José Carlos Andrade

José Carlos Andrade
Cooperativa de Ensino Superior, Politécnico e Universitário | CESPU · Departamento de Ciências Farmacêuticas

PhD

About

39
Publications
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Publications

Publications (39)
Article
Full-text available
Akkermansia muciniphila is a common human intestinal commensal with a mucin-degrading nature. Its immunomodulatory characteristics and regulatory role of mucus layer and gut barrier integrity highlight the potential benefits of using this bacterium as an interventional player against inflammatory/cardio-metabolic disorders. In this work, we evaluat...
Article
Full-text available
Akkermansia muciniphila is a Gram-negative intestinal anaerobic bacterium recently proposed as a novel probiotic candidate to be incorporated in food and pharmaceutical forms. Despite its multiple health benefits, the data addressing its antimicrobial susceptibility profile remain scarce. However, the absence of acquired resistance in probiotic str...
Article
Full-text available
Akkermansia muciniphila is regarded as a promising next-generation probiotic or live biotherapeutic candidate. Effective delivery strategies must be developed to ensure high enough viability of the probiotic strain throughout its industrial formulation, distribution chain, shelf-life, and, ultimately, the host’s gastrointestinal tract, where it sho...
Chapter
In the last years, the scientific community has recognized that specific microbial strains resident in the intestinal ecosystem play a key role in human health, participating in several functions beneficial to the host. Such microorganisms have been termed as next-generation probiotics and they are presently considered as food/nutraceutical supplem...
Article
Faecalibacterium prausnitzii, a resident anaerobic bacterium commonly found in healthy gut microbiota, has been proposed as a next generation probiotic with high potential for application in food matrices and pharmaceutical formulations. Despite its recognized health benefits, detailed information regarding its antimicrobial susceptibility profile...
Article
Candidiasis (e.g., oral, gastrointestinal, vaginal, urinary tract, systemic) is a worldwide growing problem, since antifungal resistance and immunosuppression states are rising. To address this problem, very few drugs are available for the treatment of Candida spp. infections. Therefore, novel therapeutic strategies are urgently required. Probiotic...
Chapter
Nanotechnology is a fast-rising industry not defined by a single field of research, but as the convergence of disciplines, such as chemistry, biology, physics, mathematics, and engineering, which exploits the benefits of nanoscale dimensions and characteristics for application in the macroworld. Current applications vary widely from nanorobotic ind...
Chapter
Anthocyanins (ACNs) have a widespread spectrum of biological activities, such as antioxidant, anti-inflammatory, or chemopreventive features, which support human health, although their low bioavailability and extensive biotransformation interfere with these advantages. This chapter underlines the various ACN bioactivities, their bioavailability and...
Article
Full-text available
In the last years several human commensals have emerged from the gut microbiota studies as potential probiotics or therapeutic agents. Strains of human gut inhabitants such as Akkermansia, Bacteroides, or Faecalibacterium have shown several interesting bioactivities and are thus currently being considered as food supplements or as live biotherapeut...
Article
Data regarding Akkermansia muciniphila viability under stress remains scarce despite its beneficial potential. Therefore, the main goal was to assess A. muciniphila culturability when exposed to different temperatures, atmospheres and gastrointestinal simulated conditions. Cultivable cell numbers A. muciniphila remain high after refrigerated and ro...
Article
In recent years, scientific community has been gathering increasingly more insight on the dynamics that are at play in metabolic and inflammatory disorders. These rapidly growing conditions are reaching epidemic proportions, bringing clinicians and researcher’s new challenges. The specific roles and modulating properties that beneficial/probiotic b...
Chapter
Conjugated derivatives of fatty acids, namely conjugated linoleic acid (CLA) and conjugated α-linolenic acid (CLNA), have attracted much attention of the scientific community over the last two decades due to their biological properties. In fact, several studies realized in animal models and/or cell cultures have shown anticarcinogenic, antiobesity,...
Chapter
The increasing awareness of the link between diet and health by the scientific community and by the population, in general, over the last years, has led to an important development of foods containing specific components with potential beneficial physiological activities that go beyond basic nutrition, generally designed as functional foods. Within...
Article
Introduction: Alginate-based particles have emerged as one of the most extensively searched drug delivery platforms due to their inherent properties, including good biocompatibility and biodegradability. Moreover, the low price, easy availability, natural origin, versatility and sol-gel transition properties, make alginate an ideal candidate to pro...
Chapter
Pectin is a family of complex polysaccharides that occur as structural materials in all land-growing plants. Its main utilization is on the food industry mainly due to his gelling properties. Recently, pectin has been exploited for different biomedical applications namely for drug delivery and for tissue engineering. This chapter will discuss the c...
Chapter
Soy protein products such as flour, concentrates and isolates are used in the food industry because of their functionality, nutritional value and low cost. This chapter presents an overview current knowledge of soy proteins, manufacture processes and modifications. The health benefits attributed to soy proteins are alsodiscussed. In addition the bi...
Chapter
Milk contains many types of proteins which are classified in two general categories – caseins and whey proteins. Due to their nutritional and functional properties milk proteins products are widely used in the food industry. This chapter summarizes the current knowledge on milk protein fraction and their biological properties. The production of the...
Chapter
