Joseph M Josephides- Bioinformatics Research Engineer at Institut Pasteur
Joseph M Josephides
- Bioinformatics Research Engineer at Institut Pasteur
About
4
Publications
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Introduction
Current institution
Publications
Publications (4)
Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disentangling scRT profiles from heterogenous samples. We use single-cell copy number data to accurately perform missing value imputation, identify cell replication states, an...
We introduce MnM, an efficient tool for characterising single-cell DNA replication states and revealing genomic subpopulations in heterogeneous samples, notably cancers. MnM uses sin-gle-cell copy-number data to accurately perform missing-value imputation, classify cell repli-cation states and detect genomic heterogeneity, which allows to separate...
Mammalian genomes are replicated in a cell type-specific order and in coordination with transcription and chromatin organization. Currently, single-cell replication studies require individual processing of sorted cells, yielding a limited number (<100) of cells. Here, we develop Kronos scRT, a software for single-cell Replication Timing (scRT) anal...
Mammalian genomes are replicated in a cell-type specific order and in coordination with transcription and chromatin organization. Although the field of replication is also entering the single-cell era, current studies require cell sorting, individual cell processing and have yielded a limited number (<100) of cells. Here, we have developed Kronos s...
