José Antonio Mata-Marín

• Mexican Institute of Social Security

Plain Language Summary Men with HIV in Mexico City have undiagnosed STIs Sexually transmitted infections (STIs) are common among men who have sex with men (MSM) living with human immunodeficiency virus (HIV) (PWH). This study looked at how often these infections occur without symptoms in MSM attending an HIV clinic in Mexico City. From May 2022 to...

Efavirenz (EFV) causes neuropsychiatric effects such as anxiety, depression, and suicidal thoughts in people with HIV (PWH). Depressive disorders have been associated with the Tryptophan hydroxylase type 2 (TPH2) gene. Objectives: This study determines the genotypes and allelic frequencies of three TPH2 single nucleotide polymorphisms (SNPs) in a M...

Direct-acting antivirals (DAA) are effective in patients with hepatitis C virus (HCV) infection, but there is little information about real-world effectiveness in people living with human immunodeficiency virus (PLH). The aim of this study was to determinate the effectiveness of DAA to achieve sustained virologic response at week 12 post-treatment...

Purpose To determine the incidence of non-alcoholic fatty liver disease (NAFLD) by non-invasive methods in people living with HIV (PLWH). Methods Prospective cohort, in PLWH naïve to antiretroviral therapy, starting bictegravir (BIC) or dolutegravir (DTG) at the Hospital de Infectología “La Raza”, in Mexico City, from February 2021 to August 2023....

Las personas con inmunocompromiso tienen en común el incremento del riesgo de infecciones en general, infecciones graves, hospitalizaciones y muerte a consecuencia de dichas infecciones; varias de ellas prevenibles por vacunación

Background Patients with Immune-mediated inflammatory diseases (IMIDs) are at high risk of reactivation of tuberculosis, the risk is determined on the type of drug disease-modifying antirheumatic drugs (DMARDs). The objective of this study was to determine the prevalence of latent tuberculosis infection (LTBI) and associated factors in people who s...

Most HIV-antiretroviral drugs have adverse effects. Efavirenz (EFV) is an example of a drug with neuropsychiatric effects, such as anxiety, depression, and suicidal thoughts, in people living with HIV (PLWH). The mechanisms by which EFV causes neuropsychiatric alterations in PLWH are complex, multifactorial, and not fully understood, although sever...

The genetic basis of severe COVID-19 has been thoroughly studied and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we have conducted the larges...

Background People living with HIV (PLWH) starting or switching to an integrase strand transfer inhibitor-based regimen are more likely to experience weight gain than other classes of antiretroviral regimens. The aim of this study was to evaluate the weight gain and metabolic disturbances in PLWH who start antiretroviral therapy (ART) with bictegrav...

Background Depressive disorders have been associated with TPH2 gene polymorphisms. Additionally, HIV-1 antiretroviral drugs (ART) such as efavirenz (EFV) have been reported to cause neuropsychiatric adverse effects. Objective This study aimed to determine the genotypes and allelic frequencies of TPH2 SNPs (rs120074175, rs1386493, rs4570625, and rs...

Background Maternal, obstetric and neonatal factors that increase the possibility of mother-to-child HIV transmission (MTCT) are known as mechanisms of transmission. Our aim was to determine the risk factors associated with MTCT in Mexico. Methods We conducted a case–control study from March to December 2015. Cases were 60 mothers with HIV infecti...

Guías SIDVI para la vacuna recombinante del Herpes Zoster (RZV) 12 CC BY-SA © El autor(s). 2022. Acceso Abierto. Esta obra está bajo una Licencia Creative Commons Atribución-CompartirIgual 4.0 Internacional, que permiten el uso sin restricciones, distribución y reproducción en cualquier medio o formato, siempre que se le dé la atribución al creador...

Antecedentes El virus de la viruela símica (monkeypox) es un virus zoonótico perteneciente al género Orthopoxvirus. El primer caso en hu-manos fue descrito en 1970 en República Democrática del Congo y desde entonces se han reportado brotes relacionados tras el contacto con reservorios salvajes, principalmente roedores; África es el continente más a...

Highlights Después de la aparición del VIH/SIDA, científicos preocupa-dos por la aparición de esta nueva enfermedad, crearon la IAS (International AIDS Society) con el objetivo de reunir a ex-pertos de todo el mundo y diversas disciplinas para promover una respuesta concertada hacia el VIH. La IAS alberga las conferencias sobre el VIH más important...

Antecedentes Con el aumento en la sobrevida, varios tipos de cáncer de nitorios y no de nitorios de SIDA se presentan en los pacientes que viven con VIH (PVVIH). El objetivo de este estudio fue identi car la prevalencia y factores asociados al diagnóstico de cáncer en PVVIH. Material y métodos Se realizó un estudio transversal, en PVVIH del hospita...

