
José Moutinho Dos SantosCentro Hospitalar de Coimbra | chc · Centro de Medicina do Sono
José Moutinho Dos Santos
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Introduction
Publications
Publications (65)
Objective/background:
The Epworth Sleepiness Scale (ESS) is one of the most used self-reported instruments to assess sleepiness. Thus, several adaptations into different Languages have been performed worldwide over the years. The scale has produced disparate psychometric properties when applied in different settings. In the current study, our aim...
Prevalence and Population Attributable Risk for Chronic Airflow Obstruction in a Large
Multinational Study - BOLD Study
Snoring is one the earliest symptoms of OSAS and is considered a coarse indicator of muscular tone deficiency that may compromise the regular breathing cycle. The present work intends to systematize the snore audio analysis in a cross-sectional study, with convenience sampling, of 67 individuals that undertook multi-parametric PSG analysis, during...
Purpose
In this study, our aim was to examine neural correlates of cognitive–behavioral therapy for insomnia (CBT-I).
Methods
It was investigated to what extent successfully tailored CBT-I modified the neural activity pattern observed before the intervention, when two insomnia patients were exposed to idiosyncratic stimuli pertaining to past/prese...
PurposeInsomnia is a highly prevalent disorder with important implications for health and well-being. It is well known the “hyperarousal hypothesis” in insomnia which assumes that patients present high levels of activation, in particular, cortical arousal.MethodsA preliminary resting-state fMRI experiment comprising two non-medicated insomnia patie...
Insomnia disorder has known striking developments over the last few years. Partly due to advances in neuroimaging techniques and brain sciences, our understanding of insomnia disorder has become more fine-tuned. Besides, developments within psychological and psychiatric fields have contributed to improve conceptualization, assessment, and treatment...
Word count, abstract : 250 words Word count, text : 3,189 words References : 35 Conflicts of interest The authors declare that they have no real or perceived conflict of interest with regard to the topic of this manuscript. ABSTRACT Background
Background:
There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD S...
Rationale: Evidence supporting the association of chronic obstructive pulmonary disease or airflow obstruction with use of solid fuels is conflicting and inconsistent. Objectives: To assess the association of airflow obstruction with self-reported use of solid fuels for cooking or heating. Methods: We analyzed 18,554 adults from the BOLD (Burden of...
We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study.Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic...
We aimed to examine associations between chronic airflow obstruction (CAO) and unemployment across the world.
Cross-sectional data from 26 sites in the Burden of Obstructive Lung Disease (BOLD) study were used to analyse effects of CAO on unemployment. Odds ratios for unemployment in subjects aged 40–65 years were estimated using a multilevel mixed...
Background and objective:
Autotitrating positive airway pressure (APAP) is an accepted titration method to determine the optimal positive airway pressure (PAP), for the treatment of obstructive sleep apnea (OSA). The required duration of APAP monitoring to determine a fixed continuous positive airway pressure level still remains to be established....
Psychophysiological insomnia (PI) is one of the most frequent sleep disorders. In this study we tested whether differences in terms
of neural activation are present between a group of PI patients and a healthy-control group while they are exposed to idiosyncratic ruminations and worries, evoked visually by words, so as to explore their hypothetical...
Psychophysiological insomnia (PI) is a clinical condition characterized by sleep-related disturbing cognitive activity and biased self-related information processing. This hypothetical cognitive arousal has been hypothesized to be associated with overactivation within different brain areas and networks, especially when individuals are at rest, e.g....
Current classifications of Chronic Obstructive Pulmonary Disease (COPD) severity are complex and do not grade levels of obstruction. Obstruction is a simpler construct and independent of ethnicity. We constructed an index of obstruction severity based on the FEV 1 /FVC ratio, with cut-points dividing the Burden of Obstructive Lung Disease (BOLD) st...
Sleep disorders and sleep disturbances are considered nowadays a major public health problem. Within sleep problems, insomnia is the most common health complaint. The maintenance of insomnia symptoms may lead to a clinical disorder – Insomnia Disorder (ID). A significant amount of literature has shown the efficacy and effectiveness of psychological...
To facilitate the performance comparison of new methods for sleep patterns analysis, datasets with quality content, publicly-available, are very important and useful. We introduce an open-access comprehensive sleep dataset, called ISRUC-Sleep. The data were obtained from human adults, including healthy subjects, subjects with sleep disorders, and s...
Introduction: Catathrenia is a rare sleep disorder characterized by a deep inspiration followed by a prolonged expiration and a vocalization. Predominates in males, usually occurring in REM sleep. The pathogenesis remains unclear and is currently considered a sleep-disordered breathing.
Methods: Revision of patients with the diagnosis of Catathreni...
In small studies and cases series, a history of tuberculosis has been associated with both airflow obstruction, which is characteristic of chronic obstructive pulmonary disease, and restrictive patterns on spirometry. The objective of the present study was to assess the association between a history of tuberculosis and airflow obstruction and spiro...
p> Introduction: To evaluate sleep deprivation and its effects on young physicians in relation to concentration capacity and psychomotor performance.
