Joseph Barsuglia

Joseph Barsuglia
VA Greater Los Angeles Healthcare System · Geriatric Research Education and Clinical Center

PhD

About

31
Publications
27,839
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
376
Citations
Additional affiliations
September 2013 - present
VA Greater Los Angeles Healthcare System
Position
  • Postdoctoral Fellow in Advanced Geriatrics

Publications

Publications (31)
Article
Full-text available
Background U.S. Special Operations Forces Veterans are at increased risk for a variety of mental health problems and cognitive impairment associated with military service. Current treatments are lacking in effectiveness and adherence. Therefore, this study examined psychedelic treatment with ibogaine and 5-methoxy-N,N-dimethyltryptamine for trauma-...
Article
Full-text available
5-MeO-DMT is a psychoactive substance found in high concentrations in the bufotoxin of the Colorado River Toad. Emerging evidence suggests that vaporized 5-MeO-DMT may occasion mystical experiences of comparable intensity to those occasioned by more widely studied psychedelics such as psilocybin, but no empirical study has tested this hypothesis. D...
Poster
Full-text available
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a potent, short-acting psychedelic substance found in the natural world and is synthetically produced. Similar to those who use other psychedelic substances (e.g., MDMA, psilocybin), anecdotal reports of individuals who use 5-MeO-DMT suggest that they employ a variety of cognitive, social, and environ...
Poster
Full-text available
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in glandular secretions of Bufo alvarius toads and is synthesized. No human laboratory studies have been conducted, but evidence suggests 5-MeO-DMT may reduce depression and anxiety symptoms among those who use for spiritual or recreational reasons. Probing the effects of...
Poster
Full-text available
Background and Aims: A recent epidemiological survey suggested that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) administration may decrease symptoms of Post Traumatic Stress Disorder (PTSD). Further exploration of the potential psychotherapeutic benefit of 5-MeO-DMT could inform future clinical trials. Therefore, we examined self-reported PTSD amo...
Article
Background: A recent epidemiological study suggested that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used for spiritual and recreational reasons is associated with subjective improvement in depression and anxiety. Further exploration of the potential psychotherapeutic effects of 5-MeO-DMT could inform future clinical trials. Objectives: We exa...
Poster
Full-text available
Aim: 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in high concentrations in the venom of the Bufo alvarius toad and in a variety of plants. Anecdotal reports are that synthetic and organic preparations of 5-MeO are used for spiritual and recreational reasons and may have psychotherapeutic effects. However, there is...
Article
We examined persisting effects, self-perceived challenges, and potential benefits associated with positive outcomes following ibogaine detoxification using data collected as part of a larger online retrospective study of patients (n=73) who received treatment for chronic opioid use in Mexico between 2012 and 2015. A mixed-methods design was used co...
Article
Full-text available
Opioid use disorder (OUD) is currently an epidemic in the United States (US) and ibogaine is reported to have the ability to interrupt opioid addiction by simultaneously mitigating withdrawal and craving symptoms. This study examined opioid withdrawal and drug craving scores in 50 participants with OUD undergoing a week-long detoxification treatmen...
Article
Background/aim: 5-Methoxy- N,N-dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in several plants and in high concentrations in Bufo alvarius toad venom. Synthetic, toad, and plant-sourced 5-MeO-DMT are used for spiritual and recreational purposes and may have psychotherapeutic effects. However, the use of 5-MeO-DMT is not well unde...
Chapter
Ibogaine is a plant-derived alkaloid and dissociative psychedelic that demonstrates anti-addictive properties with several substances of abuse, including alcohol. 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic known to occasion potent mystical-type experiences and also demonstrates anti-addictive properties. The p...
Poster
Full-text available
The presentation is about the use of 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT), including patterns of use, motives for consumption, and acute subjective effects in an international sample of individuals who have tried 5-MeO-DMT at least once in their lifetime.
Article
Background and aims: Very few studies have reported the effectiveness of ibogaine as a treatment for chronic opioid use. Therefore, this study evaluated the acute subjective effects of ibogaine, outcomes on problematic opioid consumption, and the long-term associations with psychological functioning. Methods: Using online data collection, 88 pat...
