Jose Gongora

Jose Gongora
Universidad Autónoma de Yucatán | UADY · Faculty of Medicine

MD, PhD

About

62
Publications
35,066
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874
Citations
Citations since 2017
17 Research Items
319 Citations
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Introduction
Jose Gongora currently works as a research scientist at the Regional Research Center "Dr. Hideyo Noguchi" and as Pharmacology Professor at the Faculty of Medicine, both at the Universidad Autónoma de Yucatán, Mexico. Jose does research in Neuroscience. His main interest is the study of probiotics and various nutraceuticals as neuroprotectants and treatments for Parkinsons disease and other neurodegenerative disorders.
Additional affiliations
January 1990 - present
Universidad Autónoma de Yucatán
Position
  • Senior Researcher

Publications

Publications (62)
Article
Estudios sobre el consumo de polifenoles (PF) en mexicanos, incluyendo profesionales de la salud, son escasos. El objetivo fue determinar el consumo total y subtipo de PF en egresados de la Licenciatura en Nutrición de una universidad pública del sureste de México. Se utilizó un recordatorio de 24 horas (RD-24) como instrumento de recolección de da...
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Full-text available
It is now well recognized that a bidirectional relationship between gut microbiota and the brain, referred to as the gut-brain axis, plays a prominent role in maintaining homeostasis and that a disruption in this axis can result in neuroinflammatory response and neurological disorders such as Parkinson’s disease (PD). The protective action of probi...
Article
Gut dysbiosis is considered a risk factor for Parkinson’s disease (PD), and chronic treatment with probiotics could prevent it. Here we report the assessment of a probiotic mixture [Lacticaseibacillus rhamnosus GG (LGG), and Bifidobacterium animalis lactis BB-12 (BB-12)] administered to male rats 2 weeks before and 3 weeks after injecting 6-hydroxy...
Article
The suprachiasmatic nucleus (SCN) is the most important circadian clock in mammals. The SCN synchronizes to environmental light via the retinohypothalamic tract (RHT), which is an axon cluster derived from melanopsin‐expressing intrinsic photosensitive retinal ganglion cells. Investigations on the development of the non‐image‐forming pathway and th...
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Objective: To assess whether depression and quality of life scores correlate with glycosylated hemoglobin A (HbA1c) levels in type 2 diabetes mellitus (T2DM) patients of predominant Mayan ethnicity, from a rural community in the state of Yucatán, Mexico. Materials and methods: Instruments: for depression, CES-D (cutoff ≥ 16); for quality of life, D...
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Objective: The objective of the study is to identify the risk and protective factors associated with Parkinson’s disease (PD) in inhabitants of Yucatan. Methods: Case control study. A questionnaire with the main risk and protective factors for PD described in the literature was applied to cases and controls. Results: The sample consisted of 85 case...
Article
The suprachiasmatic nucleus (SCN) of the hypothalamus is the brain structure that controls circadian rhythms in mammals. The SCN is formed by two neuroanatomical regions: the ventral and dorsal. Gamma-aminobutyric acid (GABA) neurotransmission is important for the regulation of circadian rhythms. Excitatory GABA effects have been described in both...
Article
The hypothalamic suprachiasmatic nucleus (SCN) is the leading circadian pacemaker in mammals, which synchronizes with environmental light through the retinohypothalamic tract (RHT). Although the SCN regulates circadian rhythms before birth, postnatal synaptic changes are needed for the RHT‐SCN pathway to achieve total functional development. Howeve...
Article
Blueberries (BB) are rich in antioxidant polyphenols, and their intake could prevent Parkinson’s disease (PD). Here we assessed whether rats chronically fed dried raw BB develop resistance to dopaminergic denervation and motor disorders caused by unilateral intrastriatal injection of 6-hydroxydopamine (6-OHDA), a dopaminergic neurotoxin acting main...
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El cerebro humano es uno de los órganos más complejos del organismo y es el controlador maestro del sistema nervioso que inerva todos los órganos para regular el funcionamiento de los demás sistemas, entre los que figura el aparato digestivo, el cual posee un sistema nervioso local constituido por una red neuronal cuya actividad es regulada por fib...
