Josef Richter

Zdravotní ústav se sídlem v Ústí nad Labem Czech republic · Clinical immunology allergology,

Objective The COVID-19 epidemic resulted in a global crisis of public health. Therefore, the possibility of prevention, leading to reduced infection and/or an improved disease state, is the subject of intensive attention. The novelty of this study is the direct evaluation of vitamin D levels with the risk of COVID-19 infection. Background Currentl...

In recent years, monitoring of vitamin D levels and possible use of supplementation is gaining attention. Numerous studies showed low levels of vitamin D in winter months followed by improvement during summer. These changes are mostly dependent on the level of sun exposure, but also on geographical location, genetic factors, social-economic status,...

Contributions: (I) Conception and design: J Richter, V Vetvicka; (II) Administrative support: J Richter, V Kral; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript:...

We followed up the effects of environmental contaminants on possible induction of central nervous system damage. Our attention was focused on the effects of nanoparticles and microparticles and their role in development of multiple sclerosis and other neurodegenerative diseases of the central nervous system in regions of Czech Republic with known e...

In our study, we focused on possible effects of supplementation with glucan and vitamin D on total numbers of NK cells in patients with diabetic retinopathy. We evaluated possible relations among nutritional state (BMI), leptin levels, and total numbers of NK cells in patients supplemented with (1) glucan and vitamin D, (2) vitamin D and placebo, a...

Glucans are part of a group of biologically active natural molecules and are steadily gaining strong attention not only as an important food supplement, but also as an immunostimulant and potential drug. This paper represents an up-to-date review of glucans (β-1,3-glucans) and their role in various immune reactions and the treatment of cancer. With...

Aims: Diabetic retinopathy is a common complication in Type 1 and Type 2 diabetes. A global pandemic increase in diabetes has led to the search for new preventative, diagnostic and curative methods. We aimed to evaluate levels of vitamin D, apolipoproteins A and B, and leptin after vitamin D/glucan supplementation. Methods: Using a collection of 52...

The objective of this article is to evaluate the potential effects of beta-glucan and vitamin D supplementation in patients with diabetic retinopathy. We evaluated the levels of several parameters of inflammatory reactions (C-reactive protein [CRP], serum amyloid A [SAA], and interleukin- [IL-] 6), leptin, and vitamin D. Using a 3-month interval, w...

Background Diabetes mellitus is a chronic disease manifested by an increase of blood glucose. Objective To evaluate the effects of glucan and vitamin D supplementation in patients with diabetic retinopathy. Method We evaluated the effects of 3-month supplementation with glucan and vitamin D in 54 patients with diabetic retinopathy. We measured le...

IgG-4 related disease (IgG4-RD) is a recently discovered systemic fibro-inflammatory disease which affects the ocular system. This pathology is not limited only to the orbit, but may also frequently affect the anatomical structures of the eye, as well as other organs. Suspicion of IgG4-RD is based on careful clinical, radiological and immuno-histol...

Glucan is a natural immunomodulator intensivelly studied the past twenty years. Besides the known effects in infectious and tumor immunity, the interest of researchers in the recent years focused on its other potential effects. The aim of this short review is to provide basic information about glucan. The list is completed with results of our own c...

IgG4-related disease (IgG4-RD) is a distinct entity that frequently occurs in an ophthalmic location. IgG4- RD is not limited to the orbit, but may also involve other anatomical structures in and around the eye. Careful

Sixty-six children were supplemented with beta glucan and dietary nucleotides, another 63 children served as negative control. We evaluated the effects of these supplements on several aspects of secretory immunity such as levels of secretory IgA (SIgA), albumin and SIgA/albumin ratio. In addition, in order to monitor effects of physical challenges...

AIM: The role of glucan in potentiation of immune system is well established, including effects on cancer development. In this study, we focused on effects of short term glucan supplementation in patients during complex cancer treatment. MATERIALS AND METHODS: We measured the levels of leptin and changes in NK cell numbers after oral application of...

Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with th...

Asthma Bronchiale (AB) is a chronic inflammatory disorder of the airways currently affecting around 350,000,000 patients in the world. A steady increase in prevalence of this disease was the incentive for our study of the prevalence of AB in the Czech Republic. Special attention was focused on possible differential regional incidence. We found that...

Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with th...

AIM: The role of β-glucan supplementation on cancer development is well established. In this report we focused on the effects of glucan on levels of individual classes and subclasses of immunoglobulins. MATERIALS AND METHODS: We evaluated the levels of IgM, IgG, IgA, IgG1, IgG2, IgG3 and IgG4 in 39 patients diagnosed with breast or colorectal cance...

Citation: Richter J, Kral V, Stiborova I, Rajnohova D, Vetvicka V (2015) Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue. J Nutr Health Sci 2(3): 304

Heavy industrial pollution and/or passive smoking negatively affect the overall immune health of a population. We used a model of children with chronic respiratory problems and evaluated the effects of short term supplementation of their diet with nucleotides. We measured the level of sIgA, eNO levels and total physical activity. We found positive...

The role of β-glucan in children with respiratory problems is getting more and more attention. In this report we focused on the effects of 30 days oral supplementation with β-glucan on physical activity and immune status of children with respiratory problems. We measured the level of sIgA, eNO and physical activity [using a 6-minute walking test (6...

IgG4-related disease can affect almost any organ system. Various symptoms depending on the localization of the pathological changes. The most frequently affected organs are the pancreas, hepatobiliary tract, salivary gland, orbit and the lymph nodes. Early diagnosis is the crucial for the future of each pacient. Diagnostic criteria may be helpfull...

IgG4-related disease is a recently recognized systemic fibroinflammatory disorder, which mimics many malignant, inflammatory and infectious diseases. Almost any organ can be affected. This condition is characterized by dense lymphoplasmatic infiltrate rich in IgG4-positive plasma cells, storifomi fibrosis, obliterative phlebitis and prominently (bu...

In our paper we decided to evaluate the hypothesis about the relation between living conditions, infection with Helicobacter pylori and development of allergic problems. Two groups of children, one from the Roma population and one from the majority population, were chosen for this study. Comparing the levels of total IgE and specific IgE antibodies...

Background: The role of glucan in the stimulation of immune reactions is well established. In our report, we focused on the effects of orally administered glucan on nonspecific immunity of children with chronic respiratory problems. Materials and methods: We measured the levels of albumin, lysozyme. C-reactive protein (CRP) and calprotectin in t...

Background: The stimulation of immune reactions represents a well-established effect of glucan. However, very little is known about the effects on prostate. In this report, we focused on patients with benign hyperplasia of prostate and evaluated the effects of glucan supplementation. Methods: We measured the level of CRP, levels of total (tPSA) and...

The goal of this study is to summarize the results of the detection of Bordetella pertussis (BP) and Bordetella parapertussis (BPP) by a real-time polymerase chain reaction (RT-PCR) assay and serological methods. In 2008-2010, 73 patients of the Department of Clinical Immunology and Allergology of the Centre for Immunology and Microbiology, Public...

Background: The role of glucan in stimulation of immune reactions has been studied for several decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems. Materials and methods: We measured the levels of albumin, lysozyme and CRP in saliva of 40 children aged 8-12 years and evalu...

The role of glucan in stimulation of immune reactions has been well-established. In this report, we focused on the antibody production in glucan-supplemented children with chronic respiratory problems. We measured the levels of salivary IgA, IgM and IgG in 40 children aged 8-12 years and evaluated the effects of 100 mg d −1 oral dose of glucan. We...

Exhalation values of nitric oxide (eNO) were recorded in a cohort of 117 children with diagnosed respiratory diseases, as defined by the exposure components of traffic emissions prior to, and after, in-patient therapy. A significant increase of eNO values was recorded in exposed children. Following in-patient therapy there was a statistically signi...

Introduction

The objective of the study was investigated the effect of passive smoking on the values of exhaled nitric oxide (eNO). In 227 children aged 5-15 years with respiratory disease was determined value of eNO, salivary albumin at the beginning of the treatment and again after the treatment process. For 34 children aged 10-15 years exposed to tobacco smo...

A group of 156 children aged between 10 and 12 years were screened for IgG and IgE antibodies to Ascaris lumbricoides. The study subjects were 64 children of Romany origin and 92 children from the majority population. IgG antibodies to Ascaris lumbricoides were detected in 112 (71.8%) children. No difference in the prevalence of IgG antibodies was...

