Joseph Prandota

Wroclaw Medical University · Social Pediatrics, Faculty of Public Health

This work strongly suggests that acute or chronic latent Toxoplasma gondii infections play a key role in development of Raynaaud's phenomenon, and explains several so far unknown molecular pathophysiological mechanisms involved in this clinical entity.

T. gondii is a globally distributed intracellular protozoan parasite affecting approximately 5-90% of human population and causing a variety of so far neglected diseases and clinical entities in both immunocompromised and immunocompetent individuals. Acute infection of the parasite in mice caused marked reduction in serum butyrylcholinesterase (BCh...

T. gondii is globally distributed with a high proportion of the world population estimated to be seropositive, and in the U.S. the parasite is responsible for approximately million infections each year. T. gondii tachyzoites infect almost all nucleated cells and their intracellular multiplication and lifelong persistence in the host cells play an i...

ABSTRACT Cardiovascular diseases such as atherosclerosis, atherothrombosis, coronary artery disease and stroke are the main causes of death worldwide. Atherosclerosis is a chronic, progressive immuneinflammatory and fibroproliferative disease of medium and large sized arteries with increased blood lipoprotein/cholesterol and their disposition in th...

This work for the first time provide evidence that T. gondii may be an environmental factor responisble for inducing development of autism spectrum disorders

antibody levels (range: 32.2 > 240 UI/mL, mean 120.18 UI/mL; positive value for IgG was ≥ 9 UI/mL). The avidity index (AI) ranged from 0.202 to 0.925 (scale: ≥ 0.5 high AI). The results for IgM antibodies were all negative and the obtained re-sults ranged from 0.113 to 0.25 U/mL (mean = 0.191 IU/mL) and all values below 0.8 IU/mL were considered ne...

28. Congenital and/or acquired damage of the olfactory system caused by chronic latent T. gondii infection probably plays a crucial role in development of anosmia in several autoimmune and neurodegenerative diseases. Joseph Prandota, Pediatrics & Clinical Pharmacology, Department of Social Pediatrics, Faculty of Health Sciences, Wroclaw Medical Uni...

28. Congenital and/or acquired damage of the olfactory system caused by chronic latent T. gondii infection probably plays a crucial role in development of anosmia in several autoimmune and neurodegenerative diseases. Joseph Prandota, Pediatrics & Clinical Pharmacology, Department of Social Pediatrics, Faculty of Health Sciences, Wroclaw Medical Uni...

Background Toxoplasmosis is becoming a global health hazard as it infects 30-50% of the world human population. Clinically, the life-long presence of the parasite in tissues of a majority of infected individuals is usually considered asymptomatic. However, a number of studies show that this 'asymptomatic infection' may also lead to development of o...

Prandota J. Unexplained liver damage, cryptogenic liver cirrhosis, and stesteatohepatitis mamay be caused by latent chronic toxoplasmosis. OA Hepatology 2014 Feb 10;2(1):2. Abstract T. gondiiis a globally distributed intracellular protozoan parasite affecting approximately 5-90% of human population and causing a variety of so far neglected disea...

35. T. gondii infection acquired during pregnancy and/or after birth may be responsible for development of both type 1 and 2 diabetes mellitus. Joseph Prandota, Pediatrics & Clinical Pharmacology, Former Fulbright-Hays and The Kosciuszko Foundation, Wroclaw Medical University, Wroclaw, Poland. Summary: Background. Recently, it was suggested that ma...

ABSTRACT During febrile episodes, some children diagnosed with autism spectrum disorders (ASD) exhibited changes in behavior and enhanced communication. These improvements have appeared before or soon after the onset of fever and have subsided within one to few days after the fever was gone. It was suggested that the explanations for these effects...

Idiopathic intracranial hypertension (IIH), pseudotumor cerebri (PTC), and/or aseptic meningitis (AM) present with headaches and an increased cerebrospinal fluid pressure. Recently, we found that recurrent headaches in non-HIV-infected subjects were due to acquired cerebral toxoplasmosis (CT). The aim of this work was therefore to analyze molecular...

It was reported that in humans the response of the host to latent chronic T. gondii infection was dependent on RhD phenotype. Rh-positive individuals, and RhD-positive heterozygotes in particular, appeared to be protected against latent toxoplasmosis-induced changes of personality, increased frequency of traffic accidents, and weight gain disturban...

