Jose Lara

Jose Lara
Northumbria University · Applied Sciences, Faculty of Health and Life Sciences

MSc, PhD

About

131
Publications
20,860
Reads
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4,615
Citations
Citations since 2016
48 Research Items
3925 Citations
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
Additional affiliations
February 2016 - present
Northumbria University
Position
  • Professor (Associate)
March 2010 - February 2016
Newcastle University
Position
  • Research Associate

Publications

Publications (131)
Article
Full-text available
Blueberries are rich in polyphenols, and their effect on cardiovascular health, including risk factors for endothelial dysfunction and hypertension, has been investigated in interventional studies. However, the difference between blueberry treatments in varied forms for their cardiovascular-protective effect remains poorly understood. The current s...
Article
Full-text available
Objectives The cognitive-protective effects related to the consumption of a variety of fruits are supported by several intervention studies. This systematic review and meta-analysis compared the magnitude of effects following chronic (≥1 week) consumption of frozen, freeze-dried powder including extracts and juices of fruits, covering berries, cher...
Article
Full-text available
Background Sarcopenia is defined as the loss of muscle mass and strength. Despite the seriousness of this disease, a single diagnostic criterion has not yet been established. Few studies have reported the prevalence of sarcopenia globally, and there is a high level of heterogeneity between studies, stemmed from the diagnostic criteria of sarcopenia...
Thesis
Among the physiological and metabolic changes occurring with ageing, the ageing of heart function is a key determinant of health. The death number from CVDs is expected to reach over 23.6 million by 2030. An estimated 17.9 million people died from CVDs in 2019 in the UK, representing 32% of all global deaths. Evidence suggested that the Mediterra...
Article
Full-text available
Purpose This review aims to compare the magnitude of the effects of chronic consumption of fruits; specifically berries, citrus and cherries on cardiovascular disease (CVD) risk factors.Methods PubMed, Web of Science, Scopus, and psycARTICLES were searched from inception until January 2020. Forty-five chronic (≥ 1 week) randomised controlled trials...
Article
Full-text available
In the original publication, a study supplementing orange juice by Morand, et al., 2011 (France) was incorrectly reported for the diastolic blood pressure (DBP) outcome.
Article
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Ageing is a multifactorial process associated with reduced function and increased risk of morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have been identified, which characterise the ageing process, and collectively, may be key determinants of the ageing trajectory. These include genomic instability, telomere attr...
Article
Full-text available
Background Previous evidence has demonstrated that serum leptin is correlated with appetite in combination with, but not without, modest exercise. Aim The present experiments investigated the effects of exogenous adrenaline and α/β adrenoceptor blockade in combination with moderate exercise on serum leptin concentrations, appetite/satiety sensatio...
Article
Full-text available
Background Lunch clubs are community-based projects where meals are offered with opportunities for social interaction, and a unique dining experience of dual commercial and communal nature. Aim The aim of the present cross-sectional study was to assess differences in the dietary intake between lunch club and non-lunch club days among community-dwe...
Article
Clustering of adherence to personalised dietary recommendations and changes in healthy eating index within the Food4Me study – CORRIGENDUM - Volume 22 Issue 11 - Katherine M Livingstone, Carlos Celis-Morales, Jose Lara, Clara Woolhead, Clare B O’Donovan, Hannah Forster, Cyril FM Marsaux, Anna L Macready, Rosalind Fallaize, Santiago Navas-Carretero,...
Presentation
The effects of food intervention on measures of arterial stiffness and microvascular vasodilation: Systematic Review and meta-analysis - Volume 78 Issue OCE2 - H. M. Cheng, D. Farsi, J. Lara
Presentation
The effect of consuming red and orange cherry tomatoes on blood-borne circulating biomarkers in free-living normotensive males: a randomised cross-over trial - Volume 78 Issue OCE2 - H. M. Cheng, G. Koutsidis, J.K. Lodge, K. Keane, M. Siervo, J. Lara
Article
Full-text available
Objective The aim of the study was to determine the main factors (sociodemographic, anthropometric, lifestyle and health status) associated with high Na excretion in a representative population of Chile. Design Na excretion (g/d), a valid marker of Na intake, was determined by urine analysis and Tanaka’s formulas. Blood pressure was measured by tr...
