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Publications
Publications (166)
Paternal exposure to high-fat diets or individual fatty acids (FAs) including arachidonic acid (AA) modifies progeny traits by poorly understood mechanisms. Specific male reproductive system FAs may be involved in paternal inheritance, as they can modify a range of cellular components, including the epigenome. Our objective was to determine FAs in...
The alkamide content and specific tissue localization in the cypselae of Heliopsis longipes were investigated using gas chromatography–electron ionization mass spectrometry (GC-EIMS) and multiphoton fluorescence microscopy (MPFM). GC-EIMS analysis identified two olefinic alkamides: affinin (spilanthol) and N-2-methylbutyl-2E,6Z,8E-decatrienamide. M...
Thevetia thevetioides is a species within the Apocynaceae family known for containing cardenolide-glycosides, commonly referred to as cardiac glycosides, which are characteristic of this genus. The seeds of the Thevetia species are frequently used as a model source for studying cardiac steroids, as these glycosides can be more readily extracted fro...
[This corrects the article DOI: 10.1371/journal.pone.0300141.].
Background
This study aimed to investigate the possible associations of the rs12504538 and rs6824447 polymorphisms of the Elovl6 gene with estimated elongase and desaturase activity and saturated fatty acid concentrations in Mexican women with gestational diabetes mellitus (GDM).
Methods
. We recruited 172 women in the second and third trimesters...
Increasing evidence hints that DNA hypermethylation may mediate the pathogenic response to cardiovascular risk factors. Here, we tested a corollary of that hypothesis, that is, that the DNA methyltransferase inhibitor decitabine (Dec) ameliorates the metabolic profile of mice fed a moderately high-animal fat and protein diet (HAFPD), a proxy of car...
Arachidonic acid (AA) is involved in inflammation and plays a role in growth and brain development in infants. We previously showed that exposure of mouse sires to AA for three consecutive generations induces a cumulative change in fatty acid (FA) involved in inflammation and an increase in body and liver weight in the offspring. Here, we tested th...
Psittacanthus calyculatus parasitizes mesquite trees through a specialized structure called a haustorium, which, in the intrusive process, can cause cellular damage in the host tree and release DAMPs, such as ATP, sugars, RNA, and DNA. These are highly conserved molecules that primarily function as signals that trigger and activate the defense resp...
Stressed organisms identify intracellular molecules released from damaged cells due to trauma or pathogen infection as components of the innate immune response. These molecules called DAMPs (Damage-Associated Molecular Patterns) are extracellular ATP, sugars, and extracellular DNA, among others. Animals and plants can recognize their own DNA applie...
Psittacanthus calyculatus is a hemiparasitic plant of an arboreal species (e.g., forest, fruit trees). Its foliage has therapeutic potential; however, little is known about its fruits. In this study, the phytochemical profile and biological activities of P. calyculatus fruits hosted by Prosopis laevigata and Quercus deserticola were evaluated. The...
Volatile organic compounds (VOCs) comprises a broad class of small molecules (up to ~300 g/mol) produced by biological and non-biological sources. VOCs play a vital role in an organism’s metabolism during its growth, defense, and reproduction. The well-known 6-pentyl-α-pyrone (6-PP) molecule is an example of a major volatile biosynthesized by Trich...
Background
Fatty acids (FA) likely affect human fertility at multiple levels, as deviations from physiological FA profiles are obesogenic, and FA can modify DNA methylation (DNAm). Yet, the interplay of follicular fluid (FF) and serum FA with BMI and percentage body fat (PBF) in human fertility is not completely understood. Also, associations of DN...
Introduction:
Triglycerides (TG) represent 98 % of the vegetable oils composition. The evaluation of TG in pumpkin seed extracts is valuable to perceive effects caused by domestication.
Objective:
To compare the triglyceride profile of wild versus domesticated pumpkins by reversed-phase HPTLC.
Materials and methods:
Wild pumpkins (Cucurbita foeti...
