Jose Guillermo López-Cervantes

• UNIVERSIDAD DE SONORA
• Maestro de Tiempo Completo at University of Sonora

Medical educators consider that clinical exposure should be taught mainly during clinical rotations. Ear�ly clinical exposure teaching strategies such as acti�vities that correlate clinical concepts with basic sub�jects facilitate understanding of these subjects and allow the development of clinical reasoning skills. This study pretends to gener...

Classic non-homeostatic structures involved in food intake regulation are reciprocally influenced by metabolic signals. Orexigenic peptides expressed in the olfactory bulb (OB) and hippocampus (HP) modulate olfactory processing and memory, respectively. Hypothalamic circuits also modulate feeding behavior by activating and releasing Agouti-related...

Objectives: Adaptive immunity is crucial in controlling Giardia lamblia infection in the intestinal mucosa, and some dietary lipids may improve mucosal immune function. The aim of this study was to evaluate conjugated linoleic acid (CLA) on the Th17/Treg response and secretory IgA production in a model of giardiasis infection. Materials and metho...

Purposes: Most molecular-based published studies on breast cancer do not adequately represent the unique and diverse genetic admixture of the Latin American population. Searching for similarities and differences in molecular pathways associated with these tumors and evaluating its impact on prognosis may help to select better therapeutic approaches...

The neurovascular unit, composed of neurons, brain endothelial cells, pericytes, microglia, and astrocytes, regulates cerebral blood flow. The physical and chemical signals govern the physiology of the neurovascular unit within the network composed of its cellular components. Astrocytes have an essential role in this network since they have a privi...

The meninges shield the nervous system from diverse, rather harmful stimuli and pathogens from the periphery. This tissue is composed of brain endothelial cells (BECs) that express diverse ion channels and chemical‐transmitter receptors also expressed by neurons and glial cells to communicate with each other. However, information about the effects...

Exponer la semblanza de mi querido colega, el Dr. Norberto Sotelo Cruz, es al mismo tiempo un ejercicio placentero, por lo destacado de su trayectoria, y triste, porque hemos perdido a un entrañable amigo y a un baluarte de la medicina científica. Toda su vida la desarrolló como un ser humano excepcional, que creó, transformó y construyó una obra d...

Background: Reports in a northwestern Mexico state linked arsenic (As) in drinking water to DNA damage in people from indigenous communities. However, this correlation remains under discussion due to unknown variables related to nutrition, customs, and the potential presence of other metal(oid)s. Methods: To determine this association, we sample...

Recently, soluble forms of aluminum for human use or consumption have been determined to be potentially toxic due to their association with hepatic, neurological, hematological, neoplastic, and bone conditions. This study aims to assess the genotoxic effect of aluminum chloride on genomic instability associated with the onset of N-nitroso-N-methylu...

RESUMEN La fotografía es un recurso visual antiguo utilizado como estrategia para enseñanza. El limitado número de mi-croscopios en un laboratorio, exige motivar al estudiante a través del uso de una cámara digital como herramienta para que realice un atlas de histología; es relevante conocer su opinión sobre tal ejercicio. En este caso, se presen-...

Introduction: Giardia lamblia, a protozoan intestinal parasite is able to evade or suppress defense mechanisms, such as innate response. Antigen presenting cells (APC) like dendritic cells may orchestrate an immune response and support a more effective adaptive defense. Conjugated linoleic acid (CLA), a dietary lipid, has shown biological activity...

105 Presentar la semblanza del Dr. Nor-berto Sotelo es un ejercicio placentero, porque implica describir toda una vida convertida en testimonio de capacidad. Fue un ser humano con ética y moral en mano, que se reflejaron en cada una de sus acciones. Más que relatar la vida productiva de un profesional e investigador como fue el Dr. Sotelo, me refer...

T e LACRN comprises a coalition of research institutions; hospitals (mostly public); basic, translational, and clinical science investigators; and government of cials through bilateral collaborative agreements between the U.S. Department of Health and Human Services and the governments of Argentina, Brazil, Chile, Mexico, and Uruguay. LACRN’s f rst...

Abstract Autoimmune hepatitis (AIH) is a liver disease that runs a course of chronic and progressive inflammation. This occurs in young children and adolescents. AIH can also be manifested in an acute and aggressive form. Its etiology is unknown. Two varieties have been reported. These are autoimmune hepatitis type 1 (AIH-1) and type 2 (AIH-2). AIH...

ABSTRACT PF2 is a lectin from Olneya tesota (Palo fierro) seeds with high affinity towards triantennary tetrasialylated complex carbohydrates. The goal of this study was to localize PF2-interacting glycoconjugates in spleen tissue thin sections, and to purify glycoproteins using PF2 affinity chromatography. Biotinylated PF2 was incubated with thin...

Autoimmune hepatitis (AIH) is a liver disease that runs a course of chronic and progressive inflammation. This occurs in young children and adolescents. AIH can also be manifested in an acute and aggressive form. Its etiology is unknown. Two varieties have been reported. These are autoimmune hepatitis type 1 (AIH-1) and type 2 (AIH-2). AIH-1 affect...