Article
Background/Objectives: There is no consensus on the definition of sarcopenic obesity (SO), resulting in inconsistent associations of SO with mortality risk. We aim to evaluate association of dual energy x-ray absorptiometry (DXA) SO models with mortality risk in a US adult population (≥50 years). Subjects/Methods: The study population consisted of...
Article
Full-text available
DNA methylation is a key component of the epigenetic machinery that is responsible for regulating gene expression and, therefore, cell function. Patterns of DNA methylation change during development and ageing, differ between cell types, are altered in multiple diseases and can be modulated by dietary factors. However, evidence about the effects of...
Presentation
The effect of consuming red and yellow cherry tomatoes on endothelial function in free-living normotensive males: a randomised cross-over trial - Volume 77 Issue OCE4 - H.M. Cheng, G. Koutsidis, J.K. Lodge, K. Keane, M. Siervo, J. Lara
Article
Full-text available
Efficacy of nutritional interventions supplementing nuts on cardiovascular risk factors among adults individuals: A systematic review and meta-analysis of intervention studies - Volume 77 Issue OCE4 - F Liang, J Young, J Lara
Article
Adherence to and acceptability of the Mediterranean diet amongst young adults in the North East of England - Volume 77 Issue OCE4 - L. Francis, J. Young, J. Lara
Article
Weight loss behaviours and their association with diet and perceived barriers to healthy eating among young adults in North East England - Volume 77 Issue OCE4 - L. Francis, J. Young, J. Lara
Presentation
Effect of supplementation with antihypertensive peptides from food proteins on cardiovascular risk factors: A systematic review and meta-analysis of randomised controlled trials - Volume 77 Issue OCE4 - H.M. Cheng, A. Kazi, N. Mavroudis, J. Lara
Article
Sarcopenic obesity and insulin resistance: application of novel body composition models - Volume 77 Issue OCE4 - I. Mendes, E. Poggiogalle, B. Lee, C.M. Prado, G. Mocciaro, G. Mariniello, J. Lara, C. Lubrano, A. Lenzi, L.M. Donini, M. Siervo
Article
Background/objectives: There is no consensus on the definition of sarcopenic obesity (SO), resulting in inconsistent associations of SO with mortality risk. We aim to evaluate association of dual energy x-ray absorptiometry (DXA) SO models with mortality risk in a US adult population (≥50 years). Subjects/methods: The study population consisted...
Article
Background and aims: Epidemiological evidence of the beneficial health effects of fish consumption is strong, but the evidence from intervention trials is less documented. Our aim was to evaluate the state of the evidence on the potential effects of fish consumption on vascular risk factors arising from intervention trials. Methods: A systematic...
Article
Background and aims: Worldwide, cardiovascular diseases (CVDs) remains as the main cause of mortality. Observational studies supports an association between intake of tomato products or lycopene with a reduced CVDs risk. Our aim was to undertake a systematic review and meta-analysis of the evidence on the topic. Methods: Medline, Web of Science, an...
Article
Randomised controlled trials (RCTs) have observed contrasting results on the effects of vitamin C on circulating biomarkers of glycaemic and insulin regulation. We conducted a systematic review and meta-analysis of RCTs testing the effect of vitamin C administration on glucose, HbA1c and insulin concentrations. Four databases (PubMed, Embase, Scopu...
Article
Objectives: Dietary nitrate supplementation has been shown to lower blood pressure (BP) particularly in short-term clinical trials. Whether these effects are sustained in the long-term remains to be established. The objective was to conduct a meta-analysis of randomized controlled trials that examined whether dietary nitrate supplementation for mo...
Article
Background and aims: Epidemiological evidence suggests an association between consumption of tomato products or lycopene and lower risk for cardiovascular diseases (CVD). Our aim was to evaluate the state of the evidence from intervention trials on the effect of consuming tomato products and lycopene on markers of cardiovascular (CV) function. We...
