Joseph Pizzorno

Joseph Pizzorno
Bastyr University

Bachelor of Science

About

186
Publications
13,923
Reads
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851
Citations
Citations since 2016
125 Research Items
436 Citations
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2016201720182019202020212022020406080100
2016201720182019202020212022020406080100
Introduction
Skills and Expertise

Publications

Publications (186)
Article
While Cushing syndrome is rare, but well-recognized, subclinical hypercortisolism (defined as excessive cortisol secretion without the classic manifestations of Cushing syndrome) is significantly more common. Subclinical hypercortisolism contributes to several chronic diseases, such as diabetes, osteoporosis, sarcopenia and hypertension. The incide...
Article
Mitochondria are required for life, and dysfunction leads to chronic disease and shortened life expectancy. Unfortunately, suboptimal mitochondrial function is very common. While genetic mutations play a role, far more common is the damage from nutrient deficiencies and regular accidental and intentional exposure to mitotoxic metals and chemicals....
Article
Nutritional deficiencies are rampant throughout the world. Health care professionals have a unique responsibility and opportunity to help their patients understand the critical impact of nutrition on health. While nutritional supplements are of great clinical benefit, they are not a substitute for eating healthfully. In this editorial I discuss way...
Article
The relentless continuation of the COVID-19 (coronavirus disease 2019) pandemic clearly indicates the need to broaden our approach to this serious, worldwide problem. An important factor that has received little attention is the protective role of dietary antiviral flavonoids. Many flavonoids have been shown through molecular docking assays, as wel...
Article
Full-text available
As the COVID-19 pandemic has raged on, considerable research has been performed around the world evaluating the environmental, genetic, lifestyle, and nutritional factors that significantly impact the COVID-19 pandemic. Many studies have now shown that key risk factors for SARS-CoV-2 infection, severity, and even death are modifiable. Patients, whe...
Article
About a century ago when research into the nutritional components of food began, scientists were limited by the technology and physiological understanding of the time. Nonetheless, this pioneering research revealed the importance of many nutrients for the maintenance of life and prevention of overt deficiency diseases. Unfortunately, the necessary...
Article
In this second of a 2-part editorial, we continue our discussion of the importance of being aware that some clinically important prescription drugs can impair bone metabolism. While obviously most critical for women (and men) with osteopenia or osteoporosis, the guidance here is directly relevant to all patients as many are already experiencing dec...
Article
Prescription and over-the-counter drugs have been effectively used to manage many diseases and to provide symptom relief. Unfortunately, their use may also result in adverse drug reactions and unintended consequences. Proper use of these powerful agents requires understanding both their desired effects and their potential downsides. Fully understan...
Article
The environmental metals cadmium, lead, and mercury, and chemicals such as pesticides, phthalates, and bisphenols, disrupt bone metabolism in many ways. Body levels of these toxins directly correlate, in a dose-dependent manner, with risk of fracture and osteoporosis. This editorial provides a brief summary of key research showing mechanisms of dam...
Article
Humans suffer the highest burden of chronic disease in every age group ever in human history. Why? While many theories have been proposed, presented here are thoughts on a unified theory of disease to understand causes and provide guidance for health restoration and disease prevention. My thesis is that the combination of high and increasing body l...
Article
This paper presents an evidence-based strategy for improving clinical outcomes in COVID-19. Recommendations are based on the phases of the disease, because optimal interventions for one phase may not be appropriate for a different phase. The four phases addressed are: Prevention, Infection, Inflammation and Recovery. Underlying this phased approach...
Article
Foundational to the standard of care is diagnosis of overt disease as well as testing for early predictors of future disease. Obvious examples of the later include measurement of blood pressure and cholesterol. The time has come to add to this thinking early detection of the environmental causes of disease. Substantial research now shows that metal...
Article
For 200 years there has been a largely untold, even actively hidden, history of Western medicine. Individuals, organization and professions have for centuries striven to elucidate and advance a way of healthcare based on the individual and health promotion in contrast to the disease diagnosis and treatment focus of mainstream medicine. An optimal h...
Article
Full-text available
The next step in reestablishing credibility seams to us honesty and recognizing we all share a common goal of the health and wellness of the human community and the planet. Everyone agrees that the current healthcare system, despite its many incredible successes, is also showing its limitations and is no longer sustainable. We believe the solution...
Article
The rising prevalence of chronic diseases, complex diseases, unknown etiologies, and comorbidities have made efforts to practice curative medicine ever-more difficult to achieve. Autism spectrum disorder illustrates this challenge well as procedures, protocols, and algorithms that were successful in the past are no longer effective. The time has co...
Article
According to conventional wisdom, genetics accounts for only approximately 15% to 25% of disease, with the rest being due to lifestyle, diet, and environment. However, taking only the direct gene-to-disease approach is hugely, and unnecessarily, limiting. If we instead look at genetics from the perspective of metabolism, nutrient needs, and environ...
Article
While much of the decrease in fertility worldwide is by choice, an increasing number of couples, especially in industrialized countries, are finding conception more difficult and damaged babies more common. The research is quite clear that metals and chemicals in air, water, food, and health-And-beauty AIDS are damaging fertility in many ways. Thes...
Article
Throughout the recorded history of Western medicine, 2 apparently contradictory paradigms have competed for dominance. One sees health and disease as dependent on the function of the body, while the other sees the body as making mistakes and the victim of a hostile environment. The first leads to the physician prioritizing promoting health, while t...
Article
With evidence growing for the huge contribution of environmental toxins to chronic disease, the need to help our patients decrease their toxic load has never been more urgent. Some of these toxins-such as DDT, PCBs, and cadmium-have half-lives ranging over a decade. Since so many are extremely difficult to breakdown or excrete, avoidance is critica...
Article
As the research foundation documenting the major role of toxins in most chronic diseases continues to grow, clinicians are facing the challenge of having to learn how to practice environmental medicine. The great diversity of toxins and their damaging effects, the uniqueness of each person's biochemistry greatly affecting susceptibility, and incons...
Article
Obesity is a well-known risk factor for many chronic diseases as well as early mortality. However, since body mass index does not distinguish between fat mass, fat-free mass, and lean mass, individuals with similar body mass indices may have very different body composition and physiological function. Further, how a person became obese appears as im...
Article
Arsenic toxicity is far more of a clinical problem than commonly recognized. At least 10% of the public water supplies contain levels of arsenic known to increase risk of many chronic diseases, such as cardiovascular disease, many cancers, peripheral neuropathy, and diabetes. Some parts of the country have very high arsenic levels, but because fewe...

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