Jorge Jovicich

Jorge Jovicich
Università degli Studi di Trento | UNITN · CIMeC - Center for Mind/Brain Sciences

Professor

About

187
Publications
29,460
Reads
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6,954
Citations
Introduction
Group website: http://r.unitn.it/en/cimec/mri With a background in physics my interest is in magnetic resonance imaging acquisition and analysis methods. I am interested in optimizing the quantitative information that can be extracted from human brains. Interests include: geometric accuracy, functional specificity, spatial/temporal resolution, reliability, information in temporal signal dynamics, evaluation of brain MRI biomarkers for neurodegenerative diseases (e.g., Alzheimer's disease).
Additional affiliations
January 2006 - March 2020
Università degli Studi di Trento
Position
  • Professor (Associate)
Description
  • Head of the MRI lab and the MRI Methods Group.
May 2002 - December 2005
Massachusetts General Hospital
Position
  • Research Assistant
Description
  • Scientific Project Manager and Co-Investigator of Morphometry BIRN project (http://www.birncommunity.org/).
May 2002 - December 2005
Harvard Medical School
Position
  • Instructor
Description
  • Scientific Project Manager and Co-investigator of Morphometry BIRN project (http://www.birncommunity.org/).
Education
September 1996 - January 1999
Max Planck Institute for Human Cognitive and Brain Sciences
Field of study
  • MRI Pulse Sequence Programming & Testing
September 1993 - September 1994
University of Aberdeen
Field of study
  • Medical Imaging
January 1987 - March 1993

Publications

Publications (187)
Article
Full-text available
Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not cle...
Article
Background: The use of concurrent EEG-fMRI recordings has increased in recent years, allowing new avenues of medical and cognitive neuroscience research; however, currently used setups present problems with data quality and reproducibility. New method: We propose a compact experimental setup for concurrent EEG-fMRI at 4T and compare it to a more...
Article
Full-text available
Sleep has been shown to subtly disrupt the spatial organization of functional connectivity networks in the brain, but in a way that largely preserves the connectivity within sensory cortices. Here we evaluated the hypothesis that sleeps does impact sensory cortices, but through alteration of activity dynamics. We therefore examined the impact of sl...
Article
Full-text available
We studied a group of verbal memory specialists to determine whether intensive oral text memory is associated with structural features of hippocampal and lateral-temporal regions implicated in language processing. Professional Vedic Sanskrit Pandits in India train from childhood for around 10 years in an ancient, formalized tradition of oral Sanskr...
Article
Full-text available
Understanding how to reduce the influence of physiological noise in resting state fMRI data is important for the interpretation of functional brain connectivity. Limited data is currently available to assess the performance of physiological noise correction techniques, in particular when evaluating longitudinal changes in the default mode network (...
Article
hMT+/V5 is a region in the middle occipito-temporal cortex that responds preferentially to visual motion in sighted people. In case of early visual deprivation, hMT+/V5 enhances its response to moving sounds. Whether hMT+/V5 contains information about motion directions and whether the functional enhancement observed in the blind is motion specific,...
Conference Paper
The Correlation Tensor MRI (CTI) framework has been recently formulated to disentangle anisotropic, isotropic, and microscopic kurtosis sources without a priori assumptions from Double-Diffusion-Encoding (DDE) data. In this work, group average maps (templates) are presented for the first time, thereby mapping the contrasts for anisotropic and isotr...
Article
Full-text available
The study of patients after glioma resection offers a unique opportunity to investigate brain reorganization. It is currently unknown how the whole-brain connectomic profile evolves longitudinally after surgical resection of a glioma and how this may be associated with tumor characteristics and cognitive outcome. In this longitudinal study, we inve...
Article
Full-text available
Diffusion MRI (dMRI) has become one of the most important imaging modalities for noninvasively probing tissue microstructure. Diffusional Kurtosis MRI (DKI) quantifies the degree of non-gaussian diffusion, which in turn has been shown to increase sensitivity towards, e.g., disease and orientation mapping in neural tissue. However, the specificity o...
Article
Full-text available
The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a...
Article
Full-text available
Proton beam therapy (PBT) is an effective pediatric brain tumor treatment. However, the resulting microstructural changes within and around irradiated tumors are unknown. We retrospectively applied diffusion tensor imaging (DTI) and free-water imaging (FWI) on diffusion-weighted magnetic resonance imaging (dMRI) data to monitor microstructural chan...
