José Javier Serrano Olmedo

Universidad Politécnica de Madrid | UPM · Centre for Biomedical Technology

Human Activity Recognition (HAR) is having a growing impact in creating new applications and is responsible for emerging new technologies. Also, the use of wearable sensors is an important key to exploring the human body's behavior when performing activities. Hence, the use of these dispositive is less invasive and the person is more comfortable. I...

Background and purpose: Chronic kidney disease (CKD) is a common chronic disease usually associated with cardiovascular disease (CVD), and premature death and millions of people are at increased risk for CKD. As this disease is extremely complex, multidisciplinary care (MDC) is needed to provide complete and continuous care. Usually, the nephrology...

Magnetic hyperthermia (MHT) is an oncological therapy that uses magnetic nanoparticles (MNPs) to generate localized heat under a low-frequency alternating magnetic field (AMF). Recently, trapezoidal pulsed alternating magnetic fields (TPAMFs) have proven their efficacy in enhancing the efficiency of heating in MHT as compared to the sinusoidal one....

Photothermal therapy (PTT) is a non invasive and emergenced treatment against cancer. It is an alternative toconventional theraphies such as chemotherapy or radiotherapy, but also, PTT could be used incombination with usual treatments due to sinergic effect produced between them. PTT increases thetemperature of the target tissue killing the cancer...

Human activity recognition (HAR) has applications ranging from security to healthcare. Typically these systems are composed of data acquisition and activity recognition models. In this work, we compared the accuracy of two acquisition systems: Inertial Measurement Units (IMUs) vs Movement Analysis Systems (MAS). We trained models to recognize arm e...

Gold nanorods are the most commonly used nanoparticles in photothermal therapy for cancer treatment due to their high efficiency in converting light into heat. This study aimed to investigate the efficacy of gold nanorods of different sizes (large and small) in eliminating two types of cancer cell: melanoma and glioblastoma cells. After establishin...

In rehabilitating orientation and mobility (O&M) for visually impaired people (VIP), the measurement of spatio-temporal gait and postural parameters is of specific interest for rehabilitators to assess performance and improvements in independent mobility. In the current practice of rehabilitation worldwide, this assessment is carried out in people...

The synovial fluid (SF) analysis involves a series of chemical and physical studies that allow opportune diagnosing of septic, inflammatory, non-inflammatory, and other pathologies in joints. Among the variety of analyses to be performed on the synovial fluid, the study of viscositycan help distinguish between these conditions, since this property...

Hydrogel biomaterials have found use in various biomedical applications partly due to their biocompatibility and tuneable viscoelastic properties. The ideal rheological properties of hydrogels depend highly on the application and should be considered early in the design process. Rheometry is the most common method to study the viscoelastic properti...

Deep learning (DL) models are very useful for human activity recognition (HAR); these methods present better accuracy for HAR when compared to traditional, among other advantages. DL learns from unlabeled data and extracts features from raw data, as for the case of time-series acceleration. Sliding windows is a feature extraction technique. When us...

According to the World Health Organization (WHO) in 2019, cancer is the first reason of death in 112 of 183 countries. Cancer incidence and mortality are increasing worldwide rapidly. Conventional treatments such as chemotherapy, radiotherapy, and surgery are the most common cancer therapies. Although, these strategies trigger unwanted side effects...

Augmented Reality Mobile Applications were developed to help blind users navigate unfamiliar spaces and to determine their cognitive load during that task. The present study compared two navigation configurations: guided and unguided, to assess the differences in cognitive load in blind adults to perform a secondary auditory task during navigation....

For decades now, conventional sinusoidal signals have been exclusively used in magnetic hyperthermia as the only alternating magnetic field waveform to excite magnetic nanoparticles. However , there are no theoretical nor experimental reasons that prevent the use of different waveforms. The only justifiable motive behind using the sinusoidal signal...

In the Orientation and Mobility (O&M) training for visually impaired people (VIP), the spatio-temporal gait parameters are of specific interest for rehabilitators to assess performance and improvements. Thus, the objective of this research was to propose a simple architecture based on the use of inertial sensors for quantitative estimation of dista...

Human Activity Recognition (HAR) plays an important role in behavior analysis, video surveillance, gestures recognition, gait analysis, and posture recognition. Given the recent progress of Artificial Intelligence (AI) applied to HAR, the inputs that are the data from wearable sensors can be treated as time-series from which movement events can be...

This article shows the use of a high-frequency Full-Bridge inverter to design an alternating magnetic field generator for experimental studies on anti-cancer treatment with magnetic nanoparticles. In magnetic hyperthermia, nanoparticles are used to raise the pathological cancerous cell’s temperature high enough to induce their death by apoptosis, b...

A diverse array of assistive technologies have been developed to help Visually Impaired People (VIP) face many basic daily autonomy challenges. Inertial measurement unit sensors, on the other hand, have been used for navigation, guidance, and localization but especially for full body motion tracking due to their low cost and miniaturization, which...

The rehabilitation of a visually impaired person (VIP) is a systematic process where the person is provided with tools that allow them to deal with the impairment to achieve personal autonomy and independence, such as training for the use of the long cane as a tool for orientation and mobility (O&M). This process must be trained personally by speci...