Chapter
Significant evidence indicates that an unhealthy diet, physical inactivity, smoking, excessive alcohol consumption, and other factors such as social conditions contribute significantly to the accelerated molecular and cellular damage associated with aging, whereas a healthier diet, regular physical activity, not smoking, and drinking sensibly may r...
Article
The scope, efficacy and effectiveness of Mediterranean diet interventions outside Mediterranean countries: A systematic review and meta-analysis of intervention studies - Volume 76 Issue OCE2 - L. Francis, J. Young, J. Lara
Article
The impact of intermittent fasting on body composition and cardiovascular biomarkers: a systematic review and meta-analysis - Volume 76 Issue OCE2 - L. Francis, J. Young, J. Lara
Chapter
Consumption of fish is associated with significant health benefits, particularly improvements of cardiovascular risk, but natural supply from the wild is limited. Salmon farming is a successful alternative. The aim of this chapter is to review the evidence from studies examining the health effects of salmon eating in adult subjects. A systematic re...
Article
The ratio between fat mass (FM) and fat-free mass (FFM) has been used to discriminate individual differences in body composition and improve prediction of metabolic risk. Here, we evaluated whether the use of a visceral adipose tissue-to-fat-free mass index (VAT:FFMI) ratio was a better predictor of metabolic risk than a fat mass index to fat-free...
Article
Objective To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. Design Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials. Data sources Ovid Medline, Scopus, Embase, and Cochrane from in...
Article
Purpose of review: There is great interest in developing tools to measure healthy ageing and to identify early stages of health impairment, which may guide the implementation of interventions to prevent or delay the development of disease, disability, and mortality. Here, we review the most recent developments directed to operationalize, and test,...
Article
Full-text available
Nitrate-rich beetroot juice (BRJ) increases plasma nitrite concentration, lowers the oxygen cost (V̇O2) of steady-state exercise and improves exercise performance in sedentary and moderately-trained, but rarely in well-trained individuals exercising at sea-level. BRJ supplementation may be more effective in a hypoxic environment, where the reductio...
Article
Objective: To characterise clusters of individuals based on adherence to dietary recommendations and to determine whether changes in Healthy Eating Index (HEI) scores in response to a personalised nutrition (PN) intervention varied between clusters. Design: Food4Me study participants were clustered according to whether their baseline dietary int...
Article
Populations are aging worldwide. Aging is a complex process that affects the majority of body systems resulting in a gradual loss of function that when significant translates into greater risk for health problems and disability in later life. Thus the overall burden of medical and social care is increasing. It is now widely acknowledged that multid...
Data
Table A. CONSORT 2010 checklist; Table B. TIDieR (Template for Intervention Description and Replication) Checklist; Box A. Description of the Living, Eating, Activity and Planning through retirement (LEAP) intervention; Table C Nutritional intakes before and after interventions. (DOCX)
Data
Protocol for LiveWell pilot RCT. (DOCX)
Article
Full-text available
Background Lifestyle interventions delivered during the retirement transition might promote healthier ageing. We report a pilot randomised controlled trial (RCT) of a web-based platform (Living, Eating, Activity and Planning through retirement; LEAP) promoting healthy eating (based on a Mediterranean diet (MD)), physical activity (PA) and meaningfu...
Article
div class="title">Perceived barriers to healthy eating: a systematic review - Volume 75 Issue OCE3 - J. Lara, V. Yong, J.C. Mathers
Article
div class="title">The association between sarcopenic obesity, metabolic risk and the metabolic syndrome in Northern Italian adults - Volume 75 Issue OCE3 - J. Lara, M. Powell, M. Siervo, A. Batezzati, A. Leone, A. Tagliabue, A. Spadafranca, S. Bertolli
Article
This is the protocol for a review and there is no abstract. The objectives are as follows: In this review we will set out to evaluate the effects of dietary interventions for maintaining cognitive function in cognitively healthy people in late-life.
Article
Full-text available
Background There is no criterion reference for assessing healthy ageing and this creates difficulties when conducting and comparing research on ageing across studies. A cardinal feature of ageing is loss of function which translates into wide-ranging consequences for the individual and for family, carers and society. We undertook comprehensive revi...
