Jose I Emparanza

Jose I Emparanza
University Hospital Donostia · Clinical Epidemiology and Research

MD, PhD

About

278
Publications
38,900
Reads
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4,609
Citations
Citations since 2016
47 Research Items
2074 Citations
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2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
2016201720182019202020212022050100150200250300
Additional affiliations
February 1991 - present
University Hospital Donostia
Position
  • Head of Dept Clinical Epidemiology and Research

Publications

Publications (278)
Article
Full-text available
Healthcare workers (HCW) are at high risk for suicide, yet little is known about the onset of suicidal thoughts and behaviors (STB) in this important segment of the population in conjunction with the COVID-19 pandemic. We conducted a multicenter, prospective cohort study of Spanish HCW active during the COVID-9 pandemic. A total of n = 4809 HCW par...
Article
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The therapeutic approach is crucial to prostate cancer prognosis. We describe treatments and outcomes for a Spanish cohort of patients with prostate cancer during the first 12months after diagnosis and identify the factors that influenced the treatment they received. This multicenter prospective cohort study included patients with prostate cancer f...
Article
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Background Healthcare workers are a key occupational group at risk for suicidal thoughts and behaviors (STB). We investigated the prevalence and correlates of STB among hospital workers during the first wave of the Spain COVID‐19 outbreak (March–July 2020). Methods Data come from the baseline assessment of a cohort of Spanish hospital workers (n =...
Article
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Introduction Healthcare workers are vulnerable to adverse mental health impacts of the COVID-19 pandemic. We assessed prevalence of mental disorders and associated factors during the first wave of the pandemic among healthcare professionals in Spain. Methods All workers in 18 healthcare institutions (6 AACC) in Spain were invited to web-based surv...
Article
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Introduction and objectives: We aimed to study the liver iron concentration in patients referred for hyperferritinemia to six hospitals in the Basque Country and to determine if there were differences between patients with or without metabolic syndrome. Patients and methods: Metabolic syndrome was defined by accepted criteria. Liver iron concent...
Conference Paper
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Aims: Liver steatosis is often suspected in patients with hyperferritinemia. To study the BMI and alcohol consume of patients referred for HF to 6 hospitals in the Basque country, Spain. To study the prevalence of hepatic steatosis determined by MRI in these patients. Methods: A prospective study of 312 consecutive with HF (>200 μg/L women; 300 μg/...
Conference Paper
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Aims: To study the cases of DIOS in a cohort of patients with hyperferritinemia and to determine its relationship with mutations of the HFE gene and with liver steatosis (LS). Methods: A prospective study of consecutive patients with HF was conducted from December 2010 to April 2013. DIOS was diagnosed when LIC >36, one or more MtS criteria or BMI...
Article
Introduction Recent studies provided evidence that patients with myotonic dystrophy (DM) are at excess risk of cancer. However, inconsistencies regarding affected anatomic sites persist. Methods We performed a meta‐analysis of cancer risk in DM, searching studies published between January 1, 1990 and December 31, 2016. Eligible studies were full r...
Article
Background: Evidence-based clinical practice guidelines provide recommendations to assist clinicians in decision-making and to reduce the gap between best current research evidence and clinical practice. However, some argue that providing pre-appraised evidence summaries alone, rather than recommendations, is more appropriate. Objectives: To eva...
Article
Objectives: To assess the impact of a history of liver metastases on survival in patients undergoing surgery for lung metastases from colorectal carcinoma. Methods: We reviewed recent studies identified by searching MEDLINE and EMBASE using the Ovid interface, with the following search terms: lung metastasectomy, pulmonary metastasectomy, lung m...
Article
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Background: The implementation of evidence-based clinical practice guidelines (CPG) can improve patients care. To date, the impact of implementation strategies has not been evaluated in our context. This study is aimed to evaluate the effectiveness of a multifaceted tailored intervention targeting clinician education for the implementation of thre...
Article
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Introduction Glioblastoma is the most common primary brain tumour. Despite advances in treatment, its prognosis remains dismal, with a mean survival time of about 14 months. Many articles have addressed direct costs, those associated with the diagnosis and treatment of the disease. Indirect costs, those associated with loss of productivity due to t...
Article
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Objective We performed a cohort study in seven hospitals in Spain to determine the clinical characteristics of incident patients with bladder cancer, the diagnostic process, and the conditions that might affect health care interval times. Results314 patients with bladder cancer were included, 70.3 (Standard Deviation [SD] 11.2) years old and 85.0%...
