About
162
Publications
80,897
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,660
Citations
Citations since 2017
Introduction
Neurobiology of Autism
Additional affiliations
July 1992 - October 2021
Publications
Publications (162)
El trastorno del espectro autista (TEA) pertenece al grupo de trastornos del neurodesarrollo. De acuerdo con la quinta edición del Manual diagnóstico y estadístico de desórdenes mentales (DSM-5) las personas con TEA se caracterizan por presentar alteraciones en la interacción y la comunicación social, así como intereses restringidos y comportamient...
Understanding the autonomic supply at the gastrointestinal tract is one of the significant challenges for science. Its complex network of neurons exists on a broad evolutionary scale, from Hydra to mammals, and in a higher number than those found in the vertebrate spinal cord. Inside the gastrointestinal tract, enteric neurons regulate several func...
The role of diet in health is crucial, with calorie intake playing a significant role. Hypercaloric diets (HD) often lead to adipose tissue accumulation and increased risk of chronic diseases, including reproductive impairments. By contrast, restriction diets (RD) help with weight loss, improve cardiovascular function, and ameliorate reproduction....
Autism in humans is a lifelong behavioral disorder that typically manifests in early infancy, primarily affecting boys. It arises from neurodevelopmental changes that significantly impact social behavior, with the cerebellum being one of the principal affected regions. In this study, we investigated the cerebellum in an autism animal model, recordi...
Parkinson's disease (PD) is known for its motor alterations, but the importance of non-motor symptoms (NMSs), such as olfactory dysfunction (OD), is increasingly recognized. OD may manifest during the prodromal period of the disease, even before motor symptoms appear. Therefore, it is suggested that this symptom could be considered a marker of PD....
Citation: Vásquez-Celaya, L.; Marín-Márquez, G.; Manzo, J.; Carrillo-Castilla, P.; Martínez, A.J.; Ortiz Pulido, R.; Zempoalteca Ramírez, R.; Coria-Avila, G.A.; García, L.I. Electrophysiological Characterization of Cerebellar Responses during Exploration and Grooming Behaviors in a Rat Model of Parkinsonism. Brain Sci. 2023, 13, 537. https://doi. A...
Autism is a complex alteration in children’s developing nervous system that manifests in behavioral patterns that do not match those of typical subjects. Moreover, starting at puberty, these children may encounter problems regarding social interaction related to sexual encounters. As studies are scarce, we used the valproate model of autism in the...
Poster presented in the framework of the event "Focus on fish: practical refinements for fishes in research and testing" by Royal Society for the Prevention of Cruelty to Animals (RSPCA) on 23rd February 2023.
Among the different species of mammals, the expression of maternal behavior varies considerably, although the end points of nurturance and protection are the same. Females may display passive or active responses of acceptance, recognition, rejection/fear, or motivation to care for the offspring. Each type of response may indicate different levels o...
For years, the biochemical processes that are triggered by harmful and non-harmful stimuli at the central nervous system level have been extensively studied by the scientific community through numerous techniques and animal models. For example, one of these techniques is the use of immediate expression genes, which is a useful, accessible, and reli...
Objective
Environmental enrichment is used to treat social, communication, and behavioral deficits and is known to modify the expression of synaptic receptors. We compared the effects of environmental enrichment in the expression of glutamate and endocannabinoid receptors, which are widely expressed in the cerebellar cortex. These two receptors int...
El trastorno del espectro autista (TEA) es un desorden del neurodesarrollo de alta prevalencia, con manifestaciones significativas en las áreas socioafectiva y comportamental, cuyas causas aún permanecen indeterminadas. La investigación de sus posibles causas y tratamientos se apoya en modelos animales manipulados genéticamente y los no genéticos c...
El autismo es un trastorno del neurodesarrollo que se presenta en niños y tiene al cerebelo como una de las principales áreas afectadas, incluyendo alteraciones en la neurotransmisión del ácido gamma-aminobutírico (GABA). Esto ha estimulado el desarrollo de tratamientos dirigidos al sistema GABAérgico, aunque también se sabe que el ambiente enrique...