Lemongrass (Cymbopogon citratus) essential oil (EO) is a major source of bioactive compounds (BC) with anticancer activity such as α-citral, limonene, geraniol, geranyl acetate, and β-caryophyllene. Comparative studies about cytokinin effects on BC profiles in lemongrass are missing. Here, we evaluated four cytokinins (2iP, tZ, BAP, and KIN) in two...
Microbial volatile organic compounds (mVOCs) play important roles in inter- and intra-kingdom interactions, and they are also important as signal molecules in physiological processes acting either as plant growth-promoting or negatively modulating plant development. We investigated the effects of mVOCs emitted by PGPR vs non-PGPR from avocado trees...
Background. Fatty acids (FA) likely affect human fertility at multiple levels, as deviations from physiological FA profiles are obesogenic, and FA can modify DNA methylation (DNAm). Yet, the interplay of follicular fluid (FF) and serum FA with BMI and percentage body fat (PBF) in human fertility is not completely understood. Also, associations of D...
Several aflatoxin inhibitors can modulate the antioxidant system in fungi. In this work, the effect of the ethanolic extract of Capsicum chinense and Piper nigrum fruits, capsaicin, and piperine on the expression of the aflE, aflG, aflH, aflI, aflK, aflL, aflO, aflP, and aflQ genes involved in the aflatoxin biosynthetic pathway in Aspergillus paras...
Apart from the known associations between arachidonic acid (AA), weight gain, and neurological and immune function, AA exposure leads to alterations in global and gene-specific DNA methylation (DNAm) and fatty acid (FA) content in human cultured cells. However, it is unknown as to whether the latter effects occur in vivo and are maintained over ext...
Alkamides are alpha unsaturated N- acylamides structurally related to N -acyl ethanolamides (NAEs) and N -acyl-L-homoserine lactones (AHLs). Studies have shown that alkamides induce prominent changes in root architecture, a significant metabolic readjustment, and transcriptional reprogramming. Some alkamide responses have been associated with redox...
The genus Vaccinium contains about 400 species distributed worldwide, but only a few species and varieties have had their phenolic composition and biological activity documented. In this study, phenols, flavonoids, anthocyanins, antioxidant and antimicrobial activity of methanolic extracts of Vaccinium stenophyllum Steud. fruits: 1-totally immature...
Piper spices haven showed a great biological potential as natural biocide, in different organism. This is attributed to the diversity bioactive metabolites present in tissue. In this research we evaluated the nematicidal activity of different foliar extracts from
Piper spices against Caenorhabditis elegans . We evaluated the nematicide activity of...
Cucurbita foetidissima and C. radicans are scarcely studied wild pumpkin species that grow in arid and semi-arid areas of Mexico and the United States. This study describes the morphological, proximal composition, metabolic finger-prints and seed protein profiles of C. foetidissima and C. radicans fruits collected in the wild during a one-year peri...
Affinin present in Heliopsis longipes roots has been identified as an anti-aflatoxin molecule. However, its mechanism of action has yet to be clarified. Aflatoxins biosynthesis involves not less than 27 enzymatic reactions. In this work, the genes aflG, aflH, aflI, aflK, aflL, aflM, aflO, aflP, and aflQ of the aflatoxins cluster and the aflS gene e...
The metabolic capacity of probiotic mixed cultures formed by Lactobacillus and Bifidobacterium strains was assessed through the determination of the acidification profile and the production of amino acids and volatile compounds, during the fermentation of ultra-pasteurized skim milk. Two mixed cultures formed by [L. acidophilus + B. bifidum] and [L...
Heliopsis longipes is a valuable source of specialized metabolites (or secondary metabolites) with medicinal properties mainly in roots. However, little is known about genes involved in the biosynthesis of these metabolites, primarily due to the lack of genome or transcriptome resources. In this work, the genes of the biosynthetic pathway of the sp...
Alkamides have been observed to interact in different ways in several superior organisms and have been used in traditional medicine in many countries e.g., to relieve pain. Previous studies showed that affinin when applied to other plant species induces prominent changes in the root architecture and induces transcriptional adjustments; however, lit...
