José Roberto Vega-Baudrit

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Verified

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• PhD, MSc
• Managing Director at National University of Costa Rica

An enormous develop is experimented on the porous materials. The porous was considered a defect on solid materials some years ago, but right now, this defect is an advantage, based on the properties obtained from a micro and mesoporous materials. Microporous, mesoporous and ma-croporous materials with an uniformed pore distribution offer new proper...

A composite material using unsaturated commercial polyester resin (UPE) and olive brush seed (OBS) was prepared. OBS was treated with sodium hydroxide and maleic anhydride (MAN) and subsequently utilized in a proportion of 35 wt.% to prepare a composite material. These materials were evaluated in terms of moisture absorption, surface density, and m...

Progesterone (PRG) is an essential hormone in regulating the female reproductive system. It is used in gynecology, including contraception, medical abortion, and treatment of conditions related to endometrial and myometrial growth [1]. This drug exhibits two different crystal structures: forms 1 (PRG-1) and 2 (PRG-2); both with equal pharmacologica...

Structural heterogeneity of polyphenols from cranberries, grape seed extracts, sorghum and pomegranate was characterized by MALDI-TOF MS. Polyphenolics were isolated by liquid chromatography and subjected to MALDI-TOF MS using trans-3-indoleacrylic acid as the matrix. Spectral analysis gave information on degree of polymerization, monomeric substit...

The kinetics of thermal degradation process on thermoplastic polyurethanes (TPUs) adhesives with hydrophilic nanosilicas was studied using isothermal thermogravimetric analysis within the temperature range from 360 degrees C to 460 degrees C in nitrogen. The effect of nanosilicas with different hydrophilic degree in the thermoplastic polyurethanes...

This review covers the background of nanochitin, including methods for its extraction and refining and its principal physicochemical and biological properties. It further discusses various hydrolysis and enzymatic approaches for the structural and functional characterization of nanochitin and highlights some pharmaceutical applications where this b...

Spent coffee grounds constitute a waste product that has attracted potential interest as a rich source of secondary metabolites such as polyphenolic compounds with antioxidant properties. In this work, aqueous extracts from samples of different spent coffee grounds from Costa Rica were prepared and analyzed using ultra-performance liquid chromatogr...

Trichoderma is an antagonistic fungus used commercially; however, the viability of these formulations is affected by biotic and abiotic factors. In this research, microcapsules of sodium alginate reinforced with nanocellulose and/ or chitosan were developed to encapsulate T. longibrachiatum conidia and characterized by SEM, FTIR, and TGA. The viabi...

Trichoderma is an antagonistic fungus used commercially; however, the viability of these formulations is affected by biotic and abiotic factors. In this research, microcapsules of sodium alginate reinforced with nanocellulose and/or chitosan were developed to encapsulate T. longibrachiatum conidia and characterized by SEM, FTIR, and TGA. The viabil...

This study focuses on the extraction of phenolic compounds from the fermentation of Phanerochaete chrysosporium and Gloeophyllum trabeum. The main goal was to synthesize phenol/chitosan microspheres and PVA films and characterized using FTIR, TGA, DSC, SEM, and mechanical tests to evaluate their physical, chemical, and mechanical properties for ant...

Saquinavir is a drug used as an HIV treatment, with recent reports of new uses. It has poor aqueous solubility and very low oral bioavailability. However, when prepared in a eutectic mixture with the natural bioenhancer, piperine, it demonstrated improvements in these drawbacks. Therefore, considering that EMs can be easily produced and scaled-up,...

Bionanotechnology research has surged to the forefront of scientific innovation, propelling the exploration of cutting-edge technologies and interdisciplinary collaboration. Biomimicry, which harnesses nature's ingenuity, drives the development of novel research-based solutions in diverse fields such as vaccines, medicine, and biomedical devices. N...

In the face of a pressing global issue-the escalating threat of antibiotic resistance-the development of new antimicrobial agents is urgent. Nanotechnology, with its innovative approach, emerges as a promising solution to enhance the efficacy of these agents and combat the challenge of microbial resistance. Chitosan nanoparticles (CSNPs) stand out...

The aim of this investigation was to evaluate the effect of etching protocols on bond strength, surface roughness, and mechanical properties of a zirconia-reinforced lithium silicate (ZLS) CAD/CAM-ceramic. In total, 100 bars (ISO 6872), 75 plaques, and 25 cubes were cut from ZLS blocks(Vita Suprinity®). The surfaces were standardized, crystallized...