Article
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Objective: : To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung metastases. Methods: : We conducted a review of literature published from 2007 to 2014. The studies were identified by searching PubMed, MEDLINE, and Embase and were supplemented by a manual search of the references...
Conference Paper
Full-text available
Background and Aims: Approximately 25% of adult population in western countries have metabolic syndrome (MS). Hyperferritinemia (HF) is frequently present in patients with MS (dysmetabolic hyperferritinemia). Liver steatosis is often suspected in patients with MS. To study the prevalence of the MS in patients referred for HF to 6 hospitals in the B...
Conference Paper
Full-text available
Background and Aims: Aproximately 25% of adult population in western countries have metabolic syndrome (MS). Hyperferritinemia (HF) is frequently present in patients with MS (dysmetabolic hyperferritinemia). There are some publications that support that HF is associated with a raised liver iron concentration (LIC) in these patients, but some doubts...
Article
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Background: Olynyk et al. studied the liver iron concentration (LIC) by MRI of 52 consecutive patients of northern European origin who were referred to a tertiary hospital for hyperferritinemia (HF). They described three groups according to HFE mutations and the transferrin saturation index (TSI) (group A: no predisposing mutations (PM) for heredit...
Article
Background Oxygen (O2) is widely used in people with acute myocardial infarction (AMI). Previous systematic reviews concluded that there was insufficient evidence to know whether oxygen reduced, increased or had no effect on heart ischaemia or infarct size. Our first Cochrane review in 2010 also concluded there was insufficient evidence to know whe...
Article
Background: Previous reports suggest that small airway dysfunction (SAD) is associated with poor asthma control. Objective: To determine the usefulness of the study of the SAD in assessing asthma control. Methods: A cross-sectional study was performed in children aged between 6-15 years old diagnosed with moderate asthma and FEV1 >80% at the time o...
Article
Objective: Describe the incidence of cancer in a large cohort of patients with myotonic dystrophy type 1 (DM1) and to unravel the underlying molecular mechanisms. Methods: Standardized incidence ratios (SIRs) were calculated in the Gipuzkoa DM1 cohort (1985-2013), dividing observed numbers by expected numbers for all cancers combined and stratif...
Article
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Material and methods: We conducted a prospective study of 132 consecutive patients with HF from January to December 2010. The MS was defined by the International Diabetes Federation criteria (2005). LIC was determined by Magnetic resonance imaging (MRI). Results: The number of patients for which there was enough data to determine MS was 97, out...
Article
Background: Obesity is the major trigger of nonalcoholic fatty liver disease (NAFLD). NAFLD is further favored by the patatin-like phospholipase domain-containing 3 (PNPLA3) p.I148M, transmembrane 6 superfamily member 2 (TM6SF2) p.E167K, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738 variants. Objectives: To investiga...
Article
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Introducción: El glioblastoma es el tumor cerebral más frecuente. A pesar de los avances en su tratamiento, el pronóstico sigue siendo pobre, con una supervivencia media en torno a los 14 meses. Los costes directos, aquellos asociados al diagnóstico y el tratamiento de la enfermedad, han sido descritos ampliamente. Los costes indirectos, aquellos d...
Article
Objectives: To examine the intra-observer reliability and agreement between five methods of measurement for dorsiflexion during Weight Bearing Dorsiflexion Lunge Test and to assess the degree of agreement between three methods in female athletes. Design: Repeated measurements study design. Setting: Volleyball club. Participants: Twenty-five...
Research
Full-text available
To summarize the evidence from systematic reviews on the efficacy of mindfulness. PICO question: • Participants. Individuals affected by conditions for which mindfulness is employed as a therapy. • Intervention. Mindfulness as defined above. • Control. We intend to include whichever controls are considered in the systematic reviews employed, includ...
Article
Objective: To describe the development of a novel on-line database aimed to serve as a source of information concerning healthcare interventions appraised for their clinical value and appropriateness by several initiatives worldwide, and to present a retrospective analysis of the appraisals already included in the database. Methods and findings:...
Data
Excel spreadsheet obtained when selecting Vascular Surgery in the field of medical speciality (n = 73 appraisals). (XLSX)
Article
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Background: Many new clinical prediction rules are derived and validated. But the design and reporting quality of clinical prediction research has been less than optimal. We aimed to assess whether design characteristics of validation studies were associated with the overestimation of clinical prediction rules' performance. We also aimed to evalua...
Data
Systematic reviews of clinical prediction rule studies included in analysis. (PDF)
Data
Search strategies for systematic reviews of clinical prediction rule studies. (PDF)
