Jose M Martinez-Lage

Jose M Martinez-Lage
Universidad de Navarra | UNAV · Department of Neurology and Neurosurgery

Full Professor of Neurology (1983-2005)

About

157
Publications
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3,589
Citations
Additional affiliations
January 2006 - present
January 2002 - present
January 1984 - December 1988
Universidad de Navarra
Education
October 1952 - May 1959

Publications

Publications (157)
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According to the Dictionary of Epilepsies of the World Health Organization (Gastaut, 1973), epilepsy is a chronic brain disorder of various aetiologies characterized by recurrent seizures due to excessive discharge of cerebral neurones. Single or occasional epileptic seizures as well as those provoked during an acute illness should not be classifie...
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In recognition of the global problem posed by Alzheimer's disease and other dementias, an international think-tank meeting was convened by Biocat, the Pasqual Maragall Foundation, and the Lou Ruvo Brain Institute in February 2009. The meeting initiated the planning of a European Union-North American collaborative research enterprise to expedite the...
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Amnestic mild cognitive impairment represents, in many cases, the earliest clinical phases of Alzheimer disease. Anti-inflammatory agents have epidemiologic support as drugs potentially beneficial in Alzheimer disease. In vivo studies have shown that Triflusal and its active metabolite 2-hydroxy-4-trifluoromethyl-benzoic acid have potent anti-infla...
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Objective To describe the initial treatment of patients >60 years who had subjective memory complaints and/or cognitive impairment for at least 6 months. Design Observational, longitudinal, multicentre, and naturalistic study, with a follow-up period of 12 months. Setting A total of 105 primary care centres. Participants The study included 921 p...
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To describe the initial treatment of patients >60 years who had subjective memory complaints and/or cognitive impairment for at least 6 months. Observational, longitudinal, multicentre, and naturalistic study, with a follow-up period of 12 months. A total of 105 primary care centres. The study included 921 patients who attended a clinic. In the bas...
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Objectiveto evaluate the interval between symptom onset and diagnosis by a general practitioner (GP) in patients with cognitive impairment and/or memory complaints.
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As we commemorate the first centennial since Alzheimer's disease (AD) was first diagnosed, this article casts back into the past while also looking to the future. It reflects on the life of Alois Alzheimer (1864-1915) and the scientific work he undertook in describing the disorder suffered by Auguste D. from age 51 to 56 and the neuropathological f...
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Contrary to early case-control studies that suggested smoking protects against Alzheimer disease (AD), recent prospective studies have shown that elderly who smoke may be at increased risk for dementia. To examine prospectively the effect of smoking on cognition in nondemented elderly. In a multicenter cohort, the European Community Concerted Actio...
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The hypotesis that a low educational level increases the risk for Alzhelmer's disease remains controversial. The authors studied the asociation of years of schooling with the risk for incident Dementla cases were identifled in a two-stage procedure that included a detailed diagnostic assessment of screen-postive subjects. Dementia and Alzheimer's d...
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To study the difference in risk for dementing diseases between men and women. Previous studies suggest women have a higher risk for dementia than men. However, these studies include small sample sizes, particularly in the older age groups, when the incidence of dementia is highest. Pooled analysis of four population-based prospective cohort studies...
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Unlabelled: Thirty-four patients with a probable Alzheimer's Disease (AD) (mild AD = 16; moderate AD = 18) and 12 matched controls were evaluated using semiquantitative SPECT-99mTc-HMPAO and neuropsychological tests (CERAD). Results: Both temporal hypoperfusion (p < 0.01) and memory tests (p < 0.001) made it possible to differentiate the control...
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To investigate the risk of AD associated with a family history of dementia, female gender, low levels of education, smoking, and head trauma. These putative factors have been identified in cross-sectional studies. However, those studies are prone to bias due to systematic differences between patients and control subjects regarding survival and how...
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The Mini-Mental-State Examination (MMSE) is widely used as a screening tool for dementia in epidemiological studies. Its applicability in population-based studies is nevertheless limited by its low specificity. The effect of age and educational level have been usually ignored when cut-off scores have been selected. The aim of this study was to eval...
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The Mini-Mental-State Examination (MMSE) is widely used as a screening tool for dementia in epidemiological studies. Its applicability in population-based studies is nevertheless limited by its low specificity. The effect of age and educational level have been usually ignored when cut-off scores have been selected. The aim of this study was to eval...
