healthcare with the UK amongst the countries most severely impacted. The aim of this study was to examine how COVID-19 challenged the neurosurgical delivery of care in a busy tertiary unit serving a socio-econo...
Article
Background: Diffuse gliomas have an increased biological aggressiveness across the World Health Organization (WHO) grading system. The implications of glioma grading on the primary motor cortex (M1)-corticospinal tract (CST) excitability is unknown. Objective: To assess the excitability of the motor pathway with navigated transcranial magnetic s...
Article
Full-text available
Background Patient-reported experience measures (PREMs) are a unique measure of experience of patients which can help address the quality of care of the patients.Objective Our aim of the study is to collect quality of care outcomes with our newly navigated transcranial magnetic stimulation patient-reported experience measure (nTMS-PREMs) questionna...
Article
Full-text available
Background In recent years an increasing number of patients with cerebral metastasis (CM) have been referred to the neuro-oncology multidisciplinary team (NMDT). Our aim was to obtain a national picture of CM referrals to assess referral volume and quality and factors affecting NMDT decision making. Methods A prospective multicenter cohort study i...
Article
Full-text available
Background Over the recent years an increasing number of patients with brain metastasis are being referred to the neuro-oncology multi-disciplinary team (NMDT). Our aim was to determine if referrals of this group of patients to the NMDT in the UK & Ireland comply with NICE guidelines and to assess referral volume, quality of information provided an...
Article
Full-text available
Objectives To study clinical features and treatment options between 2007–2018 in a population of diffuse low grade glioma (DLGG) patients (WHO Grade2). Methods Single centre retrospective cohort study. Variables reviewed: demographics, extent of resection (biopsy – Bx, subtotal resection – STR, gross total resection – GTR), molecular genetics and...
Article
Full-text available
Background Spheno-orbital meningiomas are complex tumours involving the sphenoid wing and orbit. Various surgical strategies are available but treatment remains challenging and patients often require more than one surgical procedure. This study evaluated whether smaller surgical approaches and newer reconstructive methods impacted the surgical and...
Poster
Full-text available
Objectives: Navigated Transcranial Magnetic Stimulation (nTMS) for brain mapping is becoming increasingly frequent for pre-surgical non invasive brain mapping. No data about Patient Reported Outcome Measure is currently available about TMS, which can be associated with anxiety or discomfort. Therefore patient collaboration and understanding of TMS...
Article
Full-text available
Glioblastoma is the most common and malignant primary brain tumour in adults, with a dismal prognosis. This is partly due to considerable inter- and intra-tumour heterogeneity. Changes in the cellular energy-producing mitochondrial respiratory chain complex (MRC) activities are a hallmark of glioblastoma relative to the normal brain, and associate...
Article
Background: Symptomatic spinal epidural lipomatosis (SSEL) is characterized by hypertrophy of adipose tissue within the spinal canal and consequent neural compromise. The exact pathogenesis remains enigmatic. The authors describe a retrospective case series, define the full clinical spectrum, and discuss possible pathogenetic mechanisms. Methods:...
Article
Full-text available
Objectives To understand the risk factors for and patterns of progression of low grade glioma (LGG). Design Single centre retrospective cohort study. Subjects Patients undergoing at least two neurosurgical procedures for LGG, the first being for diffuse LGG (WHO 2). 22 patients included (14M; 8F); mean age at time of first operation 37.7±2.7 year...
Article
Full-text available
BACKGROUND Correctly distinguishing gliomas as low or high grade (LGG or HGG) during surgery can influence the surgical procedure, enhancing resection and improving survival. The UK NCRI GALA-BIDD study was designed to prospectively investigate whether the presence of visible fluorescence is a pragmatic intra-operative diagnostic surgical biomarker...
Article
Background: Surgery for lesions in eloquent brain areas remains challenging owing to the risk of permanent neurological deficits. To date, direct electrical stimulation (DES) and intraoperative neuromonitoring represent the reference standard. Recently, navigated transcranial magnetic stimulation (nTMS) has emerged as a mapping tool to optimize sur...
Article
Full-text available
OBJECTIVE To determine if brain metastasis referrals to the neuro-oncology multidisciplinary team (MDT) in the UK & Ireland comply with current NICE guidelines and to understand how patients are being stratified based on recursive partitioning analysis (RPA) and/or graded prognostic assessment (GPA). METHODS Prospective multi-centre national audit...
Article
Full-text available
OBJECTIVES Surgery for lesions in eloquent brain areas is challenging due to the underlying risk of causing permanent neurological deficits. To date, Direct Cortical Stimulation (DCS) and intra-operative neuro-monitoring (IOM) represent the gold standard in minimising such risk. Recently, Transcranial Magnetic Stimulation (TMS) has emerged as a map...
Article
Background: and importance: Navigated Transcranial Magnetic Stimulation (nTMS) is a non-surgical mapping technique used in mapping of motor and language eloquent areas within and / or surrounding brain tumours. Previous reports support this as a safe technique with minor side effects associated with minor headaches and discomfort around the stimul...
Article
Background Conus medullaris arteriovenous malformations (AVMs) are rare spinal vascular malformations presenting most frequently with features of myelopathy (Foix-Alajounine syndrome), radiculopathy, bowel/bladder dysfunction, or acute spinal hemorrhage (Coup de poignard of Michon) causing profound neurological deficit. Here we present the case of...

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Projects (3)