Joseph Sollini

Joseph Sollini
University of Nottingham | Notts · School of Medicine

PhD

About

17
Publications
1,348
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132
Citations
Additional affiliations
June 2016 - April 2020
University College London
Position
  • PostDoc Position
May 2013 - May 2016
Imperial College London
Position
  • PostDoc Position

Publications

Publications (17)
Preprint
The cochlea decomposes sounds into separate frequency channels, from which the auditory brain must reconstruct the auditory scene. To do this the auditory system must make decisions about which frequency information should be grouped together, and which should remain distinct. Two key cues for grouping are temporal coherence, resulting from coheren...
Article
Full-text available
Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggregation studies. The genetic contribution to severe tinnitus is unknown since large genomic studies...
Preprint
Full-text available
Broad organizational features of the auditory pathway have been replicated by artificial neural networks trained on diverse and naturalistic stimuli. It is credible that neural network analogues could also reveal specific neural computations underlying targeted auditory phenomena. This remains to be established. Here, we examined a modified autoenc...
Article
Full-text available
Ferrets (Mustela putorius furo) are a valuable animal model used in biomedical research. Like many animals, ferrets undergo significant variation in body weight seasonally, affected by photoperiod, and these variations complicate the use weight as an indicator of health status. To overcome this requires a better understanding of these seasonal weig...
Preprint
Full-text available
Ferrets (Mustela putorius furo) are a valuable animal model used in biomedical research. Ferrets undergo significant variation in body weight seasonally, affected by photoperiod, and these variations make it difficult to use weight as an indicator of health status. To overcome this requires a better understanding of these seasonal weight changes. W...
Article
Full-text available
Frequency analysis of sound by the cochlea is the most fundamental property of the auditory system. Despite its importance, the resolution of this frequency analysis in humans remains controversial. The controversy persists because the methods used to estimate tuning in humans are indirect and have not all been independently validated in other spec...
Article
Full-text available
Neurons in the auditory cortex exhibit distinct frequency tuning to the onset and offset of sounds, but the cause and significance of ON and OFF receptive field (RF) organisation are not understood. Here we demonstrate that distinct ON and OFF frequency tuning is largely absent in immature mouse auditory cortex and is thus a consequence of cortical...
Article
Full-text available
The cochlea behaves like a bank of band-pass filters, segregating information into different frequency channels. Some aspects of perception reflect processing within individual channels, but others involve the integration of information across them. One instance of this is sound localization, which improves with increasing bandwidth. The processing...
Article
Full-text available
Acoustic environments are composed of complex overlapping sounds that the auditory system is required to segregate into discrete perceptual objects. The functions of distinct auditory processing stations in this challenging task are poorly understood. Here we show a direct role for mouse auditory cortex in detection and segregation of acoustic info...
Article
Full-text available
Psychophysical experiments seek to measure the limits of perception. While straightforward in humans, in animals they are time consuming. Choosing an appropriate task and interpreting measurements can be challenging. We investigated the localization of high-frequency auditory signals in noise using an “approach-to-target” task in ferrets, how task...
Article
Frequency selectivity is a fundamental property of hearing which affects almost all aspects of auditory processing. Here auditory filter widths at 1, 3, 7, and 10 kHz were estimated from behavioural thresholds using the notched-noise method [Patterson, Nimmo-Smith, Weber, and Milroy, J. Acoust. Soc. Am. 72, 1788–1803 (1982)] in ferrets. The mean ba...
Article
Full-text available
The work in this thesis involves two separate projects. The first project involves the behavioural measurement of auditory thresholds in the ferret (Mustela Putorius). A new behavioural paradigm using a sound localisation task was developed which produces reliable psychophysical detection thresholds in animals. Initial attempts to use the task fail...
Article
Full-text available
Signal detection theory (SDT) provides a framework for interpreting psychophysical experiments, separating the putative internal sensory representation and the decision process. SDT was used to analyse ferret behavioural responses in a (yes-no) tone-in-noise detection task. Instead of measuring the receiver-operating characteristic (ROC), we tested...