Data
Dataset for multivariable model. (XLSX)
Data
Flow diagram. Selection of (a) systematic reviews and (b) validation studies. (PDF)
Data
Univariable analysis. Influence of design characteristics on the performance of clinical prediction rule. (PDF)
Article
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Introduction: The calculation of exertion intensity, in which a change is produced in the metabolic processes which provide the energy to maintain physical work, has been defined as the Anaerobic Threshold. The direct calculation of MLSS would require exertion intensities over a long period of time and with sufficient rest periods which would prov...
Article
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Rationale, aims and objectives: Evidence-based practice (EBP) is widely promoted, but does EBP produce better patient outcomes? We report a natural experiment when part of the internal medicine service in a hospital was reorganized in 2003 to form an EBP unit, the rest of the service remaining unchanged. The units attended similar patients until 2...
Article
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Las enfermedades cardiovasculares son las más prevalentes en la sociedad occidental. En las últimas décadas, innumerables publicaciones informan del poder terapéutico del ejercicio físico (EF) en estas patologías. El objetivo de este trabajo ha sido buscar, valorar y resumir los resultados de las mejores pruebas científicas publicadas, sobre el efe...
Article
Background: Previous reports suggest that small airway dysfunction (SAD) is associated with asthma control. Objective: To determine the usefulness of the study of the SAD in assessing asthma control in children. Methods: A cross-sectional study was performed in children aged between 6-15 years old diagnosed with persistent asthma (GINA 2014) and FE...
Article
Full-text available
Little is known about the healthcare process for patients with prostate cancer, mainly because hospital-based data are not routinely published. The main objective of this study was to determine the clinical characteristics of prostate cancer patients, the, diagnostic process and the factors that might influence intervals from consultation to diagno...
Article
Full-text available
There are limited data on clinical and phenotypic characteristics of outpatients referred for hyperferritinemia (HF). To determine the causes of HF in outpatients referred to a secondary hospital. A prospective study of 132 consecutive patients with HF (> 200 μg/L, women; > 300 μg/L, men) was conducted from January-December 2010. Mean age, 54.42 ye...
Article
Full-text available
A cohort study of patients included in the Basque Country colorectal cancer (CRC) screening programme was carried out to assess the risk of adenomatous polyps and CRC (P-CRC) associated with HFE gene mutations, with gender and with iron biomarkers (serum ferritin (SF), iron (Fe) and transferrin saturation index (TSI)). Among 432 included patients (...
Article
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Purpose: The objectives were (i) construction of a phantom to reproduce the behavior of iron overload in the liver by MRI and (ii) assessment of the variability of a previously validated method to quantify liver iron concentration between different MRI devices using the phantom and patients. Materials and methods: A phantom reproducing the liver...
Article
An abdominal aortic aneurysm (AAA) is a pathological dilation of the abdominal aorta that may lead to a rupture with fatal consequences. Endovascular aneurysm repair (EVAR) is a minimally invasive surgical procedure consisting of the deployment and fixation of a stent-graft that isolates the damaged vessel wall from blood circulation. The technique...
Article
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Study aim: to test the hypothesis that an eccentric training programme applied on women football players would reduce the hamstring injury rate by improving thigh muscle balance and, particularly, hamstring strength. Material and methods: three football teams were recruited for this randomised controlled trial. They played in the first and second d...
Article
Full-text available
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by abnormal accumulation of lipids within liver cells. Its prevalence is increasing in developed countries in association with obesity, and it represents a risk factor for non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Since NAFLD is usually asymptomatic...
Article
Full-text available
Most information about clinical trials sites contains advice for patients to make sure the trials they choose to be a part of are registered. The WHO’s decision to adopt a statement on clinical trial reporting reflects the Declaration of Helsinki which states that “every research study involving human subjects must be registered in a publicly acces...
Article
Few studies describe the effect of non-muscle-invasive bladder cancer (NMIBC) on health-related quality of life (HRQL), although patients are mostly diagnosed at this stage of the disease. Taking into account this current evidence gap and the high incidence rates in Spain, we aimed to describe the evolution over time of HRQL in Spanish patients wit...
Article
Introduction: Nitric oxide (NO) levels can be measured at proximal (maximum airway NO flux [J'aw(NO)]) and distal (alveolar NO concentration [C(ANO)]) levels. Four inflammatory patterns have been described in asthmatic individuals, although their relevance has not been well established. The objective was to determine J'aw(NO) and C(ANO) in order t...
Data
Full-text available