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La enfermedad de Parkinson (EP) es un trastorno neurodegenerativo progresivo e incurable, que afecta con mayor frecuencia a personas de edad avanzada. Su diagnóstico es clínico y se basa en la aparición de varios síntomas motores como: temblor en reposo, bradicinesia, rigidez muscular e inestabilidad postural. Sin embargo, en las últimas décadas se...
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Introducción: Numerosos estudios epidemiológicos indican que la enfermedad de Parkinson (EP) resulta de una interacción compleja entre diversos factores, algunos de los cuales confieren riesgo y otros protección. Sin embargo, cuando se analiza a fondo el diseño metodológico de cada estudio, se descubre que muchos no controlaron diversos factores de...
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RationaleWe have previously shown that in rats, capsaicin (Cap) has antidepressant-like properties when assessed using the forced swimming test (FST) and that a sub-threshold dose of amitriptyline potentiates the effects of Cap. However, synergistic antidepressant-like effects of the joint administration of Cap and the selective serotonin reuptake...
Article
Serotonin modulates cognitive processes and is related to various psychiatric disorders, including major depression. Administration of citalopram reduces the amplitude of auditory evoked potentials in depressed people and animal models, suggesting that 5-HT has an inhibitory role. Here, we characterize the modulation of excitatory post-synaptic cur...
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El diagnóstico de la enfermedad de Parkinson (EP) se basa en la presencia obligatoria de bradicinesia y al menos uno de los siguientes síntomas: rigidez muscular, temblor en reposo, o inestabilidad postural. Se ha estimado que la duración promedio de la fase prodrómica de la EP es de 10 años antes de su diagnóstico. En la fase prodrómica pueden pre...
Chapter
Prospective studies of large human cohorts agree that prolonged consumption of caffeinated beverages attenuates cognitive decline during aging. A study in rats treated with caffeine at doses similar to habitual human consumption (5mg/kg/day for 6 months) followed by a withdrawal period of 2 weeks found a lower decline of nonassociative and working...
Article
Continuous spontaneous alternation behavior (SAB) in a Y-maze is used for evaluating working memory in rodents. Here, the design of an automated Y-maze equipped with three infrared optocouplers per arm, and commanded by a reduced instruction set computer (RISC) microcontroller is described. The software was devised for recording only true entries a...
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Abstract Background: The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. The reduction of BDNF expression in Parkinson’s disease substantia nigra (SN) might contribute to the death of dopaminergic neurons because inhibiting BDNF expression in the SN causes parkinso...
Chapter
During the aging process, people frequently experience a progressive deterioration in several areas of brain function, such as the ability to acquire new knowledge and recall it. When this functional decline expands enough to significantly interfere with the personal, social, or professional activities of the individual, and yet he or she is still...
Article
In order to test the influence of the sympathetic nervous system on Leishmania mexicana infection, groups of female BALB/c mice were treated (i.p.) with the non-selective β-adrenergic receptor (β-AR) antagonist (S)-propranolol (5 mg/kg thrice a day), the β2-AR agonist clenbuterol (1 mg/kg once a day) or the α2-AR antagonist yohimbine (2 mg/kg twice...
Article
Extrapyramidal syndromes (EPS) caused by antipsychotic therapy are currently treated with anticholinergics that lack selectivity for the five muscarinic receptor subtypes. Since these receptors are heterogeneously expressed among the different classes of striatal neurons and their afferents, it can be expected that their simultaneous blockade will...
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En este capítulo se describen los mecanismos generales de acción de los medicamentos. Forma parte de un libro de texto dirigido a estudiantes de Licenciatura y Postgrado del área de Ciencias de la Salud (Medicina, Enfermería, Odontología).
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En este capítulo se describen diferentes clases de interacciones farmacocinéticas y farmacodinámicas que pueden ocurrir cuando se administran simultáneamente dos o más medicamentos. Forma parte de un libro de texto dirigido a estudiantes de Licenciatura y Postgrado del área de Ciencias de la Salud (Medicina, Enfermería, Odontología).