Mansoa hymenaea (DC.) A.H. Gentry is used in traditional medicine to treat pain, arthritis, and rheumatoid disease. It has also been demonstrated that species belonging to the Mansoa genus exert cytotoxic activity. Despite this data, biological properties and phytochemistry of M. hymenaea remain poorly understood. Therefore, we determined the metab...
It is clear the importance of plant-microbe interactions to accomplish food safety and sustainable agriculture. Many plant-microbe interactions depend on bacterial quorum sensing (QS) systems, so the manipulation of these communication systems could be a powerful instrument to modulate plant development. The search of compounds with the capacity to...
The pandemic caused by the SARS-CoV-2 has quickly spread globally, infecting millions, and killing hundreds of thousands of people. Herein, to identify potential antiviral agents, 97 natural amide-like compounds known as alkamides and piperamides were tested against SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), and the hu...
Background: Alkamides are plant-specific bioactive molecules. They are low molecular weight N-substituted a-unsaturated acyl amides that display biological explicit activities in different organisms from bacteria, fungi, insects to mammals and plants. The acyl chain has been proposed to be biosynthesized from a fatty acid; however, this has not bee...
Aflatoxins produced by Aspergillus parasiticus are toxic and carcinogenic metabolites. The biosynthesis of this mycotoxins is a complex process and involves at least 30 genes clustered within an approximately 82kB gene cluster. In the present study, the effect of Capsicum chinense and Piper nigrum fruits on Aspergillus parasiticus growth and aflato...
Naphthenic acids (NAs) are complex mixtures of carboxylic acids from petroleum that have industrial applications and that may be released to the environment after oil spills. There is significant research on the chemical composition and toxicity of water-soluble NAs derived from oil sands mining in Alberta, Canada. Yet, little is known about low mo...
Thin-layer chromatography (TLC) is a classic method for the separation and analysis of complex mixtures. Biological assays, chemical derivatisation and spectroscopy techniques are compatible with TLC and provide extra information about isolated compounds. However, coupling TLC to mass spectrometry is hampered by the difficulty to desorb the analyte...
Numerous plant-derived volatile organic compounds (VOCs) induce the expression of resistance-related genes and thereby cause an “associational resistance” in neighbouring plants. However, VOCs can also be sequestered by plant cuticular waxes. In case that they maintain their biological activity, such sequestered VOCs could generate a “passive” asso...
In the search of new and safe antibacterial compounds, the quorum sensing system (QS) modulation by natural products has been studied. As a result, many plant-derived compounds have been identified as potent quorum sensing inhibitors. Piper nigrum L. (black pepper) ethanolic extract inhibits the QS in some Gram-negative bacteria but the active comp...
Domesticated tomato (Solanum lycopersicum L.) crops have presented an increased susceptibility to pests under field and greenhouse conditions. Among these pests is tomato/potato psyllid, Bactericera cockerelli Sulc (Hemiptera: Triozidae), a major pest in solanaceous crops. In this study, we evaluated volatile organic compound (VOC) emissions from t...
Leaves of semi-domesticated Diospyros digyna and wild D. rekoi trees, sampled seasonally in Mexico in 2014, were analyzed. Metabolic fingerprints revealed higher metabolite diversity in D. rekoi leaves. The TLC bands characteristic of glycosylated flavonoids, predominant in this species, matched the detection of quercetin and quercetin 3-O-glucuron...
In the present study, ethanolic extract from Heliopsis longipes roots and affinin/spilanthol against Aspergillus parasiticus growth and aflatoxins production were studied in relation to the expression of aflD and aflR, two key genes of aflatoxins biosynthetic pathway. Phytochemical analysis of the ethanolic extract by GC-EIMS identified affinin/spi...
Water deficit stress (WDS)-tolerance in grain amaranths (Amaranthus hypochondriacus, A. cruentus and A. caudatus), and A. hybridus, their presumed shared ancestor, was examined. A. hypochondriacus was the most WDS-tolerant species, a trait that correlated with an enhanced osmotic adjustment (OA), a stronger expression of abscisic acid (ABA) marker...