Gellan gum is a natural anionic extracellular polysaccharide obtained by fermentation of the bacteria Sphingomonas elodea. It has the distinctive property of temperature-dependent and cation-induced gelation. This chapter summarizes the current knowledge on production, structure and properties of gellan gum. In addition, an overview of the current...
Chapter
Functional foods containing probiotics and/or prebiotics have gained much interest in the last years due to their health-promotion capacity. Different cheese types containing probiotic starter or adjunct cultures have shown to be good carriers for lactobacilli or bifidobacteria strains without technological or sensorial impairment. Prebiotic compou...
Article
Full-text available
Numerous studies in humans, animal models and cell lines have suggested the potential benefits from the consumption of green tea polyphenols, including prevention of cancer and heart diseases. However these potential effects have been strongly limited by green tea catechins low bioavailability, which hinders the development of therapeutic applicati...
Article
In recent years, much attention has been given to dietary antioxidants, especially polyphenols. Several peptides derived from protein molecules have also been found to show antioxidant capacity along with other biological properties and thus there is an increasing interest in these compounds as health promoters. This review summarizes and discusses...
Article
Conjugated linoleic acid (CLA) is a group of isomers of linoleic acid (LA) with several potential health benefits which justifies the efforts to obtain foods with enhanced CLA contents. A possible way to obtain CLA-enriched products is via fermentation since several microorganisms, many of which are employed in the manufacture of foods, are known t...
Article
Full-text available
PLGA nanoparticles are useful to protect and deliver proteins in a localized or targeted manner, with a long-term systemic delivery pattern intended to last for a period of time, depending on polymer bioerosion and biodegradability. However, the principal concern regarding these carriers is the hydrolytic instability of polymer in aqueous suspensio...
Chapter
Full-text available
Therapeutic proteins represent a significant part of the new pharmaceuticals coming on the market every year and are now widely spread in therapy to treat or relief symptoms related to many metabolic and oncologic diseases. The parenteral route remains as a primary strategy for protein administration essentially due to its specific physicochemical...
Article
Foods are no longer regarded by consumers only in terms of taste and immediate nutritional needs but also in terms of their ability to provide specific benefits beyond their basic nutritional value. In many parts of the world, cheese is consumed at least once daily, making it a potentially excellent carrier for probiotics. Probiotic bacteria can be...
Poster
Full-text available
Colorectal cancer incidence continues increasing in the Western countries and if precocious diagnosis favors the survival of the affected ones, the rate of mortality is still high. In most people, this cancer de-velops slowly over several years. Overall, the lifetime risk of developing colorectal cancer is about 1 in 20 (5.1%) (American Cancer Soci...
Poster
Full-text available
Due to their health benefits, bifidobacteria have been increasingly included in food products, especially in yoghurt and in fermented milks, during the past two decades. In order to these microorganisms exert positive health effects, they have to reach the large intestine of the host, alive and in sufficient number. However, considerable loss in ce...
Article
The effects of dilution rate and substrate feed concentration on continuous glycerol fermentation by Clostridium butyricum VPI 3266, a natural 1,3-propanediol producer, were evaluated in this work. A high and constant 1,3-propanediol yield (around 0.65 mol/mol), close to the theoretical value, was obtained irrespective of substrate feed concentrati...
Article
Clostridium butyricum is to our knowledge the best natural 1,3-propanediol producer from glycerol and the only microorganism identified so far to use a coenzyme B12-independent glycerol dehydratase. However, to develop an economical process of 1,3-propanediol production, it would be necessary to improve the strain by a metabolic engineering approac...
Article
Growth inhibition of Clostridium butyricum VPI 3266 by raw glycerol, obtained from the biodiesel production process, was evaluated. C. butyricum presents the same tolerance to raw and to commercial glycerol, when both are of similar grade, i.e. above 87% (w/v). A 39% increase of growth inhibition was observed in the presence of 100 g l(-1) of a low...
Article
Continuous cultures of two strains of Clostridium acetobutylicum were stable for over 70 d when grown on glucose/glycerol mixtures. Butanol was the major fermentation end-product, accounting for 43 to 62% (w/w) of total products. Low-grade glycerol [65% (w/v) purity] could replace commercial glycerol [87% (w/v) purity], leading to a similar ferment...
Article
Full-text available
The metabolism of Clostridium butyricum was manipulated at pH 6.5 and in phosphate-limited chemostat culture by changing the overall degree of reduction of the substrate using mixtures of glucose and glycerol. Cultures grown on glucose alone produced only acids (acetate, butyrate, and lactate) and a high level of hydrogen. In contrast, when glycero...

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Projects

Projects (6)
Project
The open-access journal Foods (IF 6.321) is arranging a special issue on " Delivery Systems of Live Biotherapeutics ". As Guest Editors we cordially invite you to contribute with a review or research article to this special issue. The submission deadline will be 31 December 2021. Your ongoing work would be an excellent topic to include in this special issue. Please access to the following link for further reading about this special issue: https://www.mdpi.com/journal/pharmaceutics/special_issues/live_biotherapeutics
Project
Screening of anti-Candida activity by Lactic Acid bacteria from saliva samples of healthy subjects
Project
The open-access journal Foods (IF 4.092) is arranging a special issue on " Probiotic Food: Latest Advances and Prospects". As Guest Editors we cordially invite you to contribute with a review or research article to this special issue. The submission deadline will be 10 September 2021. Your ongoing work would be an excellent topic to include in this special issue. Please see more details in: https://www.mdpi.com/journal/foods/special_issues/probiotic_food