The aim of this study is to develop a nanoemulgel encapsulating a Tunisian Prickly Pear (Opuntia ficus-indica L.) seed oil (PPSO) to assess, for the first time, the in vivo efficacy of this nanoformulation on wound healing. Phytocompounds of this oil have been reported in the literature as having powerful pharmacological activities. However, it rem...

Objective: This study aimed to address the lack of comparative analyses of newly developed bioceramic materials by examining the chemical composition, thermodynamic profile, and microscopic surface features of three bioceramic putties: EndoSequence BC Root Repair Material Fast Set Putty (ESRRM-FS), BIO-C Repair (BCR), and Cera Putty (CP). Methods:...

Objective: This work aims to present a Quality-by-Design (QbD) step-by-step methodology to formulate anti-ulcer and gastro-protective oral suspensions. Methods: Sucralfate was used as a drug model. The Quality Target Product Profile was established early during preformulation. Viscosity, resuspendability, pH, and density were assessed through th...

This study investigates the perspectives of individuals, primarily Costa Ricans, on the necessity of implementing regulations for nanotechnology. Through a survey-based methodology, our findings reveal that approximately 98 per cent of respondents consider such regulation essential. The consensus on the need for regulation is significantly influenc...

Este segundo volumen de la Red NANOCELIA se enfoca en compartir las experiencias de países iberoamericanos en la investigación, desarrollo y transferencia de la nanocelulosa. La publicación se estructura en dos partes fundamentales: la primera presenta trabajos concretos realizados por los grupos miembros de la Red, mientras que en un Anexo se exhi...

This article provides a comprehensive review of the state-of-the-art technology of polymeric mixed-matrix membranes for CO2/CH4 separation that can be applied in medium, small, and domestic biogas systems operating at low pressures (0.2–6 kPa). Critical data from the latest publications of CO2/CH4 separation membranes were analyzed, considering the...

Citation: Chambi, D.; Romero-Soto, L.; Villca, R.; Orozco-Gutiérrez, F.; Vega-Baudrit, J.; Quillaguamán, J.; Hatti-Kaul, R.; Martín, C.; Carrasco,

The global textile sector, pivotal to economic development, significantly contributes to environmental degradation, prompting a shift towards sustainable raw material sources. Embracing circular economy principles, this industry is exploring the valorization of agricultural by-products. This study introduces an innovative approach to repurposing ma...

The pervasive presence of microplastics (MPs) and nanoplastics (NPs) across various ecological settings, organisms, and products has underscored the urgent need to collect data on their abundance and identify the polymer types in diverse substrates. NPs distinguish themselves from MPs by their smaller size. The application of magnetic composites in...

Atorvastatin calcium trihydrate (ACT) is a synthetic lipid-lowering agent whose thermal character remains largely unknown or else mischaracterized due to being called both “atorvastatin” and “atorvastatin form I” indiscriminately in the literature. Developing stable drugs, however, requires ensuring and thus understanding the reliable thermal behav...

This study explores a nanoemulsion (NE)-based gel incorporating Tunisian Pituranthos tortuosus essential oil, with a focus on its wound-healing potential. The essential oil, extracted via hydrodistillation, underwent GC-MS analysis for compositional verification. The physicochemical characterization included dynamic light scattering (DLS), transmis...

Maca (Lepidium meyenii), a biennial herbaceous plant indigenous to the Andes Mountains, has a rich history of traditional use for its purported health benefits. Maca’s chemical composition varies due to ecotypes, growth conditions, and post-harvest processing, contributing to its intricate phytochemical profile, including, macamides, macaenes, and...

Green‐synthesized iron nanoparticles (GAP‐FeNP) were used as particle electrodes in a three‐dimensional electro‐Fenton (3DEF) process to accelerate the removal of hexavalent chromium [Cr (VI)]. Removal was evaluated by varying the pH (3.0, 6.0, and 9.0) and initial Cr (VI) concentrations (10, 30, and 50 mg/L) at 5 and 25 min. These results demonstr...

The biological activities of curcuminoids, the main polyphenol constituents of Curcuma longa (turmeric), have been the subject of many studies in recent years. However, these studies have focused on the major active compound, curcumin (CUR), while other important constituents, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDM) have been less st...