Poster
Full-text available
Human studies on the efficacy of ibogaine in interrupting substance use disorders are limited, and studies on the long-term outcomes are even fewer. Therefore, we designed the current retrospective study to evaluate the subjective effectiveness of ibogaine treatment on problematic opioid consumption, and the long-term associations of treatment with...
Poster
Full-text available
Background: Problematic opioid consumption is currently an epidemic in the United States. Ibogaine is reported to have the ability to interrupt opioid addiction by simultaneously mitigating withdrawal and craving symptoms. Objective: Evaluate opioid withdrawal and drug craving scores using validated clinical instruments in subjects with problematic...
Poster
Full-text available
Background : 5-MeO-DMT is a potent tryptamine found in high concentrations in the venom of the Colorado River Toad. Practical experience suggests that vaporized 5-MeO-DMT may induce mystical experiences that are relatively brief, yet have comparable or greater intensity than those induced by psilocybin. Quantitative evaluations of 5-MeO-DMT induced...
Article
Full-text available
Background: While much disinhibition in dementia results from generalized impulsivity, in behavioral variant frontotemporal dementia (bvFTD) disinhibition may also result from impaired social cognition. Objective: To deconstruct disinhibition and its neural correlates in bvFTD vs. early-onset Alzheimer's disease (eAD). Methods: Caregivers of 1...
Article
Full-text available
Traditional neuropsychological batteries may not distinguish early behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) without the inclusion of a social behavioral measure. We compared 33 participants, 15 bvFTD, and 18 matched patients with early-onset AD (eAD), on the Social Norms Questionnaire (SNQ), neuropsychologica...
Article
Full-text available
The clock-drawing test (CDT) is widely used in clinical practice to diagnose and distinguish patients with dementia. It remains unclear, however, whether the CDT can distinguish among the early-onset dementias. Accordingly, we examined the ability of both quantitative and qualitative CDT analyses to distinguish behavioral variant frontotemporal dem...
Article
Full-text available
Diffusion imaging and brain connectivity analyses can reveal the underlying organizational patterns of the human brain, described as complex networks of densely interlinked regions. Here, we analyzed 1.5-Tesla whole-brain diffusion-weighted images from 64 participants - 15 patients with behavioral variant frontotemporal (bvFTD) dementia, 19 with ea...
Article
Full-text available
Early social dysfunction is a hallmark symptom of behavioral variant frontotemporal dementia (bvFTD); however, validated measures for assessing social deficits in dementia are needed. The purpose of the current study was to examine the utility of a novel informant-based measure of social impairment, the Socioemotional Dysfunction Scale (SDS) in ear...
Poster
Full-text available
This study identified characteristics of social disturbances in EOAD and BvFTD utilizing the Socioemotional Dysfunction Scale (SDS). Social behavioral changes occurred in EOAD, and to a greater extent in bvFTD as expected. However, this study is one of the first to help characterize the type and prevalence of social disturbances in a small EOAD gro...
Article
Full-text available
Background Caregivers report early disturbances in social behavior among patients with behavioral variant frontotemporal dementia (bvFTD); however, there are few direct observational studies of these social behavioral disturbances. This study aimed to identify social behavioral themes in bvFTD by direct observation in naturalistic interactions. The...
Poster
Full-text available
OBJECTIVE: To examine clinician accuracy in directly rating the symptoms of patients with bvFTD by comparing their ratings with those of family caregivers. BACKGROUND: Behavior variant frontotemporal dementia (bvFTD) presents with insidious changes in social and emotional behavior. Clinicians have difficulty recognizing these manifestations of bvFT...
Article
Full-text available
Background: Emotional blunting is a major clinical feature of behavioral variant frontotemporal dementia (bvFTD). Assessing the change in emotional blunting may facilitate the differential diagnosis of this disorder and can quantify a major source of distress for the patients' caregivers and families. Methods: We evaluated investigator ratings o...
Article
Full-text available
Background: Caregivers report early disturbances in social behavior among patients with behavioral variant frontotemporal dementia (bvFTD); however, there are few direct observational studies of these social behavioral disturbances. This study aimed to identify social behavioral themes in bvFTD by direct observation in naturalistic interactions. Th...

Network

Cited By