Material and Methods: Eighteen physicians aged 26 - 33 years were divided into 2 groups: non-sleep deprived group (with no night work) and sleep deprived group (minimum 12 hour of night work/week). We...
Primary insomnia (PI) is one of the most prevalent sleep disorders. For this reason, over the last decades, several comprehensive and etiological theories have been proposed. In this paper we review some of the main theoretical models of insomnia and discuss the two most studied processes for comprehension of insomnia: the hyperarousal and the fail...
Adaptive servoventilation is a recent ventilatory mode initially designed to treat Cheyne-Stokes respiration (CSR). Recently, the efficacy of ASV has been discussed for the treatment of central sleep apnea (CSA) and treatment-emergent central sleep apnea (treatment-emergent CSA) where other forms of traditional positive airway pressure (PAP) may be...
Obstructive sleep apnea syndrome (OSAS) and insomnia often coexist, and it is estimated that nearly half of those who suffer from the former report symptoms of the latter. The fact that these patients have no other causes of insomnia indicates that it is a sign of OSAS.
The aim of the study is to evaluate the effectiveness of nocturnal ventilatory...
OSA PostersSESSION TYPE: Poster PresentationsPRESENTED ON: Saturday, March 22, 2014 at 01:15 PM - 02:15 PMPURPOSE: Drug Induced Sleep Endoscopy (DISE) is a technique used to evaluate the point of airway obstruction in patients with obstructive sleep apnea syndrome (OSAS) in order to plan corrective surgery. The standard treatment for OSAS is nasal...
The use of different spirometric definitions for chronic obstructive pulmonary disease (COPD) has made an informative review of the available prevalence surveys impossible. O B J E C T I V E : To derive adjustment factors that allow the comparison of studies using different spirometric criteria. M E T H O D S : Pre-and post-bronchodilator one-secon...
Background Chronic obstructive pulmonary disease (COPD) is a commonly reported cause of death and associated with smoking. However, COPD mortality is high in poor countries with low smoking rates. Spirometric restriction predicts mortality better than airflow obstruction, suggesting that the prevalence of restriction could explain mortality rates a...
Introduction
Mandibular Advancement Splint (MAS) is a simpler alternative to continuous positive airway pressure (CPAP) for the treatment of mild and moderate OSA. The aim of the study was to evaluate the effectiveness of MAS for the treatment of OSA and determine if sleep apnea symptoms, cephalometric measurements and sleep study data are associat...
Introduction
Hyper-arousal processes are believed to have an important role in the pathophysiology of primary insomnia, and are also a maintaining factor in co-morbid insomnia. Our purpose is to present the psychometric proprieties of a Portuguese instrument developed to access arousal in insomnia, originated from vast clinical experience, which ma...
Background
There is a great heterogeneity in the prevalence of Chronic Obstructive Pulmonary Disease (COPD) demonstrates a great heterogeneity across the world. The Burden of Obstructive Lung Disease (BOLD) initiative was started to measure the prevalence of COPD in a standardized way. We aimed to estimate the prevalence of COPD in Portuguese adult...
Background: There is a great heterogeneity in the prevalence of Chronic Obstructive Pulmonary Disease (COPD) across the world. The Burden of Obstructive Lung Disease (BOLD) initiative was started to measure the prevalence of COPD in a standardized way. We aimed to estimate the prevalence of COPD in Portuguese adults aged 40 years or older of a targ...
Background:
There is a great heterogeneity in the prevalence of Chronic Obstructive Pulmonary Disease (COPD) demonstrates a great heterogeneity across the world. The Burden of Obstructive Lung Disease (BOLD) initiative was started to measure the prevalence of COPD in a standardized way. We aimed to estimate the prevalence of COPD in Portuguese adu...
Background:
Chronic Obstructive Pulmonary Disease (COPD) has been a leading cause of morbidity and mortality worldwide, over the years. In 1995, the implementation of a respiratory function survey seemed to be an adequate way to draw attention to neglected respiratory symptoms and increase the awareness of spirometry surveys. By 2002 there were ne...
Snoring is a widely occurring problem in our society and it is highly associated with pathologies like Obstructive Sleep Apnea Syndrome (OSAS) being, usually, one of the first symptoms to appear. Economically, OSAS has a great impact since sleep disorders affect the daily performance of people in their professional activities. The extensive study o...
The aim of this study was to describe the impact of chronic obstructive pulmonary disease (COPD) on health status in the Burden of Obstructive Lung Disease (BOLD) populations. We conducted a cross-sectional, general population-based survey in 11 985 subjects from 17 countries. We measured spirometric lung function and assessed health status using t...
Excessive daytime sleepiness is a major symptom in obstructive sleep apnea syndrome (OSAS) and can be evaluated using both subjective and objective methods. The Epworth Sleepiness Scale (ESS) is a simple and validated questionnaire for assessing subjective daytime sleepiness in the context of sleep disorders. Although its subjective character may l...