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In developing the author's view of an Alzheimer Global ® action to disseminate information and knowledge on Alzheimer's disease and related dementias, a report on several meetings held along 1998 is offered emphasizing the Barcelone-Pittsburgh Seminar organized by ACE Fundación of Catalunya. The breakthroughs on molecular genetic, physio-pathology,...
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We describe a Spanish adaptation and standardization of the Alzheimer's Disease Assessment Scale (ADAS) carried out as part of a prospective, coordinated study performed simultaneously in two Spanish health centers. Three diagnostic groups were defined: 21 healthy volunteers (normal group); 22 patients with cognitive deterioration but no dementia (...
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In order to evaluate the relationship between perfusion brain SPECT and specific cognitive functions as well as the possible influence of the illness severity on them, 34 patients clinically diagnosed as probable Alzheimer disease (AD) and 12 elderly controls were studied. AD patients were subdivided according to severity as 16 mild AD and 18 moder...
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Creutzfeldt-Jakob disease (CJD) is characterized by a rapidly progressive dementia that often leads to death within a few months of onset. However, some cases evolve over a much longer period of time and have a clinical picture that is difficult to distinguish from other progressive dementias that occur in the adult, especially Alzheimer's disease...
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We studied a ten-year old girl with livedo reticularis and multiple central nervous system ischemic attacks beginning when she was five. Blood tests were positive for cryoglobulins and antiphospholipid antibodies; superior limb angiography showed occlusion and irregularities of the vessel walls and temporal artery biopsy revealed concentric thicken...
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We investigated the prevalence of dementing disorders in the city of Pamplona, Spain, using a door-to-door two-phase approach. We first administered the Cambridge Examination of Mental Disorders of the Elderly (CAMDEX) to all survivors, as of March 1, 1991, of a probability sample of the total population identified in 1989 (n = 1,127). Using specif...
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Although substantial therapeutic advances have been developed during the last decade, L-dopa remains as the most successful treatment for Parkinson's disease. However, about 80% of the patients show motor and psychiatric complications after several years of levodopa treatment. Thus, new therapeutic approaches have been undertaken during the last de...
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We have studied the motor response induced by independent administration of 4 different doses of a dopamine D2 [(+)-PHNO] and a dopamine D1 (CY 208-243) receptor agonist in 5 MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkeys. Both drugs had similar antiparkinsonian effects and both elicited choreic dyskinesias. Simultaneous administration...
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We report anticipation in an extensive sample of myotonic dystrophy (MyD) kindreds taken from an epidemiological survey recently conducted in Guipúzcoa, Spain. Analysis of the parent-child pairs ascertained showed a mean anticipation of 2.86 decades (range 0-6). Greater anticipation occurred when the transmissor parent was the mother. These results...
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We report a patient who presented palatal myoclonus (PM) after anoxic brain damage that was completely abolished by the administration of opioid agonists. This suggests the involvement of peptide systems in the development of PM.
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Prevalence figures for inherited neuromuscular disorders are important both for health care planning purposes and for evaluating the need for DNA diagnostic services for eugenic approaches. We screened for the prevalence of myotonic dystrophy (MyD) through extensive inquiry of neurologic and primary health services of Guipúzcoa (Basque Country, nor...
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We studied the motor response induced by the administration of the AMPA receptor antagonist, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline(1H,4H)dione sodium salt), in two parkinsonian monkeys and its interaction with the selective D-2 dopamine receptor agonist, (+)-PHNO [(+)-4-propyl-9-hydroxynaphthoxazine], and the partial dopamine D...
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The correlation between clinical signs and symptoms, Evoked Potentials (EP) and Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) is still uncertain. It seems necessary to perform comparative studies with homogeneous groups of patients to avoid the error provoked by the selection of patients and the use in the diagnosis of EP and MRI. The...
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Although the presence of intellectual impairment in multiple sclerosis (MS) is known since the first studies of the disease frequently the impairment goes equally undetected for the patients, their family and the physician because the physical dysfunction is much more outstanding. In this study a population of 50 persons suffering clinically defini...
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Recent studies giving subcutaneous apomorphine or intravenous levodopa boluses have not found clear evidence of behavioral hyposensitivity to repeated dopaminergic stimulation in Parkinson's disease (PD). Here we analyze that data, and review experimental findings in animal models and our previous experience with parkinsonian patients. We conclude...
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Recent studies giving subcutaneous apomorphine or intravenous levodopa boluses have not found clear evidence of behavioral hyposensitivity to repeated dopaminergic stimulation in Parkinson's disease (PD). Here we analyze that data, and review experimental findings in animal models and our previous experience with parkinsonian patients. We conclude...