Article
To assess (i) understanding, acceptability and preference for two graphical displays of the Mediterranean diet (MD); and (ii) feasibility of a brief MD intervention and cost of adherence to this diet among British older adults. Two studies undertaken at the Human Nutrition Research Centre, Newcastle University are reported. In study-1, preference a...
Article
Ageing is directly associated with visceral fat (VAT) deposition and decline of metabolically active cellular mass, which may determine age-related shifts in substrate oxidation and increased cardiometabolic risk. We tested whether VAT and fasting respiratory quotient (RQ, an index of macronutrient oxidation) changed with age and if they were assoc...
Article
Summary Risk variants of fat mass and obesity-associated (FTO) gene have been associated with increased obesity. However, the evidence for associations between FTO genotype and macronutrient intake has not been reviewed systematically. Our aim was to evaluate the potential associations between FTO genotype and intakes of total energy, fat, carbohyd...
Article
Hypertension is a major contributor to the global burden of cardiovascular diseases and its prevalence increases progressively with ageing. Therefore the identification of effective, age-friendly exercise and nutritional interventions which lower blood pressure (BP) is a research priority. To undertake a pilot RCT examining the efficacy of isometri...
Article
Full-text available
Background: Lifespan and the proportion of older people in the population are increasing, with far reaching consequences for the social, political and economic landscape. Unless accompanied by an increase in health span, increases in age-related diseases will increase the burden on health care resources. Intervention studies to enhance healthy age...
Article
Risk variants of fat mass and obesity-associated (FTO) gene have been associated with increased obesity. However, the evidence for associations between FTO genotype and macronutrient intake has not been reviewed systematically. Our aim was to evaluate the potential associations between FTO genotype and intakes of total energy, fat, carbohydrate and...
Article
Abnormal circadian oscillations of blood pressure (BP) and nocturnal-diurnal BP differences (i.e., dipping) increase cardiovascular risk. Whether inorganic nitrate supplementation influences 24-hr BP variability is currently unknown. We studied the effects of high-nitrate beetroot juice supplementation on BP variability measured by 24-hr ambulatory...
Article
Full-text available
Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different changes in total and resting EE and if (2) they influenced the level of adaptive thermogenesis, defined as the decline in total or resting EE not accounted b...
Article
Full-text available
The aims of this study were to (i) investigate instrumented physical capability (iCap) as a valid method during a large study and (ii) determine whether iCap can provide important additional features of postural control and gait to categorise cohorts not previously possible with manual recordings. Cross-sectional analysis involving instrumented tes...
Article
Randomised controlled trials (RCT) testing the effects of antioxidant supplements on endothelial function (EF) have reported conflicting results. We aimed to investigate the effects of supplementation with antioxidant vitamins C and E on EF and to explore factors that may provide explanations for the inconsistent results. We searched four databases...
Article
Full-text available
Diets rich in inorganic nitrate are associated with lower blood pressure, an effect that may be mediated by an improvement of endothelial function (EF). Therefore, a systematic review and meta-analysis of randomised controlled trials (RCTs) were conducted to examine the effects of inorganic nitrate and beetroot supplementation on measures of EF. ME...
Article
Full-text available
Recent work has identified subdomains (tests) of physical capability that are recommended for assessment of the healthy ageing phenotype (HAP). These include: postural control, locomotion, endurance, repeated sit-to-stand-to-sit and TUG. Current assessment methods lack sensitivity and are error prone due to their lack of consistency and heterogenei...
Article
Global dietary and lifestyle trends are primary risk factors for communicable and non-communicable diseases. An ecological analysis was conducted to examine the association of global dietary and lifestyle patterns with total cholesterol concentrations. This study also investigated whether total cholesterol modified the association between dietary a...
Article
Full-text available
Content, delivery and effects of physical activity (PA) interventions are heterogeneous. There is a need to identify intervention features (content and delivery) related to long-term effectiveness. Behaviour change techniques (BCTs) and modes of intervention delivery were coded in 19 randomised controlled trials included in a systematic review of P...