En el Sistema Nervioso Central existen diferentes tipos de neuronas. Una de ellas son las células motoras o motoneuronas. Estas células son de gran importancia ya que llevan la información a los músculos del cuerpo. Debido a la degeneración de neuronas motoras piramidales en la corteza motora, neuronas del tallo cerebral y neuronas del asta anterio...
Deep brain stimulation (DBS) is a surgical procedure used to treat various neurological pathologies, being its greatest use in movement disorders. The FDA first approved deep brain stimulation in 1997 to treat essential tremor, in 2002 it was approved for Parkinson's disease, in 2003 for dystonia, and in 2009 for obsessive compulsive disorder. Howe...
The prostate is an accessory sex gland responsible for producing and excreting prostate fluid. In the male rat, hormones such as testosterone (T) and prolactin (PRL) and the pelvic and hypogastric nerves regulate the gland, providing afferent information and adrenergic and cholinergic innervation to the prostate. Damages in the innervation or alter...
The cerebellum is a small structure of the Central Nervous System that occupies 10% of the total volume of the brain, connecting to the brain and the brainstem through the cerebellar peduncles. Its anatomical division is based on three criteria: midline, fissures, and phylogeny. Based on these criteria, the cerebellum is divided into three layers (...
Brain mechanisms of sexual attraction toward reproductive partners develop from a systematic interrelationship between biology (nature) and learning (nurture). However, the causes of attraction toward non-reproductive partners are poorly understood. Here, we explored the role of Pavlovian learning under dopaminergic agonism on the development of se...
La próstata es una glándula sexual accesoria encargada de producir y secretar el líquido prostático. En la rata macho este órgano está regulado por hormonas tales como testosterona (T) y prolactina (PRL), así como por el sistema nervioso autónomo (SNA), quien, a través de los nervios pélvico e hipogástrico que convergen en el ganglio pélvico mayor...
Background:
Autism spectrum disorder is an alteration of neurodevelopment with a conspicuous display of behaviors in children between 2 and 3 years of age. Basic behavioral manifestations are social isolation, language impairment, and motor problems. However, there are also manifestations related to sensory perception, although knowledge about tact...
El ganglio pélvico mayor es un complejo autonómico compuesto por una mezcla de fibras noradrenérgicas y colinérgicas cuyo objetivo es inervar órganos de la visera pélvica. Para llevar a cabo esto, las neuronas expresan receptores a andrógenos, noradrenalina y acetilcolina. Se conoce que la conducta sexual produce una importante actividad neuronal d...
The organizational-activational hypothesis indicates that activation of adult sexual behavior in males depends on organization of the masculine brain during the perinatal sensitive period. In the medial preoptic area such masculinization depends on a neuroendocrine cascade that includes exposure to testosterone, aromatization to estradiol, activati...
Prostate function is regulated by androgens and a neural control via the pelvic and hypogastric nerves. As such, this sexual gland contains receptors for acetylcholine and noradrenaline, although it is unknown whether the expression of these receptors is affected by sexual behavior and even less by denervation of the gland. Thus, the purpose of thi...
La música es una expresión artística establecida durante la evolución, existen en el cerebro regiones especializadas para su percepción, elaboración y ejecución. La percepción musical activa al sistema nervioso autónomo que modula cambios cardiorrespiratorios. En el autismo se presenta una actividad autonómica elevada, por ello el objetivo aquí fue...
Previous research in female rats showed that induction of status epilepticus (SE) during infancy impairs proceptive sexual behavior at the long run in adulthood but temporarily, since full proceptivity is recovered after four mating trials. In male rats, such equivalent effects have not been explored yet. Thus, SE was experimentally induced by inje...