T. gondii is an obligate intracellular parasite estimated to infect approximately 30-50% of the world’s population. Markedly elevated levels of antitoxoplasmal IgG antibodies reported in the patients with first-onset schizophrenia, migraine, Parkinson’s disease, AD, obsessive-compulsive syndrome, attention-deficit hyperactive disease, facial nerve...

Idiopathic intracranial hypertension (IIH) presents with headaches associated with an increased cerebrospinal fluid pressure. Recently, we have demonstrated that recurrent headaches in non-HIV-infected subjects were due to acquired cerebral toxoplasmosis (CT). The aim of this chapter was therefore to focus on the pathomechanisms that may lead to re...

During febrile episodes, some children diagnosed with autism spectrum disorders (ASD) exhibited changes in behavior and enhanced communication. These improvements have appeared before or soon after the onset of fever and have subsided within one to few days after the fever was gone. It was suggested that the explanations for these effects of fever...

Toxoplasma gondii is a protozoan parasite that infects about a third of human population. It is generally believed that in immunocompetent hosts, the parasite infection takes usually asymptomatic course and induces self-limiting disease, but in immunocompromised individuals may cause significant morbidity and mortality. T. gondii uses sulfated prot...

Anatomic, histopathologic, and MRI/SPET studies of autistic spectrum disorders (ASD) patients’ brains confirm existence of very early developmental deficits. In congenital and chronic murine toxoplasmosis several cerebral anomalies also have been reported, and worldwide, approximately two billion people are chronically infected with T. gondii with...

Worldwide, approximately 2 billion people are chronically infected with Toxoplasma gondii with largely yet unknown consequences. Patients with autism spectrum disorders (ASD) similarly as mice with chronic toxoplasmosis have persistent neuroinflammation, hypercytokinemia with hypermetabolism associated with enhanced lipid peroxidation, and extreme...

Approximately two billion people worldwide are chronically infected with T. gondii and yet with largely unknown consequences. On the other hand, several authors reported an association between migraine and patent foramen ovale (PFO), and different types of headaches, including migraine, may be precipitated by various diseased states or medications...

Worldwide, approximately 2 billion people are chronically infected with T. gondii with largely unknown consequences. This review presents clinical symptoms, differential diagnosis, triggering factors, treatment, and pathomechanisms responsible for idiopathic intracranial hypertension, pseudotumor cerebri, and aseptic meningitis. Literature cited in...

During developmental age, differences in pharmacodynamic reactions to several drugs may reflect polymorphisms of genes encoding drug-transporting proteins, receptors, drug targets, and gene products, whose disturbed activity sometimes plays an important role in certain diseases. Administration of drugs with a narrow therapeutic index may quite easi...

Idiopathic intracranial hypertension (IIH), pseudotumur cerebri (PTC) and aseptic meningitis (AM) are usually self-limited clinical states that occur predominantly in obese women of reproductive age, and manifest by headache, papilledema, and a raised cerebrospinal fluid pressure. Development of these entities has usually been associated with admin...

Mollaret meningitis (MM) occurs mainly in females and is characterized by recurrent episodes of headache, transient neurological abnormalities, and the cerebrospinal fluid containing mononuclear cells. HSV-2 was usually identified as the causative agent. Recently, we found that recurrent headaches in non-HIV-infected subjects were due to acquired c...

Headaches are one of the most frequent abnormal symptoms observed in children. They are also the third cause of absenteeism children in school. The aim of this work was to review up-dated literature data on headaches in children. We presented currently accepted data on epidemiology of headaches, new clinical classification system of headaches, and...

Headache and/or migraine, a common problem in pediatrics and internal medicine, affect about 5% to 10% children and adolescents, and nearly 30% of middle-aged women. Headache is also one of the most common clinical manifestations of acquired Toxoplasma gondii infection of the central nervous system (CNS) in immunosuppressed subjects. We present 11...

Analysis of literature data on drug-induced hepatotoxicity reveals that often upper respiratory febrile illnesses and/or inflammation states precede liver injury/diseases related to administration of drugs or hepatotoxicity associated with administration of therapeutic doses of acetaminophen in some genetically predisposed subjects. The goals of th...

Prophylactic vaccinations may sometimes shorten incubation period of some illnesses and/or convert a latent infection/inflammation into a clinically apparent disease. Cytokines play a major role in mediating inflammatory processes in various clinical entities and also represent a potential source of tissue damage if their production is not sufficie...

In some patients, differences in pharmacodynamic reactions to many drugs may reflect polymorphisms of genes encoding drug transporting proteins, receptors and drug targets, and gene products whose altered activity may play an important role in development of some diseases. Administration of drugs with narrow therapeutic index may also be associated...