Introduction: The work of a teacher in a medical career should not focus on the domain of medical science but to know well psychophysiological processes that constitute the learning process that influence teaching. The innovation in the use of pedagogical strategies is an important cognitive tool. Methods and Material: In 38 first-year medicine stu...

The word observatory brings to mind an image like whitish rounded domes with telescopes optical and radio-telescopes. It is not intended to give information as to its functioning as such, but to emphasis on what astronomers observe through optical engineering of those artifacts. These scholars of the cosmos, observing could infer many findings, amo...

The Kikuchi-Fujimoto diseases (KFD), also known as histiocytic necrotizing lymphadenitis was described in 1972 by Kikuchi and Fujimoto. Is a rare disease of unknown etiology that involve main cervical lymph nodes, the evolution is benign and self-limited; during pediatrics ages is most frequently in scholars and adolescents, also in young adults. T...

Abstract: Spirotetramat induces histological and biochemical changes in Wistar rats. Spirotetramat, derived from tetramic acid, and commercially known as Movento®, is applied in grapevine orchards and other vegetable for the control of sucking pests. Published in vivo toxicological studies report only a general description of its metabolism. The ob...

The Kikuchi-Fujimoto diseases (KFD), also known as histiocytic necrotizing lymphadenitis was described in 1972 by Kikuchi and Fujimoto. Is a rare disease of unknown etiology that involve main cervical lymph nodes, the evolution is benign and self-limited; during pediatrics ages is most frequently in scholars and adolescents, also in young adults. T...

Spirotetramat, derived from tetramic acid, and commercially known as Movento®, is applied in grapevine orchards and other vegetable for the control of sucking pests. Published in vivo toxicological studies report only a general description of its metabolism. The objective of this study was to detect changes in the behavior, in blood biochemical mar...

Background: Physicians in daily practice frequently attend children who present an increase in lymph node size. Care should be undertaken to determine which children require biopsy. Our objective was to analyze the usefulness of the peripheral lymph node biopsy in pediatric diagnosis. Methods: We reviewed histological reports of 364 lymph node biop...

Resumen Introducción: En niños con ganglios linfáticos superficiales au-mentados de tamaño se debe tener cuidado en definir quién requerirá biopsia. El objetivo de esta investigación fue analizar la utilidad de la biopsia de ganglio linfático superficial en el diag-nóstico pediátrico. Métodos: De los informes histopatológicos de 364 biopsias de niñ...

Physicians in daily practice frequently attend children who present an increase in lymph node size. Care should be taken to determine which children require biopsy. Our objective was to analyze the usefulness of the peripheral lymph node biopsy in pediatric diagnosis. We reviewed histological reports of 364 lymph node biopsies. Variables were age,...

Introduction. Ascariasis is one of the most common infections with the 25% of world prevalence and represent a public problem health in tropical and subtropical areas. Case. A male infant 27-month-old with clinical history of ascariasis, and sudden death. The day of his death he did not throw parasites or round worms. Postmorten examination showed...

RESUMEN: Objetivo. Patología anexial bilateral es muy rara cuando se presentan con sintomatología simultánea, ya que ocasiona problema diagnóstico y quirúrgico. Caso Clínico. Mujer de 26 años con problema inicial de tumor quístico de anexo derecho sin complicaciones, que durante el proceso complementario de estudio, presentó abdomen agudo en forma...

At present, show woman 46-years-old, presented hiperpolimenorrea, pelvis ultrasound appearance with cystic giant mass in the uterine corpus; histopathological revealed a epithelioid leiomyoma with giant cystic degeneration. We considered it is the first reported case of this variant of the epithelioid leiomyoma.

Introduction. Cushing syndrome is associated with high levels of glucocorticoids in the circulation and is infrequently in infants.

Introduction. Cushing syndrome is associated with high levels of glucocorticoids in the circulation and is infrequently in infants. Case report. We present a case of congenital cortical adrenal adenoma-associated endogenous hypercortisolism in a 3-month-old infant. The patient manifested polyphagia, weight gain, and changes in sleep patterns. Durin...

EL EMBARAZO ECTÓPICO DE LOCALIZACIÓN EN EL OVARIO (EEO) SE PRESENTA EN 1:7000-40000 EMBARAZOS Y CORRESPONDE AL 0.5% Y 6% DE LOS EMBARAZOS ECTÓPICOS EN GENERAL. EN LA ACTUALIDAD EL DIAGNÓSTICO TEMPRANO PERMITE UTILIZAR LAPAROSCOPIA QUIRÚRGICA CON EXCELENTES PRONÓSTICOS: MENOR ESTANCIA HOSPITALARIA, RECUPERACIÓN POSOPERATORIA TEMPRANA, MENOR FORMACIÓ...

Objetivo. En este informe se revisan los expedientes clínicos para examinar los hallazgos relacionados con la biopsia practicada en los niños hospitalizados con problemas hepáticos. Material y métodos. Retrospectivamente revisamos los resultados histológicos de tejidos obtenidos por biopsia hepática en 63 niños durante los últimos 17 años. Se obtuv...

