José Abellán

Universidad Católica San Antonio de Murcia | UCAM · Departamento de Ciencias de la Salud

Objetivo: Se ha postulado que el uso de inhibidores del enzima de conversión de angiotensina (IECA) o de antagonistas de sus receptores AT1 (ARA) podrían favorecer la infección por SARSCov-2 al incrementar la expresión del enzima convertidor de angiotensina 2 (ECA2), sobre todo a nivel pulmonar. Por otra parte, el descenso en el efecto de angiotens...

Food peptides contain a very wide range of diversified structures, which explains their diverse range of functional activities. Proatherogenic endothelium is related to vasoconstriction, inflammation, and oxidative stress. In this line, four synthetic bioactive peptides from dry-cured pork ham, previously identified according to their Angiotensin I...

Increased oxidative stress has been suggested as an early event in the development of the metabolic syndrome and, as such, might contribute to disease progression. The aim of de present study was to evaluate Total Antioxidant Status and endogenous antioxidant enzymes in metabolic syndrome patients after consumption of a citrus-based juice compared...

The effect of diet on cardiovascular disease prevention has been widely studied for many years. Numerous studies have confirmed that diets rich in fruits and vegetables (Mediterranean diet) are beneficial to the cardiovascular system and various bioactive food components have preventive effect on chronic diseases such as cardiovascular disease. In...

Background: Owing to the proposal of the increase of oxidative stress (OxS) as an early event in the development of the metabolic syndrome (MetS), the aim of the present study was to evaluate certain OxS biomarkers in patients with MetS compared to healthy people age-matched and younger to assess the relevance of aging in OxS and MetS. Methods: A t...

Consumption of broccoli sprouts in obese postmenopausal women produces a beneficial effect on reducing the weight and improving lipid parameters and inflammatory profile. Conducting a larger scale intervention could help us in establishing cause-effect relationships knowledge beyond the state of the art to treat obesity with naturally healthy foods...

Metabolomics has emerged in the field of food and nutrition sciences as a powerful tool for doing profiling approaches. In this context, HPLC-q-TOF-based metabolomics approach was applied to unveil changes in the urinary metabolome in human subjects (n = 51, 23 men and 28 women) after regular aronia-citrus juice (AC-juice) intake (250 ml/day) durin...

Objective The objective of this study was to determine the pattern of use of antihypertensive drugs in the Murcia Region, comparing the results with the national data, and detecting problems in order to make improvements, or establish hypotheses and to plan new studies.

The objective of this study was to determine the pattern of use of antihypertensive drugs in the Murcia Region, comparing the results with the national data, and detecting problems in order to make improvements, or establish hypotheses and to plan new studies. Pharmacoepidemiological study (from 2004 to 2008) in accordance with the recommendations...

Inflammation and oxidative stress plays a critical role in cardiovascular disease and metabolic syndrome often occurs with these two variables. The aim of the study is to estimate variations on cardiovascular risk factors in Metabolic Syndrome patients after consume of a citrus-based juice compared with control groups. The study comprised 20 health...

Introduction The study has aimed to evaluate the effectiveness of lercanidipine in the control of the hypertension as well as its clinical tolerability and biochemistry. Material and method This is an observational, multicenter, open label study with a mean follow-up period in primary care sites. A total of 206 primary care physicians participated,...

To investigate effects of 24 weeks of resistance training with aquatic resistance devices or elastic bands (EB) on markers of cardiovascular health and physical capacity. Forty-six healthy, sedentary postmenopausal women participated. The groups were aquatic exercise (AE; n = 15), EB (n = 21), and control (n = 10). Venous blood chemistry included c...

Obesity has become an epidemic problem, contributing to metabolic syndrome, type 2 diabetes, hypertension, and cardiovascular disease. An adequate blood pressure control in this population of obese individuals is extremely difficult to achieve, and in most cases, therapeutic combinations are required. Pharmacologic treatment with moxonidine, a cent...

Background and objective Our objective was to evaluate, through the health related quality oflife (HRQoL) questionnaire MINICHAL, the influence of socio-demographic, clinical and therapeuticvariables on health related quality of life of hypertensive patients. Patients and method An observational, prospective and multi-center study was carried out...

Objetive To analyze the use of antihypertensive drugs in Primary Health Care during the period 1999-2001, and to evaluate the introduction of angiotensin II receptor antagonists. Methods Restrospective observational study. There were selected all antihypertensive drug prescriptions issued by the Social Security Primary Health Care system in Murcia...

There have been a great number of epidemiological studies published which associate different inflammatory factors, such C-reactive protein (CRP), with cardiovascular disease. With the availability of highly-sensitive assay systems, measurement of CRP plasma concentration can provide a method for the detection of individuals at high risk for plaque...

Our objective was to evaluate, through the health related quality of life (HRQoL) questionnaire MINICHAL, the influence of socio-demographic, clinical and therapeutic variables on health related quality of life of hypertensive patients. An observational, prospective and multi-center study was carried out in hypertensive patients who were either sta...