Chronic hypoxia, viral infections/bacterial toxins, and inflammation states, are the most likely trigger of sudden infant death syndrome (SIDS). Autopsy studies have shown about 20% more muscle in the pulmonary arteries, increased airway smooth muscle cells, as well as increased fetal hemoglobin and erythropoietin which are evidence of chronic hypo...

Chronic hypoxia, viral infections/bacterial toxins, inflammation states, biochemical disorders, and genetic abnormalities are the most likely trigger of sudden infant death syndrome (SIDS). Autopsy studies have shown increased pulmonary density of macrophages and markedly more eosinophils in the lungs accompanied by increased T and B lymphocytes. T...

Prophylactic vaccinations may sometimes shorten the incubation period of some illnesses and/or convert a latent infection/inflammation into a clinically apparent disease. Cytokines play a major role in mediating the inflammatory process in various clinical entities and represent a potential source of tissue damage if their production is not suffici...

This review presents several clinical examples indicating that physiological changes in the body dependent and/or independent of developmental age, genetic polymorphisms, different disease states, acute and/or chronic inflammations, and physicochemical properties of drugs as well as some environmental factors, such as viral infections, may exert a...

The hepatotropic viruses, measles, and herpesviruses as well as different drugs were repeatedly shown to act presumably as a trigger in patients with autoimmune hepatitis (AI-H). On the other hand, it is known that viral infections stimulate interferon production, which inactivates the cytochrome P-450 enzymes involved in the metabolism of several...

Many individual variations in drug response are due to genetic metabolic polymorphisms. Pharmacogenetics links differences in gene structure with pharmacological differences in pharmacokinetics and pharmacodynamics. Clinically relevant examples include acetylator status, cytochrome P450 2D6, 2C9, 2C19, 1A2, 3A4 polymorphisms, thiopurine S-methyltra...

We present the case of a 15-year-old boy [HLA phenotype: A 1, 25 (10); B 18, 8; C 7; DR 17 (3), 6] with classic (type 1) autoimmune hepatitis presumably caused by a long-term exposure to the strong odour of food fed to a large number of tropical fish which that the boy kept in tanks in his bedroom. The boy presented with a history of recent symptom...

Accumulated experimental and clinical data suggest that adrenocorticosteroids and/or endogenous ouabain-like substances may play an important role in the mechanism of furosemide diuretic action. It was reported that the drug is highly bound in the adrenals, lungs, kidney, spleen, and liver. In patients with liver cirrhosis, furosemide exerted a mar...

Upper respiratory tract febrile illnesses caused by various viruses, mycoplasma, chlamydia infections, and/or inflammatory diseases are usually observed a few days to a few (several) weeks before the onset of Reye's syndrome, Stevens-Johnson syndrome, autoimmune hepatitis (hepatotropic virus infections), or hepatotoxicity associated with therapeuti...

Furosemide is one of the most effective and least toxic diuretics used in pediatric practice. Experimental and clinical data suggest that adrenocorticosteroids and/or endogenous ouabain-like substances may play an important role in its diuretic effect. Also, the drug appears to have anti-inflammatory properties. In children with different diseases...

Neutrophil-derived proteinases cause glomerular injury by proteolysis of the glomerular basement membrane and alterations in glomerular metabolism. Recently, a marked elevation of the plasma elastase complex with alpha1-proteinase inhibitor (alpha 1-PI) both in the acute phase and during remission of nephrotic syndrome (NS) compared with age-matche...

Systemic vasculitis is a predominant clinical symptom in Henoch-Schönlein purpura (HSP), and some studies suggested that decreased blood fibrinolytic activity, as well as blood platelets, is of importance in the development of cutaneous vasculitis. Although patients with HSP have normal blood coagulation, little is known about the fibrinolytic syst...

Furosemide is one of the most effective and least toxic diuretics used in pediatric practice. Accumulated experimental and clinical data suggested that corticosteroid(s) and/or endogenous ouabain-like substance(s) may play an important role in its diuretic action. Several studies also reported that inhaled furosemide exerted a protective effect aga...

The advances in definition, pathogenesis, diagnosis and treatment of urinary tract infections (UTI) in children have been presented. The mechanism of UTI and predisposing factors related to host and bacteria, problems in evaluating of UTI with the use of fresh urine microscopy for the presence of leukocytes, utility and reliability of ultrasonograp...