Article
Deep learning approaches for classification have the advantage of automatically learning the relevant features but require large amount of data for training. We test the efficacy of deep learning approach for prediction of risk factor for prodromal Alzheimer’s disease from whole brain MRI scans segmented into grey/white matter and CSF images. Longi...
Article
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence of beta-amyloid (Aβ42) and phosphorylated tau (P-tau) deposits in the brain, neurodegeneration in specific brain regions, and inflammation. This study aimed at investigating the association of periferal inflammatory signaling with brain structural al...
Preprint
Diffusion MRI (dMRI) has become one of the most important imaging modalities for noninvasively probing tissue microstructure. Diffusion Kurtosis MRI (DKI) quantifies the degree of non-gaussian diffusion, which in turn has been shown to increase sensitivity towards, e.g. , disease and orientation mappings in neural tissue. However, the specificity o...
Article
Background: Graph metrics of structural brain networks demonstrate to be a powerful tool for investigating brain topology at a large scale. However, the variability of the results related to applying different magnetic resonance acquisition schemes and tractography reconstruction techniques is not fully characterized. Methods: The present work a...
Preprint
Full-text available
hMT+/V5 is a region in the middle occipito-temporal cortex that responds preferentially to visual motion in sighted people. In case of early visual deprivation, hMT+/V5 enhances its response to moving sounds. Whether hMT+/V5 contains information about motion directions and whether the functional enhancement observed in the blind is motion specific,...
Article
Background: Previous studies reported default mode network (DMN) and limbic network (LIN) brain perfusion deficits in patients with amnestic mild cognitive impairment (aMCI), frequently a prodromal stage of Alzheimer's disease (AD). However, the validity of these measures as AD markers has not yet been tested using MRI arterial spin labeling (ASL)...
Article
Full-text available
Background: The mechanisms driving primary progressive and relapsing-remitting multiple sclerosis (PPMS/RRMS) phenotypes are unknown. Magnetic resonance imaging (MRI) studies support the involvement of gray matter (GM) in the degeneration, highlighting its damage as an early feature of both phenotypes. However, the role of GM microstructure is unc...
Conference Paper
Resolving the underlying sources of kurtosis in biological systems is emerging as a promising strategy for non-invasive quantitative characterization of tissue microstructure. Recently, a novel framework termed Correlation Tensor Imaging (CTI), based on double-diffusion-encoding MRI, was shown to disentangle anisotropic, isotropic, and microscopic...
Chapter
Whether gray matter (GM) regions are differentially vulnerable in Relapsing-Remitting and Primary Progressive Multiple Sclerosis (RRMS and PPMS) is still unknown. The objective of this study was to evaluate morphometric and microstructural properties based on structural and diffusion magnetic resonance imaging (dMRI) data in these MS phenotypes, an...
Preprint
Background Proton beam therapy (PBT) is an effective pediatric brain tumor treatment. However, resulting microstructural changes within and around irradiated tumors are unknown. We retrospectively applied Diffusion-Tensor-Imaging (DTI) and Free-Water-Imaging (FWI) on diffusion-weighted Magnetic Resonance Imaging (dMRI) data to monitor microstructur...
Article
Brain vascular damage accumulate in aging and often manifest as white matter hyperintensities (WMHs) on MRI. Despite increased interest in automated methods to segment WMHs, a gold standard has not been achieved and their longitudinal reproducibility has been poorly investigated. The aim of present work is to evaluate accuracy and reproducibility o...
Article
Background Patterns of coordinated variations of gray matter (GM) morphology across individuals are promising indicators of disease. However, it remains unclear if they can help characterize first-episode psychosis (FEP) and symptoms’ severity. Methods Sixty-seven FEP and 67 matched healthy controls (HC) were assessed with structural MRI to evalua...
Article
Full-text available
Center for Mind/Brain Sciences, University of Trento, Rovereto, 38068, Italy, and 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 01129 In humans, the occipital middle-temporal region (hMT1/V5) specializes in the processing of visual motion, while the planum te...
Article
Full-text available
Accurate and reproducible automated segmentation of human hippocampal subfields is of interest to study their roles in cognitive functions and disease processes. Multispectral structural MRI methods have been proposed to improve automated hippocampal subfield segmentation accuracy, but the reproducibility in a multicentric setting is, to date, not...