There is no awareness about celiac disease (CD) in Mexico. A 2.9 year old mestizo boy was admitted to a Mexican hospital with muscle cramps and fine tremors. He suffered chronic diarrhea, abdominal distention, hypotrophic limbs, stunting and wasting, and presented hypocalcemia, anemia and high titers of serological markers. Diagnosis of CD was conf...

Introduction. There is a new definition in Sudden Infant Death Syndrome (SIDS): “Is the sudden death of an infant under 1 year of age in wich there is no explained cause of death after a thorough case investigation including clinical record, auptopsy and death scene”. Objective. The present study was made to determine SIDS in Hermosillo, Sonora, Me...

Mice fed genetically modified (GM) soybean were not affected in nutritional performance, but pancreatic microscopic features were disturbed. The mechanisms for these contradictory findings are unknown. This study analysed the histology of acinar pancreatic cells and the expression of pancreatitis-associated protein (PAP) and trypsinogen mRNA in rat...

We present the first case of Aneurysm of the Ductus Arteriosus that it was found in autopsy in the Hospital Infantil del Estado de Sonora. This anomaly has been reported more frequent in new born and infant. Its importance in the diagnoses is debut to fatales potentially complications of the cardiovascular system. The clinical diagnostic more frequ...

We present the first case of left juxtaposition of the right atrial appendages that has been seen at the Children's Hospital of the state of Sonora. This anomaly was associated with a complex congenital heart defect, i.e. absence of the right atrioventricular connection and transposition of the great arteries. The two-dimensional echocardiogram is...

To study the histological and pancreatitis-associated protein mRNA accumulation changes of pancreas from acute phase of caerulin-induced pancreatitis to recuperation in rats. Acute pancreatitis was induced by caerulein in male Wistar rats and followed up for 90 d by histological and mRNA analyses of pancreas. Pancreases were dissected at 0, 9, 24 h...

Autoimmune type chronic active hepatitis (AI-CAH) is a rare pediatric disorder whose principal characteristics include hepatocellular dysfunction and active tissue damage with evolution to cirrhosis in 25-30% of cases. Our aim was to ascertain the evolution of 23 children with AI-CAH treated between 1978 and 2004 at the Hospital Infantil del Estado...

We report two cases of infants who presented seizures and persistent hypoglycemia. In both infants, we established diagnosis of persistent hypoglycemia by hyperinsulinism (PHH); glycemic/insulinic ratio was > 0.3, and we found no pancreatic changes by means of other diagnostic procedures. The medical treatment consisted of hydrocortisone, diazoxide...

Several studies suggested that branched-chain amino acids (BCAA) improve plasma amino acid imbalance as well as protein metabolism in patients with cirrhosis. However, commercial formulas supplemented with free BCAA have their limitations. We evaluated a modified soy protein diet with covalently bound BCAA (diet M) by comparing it with diets based...

The following letter comments on the excellent article by van Amerongen et al. (1), “Severe hypernatremic dehydration and death in a breast-fed infant,” and shows our experience on this topic.

A 33 year-old man developed coccidioidomycosis which resulted in pericarditis associated with congestive heart failure. A pericardial effusion developed and progressed to constrictive pericarditis. A pericardiectomy was performed and revealed that the pericarditis was due to Coccidioides immitis. The patient died after surgery. This is the second c...

Ectopic pregnancy (EP), is the consequence of an abnormal implantation of the blastocyste. EP is frequently located in the tubal (95-98%); and is located in the ovary, 0.5-1%. It is presented the clinical pathological case of a 29 year-old woman, who showed acute abdominal symptoms at her arrival to emergency room. This diagnostic case made fulfill...

Polyclonal anti-BADH serum was raised in rabbits against native BADH purified from porcine kidney. The antiserum cross-reacted strongly with BADH purified from kidney, Amaranthus palmierii, and Pseudomona aeuroginosa (1:1000), and weakly with Amaranthus hypochondriacus L (1:100). Antibodies bound to purified native kidney BADH in immunoblots showed...

There were reviewed 145 cases of children in which hepatic biopsy was done at the Hospital Infantil del Estado de Sonora, from 1978 to 1990. The larger age group were infants and preschool children (74.3 percent) males being predominant; signs and symptoms were related with hepatic illness, as well as the admission diagnoses. The indication of biop...

The authors describe the results of five pediatric patients with nonmetastatic osteosarcoma of an extremity, admitted from 1987 to 1989 to the Hospital Infantil del Estado de Sonora. Four patients presented with their primary tumor located at the distal end of the femur, whereas one had a primary lesion of the humerus. All of them received preopera...

The case of a 3 month old child with severe combined sex linked immunodeficiency is presented. The diagnosis was well doccumented, during his life. The child presented as a case of mucocutaneous moniliasis resistant to treatment. There was a history of similar cases in the family; diagnosis was made at post-mortem in one cousin and death occurred a...

RESUMEN Introducción. La cardiopatía tronco arterioso variedad tipo I es un malformación poco frecuente. Esta malformación consis-te en la emergencia de un solo vaso del corazón y lleva circulación sistémica, pulmonar y coronaria. Material y Métodos. Del archivo clínico se obtuvo el expediente de cada uno de los casos de estudio. Se revisaron varia...