El uso de terapias biológi- cas ha cambiado el manejo y evolución de las enferme- dades in amatorias autoin- munes, estos agentes tienen blancos de tratamiento más especí cos y pueden llevar a remisión de la enfermedad con tasas altas de e cacia. Tienen un uso muy amplio en reumatología, dermatolo- gía y gastroenterología y se usan en diversos prob...

La COVID-19 es la enfermedad causada por un coronavirus, SARS-CoV-2. La Organización Mundial de la Salud (OMS) tuvo noticia por primera vez de la existencia de este nuevo virus el 31 de diciembre de 2019, al ser informada de un grupo de casos de neumonía atípica que se habían declarado en Wuhan (República Popular China)1. Hasta el 04 de marzo de 20...

Introduction The Beck Depression Inventory (BDI-IA) is the most widely used instrument for assessing depression symptoms. Although it has been validated in the Mexican population, it has not been tested in people living with HIV (PLWH), who tend to have symptoms difficult to distinguish from those associated with viral infection. Objective We obta...

Introduction: Chronic obstructive pulmonary disease (COPD) is the most prevalent respiratory problem in the world. Patients with human immunodeficiency virus (HIV) infection have a higher prevalence of smoking and recurrent lung infections and are at higher risk of COPD. Objective: To determine the prevalence of COPD in HIV-diagnosed patients refe...

Introduction: Chronic obstructive pulmonary disease (COPD) is the most prevalent respiratory problem in the world. Patients with human immunodeficiency virus (HIV) infection have a higher prevalence of smoking and recurrent lung infections and are at higher risk of COPD. Objective: To determine the prevalence of COPD in HIV-diagnosed patients re...

Background: Cytomegalovirus (CMV) is able to cause serious and even deadly diseases in immunocompromised patients. It is important to have a sensitive, specific and molecular viral tests for its detection, using as targets, key genes for viral replication. The following genes have been used in the molecular detection of CMV: UL122 (replication) an...

La enfermedad pulmonar obstructiva crónica (EPOC) es el problema respiratorio de mayor prevalencia e impacto socioeconómico en el mundo. Se ha propuesto una asociación entre los pacientes infectados por el virus de inmunodeficiencia humana (VIH) y mayor susceptibilidad al desarrollo de EPOC. Los pacientes con VIH tienen mayor prevalencia de tabaqui...

The aim of the Mexican Consensus on the Treatment of Hepatitis C was to develop clinical practice guidelines applicable to Mexico. The expert opinion of specialists in the following areas was taken into account: gastroenterology, IFNectious diseases, and hepatology. A search of the medical literature was carried out on the MEDLINE, EMBASE, and CENT...

The aim of the Mexican Consensus on the Treatment of HepatitisC was to develop clinical practice guidelines applicable to Mexico. The expert opinion of specialists in the following areas was taken into account: gastroenterology, infectious diseases, and hepatology. A search of the medical literature was carried out on the MEDLINE, EMBASE, and CENTR...

The HCV 5'UTR, Core/E1 and NS5B regions of samples from fifty patients infected with the hepatitis C virus (HCV) were analysed. Seventeen patients were identified with genotype (GT) 1b, eleven with GT-1a, nine with GT-2b and four with GT-3a. Two rare subtypes were detected: GT-2j in two patients and GT-2r in one patient. Three patients had mixed in...

Background: Syphilis and human immunodeficiency virus (HIV) infections are similarly transmitted and commonly coexist. HIV affects the natural history, clinical manifestations, and treatment response to syphilis. The study goal was to determine the risk factors associated with a positive anti-Treponema pallidum antibody test in HIV-infected patient...

Background: Genotyping tests were developed to attenuate the impact of viral resistance. Data on the use antiretroviral therapy genotype based in children is rare, and even more in low and middle-income countriesMethods:16 Children with ART failure and triple-class drug resistant viruses were included. Protease and retrotranscriptase genotypes wer...

Tubular dysfunction is common in HIV-infected people and detection of proteinuria is essential to identify this problem. In low-income countries, resources for detection of proteinuria using the Kidney Disease Improve Global Outcomes (KDIGO) gold standard urinary protein/creatinine ratio (uPCR) is rarely possible, and use of the protein reagent str...

Recently, it was a current opinion that CD4 + lymphocyte counts, done as often as was currently recommended, was of little value once the patient had a good response (CD4 + elevation, viral load decreasing and steady clinical status) for one year or more. Furthermore, evidence of elevated viral load would indicate a review the patient with greater...

Neoplasia is the second most common cause of mortality in HIV patients. The prevalence of anal cancer among men who have sex with men (MSM) has continued to increase since the introduction of antiretroviral therapy. We screened 94 HIV-infected MSM patients. We found high-grade squamous intraepithelial lesions (HSIL) in six of the patients. The calc...