Article
Having ways to quickly assess cognitive impairment is critical for developing nations. Here we examine how different combinations of neuropsychiatric tests identify cognitive impairment using the Longitudinal Aging Study in India ‐ Diagnostic Assessment of Dementia (LASI‐DAD). We then investigate for brain regions that show structural morphological...
Article
Increasing evidence suggests that neurodegeneration of the locus coeruleus (LC) is an early pathological feature of Alzheimer’s Disease (AD). However, assessment of the LC in‐vivo is hampered by its small size. Here we test the feasibility of characterizing LC’s integrity in‐vivo using ultra‐high field MRI. Eight young controls (age: 23+3y, educati...
Poster
The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behaviour but their small size hampers their manual segmentation in multicenter datasets. Here, we assessed the reliability of the automated segmentation of amygdalar nuclei and hippocampal subfields across sites and vendors. We applied a new high‐...
Article
Age‐related cognitive decline is widely documented, but with substantial individual differences that are not yet understood (Vaque‐Alcazar et al., 2017). Using the recently collected neuroimaging data from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI‐DAD), we investigate the associations between cognitive fu...
Article
Significance Learning predefined sequences of actions is of everyday importance. Recent evidence suggests that improvements in performance associated with learning a motor sequence take place during the quiet rest periods interleaved with practice. This phenomenon known as micro-offline gains (MOGs) is different from offline gains in performance ob...
Conference Paper
In Double-Diffusion-Encoding sequences, concomitant gradients may introduce spatial bias in the measured MRI signal. It is important to characterize such biases since they can affect the accuracy of quantitative microstructural metrics in brain studies. In this work, we assess the signal deviations at different positions along the scanner z-axis in...
Article
Full-text available
Abstract The Harmonized Diagnostic Assessment of Dementia for Longitudinal Aging Study in India (LASI-DAD) is a population-representative, prospective cohort study of late-life cognition and dementia. It is part of an ongoing international research collaboration that aims to measure and understand cognitive impairment and dementia risk by collectin...
Article
Full-text available
Anxiety is a mental state characterized by an intense sense of tension, worry or apprehension, relative to something adverse that might happen in the future. Researchers differentiate aspects of anxiety into state and trait, respectively defined as a more transient reaction to an adverse situation, and as a more stable personality attribute in expe...
Preprint
Full-text available
In humans, the occipital middle-temporal region (hMT+/V5) specializes in the processing of visual motion, while the Planum Temporale (hPT) specializes in auditory motion processing. It has been hypothesized that these regions might communicate directly to achieve fast and optimal exchange of multisensory motion information. In this study, we invest...
Article
Full-text available
Background The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behavior, however their manual segmentation and that of their smaller nuclei/subfields in multicenter datasets is time consuming and difficult due to the low contrast of standard MRI. Here, we assessed the reliability of the automated se...
Article
Full-text available
Background: Fractional anisotropy (FA) and mean diffusivity (MD) are frequently used to evaluate longitudinal changes in white matter (WM) microstructure. Recently, there has been a growing interest in identifying experience-dependent plasticity in gray matter using MD. Improving registration has thus become a major goal to enhance the detection o...
Article
Amyloid and tau pathological accumulation should be considered for Alzheimer's disease (AD) definition and before subjects' enrollment in disease-modifying trials. Although age, APOEε4, and sex influence cerebrospinal fluid (CSF) biomarker levels, none of these variables are considered by current normality/abnormality cutoffs. Using baseline CSF da...
Conference Paper
Full-text available
Psychosis is a disorder that causes partial loss of contact with external reality in daily activities1. Neuroimaging studies have shown grey matter (GM) modifications associated with early manifestations of psychosis2. This motivates the study of neuroimaging markers that may be used as complementary clinical information for more precise differenti...
Conference Paper
Full-text available
Deafness is usually accompanied by functional brain alterations that may be thought as an alteration to connectome scaffolding1,2,3. The general goal of this study was to investigate brain structural network organization in early and profoundly deaf subjects (ED). The specific goal was to apply the structural white matter connectome formalism to ev...
Article
Full-text available
In this study we investigate the neural basis of emotional content in self-referential processing by using a combination of off-line repetitive Transcranial Magnetic Stimulation (rTMS) applied to the medial prefrontal cortex (mPFC) and whole-brain functional Magnetic Resonance Imaging (fMRI).We applied effective or ineffective (sham) 1-Hz rTMS to t...
