Jose Lanuza

• PhD on Theoretical Chemistry
• Postdoctoral Researcher at University of Florence

Hen egg-white lysozyme (HEWL) is a small polycationic protein which is highly soluble and stable. This has led to it becoming a `molecular laboratory' where chemical biological operations and structural techniques are tested. To date, HEWL accounts for 1233 PDB entries, roughly 0.5% of the total, making it the best-represented protein in the PDB. W...

The increased bioavailability of aluminum has led to a concern about its toxicity on living systems. Among the most important toxic effects, it has been proven that aluminum increases oxidative stress in biological systems, a controversial fact, however, due to its non-redox nature. In the present work, we characterize in detail how aluminum can al...

The increased bioavailability of aluminum has led to a concern about its toxicity on living systems. Among the most important toxic effects, it has been proven that aluminum increases oxidative stress in biological systems, a controversial fact, however, due to its non-redox nature. In the present work, we characterize in detail how aluminum can al...

This work provides new insights from our team regarding advances in targeting canonical and non-canonical nucleic acid structures. This modality of medical treatment is used as a form of molecular medicine specifically against the growth of cancer cells. Nevertheless, because of increasing concerns about bacterial antibiotic resistance, this medica...

A [Mo7O24]6‐ polyanion is used to catalyze the hydrolysis of a phosphoester bond, although the polyanion is not directly responsible for the catalysis. The real catalyst is produced in situ of the reaction media through the decomposition of the initial polyoxometalate leading to the [Mo2O8H4] dimeric species, which is the real catalytic species. Fo...

Phosphoester hydrolysis is an important chemical step in DNA repair. One archetypal molecular model of phosphoesters is para‐nitrophenylphosphate (pNPP). It has been shown previously that the presence of molecular metal oxide [Mo7O24]⁶⁻ may catalyse the hydrolysis of pNPP through the partial decomposition of polyoxomolybdate framework resulting in...

div>Phosphoester hydrolysis is an important chemical step in DNA repair. One archetypal molecular model of phosphoesters is para-nitrophenylphosphate (pNPP). It has been shown previously that the presence of molecular metal oxide [Mo7O24]6– may catalyse the hydrolysis of pNPP through the partial decomposition of polyoxomolybdate framework resulting...