The current chapter aims to review the degradation standards, and biodegradability of starch-based nanomaterials (SNMts), as well as their nanotoxicity, and environmental impacts. SNMts are promising biomaterials with potential applications in various fields, such as food engineering, medicine, and textiles, because of their unique properties. Howe...

Nanotechnology has significant potential in industries, medicine, and technology, but its rapid development raises concerns about health and environmental risks. Implementing regulations is crucial for responsible and safe use. Costa Rica has adopted policies and strategies, including standardization processes, to promote innovation and sustainable...

Citation: Vega-Baudrit, J.R.; Camacho, M.; Batista-Menezes, D.; Corrales-Ureña, Y.; Zúñiga, J.M.; Chacón, A.M.; Lecot, N.; Henríquez, L.C.; Lopretti, M. Acerola (Malpighia spp.) Waste: A Sustainable Approach to Nutraceutical, Pharmaceutical, and Energy Applications. Recycling 2023, 8, 96. https://doi.org/10.3390/ recycling8060096 Academic Editor: E...

Tumor heterogeneity leads to drug resistance in cancer treatment with the crucial role of sphingolipids in cell fate and stress signaling. We analyzed sphingolipid metabolism and autophagic flux to study chemotherapeutic interactions on the A549 lung cancer model. Loaded cells with fluorescent sphingomyelin analog (BODIPY) and mCherry-EGFP-LC3B wer...

Poliuna: una alternativa para el análisis, desarrollo e investigación de los polímeros naturales y sintéticos en la región centroamericana y del Caribe

Acerola (Malpighia spp.) is a tropical plant genus of shrubs and trees whose fruit is rich in nutrients and bioactive compounds. However, its production generates significant waste that could pose an environmental issue. This review aims to summarize recent research on the potential uses of acerola wastes, including the extraction of bioactive comp...

The dissolution rate of the anti-HIV drug saquinavir base (SQV), a poorly water-soluble and extremely low absolute bioavailability drug, was improved through a eutectic mixture formation approach. A screening based on a liquid-assisted grinding technique was performed using a 1:1 molar ratio of the drug and the coformers sodium saccharinate, theobr...

Acerola (Malpighia spp.) is a tropical plant genus of shrubs and trees whose fruit is rich in nutrients and bioactive compounds. However, its production generates significant waste that could pose an environmental issue. This review aims to summarize recent research on the potential uses of acerola wastes, including the extraction of bioactive comp...

In the present study, silver nanoparticles (AgNPs) were biosynthesized using the supernatant and the intracellular extract of Cupriavidus necator, Bacillus megaterium, and Bacillus subtilis. The characterization of the AgNPs was carried out using UV–Vis spectroscopy, FTIR, DLS and TEM. Resazurin microtiter-plate assay was used to determine the anti...

This study develops an efficient, low-temperature process for formulating a nanoemulsion-based gel encapsulating Pituranthos tortuosus's essential oil, investigating its wound healing potential. The novel process ensured stable encapsulation of the medicinal plant's oil. The nanoemulsion was characterized using dynamic light scattering and transmis...

Achieving food security worldwide is a major challenge because nearly 700 million people face hunger and more than 2 billion are affected by mineral and vitamin deficiencies (the so-called “hidden hunger”). Food insecurity can be addressed by implementing sustainable food systems to improve postharvest management of seeds (the propagation structure...

The use of nanomaterials in various areas of technology has generated great enthusiasm for their potential benefits. However, there is also concern about the possible negative effects on health and the environment. In Costa Rica, implementing regulations on nanomaterials is essential to ensure the safety and sustainability of this emerging technolo...

From 1988 to 2018, high school students in Costa Rica had to pass a final exam to graduate from high school and be eligible for public university education. In this context, students had to choose a national science test from the areas of physics, chemistry, and biology. Historically, chemistry was the least chosen (4-6 %) of those sciences. On the...

Objetivo] Desde el año 1988 y hasta el año 2018, el estudiantado de secundaria en Costa Rica debía aprobar un examen final para graduarse de la escuela secundaria, y ser elegible para una educación universitaria pública. En ese contexto, cada estudiante debía elegir una prueba nacional de ciencias entre las áreas de física, química y biología. Hist...

To compare the physicochemical composition of 4 MTAs commercially available in Latin America. ProRoot MTA (Dentsply, USA), MTA Angelus (Angelus, Brazil), MTA Flow (Ultradent, USA), and MTA Viarden (Viarden, Mexico) were physically and chemically compared. Scanning electron microscopy (SEM) images were obtained from the MTA powder and the prepared p...