The prevalence of latex-specific IgE computed from the results of serologic assayes reflect to a greater or lesser extent the prevalence of latex allergy. A population based sample of 522 children aged from 10-12 years was examined in cross-sectional study in the Ústí Region, Czech republic. Specific IgE levels against latex was determined by using...

The gastrointestinal tract epithelium plays an important role not only in digestion and absorption of nutrients, but also in antigen and pathogen signal translocation toward the gut associated lymphoid tissue. Malnutrition in various degrees is recognized as the most common cause of the immune system dysfunction. Research done in the past several y...

Many common viral infections induce a strong protective host response type 1. Complex questionnairy and laboratory investigation of the children population (age 9-12 year) from one region of the Czech Republic followed prevalence of the increased levels of IgE at the dependence on the frequency of the incidence of the herpes simplex infection and w...

Helicobacter pylori participates significantly on the pathogeny of chronic gastritis, duodenal and gastric ulcer, carcinoma and lymphoma of the stomach. There are some more diseases requiring attention--for example cardiovascular, dermatologic, and autoimmune. Helicobacter pylori was detected in saliva and faeces of 28 persons by the Premier platin...

Background. Helicobacter pylori participates significantly on the pathogeny of chronic gastritis, duodenal and gastric ulcer, carcinoma and lymphoma of the stomach. There are some more diseases requiring attention - for example cardiovascular, dermatologic, and autoimmune. Methods and Results. Helicobacter pylori was detected in saliva and faeces o...

Practical experiences with the administration of peroral xenogenic transfer factor named Imunor are described. The preparations has been administered in more than 20 000 doses. There are basic data on its therapeutic indications, suitable combinations and therapeutic dosagein the clinical praxis.

Within the framework of a prognostic study focused on the sound development of the young generation the authors submit a review of the Czech literature concerned with the effect of the environment and its noxious agents on child health and development. The authors follow up the developmental trends of the problem where there is a shift of interest...

The authors give an account of their initial experience with a non-invasive method for detection of Helicobacter pylori. For detection a Premier Platinum HpSA™ set was used. Detection is based on a standard ELISA method and makes rapid and unpretentious diagnosis with high specificity and sensitivity possible. In the examined 82 subjects a baseline...

The authors submit the results of supplementation of the child population with a preparation containing amino acids, polypeptides and nucleotides with an increased iron and zinc content. A significant nucleotide content was the prerequisite for influencing immune mechanisms of specific and non-specific immunity with an impact on reduced morbidity o...

Intrauterine foetal growth retardation (IUGR) implies increased risk of morbidity and mortality of the newborn. Aetiology of intrauterine retardation is probably multifactorial and may include maternal infection, malnutrition, placental dysfunction, hypertension, toxaemia, smoking, professional and environmental exposure. The work concentrates on t...

The risk to health caused by exposure to tobacco smoke has been demonstrated in a number of epidemiological surveys. The immune system is one of the most sensitive reagents to components of tobacco smoke. Based on their own experience and data in the literature the authors discuss changes induced by voluntary and involuntary smoking affecting speci...

In the submitted review the authors present information on possibilities of immunomodulating treatment of atopic dermatitis. Immunosuppressive treatment comprises systemic corticosteroid administration (possibly combined with cytostatic immunosuppressive preparations), cyclosporin A and phototherapy. Immunopotentiating treatment of AD makes use mai...

In the submitted review the authors present basic information on immunization against viral hepatitis B (VHB) in patients with chronic renal failure. These patients have a significantly lower response to the vaccine against VHB, due in particular to secondary immunodeficiency. Possible correction of this adverse situation can be achieved by modific...

In a group of women who gave birth to a foetus with marked growth retardation and 27 women who were delivered of eutrophic neonates the lead, cadmium, zinc and lysozyme levels in placental tissue were assessed. The investigation revealed the following results: the lead level was in the investigated group significantly higher than in the control gro...

The influence of traffic as a component of the environment on the life of the population living in a given locality or region interests professionals of several fields of study. From the point of view of influence on the health of the population, especially that of children by the traffic load, in the past few decades the attention of toxicologists...