This study evaluates the antibacterial, cytotoxic activities, and phytochemical composition, of Callistemon citrinus, Hibiscus rosa-sinensis and Plumbago auriculata leaves and flowers, three ornamental plants in Mexico. However, in other countries offers a range of other uses. Ethanol extracts of C. citrinus leaf and flower presented stronger antib...
In vitro plant organogenesis requires plant regulator cytokinins to be exogenously supplied to the culture media. Cytokinins are either obtained from natural sources, from purified commercial plant extracts or by chemical synthesis. Besides plants, several species of plant pathogenic bacteria also naturally produce cytokinins. For example, Pseudomo...
Studies on avocado oil have focused on the most common commercial cultivars, Hass, Fuerte, and Bacon, rather than the less common varieties, P. americana var. drymifolia and P. americana var. americana, even though the drymifolia variety has a higher oil content and the americana variety is the most common avocado grown in the tropics. The most abu...
Purpose
To evaluate changes in serum fatty acids, metabolic profile and inflammation markers after a dietary intervention of 15g of walnuts and 15g of almonds for 8 weeks in obese subjects,
Patients and Methods
We studied a total of 48 sedentary obese grade I subjects (13 men and 35 women). Anthropometric measures, body composition, serum glucose,...
GC-EIMS analysis, antifungal- and anti-aflatoxigenic activities of the ethanolic extract of Capsicum chinense and Piper nigrum fruits and their main bioactive compounds were evaluated upon Aspergillus parasiticus. The GC-EIMS analysis showed capsaicin (50.49%) and piperine (95.94%) as the major constituents in C. chinense and P. nigrum, respectivel...
The organic extracts from Heliopsis longipes roots possess interesting biological and pharmacological activities. However, the effect on Aspergillus parasiticus has not been investigated so far. This study was aimed to evaluate the antifungal effect of the ethanolic extract from H. longipes roots against A. parasiticus growth. Four extract concentr...
Psittacanthus calyculatus is a hemiparasitic plant that infects a wide range of trees. Mainly the biology reproduction of this mistletoe lies in bright colored flower development. Furthermore, it uses the nectar secretion as the only reward to engage different flower visitors. We investigated the physiological mechanisms of the flower phenology per...
Fungi emit a diverse blend of volatile organic compounds (VOCs) that mediate multiple fungus-fungus interactions. Plants emit VOCs as well, which can serve as resistance-inducing signals but might also act as direct resistance agents. We screened 22 VOCs that are emitted from infected plants for putative inhibitory effects on three fungal phytopath...
Microorganisms of subaerial biofilms, which develop on the surface of stone monuments, have been widely studied due to their impact on Cultural Heritage deterioration. Nevertheless, these extremophile microorganisms are poorly characterised. In this study, a cyanobacterial strain isolated from an archaeological zone in north-central Mexico was char...
An enzymatic method to produce N-acyl homoserine lactones (AHLs) is described. This report represents the first example of the synthesis of bioactive AHLs using immobilized Candida antarctica lipase as the catalyst. The reaction yields, evaluated by GC-EIMS, ranged from 6 to 99%.
Graphical Abstract
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This study was performed to test the working hypothesis that the primary determinants influencing seasonal driven modifications in carbon mobilization and other key biochemical parameters in leaves of poorly known Diospyros digyna (Ddg; semi-domesticated; perennial) and D. rekoi (Dre; undomesticated; deciduous) trees are determined by environmental...
Correlation matrix of biochemical and environmental variables in leaves of Diospyros rekoi trees sampled during the spring (A), summer (B), autumn (C) and winter (D) of 2015.
(PDF)
Principal component analysis showing which environmental factors (shown as vectors of varying size) most significantly influenced the overall biochemical variables (shown as dots) of Diospyros rekoi leaves.
(PDF)
Seasonal variation in photosynthetic photon flux density (PPFD) recorded in five (T1-to-T5) Diospyros digyna (Ddg) trees sampled in Taretan, Michoacán, México.
(PDF)
Correlation matrix of biochemical and environmental variables in leaves of Diospyros digyna trees sampled during the spring (A), summer (B), autumn (C) and winter (D) of 2015.