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We have studied the motor response induced by the administration of the AMPA-antagonist NBQX given alone or simultaneously with l-dopa to 2 parkinsonian monkeys. NBQX (1, 2 and 4 mg/kg im) failed to reverse parkinsonism. Similarly, co-administration of NBQX (1 mg/kg) plus l-dopa (12.5, 25 and 50 mg orally) did not modify the motor improvement and d...
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In an attempt to establish the efficacy of the most recent diagnostic tests--magnetic resonance (MR) imaging and multimodal evoked potentials (EP), 28 patients with clinically definite multiple sclerosis (MS) (1.a Poser's categories) were studied. The MR was positive in 26 (92%) patients; the EP were altered in 23 (82%)--the visual EP in 18 (64.2%)...
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MPTP administration, preferably to mice and primates, induces a selective damage of substantia nigra dopaminergic cells. Intrinsic mechanisms mediating MPTP induced toxicity, remain still under evaluation. There are very few semiological differences between Parkinson's disease (PD) and MPTP parkinsonism, but significant biochemical and neuropatholo...
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In the present study 84 patients with the diagnosis of multiple sclerosis were identified as living in Navarra on the date of prevalence (December 31, 1986). The raw yearly incidence rate was 0.49/100000, which is similar to that in Mediterranean countries. A significant increase of this rate was found between 1951 and 1986, which was interpreted a...
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The inhibitory effect of stiripentol (STP) on disposition of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZE) was quantitated to establish CBZ dosage reduction guidelines for future clinical add-on efficacy trials of STP. In seven epileptic patients, STP (1,500-3,000 mg/day for 2 weeks) inhibited CBZ clearance by 50 +/- 16% (p = 0.001) an...
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Brain single photon emission computed tomography (SPECT) with 99mTc-HMPAO is a diagnostic tool for evaluating regional cerebral blood flow. Recently, the diagnostic possibilities of the method are being investigated in some neurologic disorders, such as cerebrovascular accidents, seizures and dementia. This work has been carried out with 54 subject...
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Nimodipine is a 1,4-dihydropyridine derivative that shows a preferential cerebrovascular activity in experimental animals. Clinical data suggest that nimodipine has a beneficial effect on the neurologic outcome of patients suffering an acute ischemic stroke. Our double-blind placebo-controlled multicenter trial was designed to assess the effects of...
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We report the results of intracarotid (IC) cisplatinum and intravenous carmustine (BCNU) in 26 patients with supratentorial malignant glioma and recurrent low grade glioma. A response rate of 53.84% (95% confidence interval 33.3%-73.4%) was found. The median survival for the whole group was 11 months (range 3-70), with 35% of patients surviving for...
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Fluctuations and dyskinesias are the 2 main motor complications associated with chronic levodopa therapy. Striatal denervation following degeneration of the substantia nigra dopaminergic projections is probably the major pathophysiologic mechanism underlying motor fluctuations. In addition, pathologic modification of striatal receptors, partially r...
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Oral lisuride associated with the previous therapy (levodopa plus inhibitor) was given to 15 patients with complex fluctuations of mobility that were not controlled with usual therapy. In contrast with previous studies using this drug, in the present trial several lisuride doses (5-10 administrations) were distributed throughout the day. This thera...
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Motor complications appearing in 180 patients with Parkinson's disease who received levodopa for a long period are reviewed. The most frequently observed motor disorders were wearing off fluctuations and dyskinesias of "dose benefit". Most patients who presented a decrease in the response to levodopa developed signs during the course or findings in...
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Ischemic stroke is one of the leading causes of death and chronic disability in the world. Although great progress has been made in recent years in understanding the pathophysiology of cerebral ischemia, the treatment for the patient who has suffered a brain infarction remains controversial. A number of management strategies have been devised to re...
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Sixty-four Spanish neurological centers participated in a study designed to evaluate the efficacy and safety of flunarizine in migraine. One thousand four hundred and thirty-five outpatients (367 [25.6%] males and 1,068 [74.4%] females) fulfilling the criteria proposed by the International Headache Society for the diagnosis of migraine entered the...
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28 patients with Parkinson’s disease showing complex “on-off” fluctuations in response to chronic levodopa plus dopa decarboxylase inhibitor (po) were treated with subcutaneous lisuride using a portable infusion pump. All patients improved initially during the first weeks of treatment. Four patients abandoned the trial within the first few weeks as...
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Complex motor fluctuations and dyskinesias ("on-off" phenomenon) in Parkinson's disease can be corrected by parenteral administration of levodopa, levodopa-methyl-ester, lisuride and apomorphine. Levodopa and levodopa-methyl-ester may only be administered intravenously because of their low solubility. Lisuride and apomorphine are readily absorbed a...