Conference Paper
Full-text available
Synopsis In case of early acquired deafness, auditory deprived temporal regions massively enhance their response to stimuli from remaining senses. This so called cross-modal plasticity also alters functional connectivity between reorganized temporal regions and those from preserved senses. The extent and distribution of white matter structural alte...
Article
Full-text available
The quench of a human magnetic resonance imaging system is a critical event that may occur spontaneously, as an accident or purposely in response to an emergency. Although a magnet’s quench presents its own risks, little experimental data is available in this respect. In this study, the programmed quench of a human MRI scanner was used to measure t...
Article
Background: Assessment of human brain atrophy in temporal regions using magnetic resonance imaging (MRI), resting state functional MRI connectivity in the left parietal cortex, and limbic electroencephalographic (rsEEG) rhythms as well as plasma amyloid peptide 42 (Aβ42) has shown that each is a promising biomarker of disease progression in amnest...
Article
Antipsychotic treatment may affect brain morphology, and enlargement of the basal ganglia (BG) is a replicated finding. Here we investigated associations between antipsychotic treatment and BG volumes in patients with psychotic and bipolar disorders. We hypothesized that current treatment and, among those medicated, higher dosage, estimated D2R occ...
Preprint
Full-text available
Background Fractional anisotropy ( FA ) and mean diffusivity ( MD ) are frequently used to evaluate longitudinal changes in white matter microstructure. Recently, there has been a growing interest in identifying experience-dependent plasticity in gray matter using MD . Improving registration has thus become a major goal to enhance the detection of...
Article
Full-text available
Diffusion MRI tractography allows in-vivo characterization of white matter architecture, including the localization and description of brain fibre bundles. However, some primary bundles are still only partially reconstructed, or not reconstructed at all. The acoustic radiation (AR) represents a primary sensory pathway that has been largely omitted...
Article
Full-text available
Introduction: Molecular, functional, and structural neuroimaging biomarkers are largely used to study neurodegenerative diseases, but their benefits to patients/science might be greatly enhanced by improving standardization and cross-validation. In this EU Joint Programme-Neurodegenerative Diseases Research-funded project, we surveyed the neuroima...
Article
Full-text available
The auditory system of mammals is dedicated to encoding, elaborating and transporting acoustic information from the auditory nerve to the auditory cortex. The acoustic radiation (AR) constitutes the thalamo-cortical projection of this system, conveying the auditory signals from the medial geniculate nucleus (MGN) of the thalamus to the transverse t...
Article
Full-text available
The semantic variant of primary progressive aphasia (svPPA) is a clinical syndrome characterized by semantic memory deficits with relatively preserved motor speech, syntax, and phonology. There is consistent evidence linking focal neurodegeneration of the anterior temporal lobes (ATL) to the semantic deficits observed in svPPA. Less is known about...
Article
Introduction The Italian AD-NET project is a multicentric initiative focused on the early recognition of Alzheimer’s Disease integrating clinical, imaging, and molecular data. This preliminary study reports test-retest reproducibility of hippocampus and its subfields segmentation, using the FreeSurfer 6.0 longitudinal processing with FLAIR alone an...
Article
Full-text available
Auditory "oddball" event-related potentials (aoERPs), resting state functional magnetic resonance imaging (rsfMRI) connectivity, and electroencephalographic (rsEEG) rhythms were tested as longitudinal functional biomarkers of prodromal Alzheimer's disease (AD). Data were collected at baseline and four follow-ups at 6, 12, 18, and 24 months in amnes...
Article
Full-text available
OBJECTIVE Resting-state functional MRI (rs-fMRI) represents a promising and cost-effective alternative to task-based fMRI for presurgical mapping. However, the lack of clinically streamlined and reliable rs-fMRI analysis tools has prevented wide adoption of this technique. In this work, the authors introduce an rs-fMRI processing pipeline (ReStNeuM...
Article
Full-text available
Production of fluent speech in humans is based on a precise and coordinated articulation of sounds. A speech articulation network (SAN) has been observed in multiple brain studies typically using either neuroimaging or direct electrical stimulation (DES), thus giving limited knowledge about the whole brain structural and functional organization of...