(PDF)
Principal component analysis showing which environmental factors (shown as vectors of varying size) most significantly influenced the overall biochemical variables (shown as dots) of Diospyros digyna leaves.
(PDF)
Mean seasonal irradiation and long-wave radiation recorded in Taretan, Michoacán, México, D. digyna’s sampling site.
(PDF)
Mean seasonal irradiation and long-wave radiation recorded in Teocuitatlán de Corona, Jalisco, México, D. reloi’s sampling site.
(PDF)
Correlations between photosynthetic photon flux density (PPFD) and Chla/ Chlb ratios determined in five (T1-to-T5) Diospyros digyna (Ddg) trees for the winter 2014-15-winter 2015–16 period.
Numbers in red indicate statistically significant correlations.
(PDF)
Correlations between photosynthetic photon flux density (PPFD) and Chla/ Chlb ratios determined in five (T1-to-T5) Diospyros rekoi (Dre) trees for the winter 2014-15-winter 2015–16 period.
Numbers in red indicate statistically significant correlations.
(PDF)
Seasonal variation in photosynthetic photon flux density (PPFD) recorded in five (T1-to-T5) Diospyros rekoi (Dre) trees sampled in Teocuitatlán de Corona, Jalisco, México.
(PDF)
The analytical technique of High Performance Thin-layer Chromatography (HPTLC) is one of the most widely used instrumental techniques for the analysis of low molecular mass compounds of complex environmental, pharmaceutical and food samples. In this work, a system based on digital image processing and analysis techniques to process the HPTLC plates...
Aims:
Identify novel bacterial taxa that could increase the availability of branched-chain amino acids and the amount of distinctive volatiles during skim milk fermentation.
Methods and results:
We recovered 344 bacterial isolates from stool samples of healthy and breastfed infants. Five were selected based on their ability to produce branched-c...
Establishing a horizontally transmitted mutualism is a critical step for many organisms, particularly when an individual can engage with only one partner over its lifetime. Ant foundresses shed their wings before they start to lay eggs, which makes host choice particularly critical for plant‐ants that exclusively colonize myrmecophytes.
Volatile or...
In this study, water deficit stress (WDS)-tolerance in several cultivars of grain amaranth species ( Amaranthus hypochondriacus [Ahypo], A. cruentus [Acru] and A. caudatus [Acau]), in addition to A. hybridus (Ahyb), an ancestral amaranth, was examined. Ahypo was the most WDS-tolerant species, whereas Acau and Ahyb were WDS-sensitive. Data revealed...
Naturally plants respond to pests and infections with the emission of volatile organic compounds (VOCs).Which are involved indirect in attract pollinators or predators of herbivores, also they play roles direct way as insect deterrents and have antimicrobial properties.In this project, we focus on the role played by VOCsin the resistance of plants...
In this study, we report for the first time the efficiency of pentafluorobenzyl bromide (PFBBr) for naphthenic acid (NA) mixtures derivatization, and the comparison in the optimal conditions to the most common NAs derivatization reagents, BF3/MeOH and N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA). Naphthenic acids are carboxylic aci...
Fatty acids (FA) modify DNA methylation in vitro, but limited information is available on whether
corresponding associations exist in vivo and reflect any short-term effect of the diet. Associations
between global DNA methylation and FAs were sought in blood from lactating infants (LI; n = 49) and
adult males (AMM; n = 12) equally distributed acros...
Lamiaceae (labiatae labiadas) family have many species for example Rosmarinus officinalis L., it is one of the species with the highest antioxidant power by the presence of essential oils, monoterpenes and phenolic compounds. Its vegetative propagation in Cuba is one of its difficulties and in recent years, this species has been removed from the Na...
The genus Piper is of great significance to a commercial and
economic level into the flavoring, pharmaceutical and insecticide
industry, and great traditional use. Some species of this genus have
been well explored. The aim of this review is to provide comprehensive
information in the fields of Botany, traditional uses, phytochemistry
and phar...