50 days of free access to our article: https://authors.elsevier.com/a/1gnum6JBqDkBEo Diabetes is one of the 21st-century major health concerns, considered the sixth leading cause of death, and expected to rise to more than 642 million people by 2040. Three types of diabetes exist, differing in their etiology: Type 1 (T1DM) and 2 Diabetes Mellitus...

Pineapple leaf fibers (PALF) were biopulped using Trametes versicolor, and the resulting biopulp was bleached with xylanase-enzymatic treatments. The biopulping was extensively described using determinations of fiber morphology, color, chemical composition, extractive content, and thermal stability using the structural characteristics determined by...

This work addresses the micro and nanoplastics (MP and NP, respectively) on the American coasts of the Pacific Ocean from the perspective of the Micro & Nano Allpa Pacha Network. This network is made up of scientists from Chile, Perú, Costa Rica, Colombia, Ecuador, Pan-ama, and México, who, concerned about the impact on the environment and its repe...

The objective of the research was to disseminate nanotechnology concepts, applications, and benefits among educators from different Costa Rican provinces to increase their acceptance and dissemination of the subject to elementary students. Teachers from different areas of the country were called to participate. Five training workshops were held in...

The incorporation of the drug Isoniazid (an anti-tuberculosis drug) into nanoparticles of polyelectrolyte chitosan-poly(aspartic acid) complexes was carried out by the ionotropic gelation technique, adding a sodium polyaspartate solution containing the drug to a chitosan solution in different proportions in a mass ratio (mg/mg) Isoniazid/Chitosan....

Pineapple is a highly demanded fruit in international markets due to its unique appearance and flavor, high fiber content, vitamins, folic acid, and minerals. It makes pineapple production and processing a significant source of income for producing countries, such as Costa Rica. This review collects bibliographic information dating back to the begi...

Slime expelled by velvet worms entraps prey insects within seconds in a hardened biopolymer network that matches the mechanical strength of industrial polymers. While the mechanic stimuli-responsive nature and building blocks of the polymerization are known, it is still unclear how the velvet worms’ slime hardens so fast. Here, we investigated the...

The problem of arsenic contamination in water demands sustainable, scalable, and easy-to-implement solutions. Various nano-adsorbents flourished in the last decade, but their use alone requires additional filtering processes to avoid environmental contamination. This work presents a simple, efficient, green approach to overcome this inconvenience w...

Poor solubility and short biological half-life present a challenge that needs to be overcome in order to improve the recognized bioactivities of curcumin (CUR), the main phenolic compounds derived from the roots of Curcuma longa. However, drug delivery systems have proven to be an excellent strategy to improve and obtain greater bioavailability. Ou...

Pineapple is a highly demanded fruit in international markets, thanks to its unique appearance and flavor, high fiber content, vitamins, folic acid, and minerals. It makes the pineapple production and processing market a significant source of income for producing countries, such as Costa Rica. Nowadays, its processing produces a large amount of was...

Editorial, Revista INTERCIENCIA, 2022

Residual biomasses from agro-industries in Paraguay, including soybean hulls (SBHs) and sugarcane bagasse (SCB), were studied as a source for nanocellulose extraction for the first time. For that purpose, both biomasses were delignified in a semi-pilot stainless-steel reactor, and the cellulose pulp was subjected to a bleaching process with NaClO (...

Arsenic is a concern for its ubiquity in the environment and its accumulative and toxic properties. Water is often contaminated with this chemical, so developing simple, scalable, and green water treatment technologies is urgently needed. We show here that the ability of the L-Cysteine biomolecule to form complexes with arsenic inspires its use as...

Silk produced by silkworms or spiders offers biocompatibility, biodegradability, stability, and biomechanical strength, making it an excellent biomaterial for wound bandages/dressings and skin grafts. Silk scaffolds are also bioactive matrices necessary to restore the healing cascade and barrier properties that induce skin organogenesis in chronic...

Piperine (PIP) was evaluated as a natural coformer in the preparation of multicomponent organic materials for enhancing solubility and dissolution rate of the poorly water-soluble drugs: curcumin (CUR), lovastatin (LOV), and irbesartan (IBS). A screening based on liquid assisted grinding technique was performed using 1:1 drug-PIP molar ratio mixtur...