In 200 children residing permanently in a region with a high level of atmospheric pollution, indicators of humoral immunity, salivary immunity and specific IgE antibodies were determined before and after 14 days' attendance at an "outdoor school" in rural areas with a very low level of atmospheric pollution. A marked reduction of elevated albumine...

The authors submit a brief review of the literature concerned with the influence of nucleotide supplementation on metabolic functions, the gastrointestinal tract, liver parenchyma and immune functions. They emphasize the importance of supplementation of infant formulae with nucleotides and the effect on the sound development of the infant. The comp...

The authors investigated a group of 950 subjects aged 19-25 years living in different contaminated localities of the North Bohemian region and employed in different branches. They examined natural antibody levels as indicators influencing antibody immunity. In areas with an increased contamination of the environment in the examined subjects a highe...

In 234 children residing permanently in a region with a high level of atmospheric pollution indicators of salivary immunity were studied as criteria for assessing the efficacy of applied compensatory measures. In the saliva SlgA, IgM, IgG, lysozyme, and albumin were determined. A marked reduction of elevated albumin levels which are characteristics...

The authors discuss the contemporary progress in preventive immunology with special attention to unfavourable effects of environmental pollution. They followed-up these problems systematically for more than twenty years and in this paper they present some of their results. They stress the importance of the protective effect of balanced nutrition wi...

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The authors demonstrate the case of a female patient with a prolonged mucosal form of candidosis caused by different biotypes of Candida albicans. Despite the fact the long-term and repeated treatment with Nizoral and transfer factor was applied, relapses of the disease developed. Marked improvement of clinical manifestations occurred only after a...

The authors compare the geometrical means of titres of specific antirabic antibodies in a group of subjects immunized by the intradermal route with vaccine from a tissue culture of human diploid cell (Rabivac Behring, FRG) and in groups of subjects immunized by the subcutaneous route with the vaccine Vnukovo SAD-32 (USSR), using a short and long im...

Groups of female rats were exposed for prolonged periods to different lead concentrations in drinking water; in one group was also added to the drinking water, in the amniotic fluid of exposed females greatly reduced lysozyme values were found, as compared with controls. Concurrent Zn administration considerably reduced the effect of lead. Long-ter...

The paper gives a neat summary of experience acquired from two decades of immunological testing methods used for studying the effect of environmental contamination of the human organism. Immunological examination is part of a series of methods for a systematic follow-up of the state of health of the population. The paper underlines the complicated...

The authors provide evidence of seroconversion in 16 subjects (100%) following intradermal administration of antirabies vaccine from a tissue culture of human diploid cells [Rabivac, Behring, FRG] for the purpose of pre-exposure immunization. The immunomodulating preparation Levamisol [Decaris Richter, Hungary] did not influence the mean antibody t...

The authors describe two cases of fatal disease with the picture of acute haemoblastosis in male siblings aged 6 and 18 months. By combined retrospective evaluation of the two cases the authors reach the conclusion that it is the first case of an X chromosome-linked lymphoproliferative syndrome (XLP) described in Czechoslovakia. The authors discuss...

The authors address themselves to the issues of functional capacity of the immune system and various factors exerting positive and negative effects on it. An attempt is made at graphic representation describing differences in the immune capacity of healthy and deficient organisms in normal living conditions and under challenge, thus forming the bas...

The groups of pregnent females were exposed to growing doses of lead and an additional group was also simultaneously exposed to zinc. The relation of the lead exposure to serum lysozyme levels and the kidney tissue lysozyme level and the amniotic fluid was followed. In comparison to the control group there were marked changes in the lysozyme levels...

In 160 9-year old children in Prague schools from the center of the city (increased atmospheric pollution) and from the outskirts of the town (less polluted atmosphere), the constituents of the anti-protease system, alpha1 antitrypsin,alpha2 macroglobulin and inter alpha1 trypsin inhibitor in serum, were examined. Significant differences in the fin...

The authors investigated SigA, Lysozyme (muramidase), albumin and copper levels in the saliva of sixteen children in the course of the day. A total of nine blood samples was taken in three-hour intervals from each child. Statistically highly significant changes were found in SIgA with a minimal average at 11 a.m. and maximum at 5 a.m. In albumin th...