The genus Piper is of great significance to a commercial and economic level into the flavoring, pharmaceutical and insecticide industry, and great traditional use. Some species of this genus have been well explored. The aim of this review is to provide comprehensive information in the fields of Botany, traditional uses, phytochemistry and pharmacol...
Plants that express resistance to herbivores emit volatile organic compounds ( VOC s) that can trigger resistance responses in undamaged neighbours. Recent reports indicate that VOC s can also trigger the resistance to pathogens, an effect that might be due to different mechanisms: the priming of an induced expression of resistance genes in the rec...
Lophophora williamsii (commonly named peyote) is a small, spineless cactus with psychoactive alkaloids, particularly mescaline. Peyote utilizes crassulacean acid metabolism (CAM), an alternative form of photosynthesis that exists in succulents such as cacti and other desert plants. Therefore, its transcriptome can be considered an important resourc...
The strawberry is a fruit of high commercial demand, attractive both fresh and processed, by its color, aroma and flavor, as well as nutritional and nutraceutical properties.
Strawberry production is of economic importance for Mexico, being the state of Michoacan largest producer. Despite its benefits, the strawberry is a crop with high production...
In cartography, the combination of colour and contour lines is used to express a three-dimensional landscape on a two-dimensional map. We transferred this concept to the analysis of mass spectrometry imaging (MSI) data and developed a collection of R scripts for the efficient evaluation of .imzML archives in a four-step strategy: (1) calculation of...
Heliopsis longipes has been recognized as a potential source of insecticidal compounds called alkamides, which can be used to control populations of insect vector transmitters of several diseases that affect the human health. To determine the insecticidal activity of H. longipes against Anopheles albimanus and Aedes aegypti, crude extract of H. lon...
Microorganisms develop in the form of cellular clusters known as biofilms. Biofilm’s microbial cells are embedded in a matrix of extracellular polymeric substances (EPS). Cyanobacteria are photosynthetic prokaryotes that produce considerable amounts of EPS. This characteristic allows cyanobacteria to develop on aerial mineral surfaces, exposed to t...
Rhizobacteria promote and have beneficial effects on plant growth, making them useful to agriculture. Nevertheless, the rhizosphere of the chickpea plant has not been extensively examined. The aim of the present study was to select indole-3-acetic acid (IAA) producing rhizobacteria from the rhizosphere of chickpea plants for their potential use as...
El nurité, Satureja macrostema, tiene gran importancia en la medicina tradicional mexicana. El presente trabajo evaluó el crecimiento ycontenido de compuestos volátiles en la parte aérea de esta especie. El efecto de la fertilización mineral N – P - K se analizó en plantasmicropropagadas (clones), cultivadas por 90 días en invernadero. Se aplicaron...
La Medicina Tradicional ha desempeñado un papel importante en el tratamiento de diversas patologías, fundamentalmente en los países en desarrollo. En ellos, el 80 % de la población acude a este tipo de medicinapara satisfacer las necesidades primarias de salud. Si bien los productos de origen vegetal, particularmente las drogas secas y los extracto...
In spite of the ecological and evolutionary importance of nectar, mechanisms controlling its synthesis and secretion remain largely unknown. It is widely believed that nectar is 'secreted phloem sap', but current research reveals a biochemical complexity that is unlikely to stem directly from the phloem. We used the short daily peak in the producti...
Callistemon species are well known due to its medicinal properties and due to, among others, the relevant health benefits of their terpenic components. This paper aims to in-depth study the terpenic profile of the leaf and flower extracts of Callistemon citrinus with two ages. To fulfill this objective, initially, a screening of the terpenic compos...
High-throughput metabolic phenotyping is a challenge, but it provides an alternative and comprehensive access to the rapid and accurate characterization of plants. In addition to the technical issues of obtaining quantitative data of plenty of metabolic traits from numerous samples, a suitable data processing and statistical evaluation strategy mus...
High-throughput metabolic phenotyping is a challenge, but it provides an alternative and comprehensive access to the rapid and accurate characterization of plants. In addition to the technical issues of obtaining quantitative data of plenty of metabolic traits from numerous samples, a suitable data processing and statistical evaluation strategy mus...