Article
The sensitivity of immobility time (IT) to antidepressant-drugs differs in rats expressing high or low motor activity during the forced swimming test (FST). However, whether this heterogeneity is expressed after the administration of the most selective serotonin and norepinephrine reuptake inhibitors (SSRIs and SNRIs, respectively) is unknown. We c...
Article
In order to assess whether caffeine and theophylline have the same potency and efficacy to reverse the impairment of motor function caused by acute or chronic interruption of striatal dopamine transmission, a comparison of their dose-response relationship was made in the acute model of haloperidol-induced catalepsy, and the chronic model of unilate...
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We describe the design and evaluation of an electronic system for the automatic recording of motor activity in rats. The device continually locates the position of a rat inside a transparent acrylic cube (50 cm/side) with infrared sensors arranged on its walls so as to correspond to the x-, y-, and z-axes. The system is governed by two microcontrol...
Article
Chronic caffeine consumption has been inversely associated with the risk of developing dementia and Alzheimer's disease. Here we assessed whether chronic caffeine treatment prevents the behavioral and cognitive decline that male Wistar rats experience from young (≈3 months) to middle age (≈10 months). When animals were young they were evaluated at...
Article
Anatomical and functional studies have shown that the NADPH-diaphorase-positive cholinergic neurons of the pedunculopontine nucleus (PPN) send projections to several areas in the brain. The purpose of this work was to investigate whether bilateral lesions with quinolinic acid, a neurotoxin with greater selectivity for NADPH-diaphorase-positive neur...
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We have evaluated the use of silica-dopamine reservoirs synthesized by the sol-gel approach with the aim of using them in the treatment of Parkinson's disease, specifically as a device for the controlled release of dopamine in the striatum. Theoretical calculations illustrate that dopamine is expected to assume a planar structure and exhibit weak i...
Article
Extrapyramidal syndromes (EPS) impose a heavy burden on patients receiving antipsychotic therapy. Anticholinergics are the drugs of choice for preventing EPS, but they also produce many adverse reactions. Using the EPS model of haloperidol-induced catalepsy we evaluated the potential therapeutic value of a mixture of low doses of the non-selective...
Article
Chronic treatment with the non-selective adenosine receptor antagonist caffeine produces full recovery of the contralateral adjusting steps in hemiparkinsonian rats. In order to disclose which adenosine receptor subtype mediates this effect, a group of hemiparkinsonian rats (n=9) was treated with caffeine (5.15 mumol/kg/day), or equimolar doses of...
Article
Full-text available
Prospective epidemiologic studies performed in large cohorts of men (total = 374,003 subjects) agree in which the risk of suffering Parkinson’s disease diminishes progressively as the consumption of coffee and other caffeinated beverages increases. In the case of women (total = 345,184 subjects) the protective effect of caffeine is only observed in...
Article
Full-text available
Introduction and development: Prospective epidemiologic studies performed in large cohorts of men (total: 374,003 subjects) agree in which the risk of suffering Parkinson's disease diminishes progressively as the consumption of coffee and other caffeinated beverages increases. In the case of women (total: 345,184 subjects) the protective effect of...
Article
Chronic caffeine consumption has been inversely associated with the risk of developing Parkinson's disease. Here we assessed whether chronic caffeine treatment increases the resistance of male Wistar rats to haloperidol (1 mg/kg, s.c.)-induced catalepsy, measured in the bar test at 15 min intervals during 3 h. Caffeine (5 mg/kg/day) was delivered f...
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This article describes the design and preliminary evaluation of a small-sized and low energy consumption wearable wireless telemetry system for the recording of extracellular neuronal activity, with the possibility of selecting one of four channels. The system comprises four radio frequency (RF) transceivers, three microcontrollers, and a digital a...