Previous studies in Uncaria tomentosa have shown promising results concerning the characterization of polyphenols with leaves yielding more diverse proanthocyanidins and higher bioactivities values. However, the polyphenols-microbiota interaction at the colonic level and their catabolites avoid the beneficial effects that can be exerted by this med...

When producing stable electrodes, polymeric binders are highly functional materials that are effective in dispersing lithium-based oxides such as Li4Ti5O12 (LTO) and carbon-based materials and establishing the conductivity of the multiphase composites. Nowadays, binders such as polyvinylidene fluoride (PVDF) are used, requiring dedicated recycling...

This review aims to present the Quality by Design (QbD) model as a suitable methodology to perform research in the academic Costa Rican institutions that teach Pharmacy. Pubmed, Science Direct, and Google Scholar databases were screened for original research papers and review papers published not more than ten years ago. Institutional repositories...

Biorefineries are a model for greener production processes, based on the concept of bioeconomy. Instead of targeting first-generation biofuels—that compete with food supply—the focus relies on lignocellulosic material, considering many aspects, such as sustainable fuel production, as well as valorization of waste, as an alternative to the tradition...

Bovine Serum Albumin (BSA) lipid hybrid nanoparticles are part of the new solutions to overcome low bioavailability of poor solubility drugs such as curcuminoids, which possess multiple biological advantages; however, they are counterbalanced by its short biological half-life. In this line, we prepared the three main curcuminoids: curcumin (CUR), d...

Pineapple is a highly demanded fruit in international markets, thanks to its unique appearance and flavor, high fiber content, vitamins, folic acid, and minerals. It makes the pineapple production and processing market a significant source of income for producing countries, such as Costa Rica. Nowadays, its processing produces a large amount of was...

The design of new pharmaceutical solids with improved physical and chemical properties can be reached through in-detail knowledge of the noncovalent intermolecular interactions between the molecules in the context of crystal packing. Although crystallization from solutions is well-known for obtaining new solids, the effect of some variables on crys...

The lignocellulosic material consists of three subunits, hemicellulose, lignin, and cellulose, that are fractionated to extract and produce value-added compounds, such as food additives, organic acids, ethanol, and enzymes. Various biotechnological applications such as effluent bioremediation, hydrolysis and paper bleaching, and construction of bio...

The appearance of several multi-drug resistant strains has been linked to the extensive use of antibiotics. The use of bio-inspired plant and animal surfaces that exhibit new strategies such as contact-killing surfaces has been proposed to face this problem. Pineapple peels expose 10 µm in length and 5 µm height biogenic silica rosettes (BSR) on th...

The aim of this review is to present the Quality by Design (QbD) model as a suitable methodology to perform research in the academic Costa Rican institutions that teach Pharmacy. Pubmed, Science Direct, and Google Scholar databases were screened for original and review papers, as well as short communications published not more than 10 years ago. Pu...

Plastic accumulation's negative impact on aquatic ecosystems is a known and undeniable problem. Much of the scientific community's efforts are focused on the effects of the most common commodity plastics, but the consequences of the so-called biodegradable plastics in these ecosystems have been little discussed. Although their biodegradable charact...

A drug–drug and drug–excipient interactions and compatibilities study was conducted for two fixed-dose combination (FDC) products containing olmesartan medoxomil (OLM)/hydrochlorothiazide (HCT) 20/12.5 mg and OLM/HCT 40/12.5 mg during their development including storage. The study consisted of the evaluation of samples retrieved during all stages o...

A number of industries currently produce many tons of agroindustrial wastes with significant consequences on the environment and human and animal health. In recent years, increasing emphasis has been placed on reducing this negative impact. This review article aims to investigate the use of pretreatment methods that can be applied as an alternative...

Thrombosis can cause the occlusion of implantable medical devices, leading to the rejection of the device and subsequent mortality. Thrombosis is primarily induced by red blood aggregation and coagulation. The administration of anticoagulant drugs is generally used as a treatment to avoid these processes. Adverse effects such as bleeding in the eve...

In this work, nanoparticles of the chitosan-poly((α,β)-DL-aspartic acid) polyelectrolyte complex (PEC) were synthesized. The purpose is to develop a biodegradable, biocompatible, and non-toxic polymeric platform as a vehicle for the encapsulation of hydrophilic drugs. The ionotropic gelation method, using solutions of chitosan and poly((α,β)-DL-asp...