Introduction: The WHO estimates that 180 million people are chronically infected with hepatitis C virus (HCV) throughout the world. Despite the emergence of new therapies, the combination of pegylated interferon and ribavirin remains the accepted standard of care in low-income countries, including Mexico. Two types of peginterferon are available (...

Background: Human immunodeficiency virus (HIV) infection has become a disease in epidemiological transition since the introduction of antiretroviral therapy (ART); however, its control depends on adherence to therapy. There are some studies in Mexico regarding such adherence but they have had heterogeneous results. We aimed to determine the prevale...

Treatments in patients with multidrug resistance often involve the use of multiple agents with partial antiviral activity and overlapping metabolic toxicities. Enfuvirtide is therefore a welcome addition to the antiretroviral management of patients with multiclass resistant virus, given the low risk of systemic toxicities and novel mechanism of act...

Abstract Proximal renal tubular dysfunction (PRTD) of varying severity has been associated with antiretroviral toxicity, especially related to the use of tenofovir (TDF). The aim of this study was to investigate whether HIV-infected patients who use a tenofovir-based regimen are at increased risk of tubular dysfunction. We conducted an observationa...

The most common HBV genotypes in HIV-coinfected patients in Mexico are H and G; the response to treatment for these genotypes is unknown. The aim of the study was to examine the effectiveness of intensification with pegylated interferon (PEG-IFN) alfa-2a or alfa-2b in HBV/HIV-coinfected patients treated with a tenofovir/emtricitabine (TDF/FTC) back...

Our objective was to determine the seroprevalence of syphilis among HIV-infected patients in a tertiary care hospital in Mexico City. A cross-sectional study was developed, and 318 HIV-positive patients were evaluated from January to February 2013 at Hospital de Infectología, National Medical Center 'La Raza' (a tertiary care hospital specialising...

To identify clinical and sociodemographic factors associated with the risk of tuberculosis in HIV-infected patients. A case-control study in a cohort of hiv-infected patients. Cases: patients coinfected with HIV and pulmonary or extrapulmonary tuberculosis. Controls: no clinical tuberculosis and PPD negative, matched for age and sex. Primary data w...

The aim of this study was to evaluate the effect of antiretroviral therapy on inflammatory markers of endothelial dysfunction in HIV treatment-naïve infected patients. This was a prospective cohort study in HIV treatment-naïve infected patients. The patients were assigned to a untreated group or a treatment group according to the therapeutic strate...

Onychomycosis is a fungal infection of the nail caused by dermatophytes, yeasts, and non-dermatophyte molds. Human immunodeficiency virus (HIV)-infected patients are predisposed to this infection. In a cross-sectional study, we estimated the prevalence of onychomycosis and the frequency of fungal agents among HIV-infected patients in Mexico. We enr...

Chemotherapy induces immunosuppression which is associated with a significant increase in the frequency and severity of infections. Neutropenia is the most important factor in determining susceptibility to bacterial infections. Our aim was to establish the prevalence of bacterial infections and bacterial susceptibility patterns in patients with fev...

Background: To our knowledge, the antiviral activity of pegylated interferon alfa plus HAART has not been studied in patients with human immunodeficiency virus type 1 (HIV-1) coinfected with chronic hepatitis B virus (HBV). Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/conten...

It has been reported in Mexico that genotypes H and G are the most common, although genotypes prevalence in HIV co-infected patients is unknown. Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/content/pdf/1758-2652-13-S4-info.pdf Conference: Tenth International Congress on Drug...

Background: A significant number of HIV Mexican infected people are in virological failure, many of them are multiply experienced to antiretroviral therapy. Objective To assess the prevalence of resistance mutations in HIV Mexican infected patients heavily experienced to antiretroviral therapy (ART). Supplement: Abstracts of the Tenth International...

Hematologic manifestations of the human immunodeficiency virus (HIV) infection are a well-recognized complication of the disease and may be clinically important. Our objective was to determine the risk factors for anemia and its correlation with HIV treatment-naïve infected patients without co-infection or opportunistic diseases. We performed a cro...

To develop and validate a questionnaire to identify patients with obstructive sleep apnea (OSA) in Mexican population. We performed a cross-sectional study to develop and validate an instrument in Spanish language, consistent in an 18-item questionnaire. We enrolled patients seen from July 2008 to August 2009. We evaluated the internal consistency...

To evaluate the aspartate aminotransferase (AST) to platelet ratio index (APRI) as a predictive factor of early viral response in chronic hepatitis C naive patients. We performed an ambispective case-control study. We enrolled chronic hepatitis C naive patients who were evaluated to start therapy with PEGylated interferon alpha-2b (1.5 mug/kg per w...

Abnormalities in liver function tests could be produced exclusively by direct inflammation in hepatocytes, caused by the human immunodeficiency virus (HIV). Mechanisms by which HIV causes hepatic damage are still unknown. Our aim was to determine the correlation between HIV viral load, and serum levels of aspartate aminotransferase (AST) and alanin...