Article
The interaction of caffeine (1 mg/kg) and amitriptyline (15 mg/kg) on the immobility time (IT) during Porsolt's forced swimming test (FST) was investigated in female Wistar rats. Akaike's Information Criterion indicated that the ITs recorded from 142 rats during the first day of the FST followed a bimodal distribution. Hence, the median (125.5 s) w...
Article
The effects of chronic oral treatment with low doses of caffeine (1-3 mg/kg) and trihexyphenidyl (0.1-0.2 mg/kg) were tested on hemiparkinsonian rats, which received the following treatments in a counterbalanced order: vehicle, caffeine, trihexyphenidyl, and caffeine plus trihexyphenidyl. Three preclinical models were used: the stepping test, the c...
Chapter
Full-text available
Pyramidal neurons in the sensory-motor cortex express multiple types of metabotropic receptors. Simultaneous application of serotonin (5-HT) and GABAB agonists produces a reduction of the neurotransmitter release probability throughout the activation of the GABAB and 5-HT1A receptors. Since some of these receptors may be coexpressed in a set of neu...
Article
Catalepsy tests performed in rodents treated with drugs that interfere with dopaminergic transmission have been widely used for the screening of drugs with therapeutic potential in the treatment of Parkinson's disease. The basic method for measuring catalepsy intensity is the "standard" bar test. We present here an easy to use microcontroller-based...
Article
Full-text available
La enfermedad de Parkinson ocupa el segundo lugar entre las enfermedades degenerativas del sistema nervioso, que afligen con mayor frecuencia a las personas de edad avanzada. En México, la Secretaría de Salud ha incorporado a la enfermedad de Parkinson dentro del programa 2001-2006 de Acción en Salud Mental ya que representa una causa importante de...
Article
Activation of gamma-aminobutyric acid B (GABA(B)) and 5-hydroxytryptamine (5-HT) receptors produces presynaptic inhibition at glutamatergic terminals in the rat neocortex. To evaluate interactions between these metabotropic receptors, field potentials were recorded in layer 2/3 of somatosensory cortex. In addition, the paired pulse (PP) protocol wa...
Article
Trihexyphenidyl (THP) is a drug commonly used to reduce parkinsonian symptoms. An important side effect of this agent is memory impairment. Since caffeine enhances the potency of THP to inhibit haloperidol-induced catalepsy, caffeine may be used as an adjuvant of lower doses of THP, in order to improve its antiparkinsonian effects without causing m...
Article
The possible synergism between caffeine and muscarinic antagonists to inhibit haloperidol-induced catalepsy was investigated with the bar test in rats. Pretreatment with low doses of caffeine (1-3 mg/kg), a non-selective adenosine antagonist, dose dependently reduced the intensity and increased the onset latency of catalepsy induced by haloperidol...
Article
In rats made cataleptic with haloperidol (5.32 micromol/kg), the bar test was used to assess the possible synergism between the muscarinic antagonist trihexyphenidyl (THP) and selective adenosine A(1) and A(2A) receptor antagonists. Neither catalepsy intensity nor latency were affected by a subthreshold dose of THP (0.33 micromol/kg). The selective...
Article
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A new, low-cost rotometer, based on a reduced instruction set computer (RISC) microcontroller, is presented. Like earlier devices, it counts the number and direction of full turns for predetermined time periods during the evaluation of turning behavior induced by drug administration in rats. The present stand-alone system includes a nonvolatile mem...
Article
The nigrostriatal dopaminergic neurons of the substantia nigra pars compacta (SNc) and the nondopaminergic neurons of the substantia nigra pars reticulata (SNr) receive a dense synaptic input from the serotonergic neurons of the raphe nuclei. To assess whether serotonin [5-hydroxytryptamine (5-HT)] spontaneously released at the substantia nigra cou...
Article
We investigated whether the infection with Trypanosoma cruzi in rats could produce functional alterations of the central nervous system. The experimental group received an injection of 150,000 trypomastigotes / rat, whereas the control group received a saline injection. Spontaneous alternation behavior (SAB) tests and sleep-wake cycle recordings we...