According to the organizational-activational hypothesis, testosterone or its metabolite estradiol, can organize the brain in a male direction (permanently or for long periods) if exposure occurs during a critical (sensitive) time of brain development like the prenatal period. Male rodents with insufficient levels of testosterone during such critica...
Stress during puberty and obesity can represent conditions that facilitate the long-term development of diseases, especially for stress-related disorders that depend on neuroendocrine and immune responses. The prostate is prone to diseases that result from neuroendocrine or immune challenges, such as cancer.
Aim:
In the present study, we assessed...
La Agencia Internacional de Investigación en Cáncer (IARC por sus siglas en inglés) clasifica al formaldehído como un carcinógeno de tipo 1. Existe evidencia que indica que, aquellas personas que están expuestas en sus centros de trabajo a grandes concentraciones de este compuesto tienen una mayor probabilidad de padecer cáncer nasofaríngeo y pulmo...
El trastorno por consumo de alcohol (TCA) es una enfermedad derivada de la ingesta excesiva y prolongada de esta sustancia, con efectos negativos a nivel cognitivo. Durante muchos años se ha estudiado la etiología de la dependencia al alcohol y se ha encontrado que la impulsividad es uno de sus rasgos más distintivos, una característica cognitiva q...
La enfermedad de Parkinson es una patología neurodegenerativa que afecta la motricidad de los pacientes, la cual tiene como alteraciones principales: temblor en estado de reposo, bradicinesia, rigidez y alteración postural. Sin embargo, no son las únicas alteraciones que permiten reconocer la aparición de la enfermedad, pues existe sintomatología n...
En el presente trabajo estudiamos la conducta sexual y la histología de la próstata en un modelo de autismo en ratas macho. Los machos autistas presentaron todos los parámetros conocidos de la copula pero la mayoría de ellos fuera de los niveles normales. Los patrones de conducta indicaron un decremento en el estado motivacional y una reducción en...
El trastorno del espectro autista es una alteración del desarrollo neural que se refleja en modificaciones significativas de la conducta infantil. En la versión más reciente del Manual Diagnóstico y Estadístico de Trastornos Mentales, se describe al autismo como un conjunto de modificaciones de la conducta que incluyen decremento en la interacción...
El trastorno del espectro autista (TEA) comprende un complejo de alteraciones neurales del desarrollo, manifestadas de manera heterogénea pero destacando características constantes de anormalidades neuroanatómicas y funcionales en la estructura cerebelar. En este contexto se cuenta con amplia evidencia de que el sistema endocanabinoide desempeña un...
The cerebellum is a structure of the central nervous system which has been previously studied with different techniques and animal models and even humans, so it is associated with multiple functions such as cognition, memory, emotional processing, balance, control of movement, among others. Its relationship with sensory systems has already been exp...
Background:
In male rats, the bulbourethral glands (Bu-Gs) are the unique accessory sexual glands surrounded by striated musculature. However, until now the role of this musculature was unknown.
Objectives:
(i) To characterize the Bu-Gs striated muscular layer in male rats and determine its innervation and response to genital stimulation. (ii) T...
Purpose of Review
The aim of this review is to provide current evidence on the biological and psychological mechanisms that underlie sexual partner preferences (SPP) in humans and animals.
Recent Findings
SPP depend mainly on prenatal (adaptive) organization of the brain, but can be drastically modified via learning under enhanced dopaminergic (DA...
Introduction
Status epilepticus (SE) is an epileptic condition that can cause cerebellar atrophy and loss of Purkinje cells in both humans and research animals. Cerebellum is a region rich in γ-amino butyric acid (GABA) and glutamate, and some studies have shown that their concentrations may be altered after convulsions. However, there are no studi...
Sexual preferences can be strongly modified by Pavlovian learning. For instance, olfactory conditioned same-sex partner preference can occur when a sexually naïve male cohabits with an scented male during repeated periods under the effects of enhanced D2-type activity. Preference is observed days later via social and sexual behaviors. Herein we exp...
