Jose P Martinez

Het Oogziekenhuis Rotterdam · medical retina

Purpose To report a case of a perifoveal exudative vascular anomalous complex (PEVAC) resembling lesion in a patient with multiple myeloma. Observations A 56-year-old male with multiple myeloma presented with sudden moderate vision loss in the right eye. Best-corrected visual acuity was 20/25 in his right eye. Fundus examination showed a vascular...

Purpose: Diabetic retinopathy (DR) is a complication of type 2 diabetes mellitus (T2DM). Lipoprotein(a) (Lp(a)) contributes to the progression of DR, but how is unclear. In homeostasis of the retinal microvasculature, myeloid-derived pro-angiogenic cells (PACs) also play a pivotal role, and fail to function properly in diabetic conditions. Here, w...

Purpose Diabetic retinopathy (DR) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Myelomonocytic proangiogenic cells (PAC) have been implicated in DR pathogenesis, but their functional and developmental abnormalities are unclear. In this study we assessed PAC characteristics from healthy controls, T2DM patients with DR (DR...

Purpose: The purpose of this study was to describe the effect of topical prednisolone on intraretinal fluid in patients with peripapillary pachychoroid syndrome. Methods: We selected 11 consecutive patients (17 eyes) with a diagnosis of peripapillary pachychoroid syndrome, who were treated with topical prednisolone (Pred Forte [PF] 10 mg/mL) thr...

Purpose To study the prevalence and severity of diabetic retinopathy (DR) in patients with macular telangiectasia type 2 (MacTel2). Design Retrospective case series. Subjects Patients with a diagnosis of MacTel2 presenting to the Rotterdam Eye Hospital or Erasmus Medical Center between 2014 and 2018 were included. Methods The following informati...

Purpose Perifoveal exudative vascular anomalous complex (PEVAC) was initially described as an isolated aneurysmal lesion in healthy eyes. Similar aneurysmal abnormalities may occur in association with retinal vascular diseases such as diabetic retinopathy or retinal vein occlusions (PEVAC‐resembling). The aim of this study was to compare several im...

Purpose To explore the short‐term vascular and structural changes of type 3 neovascularization using optical coherence tomography angiography (OCT‐A) when treated with a combination of photodynamic therapy (PDT) and intravitreal bevacizumab (IVB), and to evaluate the course of different sequences of the combined therapies. Methods Thirty eyes of 2...

Purpose The purpose of the study was to demonstrate whether photodynamic therapy in patients with acute central serous chorioretinopathy, with the leakage point within one optic disk diameter from the fovea, can be safely deferred. Methods A single-center, randomized, controlled trial was conducted. Patients were randomized to photodynamic therapy...

Purpose: To report a series of 21 patients with perifoveal exudative vascular anomalous complex (PEVAC) and to investigate the anatomical changes over time. Methods: We conducted a retrospective study. Clinical data of consecutive patients, presenting at the Rotterdam Eye Hospital between 2014 and 2019, were analyzed. The data collected included...

People with diabetes mellitus need annual screening to check for the development of diabetic retinopathy. Tracking small retinal changes due to early diabetic retinopathy lesions in longitudinal fundus image sets is challenging due to intra- and inter-visit variability in illumination and image quality, the required high registration accuracy, and...

Purpose: To characterize the relevance of macular thickness changes in the inner and outer rings in the progression of macular edema in eyes/patients with diabetes type 2. Methods: A total of 374 type 2 diabetic patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20-35) were included in a 12-month prospective observational stu...

Purpose: To identify eyes of patients with diabetes type 2 that show progression of retinal disease within a 1-year period using noninvasive techniques. Methods: Three hundred seventy-four type 2 diabetic patients with mild nonproliferative diabetic retinopathy (Early Treatment Diabetic Retinopathy Study [ETDRS] level 20 or 35) were included in...

To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy Study) classified as presenting subclinical macul...

To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2. A cohort of 194 type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20/35) were examined with Cirrus spectral-domain optical coherence tomography (OCT) at the baseline visit (ClinicalTr...

Purpose: To evaluate the accuracy of a recently developed fundus image registration method (Weighted Vasculature Registration or WEVAR) and to compare it with two top-ranked state-of-the-art commercial fundus mosaicking programs (i2k Retina, DualAlign LLC and Merge Eye Care PACS, formerly named OIS AutoMontage) in the context of diabetic retinopath...

This paper presents a method to automatically assess the accuracy of image registration. It is applicable to images in which vessels are the main landmarks such as fundus images and angiography. The method simultaneously exploits not only the position, but also the intensity profile across the vasculatures. The accuracy measure is defined as the en...

Accurate registration of retinal fundus images is vital in computer aided diagnosis of retinal diseases. This paper presents a robust registration method that makes use of the intensity as well as structural information of the retinal vasculature. In order to correct for illumination variation between images, a normalized-convolution based luminosi...

Objective To evaluate long-term efficacy and safety profiles during 3 years of individualized ranibizumab treatment in patients with visual impairment due to diabetic macular edema (DME). Design Phase IIIb, multicenter, 12-month, randomized core study and 24-month open-label extension study. Participants Of the 303 patients who completed the rand...

Purpose: The purpose of this paper is to study the quality indicator appropriateness and use it for international quality comparison on diabetic retinopathy (DR) patient care process in one American and one Dutch eye hospital. Design/methodology/approach: A 17-item DR quality indicator set was composed based on a literature review and systematic...

To report a newly recognized adverse effect of oral moxifloxacin. Observational case reports. Five patients who used oral moxifloxacin therapy. In five patients, a uveitis-like episode followed oral moxifloxacin therapy, afterwards they experienced photophobia. At slitlamp investigation, the patients showed almost complete iris transillumination, n...

Loss of vision is a threatening presentation of disease. We describe a case of acute idiopathic blind spot enlargement in a 26-year-old male traveler who presented with narrow vision after a journey to Indonesia. Although the patient used mefloquine at time of presentation, we were unable to retrieve sound data incriminating mefloquine in this rare...

To test the efficiency of a microarray chip as a diagnostic tool in a cohort of northwestern European patients with Leber congenital amaurosis (LCA) and to perform a genotype-phenotype analysis in patients in whom pathologic mutations were identified. DNAs from 58 patients with LCA were analyzed using a microarray chip containing previously identif...

Objective: To compare the treatment effect and safety of photodynamic therapy with verteporfin using a standard (SF) or reduced (RF) light fluence rate with that of placebo therapy in patients with subfoveal minimally classic choroidal neovascularization (CNV) with age-related macular degeneration. Design: Phase 2, multicenter, double-masked, place...