Although optical hyperthermia could be a promising anticancer therapy, the need for high concentrations of light-absorbing metal nanoparticles and high-intensity lasers, or large exposure times, could discourage its use due to the toxicity that they could imply. In this article, we explore a possible role of silica microparticles that have high bio...

Viscosity variation in human fluids, such as Synovial Fluid (SF) or Cerebrospinal Fluid (CSF), can be used as a diagnostic factor; however, the sample volume obtained for analysis is usually small, making it difficult to measure its viscosity. On the other hand, Quartz Crystal Resonators (QCR) have been used widely in sensing applications due to th...

By definition, neuromuscular diseases are rare and fluctuating in terms of symptoms; patients are often lately diagnosed, do not have enough information to understand their condition and be proactive in their management. Usually, insufficient resources or services are available, leading to patients’ social burden. From a medical perspective, the ra...

The rehabilitation of a blind person is a systematic process where the person is dotted with tools that allow them to deal with the impairment, including the correct use of the long cane for navigation in the Orientation and Mobility training. In this process, technology as inertial measurement sensors could be included to track the motion of the c...

Virtual reality applications with sensitive interfaces for blind users were developed and tested on smart mobiles running Android as operating system with the participation of twenty blind adults; each application was built with a cognitive interface and a combination of three sensitive interfaces (voice, beeps and gestures) to allow the user to ex...

This paper describes the development of an application for mobile devices under the iOS platform which has the objective of monitoring patients with alterations or affections from cardiac pathologies. The software tool developed for mobile devices provides a patient and a specialist doctor the ability to handle and treat disease remotely while moni...

https://seib.org.es/publicaciones-cientificas-caseib/

Metallic nanorods are promising agents for a wide range of biomedical applications. We report an optical hyperthermia method capable of inducing slowdown tumor progression of an experimental in vivo CT-2A glioblastoma tumor. The tumor model used in this research is based on the transplantation of mouse astrocytoma CT-2A cells in the striatum of mic...

Biomedical applications based on the magnetic properties of superparamagnetic iron oxide nanoparticles may be altered by the mechanical attachment or cellular uptake of these nanoparticles. When nanoparticles interact with living cells, nanoparticles are captured and internalized into intracellular compartments. Consequently, the magnetic behavior...

Biomedical applications based on the magnetic properties of superparamagnetic iron oxide nanoparticles may be altered by the mechanical attachment or cellular uptake of these nanoparticles. When nanoparticles interact with living cells, nanoparticles are captured and internalized into intracellular compartments. Consequently, the magnetic behavior...

Virtual reality applications for blind people in smartphones were used to make virtual visits in advance to unknown spaces; these need to include a set of cognitive and sensitive interfaces that allow users to use their other sensory capabilities to understand information about their environment and facilitate the interaction with the application,...

Thickness Shear Mode (TSM) sensors and, in particular, Quartz Crystal Resonator (QCR) sensors are very efficient systems because of their elevated accuracy, sensitivity, and biofunctionalization capacity. They are highly reliable when measuring deposited samples, both for gaseous and liquid media. Moreover, they can be used for real time monitoring...

Negative pressure wound therapy (NPWT) is a technique that enhances the healing process by applying negative pressure on the chronic or acute wounds. It has been diffusely adopted for treatment of trauma wound, chronic wound, or deep sternal wound infections due to its excellent healing result. However, there were several injuries and death cases c...

A new instrument based on a magnetic force produced by an alternating magnetic field gradient, which is obtained through Maxwell coils, inside a constant field magnet has been designed and used to produce cell death. We have determined the interaction of microparticles and cells under different conditions such as incubation time with microparticles...

Visits to simulations of real spaces in virtual reality have been proposed as a means for blind people to gain spatial knowledge regarding the disposition of obstacles within a place before actually visiting it. Within the present study, different configurations of distant and proximity exploration were compared to each other, in order to test whet...

El objetivo principal de este artículo es proponer el diseño de un micro viscosímetro de bajo coste utilizando un resonador de cristal de cuarzo (QCR) y una tarjeta Arduino DUE. En el artículo se explican los pasos del diseño del sensor y también su evaluación con dos líquidos de diferentes características: diluciones de glicerol en agua (comportam...

The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous...

Magnetic hyperthermia mediated by superparamagnetic particles is mainly based in sinusoidal waveforms as excitation signals. Temperature changes are conventionally explained by rotation of the particles in the surrounding medium. This is a hypothesis quite questionable since habitual experimental setups only produce changes in the magnetic module,...

Gold nanorods (GNRs) are able to efficiently convert absorbed light into localized heat within a short period of time due to the surface plasmon resonance effect. This property, along with their easy bioconjugation, allows the use of GNRs in photothermal therapy as selective photothermal agents to target cancer cells. In this study, GNRs were combi...

Biomedical engineering is one of the more recent fields of engineering, aimed at the application of engineering principles, methods and design concepts to medicine and biology for healthcare purposes, mainly as a support for preventive, diagnostic or therapeutic tasks. Biomedical engineering professionals are expected to achieve, during their studi...