El trastorno del espectro autista se manifiesta con una serie de alteraciones sensoriales y del comportamiento de distinta intensidad y severidad, por lo que su diagnóstico se basa en la evaluación conductual. La activación sensorial auditiva, mediante la estimulación musical, es una de las intervenciones que se han implementado para revertir este...
En el Sistema Nervioso Central, los mecanismos celulares de auto-protección y regeneración se alteran después de algún tipo de lesión. La lesión completa o incluso parcial de la médula espinal produce un daño neural permanente y, como consecuencia, existe una nula auto-recuperación. La recuperación debida al uso de terapias es muy limitada, porque...
Poster #67.20
Sexual preferences can be strengthened, weakened or drastically modified via conditioning, specially
during certain neurochemical states. For example, cohabitation with another individual under the effects of
Quinpirole (a D2-type receptor agonist) induces a conditioned socio-sexual partner preference. Such
preference is powerful enou...
The cerebellum is a complex structure mainly recognized for its participation in motor activity and balance, and less understood for its role in olfactory processing. Herein, we assessed Fos immunoreactivity (Fos-IR) in the cerebellar vermis following exposure to different odors during sexual training in male rats. Males were allowed to copulate fo...
Justicia spicigera Schltdl. (Acanthaceae) is a plant used in traditional Mexican medicine to treat several types of cancer. Some studies reported cytotoxic effects of J. spicigera extracts on cancer cell lines, but that the androgen-independent DU-145 prostate cancer cell line resists its cytotoxic action. The aim of the present study was to invest...
The dopamine D2-type receptor agonist quinpirole (QNP) facilitates the development of conditioned same-sex partner preference in males during cohabitation, but not in ovariectomized (OVX) females, primed with estradiol benzoate (EB) and progesterone (P). Herein we tested the effects of QNP on OVX, EB-only primed females. Females received a systemic...
Cortical motor areas are influenced not only by peripheral sensory afferents and prefrontal association areas, but also by the basal ganglia, specifically the striatum. The dorsomedial striatum (DMS) and dorsolateral striatum are involved in both spatial and stimulus-response learning; however, each of these areas may mediate different components o...
Sexual partner preferences can be strengthened, weakened or even drastically modified via Pavlovian conditioning. For example, conditioned same-sex partner preference develops in sexually-naïve male rats that undergo same-sex cohabitation under the effects of quinpirole (QNP, D2 agonist). Here, we assessed the effect of prior heterosexual experienc...
Introduction: Cortical motor areas are influenced not only by peripheral sensory afferents and prefrontal association areas, but also by the basal ganglia, specifically the striatum. The dorsomedial striatum (DMS) and dorsolateral striatum are involved in both spatial and stimulus-response learning; however, each of these areas may mediate differen...
Background
Epidemiological evidence indicates epilepsy is more common in patients with autism spectrum disorders (ASD) (20–25%) than in the general population. The aim of this project was to analyze seizure susceptibility in developing rats prenatally exposed to valproic acid (VPA) as autism model.
Methods
Pregnant females were injected with VPA d...
Raw data for seizure behavioral analysis.
Introduction:
Status epilepticus (SE) is an epileptic condition that can cause cerebellar atrophy and loss of Purkinje cells in both humans and research animals. Cerebellum is a region rich in γ-aminobutyric acid (GABA) and glutamate, and some studies have shown that their concentrations may be altered after convulsions. However, there are no stud...
Valproic acid (VPA) is an anti-epileptic drug with teratogenicity activity that has been related to autism. In rodents, exposure to VPA in utero leads to brain abnormalities similar than those reported in the autistic brain. Particularly, VPA reduces the number of Purkinje neurons in the rat cerebellum parallel to cerebellar abnormalities found in...
Unlabelled:
The prostate is an exocrine reproductive gland that participates in ejaculation and it is prone to diseases, including cancer.
