Jonna Niskanen

Jonna Niskanen
University of Eastern Finland | UEF · A.I. Virtanen Institute for Molecular Sciences

Master of Science

About

4
Publications
801
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27
Citations
Introduction
Working with hiPSCs to study the pathology of Parkinson's disease. Special intrest in glial cells in relation to neurons, utilising co-culture techniques, single-cell sequencing and qPCR to name but a few methods applied.
Additional affiliations
April 2019 - January 2021
University of Eastern Finland
Position
  • Researcher
Description
  • EDCMET is an Horizon2020 funded project where I was optimizing and validating dual luciferase reporter gene assays. The goal was to create a tool that enables the screening of putative endocrine disrupting chemicals for regulatory purposes.
Education
September 2017 - June 2019
University of Eastern Finland
Field of study
  • Molecular medicine
September 2013 - May 2016
University of Eastern Finland
Field of study
  • Biomedicine

Publications

Publications (4)
Article
Full-text available
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and a major concern in drug development. Altered bile acid homeostasis via inhibition of the bile salt export pump (BSEP) is one mechanism of DILI. Dasatinib, pazopanib and sorafenib are tyrosine kinase inhibitors (TKIs) that competitively inhibit BSEP and increase serum b...
Article
Full-text available
Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism's somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been twofold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly i...
Article
Full-text available
During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug-and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules. Recent studies indicate that CAR participates, together with other nuclear receptors (NRs) and trans...
Article
Full-text available
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty li...

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Projects

Project (1)
Project