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Working with hiPSCs to study the pathology of Parkinson's disease. Special intrest in glial cells in relation to neurons, utilising co-culture techniques, single-cell sequencing and qPCR to name but a few methods applied.
April 2019 - January 2021
- EDCMET is an Horizon2020 funded project where I was optimizing and validating dual luciferase reporter gene assays. The goal was to create a tool that enables the screening of putative endocrine disrupting chemicals for regulatory purposes.
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and a major concern in drug development. Altered bile acid homeostasis via inhibition of the bile salt export pump (BSEP) is one mechanism of DILI. Dasatinib, pazopanib and sorafenib are tyrosine kinase inhibitors (TKIs) that competitively inhibit BSEP and increase serum b...
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism's somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been twofold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly i...
During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug-and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules. Recent studies indicate that CAR participates, together with other nuclear receptors (NRs) and trans...
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty li...