Aim:
In the pre-sent study, we assessed the long-term effects of copulation on the development of precancerous lesions in rats, and compared them with testosterone-induced prostatic lesions.
Materials and me...
Introduction:
Cortical motor areas are influenced not only by peripheral sensory afferents and prefrontal association areas, but also by the basal ganglia, specifically the striatum. The dorsomedial striatum (DMS) and dorsolateral striatum are involved in both spatial and stimulus-response learning; however, each of these areas may mediate differe...
http://ebooks.uv.mx/product/neurofisiologa-de-la-conducta
El cerebro es el órgano más complejo e importante de cualquier ser vivo. Su funcionamiento adecuado nos permite sentir, desear, buscar, obtener y decidir entre lo que es biológicamente importante o no. Por lo tanto, el cerebro es el principal sensor e integrador de información externa (se p...
De acuerdo con la Organización Mundial de la Salud, cada año fallecen 3,4 millones de personas adultas por consecuencias del sobrepeso u obesidad. Personas con un índice de masa corporal superior a 30, presentan cierto aumento en la incidencia de algunas enfermedades entre las que se encuentran algunos tipos de cánceres. En esta revisión de tipo na...
Addiction involves alterations in multiple brain regions that are associated with functions such as memory, motivation and executive control. Indeed, it is now well accepted that addictive drugs produce long-lasting molecular and structural plasticity changes in corticostriatal-limbic loops. However, there are brain regions that might be relevant t...
According to the World Health Organization, every year about 3.4 million adults die of consequences related to overweight or obesity. People with a Body Mass Index above 30 are more likely to express certain diseases, including some types of cancer. In this narrative review, we assess the role of adipose tissue as a modulator of the endocrine syste...
p>A niveles fisiológicos altos, Prolactina (PRL) está envuelta en muchas funciones, incluidas la lactancia, reproducción y la conducta sexual. Por otro lado, los niveles anormales altos, condición conocida como Hiperprolactinemia (HP), están asociados con desórdenes sexuales como hipogonadismo, disfunción eréctil e infertilidad. Ratas macho con HP...
Evidence indicates that prolactin plays a crucial role in the normal function and development of the prostate, but abnormal high levels of the hormone are associated with hyperplasia and cancer of the gland.
The present study was designed to describe the progressive specific histological abnormalities in the prostate of rats with chronic hyperprola...
Recibido: 03 de febrero de 2015 Aceptado: 11 de marzo 2015 Puedes encontrar este artículo en: Resumen Entre las funciones fisiológicas clásicamente atribuidas al cerebelo se encuentra el control del movimiento, la postura y el equilibrio. Los estudios clínicos como los realizados en modelos animales, indican que el cerebelo también participa en la...
The bond between mother and offspring is a fundamental aspect of individual development. The mother is the one who provides care and seeks infant survival. The quality of such care will depend largely on the state of physical health and an environment with greater opportunity to meet basic needs and a low stress. This topic has been studied from ma...
Resumen Introducción: El ácido valproico (AVP) es un fármaco comúnmente empleado para el tratamiento de la epilepsia, las manías agudas y el trastorno bipolar. A partir de su uso como antiepiléptico se identificó que su empleo durante el embarazo puede producir malformaciones congénitas, el síndrome fetal del valproato y aumenta el riesgo de padece...
Full time group housing increase the incidence of unwanted behaviors and decrease the frequency of positive behaviors in animals. Feeding devices can enrich the environment of animals in captivity and improve their behavior. Herein, we evaluated the effect of a home-made feeding bottle-device, which delivers kibbles in response to the dog manipulat...
Resumen Este trabajo hace una revisión de diferentes estudios que han reportado la relación de la diabetes mellitus (DM) con la Enfermedad de Alzheimer (EA) y viceversa. En la última década, se ha incrementado el número de trabajos centrados en encontrar nuevas evidencias que muestren la relación entre la DM y la EA. La DM y la EA comparten muchas...