Am J Hypertens (2003) 16, 205A–205A; doi:10.1016/S0895-7061(03)00630-7 P-458: Is BP measurement in pharmacy outlets reliable? Preliminary results of the Zanycontrol Study Jose Abellan1, Jaime Merino1, Vicente F. Gil Guillen1, Jose L. Llisterri1 and Angel Navarro1 Zanycontrol Study Group1Atencion Primaria, C Salud San Andres, Murcia, Spain; Clinica...

Am J Hypertens (2003) 16, 213A–213A; doi:10.1016/S0895-7061(03)00655-1 P-483: Differences on BP control between BP readings in the office by the physician vs self-measurement at home (HBPM). Preliminary results of Zanycontrol Study Jose L. Llisterri1, Jaime Merino1, Abellan Jose1, Vicente F. Gil Guillen1, Carlos Sanchis1 and Angel Navarro1 Zanycon...

The aim of this study was to evaluate the degree of control achieved with spirapril (S) in obese hypertensive subjects and to determine weight loss with a 1200 cal standard diet (diet 1) or the same diet with no fruit and vegetable restrictions (diet 2). This was a 9-month, analytical, prospective, multicenter, longitudinal, open-label study in obe...

To define the efficacy and safety of Lercanidipine (L) with Enalapril (E) in patients with essential hypertension (HBP). This is part of an extensive study aimed at assessing the value of HBPM and ABPM to monitor hypertensive patients. An open, multicentric, prospective, observational, descriptive and transversal study reported to the Spanish Medic...

To determine if the value of BP measurements obtained in the patient's home using HBPM compared to 24-hour ABPM is trustworthy and consistent. Multicentric, cross-over study to evaluate diagnostic tests used to validate HBPM in the patient's home (automatic electronic BP monitor, 3 readings with a period of 1–2 minutes) compared to the results of...

The finding that low health-related quality of life (HRQoL) can be a risk factor for future cardiovascular events in patients with hypertension emphasizes the need for disease-specific HRQoL assessment tools in this population. This study evaluated the feasibility and psychometric properties of the short form of the Spanish Hypertension Quality of...

Hypertension is twice as common in postmenopausal than in premenopausal women. This study evaluated the effectiveness of a blockade of the renin-angiotensin-aldosterone system (RAAS) with candesartan cilexetil (CC) to control blood pressure (BP) in hypertensive menopausal women, and the influence of hormone replacement therapy (HRT). This was desig...

Background. Hypertension is twice as common in postmenopausal than in premenopausal women. This study evaluated the effectiveness of a blockade of the renin-angiotensin-aldosterone system (RAAS) with candesartan cilexetil (CC) to control blood pressure (BP) in hypertensive menopausal women, and the influence of hormone replacement therapy (HRT). Me...

The purpose of the study was to determine the prevalence of renal impairment, and to assess its significance, within type 2 diabetics attending primary care settings. We performed a cross-sectional observation of patients with type 2 diabetes being the first 20 unselected cases seen by 178 family physicians from 16 of the 17 departments of Spain. F...

The purpose of the study was to determine hypertension prevalence and control within type 2 diabetics attending primary care settings. We performed a cross-sectional observation of patients with type 2 diabetes being the first 20 unselected cases seen by 178 family physicians from 16 of the 17 departments of Spain. Following variables were determi...

Patients with type 2 diabetes use to be managed in their primary care settings during the early stages of the disease. The main objective of the study was to determine renal impairment prevalence, and to assess its significance, within type 2 diabetics controlled by their family physicians. Transverse observation of patients with type 2 diabetes wh...

Despite progress in the detection and treatment of hypertension the percentage of patients with controlled hypertension has failed to increase. The problem of poor blood pressure control is even more serious in elderly hypertensives than in the rest of the population. The antihypertensive drugs of the AIIRA (non-peptide angiotension II receptor ant...

To assess the association of hot flushes during postmenopause with oxidative stress and to determine whether hormone replacement therapy (HRT) affects the plasma redox status of postmenopausal women. We conducted a prospective clinical study of 49 postmenopausal women who have (n = 29) or do not have (n = 20) hot flushes. Twelve of the postmenopaus...

Setting, Patients and Interventions: Following a 4-week placebo wash-out period (phase I), outpatients aged 60 to 87 years with systolic blood pressure (SBP) ≥ 160mm Hg and diastolic blood pressure (DBP) ≤ 95mm Hg were randomised to receive amlodipine 5 mg/day or hydrochlorothiazide 50 mg/day for 8 weeks (phase II). After 4 weeks of active treatmen...

The effects of two types of laboratory stressors, a structured interview and the cold pressor test, on blood pressure (BP) and heart rate (HR) were studied in normotensive individuals (n = 16), unmedicated hypertensive patients (n = 12), and medicated hypertensive patients (n = 46). Fifteen patients were in the bisoprolol group, 16 patients were in...

This paper analyses 205 workers at the "Murcia University". This population being formed of teachers, administration personnel, and persons working in supporting services, with a median age of 32.4 years. The research involved a questionnaire of 175 variables, physical examination and other tests (EKG, seric cholesterol, basal glycemia, uric acid,...

A prospective study on dynamic spirometric parameters on 195 healthy non-smoking men-workers, representing the non-smoking labor population from 16 to 40 years of age, in the Murcia Region (Spain), has been carried out. Men were selected upon two criteria: age and height. Lower normality limits, have been estimated with 95% reliability by developin...