Ostry nawracający ból brzucha u 13-letniej dziewczynki spowodowany krwiakiem miesiączkowym szczątkowej macicy prawej oraz jajowodu opróżniającym się do jamy otrzewnowej Acute recurrent abd.1ll!linal pain in a 13-year-old girl caused by menstrual hematoma oC-l"rudimentary right uterus and fallopian tube, which emptied to the peritoneal cavity Józef...

Wojewódzki Specjalistyczny Szpital Chorób Dziecięcych im. J. Korczaka we Wrocławiu Ordynator: prof. dr hab. n. med. Józef Prandota Opisono dwie dziewcrynki (\v wieku 15 i 13 lat) chorujące na zespół Tietzego manifestujący się silnymi bo-1{/IlIiklatki piersiowej oraz zgrubieniem polqcreti chrzęstno-kostnych żeber i mostka. Wabu przypadkach objawy cl...

Współwystępowanie bielactwa nabytego i wola z nadczynnością tarczycy oraz toksoplazmozy nabytej u 13-letniej dziewczynki z atopowym zapaleniem skóry The coincidence of acquired vitiligo and goi ter with hyperthyreosis as well as acquired toxoplasmosis in a 13-year-old girl with atopic dermatitis Józef Prandota, Krzysztof Szczęsny Wojewódzki Specjal...

An effect of EACA given in the daily dose of 85-230 mg/kg for 1-1-days on the activity of certain plasma protease inhibitors in 7 children with steroid-sensitive and steroid-dependent nephrotic syndrome (age between 3.5 and 18 years), and in 6 children with Schönlein-Henoch syndrome (aged between 3.5 and 6 years). Additionally, an effect of EACA on...

A case of an 11-year-old boy with giant lumbosacral spinal lipoma is presented. Hobbling on the left foot and its dropping was observed at the age of 9 after which left equinovarus foot and excavated foot deformities developed. Diurnal and nocturnal enuresis, infection of the urinary tract, and bilateral vesico-ureteral reflux were found. At birth,...

Vertical kidney mobility was measured in excretory urograms in 492 children of both sexes, 1 to 16 years of age. The positions of the lower poles of the kidneys were compared in radiographs taken in recumbent and erect children. The mean values and standard deviations of the mobility were calculated (in mm) in 15 one-year-age subgroups, body weight...

The biological properties, mechanism of action, spectrum of antiproteolytic activity, clinical significance and therapeutic use of several plasma proteinase inhibitors are presented.

Immunological system was tested in 14 children aged between 1.5 and 14 years (mean 5.4 years) with steroid-sensitive nephrotic syndrome during remission. Levamisole (Decaris Richter) was administered in the dose of 2-3.5 mg/kg twice a week for 2.5-6 months. Immunological tests carried out before treatment showed a decrease in total T-cells and T2 s...

A lethal case is presented of disseminated for of histiocytosis of Langerhans cells in 16-month-old girl. In the clinical course predominated high fever, opportunistic infections, cell-mediated and humoral immunity disturbances, and gross hepatocellular damage which made impossible carrying out of the treatment with cytostatics. The advances in imm...

1. Partition of furosemide into organic solvents at pH 3.8 was greatest for ethyl acetate (33:1) greater than 2-ethyl-1-hexanol (10:1) greater than ethyl ether (6:1). 2. Furosemide was highly bound to human, bovine, rabbit, and rat plasma or albumin (97.4-98.4%). 3. Furosemide was highly bound to rat tissues. One hour after i.p. injection of the dr...

The pharmacodynamics and kinetics of single oral and intravenous doses of furosemide were studied in 9 patients (mean age 18.5 y) with cystic fibrosis. The diuretic effect of furosemide lasted for 6 h after oral administration and 2 h following intravenous injection of the drug. The patients with cystic fibrosis had a more pronounced diuretic respo...

The diuretic effect of high doses of furosemide alone and furosemide plus mannitol was analysed retrospectively in 30 children with acute renal failure. In 10 children (Group 1) renal failure developed mainly during glomerulonephritis, and in 20 children (Group 2) the cause was gastroenteritis. The diuretic effects of furosemide and furosemide plus...

Levamisole (2.1-3.1 mg/kg twice a week) was administered to 6 children aged between 20 months and 6.5 years for 1 to 4 months. All children suffered form the renal diseases exacerbation (nephrotic syndrome and pyelonephritis--2 children, lipoid nephrosis and pyelonephritis--2 children, pyelonephritis with glomerular reactions--1 child, recurrent py...