Se presenta un estudio preliminar en el que se compara la operación de un resonador de cuarzo (qcr) con electrodos-oro, típicamente utilizados en biosensado, con un resonador de cuarzo con electrodos-aluminio, utilizados como osciladores en circuitos electrónicos. La principal motivación para realizar este estudio es indagar sobre la posibilidad de...

Nanotechnology is creating high hopes for treating several diseases and different therapies based in the application of nanoparticles are being developed. We have introduced a new technique to control and guide the movement of magnetic micro particle (MMP) in one direction, and it can be used therapeutically in several diseases as: cancer, thrombos...

In magnetic resonance imaging (MRI), the use of magnetic nanoparticles (MNPs) as contrast agent (CA) greatly enhances the possibility to identify several diseases hardly diagnosed by other means. The efficacy of a new CA is described by the longitudinal and transverse relaxivity. Nuclear Magnetic Relaxation Dispersion (NMRD) profiles represent the...

In this chapter we present the complete development of a novel course on “Biomedical Devices”, in the framework of the “Biomedical Engineering” Degree at Universidad Politécnica de Madrid (TU Madrid). The course is based on the “CDIO: Conceive, Design, Implement, Operate” approach, as we consider it a very remarkable way of promoting student active...

The main objective of this article is to demonstrate by performing experimental measurements how the equivalent capacitance C0 changes when a fluid sample such as water is in contact with the crystal and to relate this change with the relative permittivity of the fluid. These measurements were compared with simulations of traditional models like Bu...

Los problemas de audición que hacen necesario el uso de audífonos afectan a todo tipo de personas, pero especialmente a aquellas que presentan dificultades para realizar la audiometría tonal subjetiva por su falta de colaboración en la prueba. La inexistencia de pruebas de audiometría objetivas equivalente a la tonal da lugar a un impreciso diagnós...

Background Impaired autoregulation capacity implies that changes in cerebral perfusion follow changes in blood pressure; however, no analytical method has explored such a signal causality relationship in infants.We sought to develop a method to assess cerebral autoregulation from a mechanistic point of view and explored the predictive capacity of t...

978-84-608-3354-3. Libro de actas, pp 418-421

Cancer is one of the leading causes of death worldwide. It is expected that annual cases of cancer will increase from 14 million in 2012 to 22 million in the next two decades according to the World Health Organization [1]. On the other hand, the estimates of the Spanish Society of Medical Oncology for 2015 point out 227076 new cases only in Spain [...

Cancer is a leading cause of mortality worldwide. There were an estimated 8.2 million deaths and around 14 million new cases in 2012. It is anticipated that in the next 20 years, the number of people affected will increase by approximately 70% [1,2]. Currently, the magnetic hyperthermia mediated superparamagnetic magnetite particles (SMPs) is a pro...

A power electronics circuit allows the generation of high frequency magnetic field that can be used to increase the temperature of cancer cells previously invaded with magnetic nanoparticles. The circuit designed for this purpose is a high frequency phase-shift inverter implemented with SiC devices and natural Zero Voltage Switching (ZVS). The indu...

This paper shows an example of collaboration of people of different areas working together and achieving a promising result. In this case, a power electronics circuit allows the generation of high frequency magnetic field that can be used to increase the temperature of cancer cells previously invaded with magnetic nanoparticles. Although the resear...

The Alternating Gradient Field Magnetometer (AGFM) is an instrument whose high sensitivity (10-8 emu) allows the detection of small amounts of magnetic nanoparticles (MNPs) with high accuracy. Over the last few years, different magnetic techniques have been used for in vitro measurements of magnetic nanostructures inside biological tissues. However...

The irradiation of small suspensions of gold nanorods (GNRs) using laser pulses at 808nm and 25KHz, produces a series of effects occurring during the interaction of each laser pulse with the amount of gold nanorods in suspension. The result of the interaction laser-GNRs is the generation of acoustic waves, which may influence on cell death in an op...

Objective To describe an alternative analysis in the frequency-domain of the temporal relationship between 2 biological signals and evaluate the method's predictive capacity for classifying infants at risk for an adverse outcome. Study design We studied 54 infants (mean gestational age 27 weeks) with invasive mean arterial blood pressure monitorin...

Background Cerebral AR is a complex, developmentally regulated process still not well characterised in neonates. A number of factors interact with the smooth muscle cells regulating cerebral arterial tone and perfusion. Various analytical methods have been applied to explore AR1. Although in this multifactorial process the assessment of synchronici...

Optical hyperthermia systems based on the laser irradiation of gold nanorods seem to be a promising tool in the development of therapies against cancer. After a proof of concept in which the authors demonstrated the efficiency of this kind of systems, a modeling process based on an equivalent thermal-electric circuit has been carried out to determi...

The heating produced by the absorption of radiofrequency (RF) has been considered a secondary undesirable effect during MRI procedures. In this work, we have measured the power absorbed by distilled water, glycerol and egg-albumin during NMR and non-NMR experiments. The samples are dielectric and examples of different biological materials. The samp...