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Full-text available
Introducción. La Revista Biomédica celebró su décimo aniversario en 1999 con la publicación del número 4 del volumen 10. En este trabajo se presenta un análisis del contenido de la revista hasta ese número, así como un resumen de las opiniones de una muestra de sus lectores. Material y Métodos. Las opiniones de los lectores y los bibliotecarios fue...
Article
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El presente trabajo trata sobre los fundamentos de las patentes y su relevancia en la investigación biomédica. Se describe su origen en el contexto de la protección de la propiedad intelectual; se aclaran los términos técnicos pertinentes y se describe el procedimiento de trámite que para el efecto se sigue en México. Asimismo, se hacen algunas ref...
Article
Unitary extracellular recordings were made in in vitro rat brain slices to explore the effects of serotoninergic analogues on the spontaneous activity of substantia nigra reticulata (SNr) neurons. Most SNr neurons exhibited regular spontaneous firing (23.4 +/- 8.9 Hz, mean +/- S.E.M., n = 30) similar to that found in vivo. The most reproducible eff...
Article
We studied the interactions between glutamate and dopamine in the pars reticulata of the substantia nigra by using microdialysis in unanaesthetized rats. Increased extracellular levels of glutamate in the pars reticulata were obtained by microinjecting the muscarinic agonist carbachol into the ipsilateral subthalamic nucleus. The increase of glutam...
Article
Full-text available
We present the design of a voltage pulse generator controlled by an IBM or compatible AT Personal Computer (PC) capable of synthesizing some of the voltage pulse wave forms commonly used in electrochemical studies. The included signals are: differential pulse voltametry, differential normal pulse voltametry, and differential pulse amperometry. Addi...
Article
The influence of cholinergic transmission within the substantia nigra pars compacta on circling behavior was assessed in male rats. Microinjection of physostigmine (6-37 nmol) into the caudal part of the substantia nigra pars compacta elicited a dose-dependent contralateral circling. The circling was inhibited 93 +/- 3% by the dopamine antagonist h...
Article
Full-text available
Effect of ß-adrenergic blockers on survival, parasitemia and parasitic load of the heart of mice during the acute phase of Trypanosoma cruzi infection. the survival of infected mice compared with animals treated with saline. Neither DL-propranolol nor timolol treatments modified the time-course of parasitemia. Analysis of heart sections revealed th...
Article
Turning in circles is among the behaviors elicited by unilateral cholinergic stimulation of the substantia nigra. Recent studies have shown that microinjection of cholinergic agonists into the substantia nigra pars compacta increases dopamine release and turnover in the striatum of anesthetized rats [Hernández-López et al. (1992) Brain. Res. 598, 1...
Article
3,4-Dihydroxyphenylacetic acid (DOPAC) and ascorbic acid (AA) were measured by differential pulse voltammetry in the neostriatum of anesthetized rats. Physostigmine (2.3 nmol) applied into the substantia nigra pars compacta (SNc), increased DOPAC concentration in the ipsilateral neostriatum, but did not modify AA levels. The largest increase of str...
Article
We have studied the characteristics associated with the activation of the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor on the release of dopamine (DA) in the striatum of awake rats as measured by brain microdialysis technique. NMDA dose-dependently stimulated the striatal DA release in Mg(2+)-free Ringer's solution. The stimulation...
Article
3,4-dihydroxyphenylacetic acid (DOPAC) was measured by differential pulse voltammetry in the neostriatum of anesthetized rats. DL-Muscarine (2.9 nmol) applied into the substantia nigra pars compacta, increased DOPAC concentration in the ipsilateral neostriatum. This effect was blocked by pirenzepine (2.8 nmol), and potentiated by AF-DX 116 (2.8 nmo...
Article
The reversible acetylcholinesterase inhibitor, physostigmine, stimulated in a dose-dependent manner the accumulation of [3H]inositol monophosphate ([3H]IP1) in lithium-treated neostriatal slices. The muscarinic agonists, carbachol and oxotremorine, also stimulated [3H]IP1 accumulation. Atropine completely blocked the physostigmine-induced accumulat...

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