Obesity is considered one of the most serious public health problems of the modern world. Because it alters the relationship between the lungs, chest wall and diaphragm, it is to be expected that it impacts on the respiratory function. In Portugal, there is not much data about the relationship between obesity and pulmonary function.The aim of this...
Obesity is considered one of the most serious public health problems of the modern world. Because it alters the relationship between the lungs, chest wall and diaphragm, it is to be expected that it impacts on the respiratory function. In Portugal, there is not much data about the relationship between obesity and pulmonary function. The aim of this...
To evaluate the perception of health-related quality of life (HRQoL) in Portuguese patients with narcolepsy, and to compare the results to normative data.
Fifty-one narcoleptic adults (26M, 25F), aged between 18 and 80 years (mean=43.35, SD=15.32), were included in the final analysis of a multicentric cross-sectional study. The Medical Outcome Stud...
The use of spirometry is not yet widespread enough in chronic respiratory or at -risk patients whose diagnosis is incomplete. There is scarce knowledge and inadequate management of the burden of these diseases, particularly chronic obstructive pulmonary disease (COPD). Pneumobil, an initiative aimed at raising awareness among smokers and ex -smoker...
The use of spirometry is not yet widespread enough in chronic respiratory or at-risk patients whose diagnosis is incomplete. There is scarce knowledge and inadequate management of the burden of these diseases, particularly chronic obstructive pulmonary disease (COPD). Pneumobil, an initiative aimed at raising awareness among smokers and ex-smokers,...
The aim of the present study was to compare the evolution of pulmonary haemodynamics and of arterial blood gases in chronic obstructive pulmonary disease (COPD) patients with mild-to-moderate hypoxaemia, with or without sleep-related oxygen desaturation.
COPD patients with daytime arterial oxygen partial pressure in the range 56–69 mmHg were includ...
Nocturnal desaturation is well recnognized in patients with chronic respiratory failure (CRF). Alveolar hypoventilation, particulary in REM sleep, is frequently assumed as the main physiopathological mechanism. This ocurrence is important in patients with mild basal hypoxemia (PaO2 55-70 mmHg) because of the particular position of the PaO2 in the o...
Nocturnal desaturation is well recnognized in patients with chronic respiratory failure (CRF). Alveolar hypoventilation, particulary in REM sleep, is frequently assumed as the main physiopathological mechanism. This ocurrence is important in patients with mild basal hypoxemia (PaO2 55-70 mmHg) because of the particular position of the PaO2 in the o...
The beneficial effects of nocturnal oxygen therapy (NOT) in chronic obstructive pulmonary disease (COPD) patients with mild-to-moderate daytime hypoxaemia (arterial oxygen tension (Pa,O2) in the range 7.4-9.2 kPa (56-69 mmHg)) and exhibiting sleep-related oxygen desaturation remains controversial. The effectiveness of NOT in that category of COPD p...
Seventy one patients were enrolled to an opened, comparative and randomized study to evalute the safety and efficacy of azitbromycin administered during 3 days versus clarithromycin during 10 days in the out treatment of lower respiratory tract infections. Azithromycin was given 500 mg once daily and clarithromycin 250 mg twice daily. A total of 51...
The authors present the clinical of a male patient aged 45 years whose main complaints were loud snoring and excessive daytime sleepiness. Polysomnographic study revealed a sleep obstructive apnea syndrome with an apnea/hypopnea index of 86.5. After being treated with nasal continuous positive air pressure, (12 cm H2O), the apneas ended and sleep a...
It has been hypothesized but not firmly established that sleep-related hypoxaemia could favour the development of pulmonary hypertension in chronic obstructive pulmonary disease (COPD) patients without marked daytime hypoxaemia. We have investigated the relationships between pulmonary function data, sleep-related desaturation and daytime pulmonary...
The possibility of nocturnal oxygen desaturation (NOD) in patients with chronic bronchitis and emphysema (CBE) even with basal hypoxemia greater that 55 mmHg is well recognised. Nocturnal hypoventilation is admitted as the main cause for this NOD. In this study we evaluate how the presence of left ventricular dysfunction (LVD) could aggravate NOD....
Foi sugerido que a dessaturação nocturna (DN) presente em doentes com bronquite crónica-enfisema (BCE) e níveis de hipoxémia basal superior a 55 mmHg poderia ser uma condicionante na in stalação de hipertensão da artéria pulmonar (HTAP) permanente. No presente estudo avaliase, por um lado, as relações entre diversos parâmetros de DN e os índices fu...
A presença e magnitude da hipertensão da hipertensão da artéria pulmonar (HTAP) tem um impacto negativo no prognóstico dos doentes com Insuficiência Respiratória Crónica Grave (IRCG), definida por PaO2 < 65 mmHg, secundária a Bronquite Crónica e Enfisema (BCE). O aumento de sobrevida destes doentes depende, em grande medida, da identificação precoc...